ライフサイエンスコーパス: translational control

1 s triggered, representing a new form of post-translational control.

2 vestigated whether Unr has a general role in translational control.

3 ting posttranscriptional gene expression and translational control.

4 e, as both proteins are implicated in direct translational control.

5 ponse to diverse signals is a major point of translational control.

6 A decay in plant development and its role in translational control.

7 on rate would transform our understanding of translational control.

8 st protein may provide a novel means of post-translational control.

9 ulation of eIF2alpha phosphorylation and the translational control.

10 tylation as an important facet of eukaryotic translational control.

11 he rpoS mRNA to enable sRNA base pairing and translational control.

12 edominately in cytoplasm, where it regulates translational control.

13 ing the ribosome, suggesting a novel form of translational control.

14 eading to activation of this eIF2 kinase and translational control.

15 rapid developmental switch in the nature of translational control.

16 diated accumulation of hnRNP K resulted from translational control.

17 eotide biology including transcriptional and translational control.

18 echanism linking the cell cycle machinery to translational control.

19 anslation or removal of elements involved in translational control.

20 encoded mitochondrial genes are under strong translational control.

21 tle is known about the mechanisms underlying translational control.

22 he study of 5'-UTR RNA G-quadruplex-mediated translational control.

23 by an unanticipated, ISG15-dependent loss of translational control.

24 tic cap-dependent translation initiation and translational control.

25 le germline stem cell lineage is mediated by translational control.

26 entire cell complement of L13a and defective translational control.

27 NA regulatory processes such as splicing and translational control.

28 f the ribosome to confer transcript-specific translational control.

29 ory BC RNAs employ a two-pronged approach in translational control.

30 g as a molecular mechanism of mTOR-regulated translational control.

31 NAs lacking the ADC-box, thus bypassing this translational control.

32 gher affinity of eIF2alphaP for eIF2B drives translational control.

33 nscriptional, post-transcriptional, and post-translational control.

34 entiation, little is known about the role of translational control.

35 ulated genes and shown to be responsible for translational control.

36 nk of a SZ risk gene to neurodevelopment and translational control.

37 paralog specificity defines a novel means of translational control.

38 non-coding RNA (ncRNA) involved in neuronal translational control.

39 mRNA decay that has also been implicated in translational control.

40 cell birth, to identify mRNAs under periodic translational control.

41 repeat kinase 2 (LRRK2) to abnormalities of translational control, a pathogenic mechanism implicated

42 OLA1 thus represents a novel mechanism of translational control affecting de novo TC formation, di

43 We are just beginning to understand how translational control affects tumour initiation and mali

44 ressible 2 (GCN2) protein kinase facilitated translational control and differentiation-specific prote

45 yotic initiation factor-2 (eIF2) function in translational control and drive differentiation.

46 provide evidence of a mechanism that couples translational control and energy metabolism, two process

47 We investigated a role for PknK in translational control and established that PknK directs

48 a multifaceted signaling system coordinating translational control and gene transcription to promote

49 work provides more appropriate estimates of translational control and implies that TRmIND is under d

50 ignaling pathway has multiple layers of post-translational control and is a determinant of chronic in

51 Translational control and messenger RNA (mRNA) decay rep

52 e-associated proteins implicated in neuronal translational control and microRNA function.

53 Our results highlight the importance of translational control and mRNA decay pathways for the su

54 This is a key step in translational control and must be tightly regulated; how

55 Translation initiation is a focal point of translational control and requires the binding of eIF4E

56 tions towards regulating multiple aspects of translational control and ribosome biogenesis.

57 Here, we explore the mechanism of translational control and show that there is extensive c

58 ed expression in ET platelets, putatively by translational control (and not by mRNA target degradatio

59 ADD34 uORF affect the status of eIF2alpha-P, translational control, and cell adaptation to stress.

60 vided novel insights into ATF4 and GCN4 mRNA translational control, and demonstrated co-translational

61 rrectly elucidated many important aspects of translational control, and I thought readers would be in

62 bly and disassembly is a structural basis of translational control, and its disorder is implicated in

63 The epitranscriptome, translational control, and protein degradation have emer

64 Thus translational control appears as an important component

65 ly, it was unclear how the global effects of translational control are orchestrated by nutrient signa

66 Because such UTRs can be involved in translational control as well as in mRNA stability, we c

67 ead role of short upstream reading frames in translational control as well as slower elongation at th

68 Intriguingly, oscillations are not linked to translational control, as no differences were observed i

69 senger RNA have begun to uncover genome-wide translational control at codon resolution.

70 y, here shown for messenger ribonucleic acid translational control at the CYB561 step of transmitter

71 alpha at a conserved serine residue mediates translational control at the ISR core.

72 on of gene expression occurs in part through translational control at the synapse.

73 Post-translational control based on an environmentally sensit

74 Select 5' untranslated regions exert robust translational control between cell lines, while 3' untra

75 mechanism for this change was independent of translational control but dependent on inflammatory DCs,

76 lpha~P/ATF4 pathway is required not only for translational control, but also for activation of ATF6 a

77 karyotic initiation factor 2 (eIF2)-mediated translational control, but its physiological functions r

78 uced SGs and protein kinase R (PKR)-mediated translational control, but the mechanism of PKR interpla

79 Thus, translational control by 4E-BP1 downstream of mTOR effec

80 an unanticipated regulatory network linking translational control by and repression of a structural

81 Previously, we identified that translational control by eIF2alpha phosphorylation (p-eI

82 he dimeric form of murine CTD led to loss of translational control by GCN2, suggesting that dimerizat

83 Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synapti

84 We reveal that translational control by phosphorylation of the translat

85 unctionally mimics other mechanisms, such as translational control by PKR-like ER kinase (PERK) and r

86 UnSET) and DiOlistic labeling we found that, translational control by the eukaryotic translation init

87 Thus, translational control by the heterotrimeric GAIT complex

88 ults illustrate how eIF2 approximately P and translational control combined with transcription factor

89 ance of a mutation in CELA3B and a defect in translational control contributing to this disease.

90 This translational control culminates in reprogramming of the

91 ed at the translational level and found that translational control determines early changes in gene e

92 Translational control during cell division determines wh

93 The degree and dynamics of translational control during mammalian development remai

94 important role in maintaining mTOR-dependent translational control during the biological responses of

95 However, translational control during UPR has not been demonstrat

96 bosomal protein eS7A plays a crucial role in translational controls during the ER stress response in

97 nvestigated ribosome ubiquitination-mediated translational controls during UPR.

98 A translational control element (TCE) within the KLF4 3'-u

99 sertions before this secondary structure, or translational control element (TCE), that provide the 15

100 somes and suggest the presence of unexplored translational controls embedded in the polysome structur

101 The results suggest that translational control exerted by IL-1 and IL-17 plays an

102 Initiation is the primary target of translational control for all organisms.

103 components, ribosomal RNAs and proteins, in translational control has begun to emerge.

104 and mechanisms of cobalamin selectivity and translational control have remained unsolved.

105 Thus, with respect to mTOR's role in translational control, HCMV depends on it early in infec

106 We also examine mechanisms of translational control highlighting the mRNA cap-binding

107 dynamic range of transcript-isoform-specific translational control, identify isoform-specific sequenc

108 lts identify a direct role for eIF3-mediated translational control in a specific human disease.

109 Recent applications of translational control in Arabidopsis (Arabidopsis thalia

110 ce has now demonstrated a role for localized translational control in axon guidance decisions in vivo

111 in human keratinocytes and the importance of translational control in cell survival.

112 Recent studies highlight the importance of translational control in determining protein abundance,

113 cap-dependent initiation, a primary point of translational control in eukaryotic cells.

114 The contribution of 4E-BP2-dependent translational control in excitatory and inhibitory neuro

115 However, the role of specific nodes of translational control in extinction is unknown.

116 Our findings show the central importance of translational control in fibrosis and highlight novel pa

117 Understanding translational control in gene expression relies on preci

118 This work reveals pervasive translational control in meiosis and helps to illuminate

119 C/EBPbeta protein expression is under eIF4E-translational control in MM.

120 in mRNA biogenesis, stability, transport and translational control in most eukaryotic cells.

121 ay pivotal roles in mRNA transport and local translational control in neuronal processes.

122 ever, the fundamentals of stimulus-modulated translational control in neurons remain poorly understoo

123 These findings highlight the importance of translational control in regulating AdipoR1 protein expr

124 Although eIF2 approximately P elicits translational control in response to many different stre

125 cuss the key regulatory pathways that govern translational control in response to synaptic activity a

126 icular focus on their consequent specialized translational control in stem cells and development.

127 dings thus reveal critical roles for dynamic translational control in supporting specialized mammalia

128 thms, revealing a new and important role for translational control in the Drosophila circadian clock.

129 on for GCN2 phosphorylation of eIF2alpha and translational control in the formation of an intact huma

130 ion are critical for directing gene-specific translational control in the integrated stress response.

131 ighlight a critical role for light-regulated translational control in the physiology of the circadian

132 r findings underscore the importance of post-translational controls in epidermal cell differentiation

133 mine the role of another form of regulation, translational control, in the repeated evolution of self

134 Complex 1 (mTORC1) signaling is crucial for translational control involved in long-term memory and i

135 We recently demonstrated that this translational control involves a stress-specific reprogr

136 Translational control is a widespread mechanism that all

137 Translational control is crucial in the regulation of ge

138 Translational control is emerging as an important factor

139 Our study provides an example of how translational control is integrated with transcriptional

140 e protein that binds to the TCS and mediates translational control is not known.

141 Message-specific translational control is required for gametogenesis.

142 One powerful tool to study translational control is ribosome profiling, which is ba

143 obility and is subject to autorepression and translational control, is also regulated posttranslation

144 rotein Arpc5 sets the stage for an elaborate translational control mechanism by facilitating the sequ

145 The translational control mechanism identified is interprete

146 but also uncovers a previously unappreciated translational control mechanism in heat shock response.

147 xpression levels and cellular physiology, no translational control mechanism is known that links codo

148 An important translational control mechanism is the Ca(2+)/calmodulin

149 Herein, we describe allomorphy, a post-translational control mechanism of enzyme activity.

150 Here we report the discovery of a step-wise translational control mechanism responsible for survival

151 mRNA levels was noted, we identified a novel translational control mechanism stimulated by oxidative

152 Here, we demonstrate a novel translational control mechanism that responds to the spe

153 Thus, we have identified a translational control mechanism that selectively underli

154 gically relevant ER stress-mediated adaptive translational control mechanism.

155 ception to the activation of a gene-specific translational control mechanism.

156 Although translational control mechanisms are fundamental mediato

157 Understanding SSAT translational control mechanisms has the potential for t

158 endous insight they provide into fundamental translational control mechanisms in health and disease.

159 a combination of selective RNA retention and translational control mechanisms instills nanos accumula

160 characterized extensively, and more recently translational control mechanisms that may underlie its c

161 , and suggest that mRNA-specific and general translational control mechanisms work in tandem to regul

162 participate in transcription attenuation and translational control mechanisms, respectively.

163 endent translation and is the main target of translational control mechanisms.

164 n be a previously unappreciated substrate of translational control mediated by RBPs.

165 Posttranscriptional and translational controls mediated by microRNAs (miRNA) reg

166 BC RNA translational control, mediated via eIF4B phosphorylatio

167 f S6K1 prevented elevated phosphorylation of translational control molecules, exaggerated protein syn

168 Translational control most commonly targets the initiati

169 us of known mTOR-target proteins involved in translational control, namely ribosomal protein S6 (rS6)

170 rotein response (UPR), a transcriptional and translational control network designed to restore protei

171 Furthermore, loss of GCN2 thwarted translational control, normal epidermal differentiation,

172 translation are tightly coupled, with overt translational control occurring for less than 10% of the

173 inhibitor of translation (GAIT) complex for translational control of a subset of inflammation-relate

174 examine the influence of cholesterol in post-translational control of ABCA1 and ABCG1 protein express

175 nce for a rapid, cholesterol-dependent, post-translational control of ABCA1 and ABCG1 protein levels,

176 stream open reading frame (uORF) confers the translational control of ACC1 and adjusts Acc1p protein

177 eIF6 acts by exerting translational control of adipogenic transcription factor

178 corticoids involving the transcriptional and translational control of an important immune checkpoint.

179 In Arabidopsis, the translational control of auxin response factors (ARFs) b

180 We show extensive translational control of cardiac gene expression, which

181 consequential reprogramming of ribosomes in translational control of cell survival.

182 a roadmap for future research into the post-translational control of cholesterol synthesis, and no d

183 iscuss applications of Acr proteins for post-translational control of CRISPR-Cas systems in prokaryot

184 pathway, while exerting inhibitory effect on translational control of cytokines and chemokines.

185 previously identified specific modes of post-translational control of DHCR7, but it is unknown whethe

186 gs establish an obligatory role for upstream translational control of downstream Snail1-mediated tran

187 Restoring translational control of eIF2alpha holds the promise to

188 Hypusine-dependent translational control of essential proteins (hubs) and p

189 ecutioner caspase 3' UTRs in many metazoans, translational control of executioner caspases by RBPs mi

190 est that mitochondrial GCN5L1 modulates post-translational control of FoxO1, regulates gluconeogenesi

191 d, a detailed molecular mechanism regulating translational control of gene expression by 4EBP-1 is no

192 Translational control of gene expression contributes to

193 , these results reveal mechanisms underlying translational control of gene expression during stress.

194 Translational control of gene expression has recently be

195 age response, consistent with a role for the translational control of gene expression in cellular rad

196 The extent of translational control of gene expression in mammalian ti

197 yet we know little about the role played by translational control of gene expression in mediating th

198 More specifically, they suggest that the translational control of gene expression may provide a s

199 Translational control of gene expression plays a key rol

200 Antigen-specific T cells exerted dynamic translational control of gene expression that correlated

201 The extensive nature of this shift in translational control of gene expression was revealed us

202 response to radiation occurs at the level of translational control of gene expression.

203 critical role of early elongation events in translational control of gene expression.

204 on phase of protein synthesis is crucial for translational control of gene expression; however, in co

205 GLD4-mediated translational control of GLUT1 mRNA is dependent of an R

206 ional link between heme content and the post-translational control of GluTR stability, which helps to

207 nitrosation, providing insight into the post-translational control of GSTP1-1 as well as the process

208 m whereby O-GlcNAcylation of 4E-BP1 mediates translational control of hepatic gene expression.

209 ranslation in vivo and provide evidence that translational control of HIF2alpha expression dominates

210 Thus, our findings identify the role of translational control of hnRNP K in morphine-induced ana

211 been associated with the transcript-specific translational control of inflammatory proteins and activ

212 Due to post-translational control of its activation and high express

213 ndings unveil the previously unreported post-translational control of LGR receptors via NEDD4/NEDD4L

214 Translational control of long-term synaptic plasticity v

215 major noncanonical function of EPRS, namely translational control of macrophage inflammatory gene ex

216 ts suggest an important role for ERK2 in the translational control of MBP, a myelin protein that appe

217 Translational control of mRNAs in dendrites is essential

218 her identified unappreciated coordination in translational control of mRNAs within molecular complexe

219 of interleukin-10 which was under the direct translational control of mTOR.

220 and COX-2 occurs via PI3K- and Akt-dependent translational control of mTORC1 and PI3K-dependent, Akt-

221 e rules for both global RNA surveillance and translational control of nascent RNA.

222 The translational control of oncoprotein expression is impli

223 he potential role of this interaction in the translational control of p53 after stress.

224 work demonstrates the importance of eIF4A in translational control of pancreatic tumour metabolism an

225 Post-translational control of PERIOD stability by Casein Kina

226 Hardly anything is known about translational control of plant mitochondrial gene expres

227 ritical factors and molecular mechanisms for translational control of profibrotic genes during cardia

228 horylation is an important mechanism of post-translational control of protein kinases.

229 Our results uncover pervasive translational control of protein synthesis, with widespr

230 to any organism, these results suggest that translational control of stress response involves a cont

231 h to create orthogonal ON-switches, enabling translational control of target gene expression in respo

232 R-dependent long-term synaptic depression or translational control of target mRNAs of fragile X menta

233 We propose that global translational control of the host by eIF4E phosphorylati

234 ucial regulator of HSC function via its post-translational control of the oncoprotein N-myc (encoded

235 ally characterize three methods for the post-translational control of the PB transposon in four cell

236 ential link between alternative splicing and translational control of the resultant mRNA isoforms.

237 Post-translational control of these enzymes provides a rapid

238 e metabolism in Toxoplasma and that the post-translational control of this pathway is required for no

239 Translational control of transcription factor ATF4 throu

240 We uncovered translational control of transcripts encoding enzymes of

241 ocytes may be determined by the differential translational control of two Cyclins.

242 ysine acetylation is a key mechanism of post-translational control of various transcription factors,

243 The improved translational control offered by these designed MCSs is

244 nstrate that inclusion of uORFsTBF1-mediated translational control over the production of snc1-1 (an

245 elucidate a novel developmentally regulated translational control pathway that establishes the meiot

246 s advance our knowledge on dystonia, linking translational control pathways and calcium physiology to

247 iruses have evolved to infiltrate and hijack translational control pathways as well as to integrate s

248 ered dysregulation of eiF2alpha and Akt/mTOR translational control pathways in the DYT1 brain, a find

249 a hitherto uncharacterized link between two translational control pathways that regulate selenocyste

250 l ER protein processing and dysregulation of translational control pathways.

251 Translational control permits cells to respond swiftly t

252 S6 kinase 1 (S6K1) signaling is critical for translational control, pharmacological manipulation in v

253 Translational control plays a central role in regulation

254 ng of gene expression; additionally, precise translational control plays a critical role in many cell

255 Translational control plays a key role in regulation of

256 Translational control plays a pivotal role in the regula

257 Translational control plays a vital role in regulating g

258 eprogramming, highlighting the key role that translational control plays in regulating this process.

259 ranslation initiation factor eIF2 is a major translational control point.

260 ribe recent advances in our understanding of translational control principles; nutrient-sensing mecha

261 dentified two p53 IRES trans-acting factors, translational control protein 80 (TCP80), and RNA helica

262 otein synthesis, deficits in agonist-induced translational control, protein synthesis-independent LTD

263 that manipulation of common pathways such as translational control, rather than disease-specific appr

264 Inhibition of eIF2-P and translational control reduced viability following UVB th

265 our findings suggest that eIF2alpha-mediated translational control regulates the progression from tra

266 The magnitude of translational control relates directly to the affinity o

267 tion changes are part of a coordinated early translational control response shared across environment

268 nal transduction pathways indirectly through translational control responses.

269 lecular mechanism underlying ASDs is altered translational control resulting in exaggerated protein s

270 To explore the contribution of translational control, RNA-seq and ribosome profiling we

271 nding to different stress arrangements, this translational control scheme is referred to as the integ

272 The Translational Control Sequence (TCS) in the 3' untransla

273 t eIF2Bgamma mutations known to disrupt GCN4 translational control significantly impair GDF activity

274 bosomal proteins are themselves subjected to translational control, suggesting a means of reinforcing

275 y in FXS reduces sAPPalpha levels, restoring translational control, synaptic morphology, and behavior

276 We describe a translational control system to dynamically adjust light

277 pathways, microRNA networks and RNA-protein translational control systems.

278 Translational control targeting the initiation phase is

279 an eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis an

280 key features of uORFs that serve to optimize translational control that is essential for regulation o

281 Here we show that to quantitate translational control, the translation rate must be deco

282 Thus, translational control through 4E-BP2 represents a unique

283 Here we demonstrate that translational control through eIF2alpha phosphorylation

284 Translational control through programmed ribosomal frame

285 We further show that Ime2 mediates translational control through the meiosis-specific RNA-b

286 Altogether, this work reveals a new layer of translational control to major signalling components and

287 have focused largely on targets upstream of translational control to normalize FXS-related phenotype

288 rapeutic potential of targeting dysregulated translational control to treat cognitive disorders of sy

289 numerous aspects of posttranscriptional and translational control under both growth conditions.

290 cing as a previously uncharacterized mode of translational control under hypoxia and are supported by

291 These results show that translational control underlies ART-induced latency and

292 l translation during learning and that local translational control varies with synapse type.SIGNIFICA

293 protein translation by integrating synthetic translational control via a small-molecule-regulated RNA

294 We also discuss translational control via phosphorylation of eukaryotic

295 To provide insight into the mechanism of translational control we have determined the structures

296 inases have been implicated in cap-dependent translational control, we find that in the context of AK

297 ion than did cell origin, and differences in translational control were more prominent than alteratio

298 adult mice with reduced p-eIF2alpha-mediated translational control were more susceptible to cocaine-i

299 ulators, each subject to transcriptional and translational control, which can switch cell fate toward

300 r, selectively inhibiting eIF2alpha-mediated translational control with a small molecule ISRIB, or kn