ライフサイエンスコーパス: translational efficiency

1 yme expression in Greyhounds through reduced translational efficiency.

2 t RNA dimerization, also strongly influenced translational efficiency.

3 llular processes, regulate mRNA stability or translational efficiency.

4 tein (PABP) to achieve maximal IRES-mediated translational efficiency.

5 expression by influencing mRNA stability and translational efficiency.

6 known about the effects of radiation on gene translational efficiency.

7 heses that invoke constraints on function or translational efficiency.

8 broblasts that also binds mRNA and regulates translational efficiency.

9 tailed mRNAs, regulating their stability and translational efficiency.

10 is important in messenger RNA stability and translational efficiency.

11 considerably weaker than the enhancement of translational efficiency.

12 stem-loop structure drastically reduced the translational efficiency.

13 m messages by influencing mRNA stability and translational efficiency.

14 binding to ribosomes, and their influence on translational efficiency.

15 in exponential phase and increased rpoS mRNA translational efficiency.

16 nduction by regulating message stability and translational efficiency.

17 binding to alpha-MHC mRNA and attenuate its translational efficiency.

18 ic extracts revealed striking differences in translational efficiency.

19 ween m(6)A methylation and mRNA stability or translational efficiency.

20 egulation of MMP-9 synthesis at the level of translational efficiency.

21 at the loss of activity was due to decreased translational efficiency.

22 suggesting that polyadenylation may enhance translational efficiency.

23 rodent genes with a selective advantage for translational efficiency.

24 nes have higher codon usage bias to maximize translational efficiency.

25 criptional control of mRNA stability or mRNA translational efficiency.

26 poly(A) tail to increase synergistically the translational efficiency.

27 ated in the regulation of mRNA stability and translational efficiency.

28 s likely due to factors other than increased translational efficiency.

29 region and exhibit a significantly enhanced translational efficiency.

30 a protein kinase involved in the control of translational efficiency.

31 coding sequences have been shown to increase translational efficiency.

32 R) can alter RNA localization, stability and translational efficiency.

33 s with distinct localization, stability, and translational efficiency.

34 termined by ribosome profiling, but not with translational efficiency.

35 and this effect is mediated by a decrease in translational efficiency.

36 of the effects of tRNA charging dynamics on translational efficiency.

37 acids in the growing DnaA nascent chain tune translational efficiency.

38 region of the Rictor transcript and enhance translational efficiency.

39 regions (3'UTRs) to impact RNA stability and translational efficiency.

40 mes with the messenger RNA determine protein translational efficiency.

41 hat this effect is mediated by a decrease in translational efficiency.

42 ectrum of genetic mutations and reduced mRNA translational efficiency.

43 nd provide evidence that avoidance increases translational efficiency.

44 let-7 miRNA biogenesis or modulation of mRNA translational efficiency.

45 tory roles in modulating mRNA degradation or translational efficiency.

46 dance, fatality rates, codon adaptation, and translational efficiency.

47 ermine GRN expression via mRNA stability and translational efficiency.

48 actors that control transcript longevity and translational efficiency.

49 bias of the kaiBC genes is not optimized for translational efficiency.

50 phenotypes and the idea that i6A37 promotes translational efficiency.

51 s let-7 binding was mainly required for full translational efficiency.

52 ly codon bias, has a key role in determining translational efficiency.

53 eved through control of both mRNA levels and translational efficiency.

54 nges in mRNA expression than with changes in translational efficiency.

55 ase reporter assays significantly alter mRNA translational efficiency.

56 atory signals determining mRNA stability and translational efficiency.

57 critical determinant of their stability and translational efficiency.

58 ream open reading frames, suggesting varying translational efficiencies.

59 that are responsible for modulation of mRNA translational efficiencies.

60 is was used to generate mutants with altered translational efficiencies.

61 iffering contributions of mRNA abundance and translational efficiencies.

62 ction with glycine codon-specific defects in translational efficiencies.

63 of miRNAs on tail lengths, mRNA levels, and translational efficiencies.

64 same cell can exhibit dramatically different translational efficiencies.

65 f transcript-specific ribosome densities and translational efficiencies.

66 -wide and protein length-dependent change in translational efficiency, altering the stoichiometric tr

67 A significant difference in translational efficiency among these 5'-UTRs variants wa

68 plimentary to existing methods that focus on translational efficiency analysis.

69 better understand this control, we profiled translational efficiencies and poly(A)-tail lengths thro

70 of isoaccepting tRNAs, results in increased translational efficiency and accuracy.

71 of isoaccepting tRNA, resulting in increased translational efficiency and accuracy.

72 s indicating the dual selection pressures of translational efficiency and accuracy.

73 ces, and Drosophila indicates that it favors translational efficiency and accuracy.

74 al deficits in anabolic hormones and blunted translational efficiency and capacity.

75 addition to the expected correlation between translational efficiency and cis-regulatory features suc

76 atural amino acid was incorporated with high translational efficiency and fidelity into the dimeric p

77 ins in vivo at TAG nonsense codons with high translational efficiency and fidelity.

78 asmic positioning, plant cells may fine-tune translational efficiency and gene function.

79 imilar to a poly(A) tail in that it enhances translational efficiency and is co-dependent on a cap in

80 es in these cell types are the regulation of translational efficiency and let-7 miRNA maturation.

81 ation by miR-125 involves reductions in both translational efficiency and mRNA abundance.

82 For poly(A)+ mRNA, the translational efficiency and mRNA half-life increased on

83 cluding effects on subcellular localization, translational efficiency and mRNA half-life.

84 The poly(A) tail not only regulates translational efficiency and mRNA stability but is requi

85 sage has been identified as a determinant of translational efficiency and mRNA stability in model org

86 To examine the effect of length on translational efficiency and mRNA stability, a 20-base s

87 cation and RNA structure interplay to affect translational efficiency and mRNA stability.

88 ern of polymorphism, including selection for translational efficiency and positive selection.

89 ene and point to a strong connection between translational efficiency and RNA accumulation in mammali

90 and tissue-specific manner and regulate the translational efficiency and stability of partial or ful

91 o control gene expression by attenuating the translational efficiency and stability of transcripts.

92 om mRNA sequences is primarily influenced by translational efficiency and stability, which can be sig

93 cularly in the early stages, should increase translational efficiency and streamline resource utiliza

94 t the Fed-1 iLRE mediates a rapid decline in translational efficiency and that iLRE-containing mRNAs

95 s preferentially deposited on genes with low translational efficiency and that m(6)A does not affect

96 The WOR1 5' UTR reduces translational efficiency and the association of the tran

97 ys an important role in determining both the translational efficiency and the stability of an mRNA.

98 at codon usage is the key factor determining translational efficiency and, surprisingly, also mRNA st

99 these regulatory targets leads to decreased translational efficiency and/or decreased mRNA levels, b

100 her factors, natural selection for increased translational efficiency and/or fidelity may shape nucle

101 ownstream gene expression, including altered translational efficiency and/or messenger RNA abundance.

102 ongly correlated with its protein stability, translational efficiency, and abundance.

103 ar dsRNA structures within 3'-UTRs decreases translational efficiency, and although the structures un

104 that can influence transcript abundance and translational efficiency, and help evade host immune fac

105 ynonymous mutations can affect RNA splicing, translational efficiency, and mRNA stability, studies in

106 Ps generally exhibit high protein stability, translational efficiency, and protein abundance but thei

107 o study the roles of translational accuracy, translational efficiency, and the Hill-Robertson effect

108 tory mechanisms involving RNA processing and translational efficiency are discussed.

109 As in the regulation of mRNA turnover and/or translational efficiency are discussed.

110 e site selection on transcript stability and translational efficiency are discussed.

111 Effects on translational efficiency are minimal compared to effects

112 Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the

113 roducible protein length-dependent shifts in translational efficiency as a conserved hallmark of tran

114 of most eukaryotic mRNAs and influences its translational efficiency as well as its stability.

115 th translational machinery and modulates the translational efficiency as well as the mTOR pathway.

116 on assays demonstrated that the TE augmented translational efficiency, as well as RNA levels.

117 ocalization of the mRNA or variations in the translational efficiency at different sites along the de

118 enomes to identify those that exhibit strong translational efficiency bias (389 out of 1,700 sequence

119 ruct resulted in a corresponding increase in translational efficiency, but the most pronounced effect

120 TG for GTG as the initiation codon increased translational efficiency by 50%.

121 Re-ordering the segments reduced mRNA translational efficiency by 50%.

122 e GTG codon by one to four bases reduced the translational efficiency by 50-75%.

123 g on the context, this can strongly modulate translational efficiency by a variety of mechanisms.

124 tures are major determinants of the observed translational efficiency changes.

125 The correspondence between translational-efficiency changes and tail-length changes

126 t leaders lacking the 5'UTR intron increased translational efficiency compared to that of the unsplic

127 ol of cyclin D1 and c-myc mRNA stability and translational efficiency constitutes a coordinate respon

128 ablished in which global and individual mRNA translational efficiencies could be examined.

129 sis network(3), we hypothesized that altered translational efficiency during ageing could help to dri

130 255 transcripts that manifest an increase in translational efficiency during eIF4E-mediated escape fr

131 ed a progressive 2.3-fold decline in average translational efficiency during storage that correlates

132 ta suggest that PABP may exert its effect on translational efficiency either by increasing the format

133 inity and isoform preference correlates with translational efficiency, fluorescence spectroscopy was

134 Genes with increased translational efficiency following loss of ARF include m

135 determinant of ribosome binding strength and translational efficiency for mRNA with or without the 5'

136 her, the data link IFIT2 binding to enhanced translational efficiency for viral and cellular mRNAs an

137 ream in-frame ATG also resulted in increased translational efficiency from the downstream gp64-cat OR

138 In the absence of a functional minicistron, translational efficiency from the downstream gp64-cat re

139 5'-UUUU-3' results in a 15-fold reduction in translational efficiency; however, removing the leader a

140 ds attenuate mRNA translation at two levels: translational efficiency, i.e. translation initiation, a

141 A high-throughput screening for translational efficiency identified several antiapoptoti

142 As expected, tail lengths were coupled to translational efficiencies in early zebrafish and frog e

143 on, the different transcripts showed varying translational efficiencies in several cell lines, indica

144 Genes with up-regulated translational efficiencies in the caf20Delta mutant have

145 criminate among synonymous codons to enhance translational efficiency in a wide range of prokaryotes

146 ive secondary structure selectively regulate translational efficiency in adult cardiocytes.

147 that SD strength is not a direct hallmark of translational efficiency in all bacteria.

148 the pseudoknot structure and correlates with translational efficiency in both the PTV-1 and HCV IRES.

149 ciated with lymphoid replication and altered translational efficiency in cell culture, were found in

150 For poly(A)- reporter mRNA, translational efficiency in CHO cells increased 38-fold

151 eading frames that show greater than average translational efficiency in diverse eukaryotes.

152 R, AMP-activated protein kinase, have higher translational efficiency in DRG nociceptors.

153 nterruptions have no detectable influence on translational efficiency in either a cell-free system or

154 >A and G(243)-->A mutations showed preserved translational efficiency in HuH7 cells but reduced effic

155 and associated with RNAs with lower relative translational efficiency in mature chloroplasts.

156 ofiling, we assess global mRNA structure and translational efficiency in MCF7 cells, with and without

157 he Mek1 kinase pathways all fail to increase translational efficiency in MDA468 cells.

158 Most prominently, we provide evidence that translational efficiency in mechanistic target of rapamy

159 how that MMP-9 levels are also controlled by translational efficiency in murine prostate carcinoma ce

160 in may play an important role in determining translational efficiency in plants.

161 Translational efficiency in the presence and absence of

162 characteristics that are known to influence translational efficiency in their free-living relative.

163 te NRF-1 expression by interfering with mRNA translational efficiency in transfected cells and in an

164 these codons to more common codons increases translational efficiency in vitro and increases mRNA abu

165 These data suggest that translational efficiency is a key mechanism for regulati

166 Our data demonstrate that change in translational efficiency is a major contributor to early

167 Translational efficiency is controlled by tRNAs and othe

168 It has been hypothesized that translational efficiency is determined by the amount of

169 en our findings and the channeling theory of translational efficiency is discussed.

170 ffect of the S209L mutation on mitochondrial translational efficiency is due to reduced activity of t

171 s in the case of hereditary thrombocythemia: translational efficiency is increased by mutations that

172 ary pool of localized RNA undergoes enhanced translational efficiency is not clear.

173 nzyme identical to constitutive GGT cDNA but translational efficiency is reduced 2-fold.

174 port that of these two parameters, increased translational efficiency is the predominant source of in

175 eased Fmr1 mRNA production but impaired FMRP translational efficiency, leading to a modest reduction

176 Identification of genes with altered translational efficiency leads to the discovery of novel

177 ndicating that processes determining overall translational efficiency may vary between these two cate

178 Overall, our findings suggest that translational efficiency mechanisms, known to regulate d

179 s carrying one of these constructs show that translational efficiency mirrors gene transcription; gen

180 hat the eIF4G or eIFiso4G subunits influence translational efficiency more than the cap-binding subun

181 ) tail of an mRNA plays an important role in translational efficiency, mRNA stability and mRNA degrad

182 these types of changes were shown to affect translational efficiency, not transcript stability.

183 Due to the big differences in translational efficiency observed among weak TIS context

184 ore caused no significant differences in the translational efficiencies of GR transcripts.

185 As measured by polysome profiling, the translational efficiencies of individual NF subunit mRNA

186 that eliminating eIF4B reduces the relative translational efficiencies of many more genes than does

187 f translating 80S ribosomes reveals that the translational efficiencies of many more mRNAs are reduce

188 The translational efficiencies of mRNAs in cells progressing

189 The translational efficiencies of the brain-derived IRES seq

190 We determined the in vivo translational efficiency of 'unleadered' lacZ compared w

191 Our study provides a new mechanism that translational efficiency of a gene can be regulated thro

192 that receptor-mediated cell death has on the translational efficiency of a large number of mRNAs, tra

193 MDA receptor activity through the control of translational efficiency of a single subunit.

194 Translational efficiency of an AUG, CUG, GUG, or UUG ini

195 The translational efficiency of an mRNA engineered to form a

196 ucture, a feature previously shown to reduce translational efficiency of an mRNA.

197 The inhibitory effect of 2-PMAP on translational efficiency of APP mRNA into protein was di

198 Furthermore, IL-1beta increased the translational efficiency of ATF5 mRNA via the 5' UTRalph

199 initiation factor (elF) 4E (eIF4E) regulates translational efficiency of c-jun mRNA as measured by fl

200 Thus, translational efficiency of c-jun mRNA was not affected

201 Translational efficiency of c-jun/betaGal mRNA increased

202 ell-surface CD36 secondary to an increase in translational efficiency of CD36 mRNA.

203 o test this hypothesis, we have measured the translational efficiency of CGG-repeat mRNAs with 0-2 AG

204 and DEN 3' UTR were the main sources of the translational efficiency of DCLD RNA, and they acted syn

205 tein 1 (AUF1) regulates the stability and/or translational efficiency of diverse mRNA targets, includ

206 (A) tail act synergistically to increase the translational efficiency of eukaryotic mRNAs, which sugg

207 etaxolol is likely to reflect an increase in translational efficiency of existing mRNA and/or stabili

208 Differences in translational efficiency of full-length and deletion-mut

209 isoacceptor over-expression may increase the translational efficiency of genes relevant to cancer dev

210 formation but it regulates the stability and translational efficiency of histone mRNAs.

211 erefore allows analysis of variations in the translational efficiency of individual mRNAs by accounti

212 Most importantly, we show that the translational efficiency of injected mRNAs containing ca

213 Mechanistically, m6A depletion decreases the translational efficiency of methylated RNA encoding mito

214 hers; the addition of caffeine increased the translational efficiency of most SRSF2 transcripts.

215 A in the nucleus have a direct effect on the translational efficiency of mRNA in the cytoplasm.

216 xpression by modulating the stability and/or translational efficiency of mRNA targets in a context-sp

217 ction in Drosophila to increase the apparent translational efficiency of mRNAs by as much as 20-fold.

218 teins (ARE-BP) regulate the stability and/or translational efficiency of mRNAs containing cognate bin

219 Polysome profiles confirmed the decreased translational efficiency of mRNAs in tit1-Delta cells.

220 gies to alter the stability, solubility, and translational efficiency of nascent lacritin, and discov

221 nal upstream initiation sites, enhancing the translational efficiency of oncogenic mRNAs.

222 s in the L1 RNA could explain differences in translational efficiency of ORF1 and ORF2.

223 CUB of endogenous genes trans-regulates the translational efficiency of other genes.

224 lovastatin or C3 exoenzyme, can increase the translational efficiency of p27 mRNA.

225 xpression was the direct result of decreased translational efficiency of p53 mRNA.

226 We have also determined the translational efficiency of PDE subunits and the role of

227 in vitro transcribed mRNAs, we examined the translational efficiency of reporter genes that simulate

228 de non-coding RNA molecule, acts to increase translational efficiency of RpoS mRNA under some growth

229 In order to investigate translational efficiency of RpoS mRNA, we examined both

230 TLR-TRIF is at least partially via promoting translational efficiency of RTA mRNA.

231 overshadowed by differential effects on the translational efficiency of specific existing mRNA speci

232 er, eIF4F deregulation results in changes in translational efficiency of specific mRNA classes.

233 hat the 5'-UTR functions as a determinant of translational efficiency of specific mRNAs, such as c-ju

234 molecules that regulate the stability or the translational efficiency of target messenger RNAs (mRNAs

235 RNA molecules that regulate the stability or translational efficiency of target messenger RNAs.

236 RNAs) in bacteria modulate the stability and translational efficiency of target mRNAs through limited

237 upstream open reading frame, which restored translational efficiency of the 92-nt 5'-UTR AS mRNA.

238 of a nonsense codon led to a decrease in the translational efficiency of the mRNA.

239 Nuclear localization and translational efficiency of the NPM1 variants was studie

240 Increased translational efficiency of the parasite requires a high

241 nd ndhA are absent in ppr53 mutants, and the translational efficiency of the residual ndhA mRNAs is r

242 al operator sequence that serves to regulate translational efficiency of the s4 mRNA.

243 Elimination of these two uORFs raises the translational efficiency of the transcript by over 10-fo

244 These mutations dramatically enhance the translational efficiency of the v4 5'-UTR, leading to el

245 tein-protein interactions, and some modulate translational efficiency of their host genes.

246 , which express endogenous let-7a miRNA, the translational efficiency of these IRES-containing report

247 on of cyclin E was associated with increased translational efficiency of this mRNA, suggesting that c

248 rnate codon usage significantly enhanced the translational efficiency of this tightly regulated gene

249 The stability and translational efficiency of TNF transcript are regulated

250 Changes in the translational efficiency of upstream-encoded smORFs (uOR

251 RiboSeq permitted quantification of the translational efficiency of virus gene expression and id

252 tone stem-loop did not function to influence translational efficiency or mRNA stability in plant prot

253 gest that mechanisms such as mRNA transport, translational efficiency or mRNA turnover may be implica

254 ion of caveolin-1 does not affect caveolin-1 translational efficiency, phosphorylation, or proteasome

255 l-cell interactions and single-cell relative translational efficiency profiling to reveal variations

256 ency of a gene is positively correlated with translational efficiency rather than mRNA stability.

257 n (UTR) and regulates its expression through translational efficiency rather than RNA stability.

258 antitatively examined the effects of several translational-efficiency-related sequence features on mR

259 in receptor mRNA stability and ferritin mRNA translational efficiency, respectively.

260 riptome-proteome datasets for estimating the translational efficiencies, resulting in an increased co

261 abnormally short poly(A) tail and a reduced translational efficiency, resulting in an approximately

262 mportant determinant of RNA quality control, translational efficiency, RNA-protein interactions and s

263 - 2 fold change; O: +1.9 +/- 1 fold change), translational efficiency (S6K1 phosphorylation, Y: +10 +

264 The short isoform is characterized by higher translational efficiency since translation and decay rat

265 at the suppressors do not generally increase translational efficiency, since some alleles that strong

266 hich newly created 5'-UTR Alu exons modulate translational efficiency, such as the creation or elonga

267 quadruplex lead to a 15-fold enhancement of translational efficiency, suggesting that a possible bio

268 Translational efficiency (TE) was used as a metric for t

269 mRNA poly(A)-tail length strongly influences translational efficiency (TE), but later in development

270 ects of mutations in Ded1 or eIF4A on global translational efficiencies (TEs) in budding yeast Saccha

271 contrast to findings on mammalian cells, the translational efficiencies (TEs) of many mRNAs were alte

272 LSKs exhibit low global translation but high translational efficiencies (TEs) of mRNAs required for H

273 Delta confers widespread changes in relative translational efficiencies (TEs) that generally favor we

274 gnificantly lower mRNA stability and greater translational efficiency than proximal isoforms on avera

275 A synthetases (UaaRS) are evaluated on their translational efficiency (the extent to which they allow

276 While each is known to regulate translational efficiency, the mechanism by which they co

277 nd protein homeostasis mechanisms, including translational efficiency, translational fidelity, and co

278 ding frames (ORFs), to the quantification of translational efficiency under various physiological or

279 A cargo shifting and resultant regulation of translational efficiency upon the initiation of differen

280 r pool of RNAs that have a bias toward lower translational efficiency values in mature chloroplasts.

281 Our analysis suggests that translational efficiencies vary over a broad range durin

282 m by which mTORC2 activity stimulates Rictor translational efficiency via an AKT/HSF1/HuR signaling c

283 RNAs and because tRNA competition determines translational efficiency vs. fidelity and production of

284 Optimal translational efficiency was achieved when mRNAs contain

285 Lower translational efficiency was also associated with the po

286 Translational efficiency was calculated by measuring pro

287 s was performed to identify genes whose mRNA translational efficiency was differentially affected fol

288 yribosomes by 2.3-fold, which indicates that translational efficiency was enhanced by mobilization.

289 While global translational efficiency was reduced in mitotic cells, a

290 Translational efficiency was restored by mutations that

291 onal capacity, in E-UN offspring (P < 0.05); translational efficiency was similar across dietary trea

292 that the mRNA level of the AS form with high translational efficiency was specifically reduced in mor

293 oncogenic Ras and Akt signaling pathways on translational efficiencies, we compared the gene express

294 ader sequences of transcripts with increased translational efficiency, we find a highly enriched mess

295 it was once thought that mRNA stability and translational efficiency were directly linked, the inter

296 ive changes in poly(A)-tail length, and thus translational efficiency, were largely retained in the a

297 AtPAB binding exhibit a greater reduction in translational efficiency when AtPAB is depleted.

298 erived variants showed altered IRES-mediated translational efficiency, which might favor CNS infectio

299 ed protein synthesis resulted from decreased translational efficiency with impaired initiation of tra

300 f recombinant protein through extremely high translational efficiency without the need for viral repl