ライフサイエンスコーパス: translational regulation

1 ing protein kinases essential for their post-translational regulation.

2 We conclude that community effects exist in translational regulation.

3 ol, suggesting a means of reinforcing global translational regulation.

4 ts of three RNA-binding proteins involved in translational regulation.

5 o the model are reliable candidates for post-translational regulation.

6 known to be involved in transcriptional and translational regulation.

7 ate with the 3'UTR, which may have a role in translational regulation.

8 transcriptional, translational, and/or post-translational regulation.

9 new insights into mechanisms of plant virus translational regulation.

10 nscriptional, post-transcriptional, and post-translational regulation.

11 tal retardation-related protein 1 (FXR1) for translational regulation.

12 the rs4803217 allele modulates the extent of translational regulation.

13 intersecting with metabotropic signaling and translational regulation.

14 es a human prolyl hydroxylase with a role in translational regulation.

15 Instead, our data suggest a complex role in translational regulation.

16 l deconvolution to assess cell-type-specific translational regulation.

17 abundance of RecA isoforms, possibly through translational regulation.

18 collagen stabilization, hypoxia sensing, and translational regulation.

19 ctly to the mechanism of riboswitch-mediated translational regulation.

20 ss involving selective mRNA localization and translational regulation.

21 A-protein pairs that are candidates for post-translational regulation.

22 el of complexity to cellular transcriptional/translational regulation.

23 st and may perform noncanonical functions in translational regulation.

24 of OCT4A, but little is known about its post-translational regulation.

25 by previously uncharacterized mechanisms of translational regulation.

26 ization is the lineage-specific evolution of translational regulation.

27 evelopment, little is known about their post-translational regulation.

28 A that is important for its localization and translational regulation.

29 genes involved in chromatin modification and translational regulation.

30 the evolution of protein dual targeting and translational regulation.

31 adherin mRNA or protein levels suggests post-translational regulation.

32 CX-A reflects a role of this protein in mRNA translational regulation.

33 tle difference at the mRNA level, suggesting translational regulation.

34 characterize the mechanism of Puf6p-mediated translational regulation.

35 tial differences between transcriptional and translational regulation.

36 , followed by changes in transcriptional and translational regulation.

37 involved in post-transcriptional and/or post-translational regulation.

38 stress responses besides transcriptional and translational regulation.

39 thesis, yet little is known about their post-translational regulation.

40 s subjected to post-transcriptional and post-translational regulation.

41 ranslation events and quantify the effect of translational regulation.

42 cesses, yet little is known about their post-translational regulation.

43 he transcriptional level, largely neglecting translational regulation.

44 However, little is known about their translational regulation.

45 itoribosome itself may play in mRNA-specific translational regulation.

46 are found in nature, and their role in post-translational regulation.

47 respective impacts on transcriptional versus translational regulation.

48 ts subject to complex translational and post-translational regulations.

49 to identify patterns of transcriptional and translational regulation across different organisms and

50 However, it is not fully known whether translational regulation also occurs in subsequent immun

51 t systems to dissect mechanisms of mammalian translational regulation and continue to offer insight i

52 y responses, senescent cells showed enhanced translational regulation and endoplasmic reticulum (ER)

53 gies that seek to address the alterations in translational regulation and energy metabolism that char

54 ing Xenopus as a model, we analyzed the post-translational regulation and functional consequences of

55 However, how eIF3a participates in translational regulation and in formation of the eIF3(a:

56 induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSH

57 rols neuronal morphogenesis by mediating the translational regulation and localization of a large num

58 t, they are powerful tools for investigating translational regulation and probing ribosome structure.

59 in the mitochondrion for functional mitomiR translational regulation and provide a connecting link b

60 e, the 3'UTR of EBF2 is sufficient to confer translational regulation and required for the proper act

61 XR1 is a multifunctional protein involved in translational regulation and stabilization of its mRNA t

62 Therefore, systematic evaluations of translational regulation and the upstream factors shapin

63 ially controlled through Notch-mediated post-translational regulation and we demonstrate that the for

64 pression of somatic proteins at the level of translational regulation, and by (2) functioning with CS

65 ominently those involving synaptic proteins, translational regulation, and chromatin modifications.

66 sion in activated fibroblasts are subject to translational regulation, and dynamic variation in ribos

67 obe cell type-specific transcriptomes, study translational regulation, and probe ribosome binding of

68 unique role for actin-associated proteins in translational regulation, and suggest that mRNA-specific

69 that TRAP is an effective means for studying translational regulation, and that several nuclear-encod

70 Certain forms of translational regulation, and translation itself, rely o

71 NA repair, splicing, and transcriptional and translational regulation; and other aspects of cellular

72 genes and studying their transcriptional and translational regulation are key steps to understanding

73 mechanisms of CD39 transcriptional and post-translational regulation are not well known.

74 We further validate the importance of translational regulation as a potential mechanism for pl

75 identified ~200 mRNAs that undergo specific translational regulation at mitotic entry.

76 iversal due to post-transcriptional and post-translational regulation, both of which are highly preva

77 ple tasks in mRNA processing, transport, and translational regulation, but it also forms aggregates i

78 t summation of complex positive and negative translational regulation by 3' UTR-binding proteins, wit

79 to provide a physiological context for this translational regulation by ascribing defined functions

80 ndings provide a new mechanism for TDP1 post-translational regulation by ATM and DNA-PK.

81 of the two ATG mRNAs are necessary for their translational regulation by Dhh1.

82 We investigated combinatorial translational regulation by Drosophila Pumilio (Pum) and

83 nscript are necessary but not sufficient for translational regulation by eif3ha.

84 Bioinformatic analyses suggest that translational regulation by FMRP and transcriptional cor

85 regulates synaptic plasticity, and its local translational regulation by fragile X mental retardation

86 romiscuous phosphorylation and the attendant translational regulation by heterologous kinases, wherea

87 Coordinated translational regulation by hnRNP E1 constitutes a post-

88 es in the liver of rats indicating a lack of translational regulation by low iron levels.

89 Translational regulation by miRNAs may represent a commo

90 Thus, in addition to gene expression, translational regulation by p38 MAPK could be a novel me

91 The molecular basis of this translational regulation by RA/RARalpha signaling, howev

92 hat FMRP has a global role in miRNA-mediated translational regulation by recruiting AGO2 to a large s

93 ) of human p53 mRNA that is critical for its translational regulation by RPL26.

94 We outline the specific benefits that translational regulation by specialized ribosomes can of

95 Thus, translational regulation by TGF-beta at the elongation s

96 ate how the interplay of transcriptional and translational regulation can be exploited to control the

97 In addition, we found that cytoplasmic translational regulation can precede nuclear transcripti

98 Translational regulation contributes to plasticity in me

99 We conclude that translational regulation controls physiological levels o

100 demonstrates that nutrient availability and translational regulation controls protein and small pept

101 How this post-translational regulation coordinates VRN2 activity remai

102 Finally, translational regulation correlates positively with long

103 Due to tight post-translational regulation, determination of the expressio

104 lar functions, including transcriptional and translational regulation, DNA repair, drug resistance, a

105 es, has implicated it in transcriptional and translational regulation, DNA replication and repair, an

106 However, the importance of translational regulation during mitosis remains poorly u

107 ting responses to ozone were used to examine translational regulation during ozone stress.

108 of RNA binding proteins in shaping selective translational regulation during stress and the mechanism

109 study we have investigated the occurrence of translational regulations during light stress in Arabido

110 In contrast, our understanding of how translational regulation evolves has lagged far behind.

111 dies have highlighted the importance of post-translational regulations for the parasite's progression

112 atus, but their importance in the process of translational regulation had until recently been greatly

113 20 enzymes in cholesterol biosynthesis, post-translational regulation has only been examined for a sm

114 e participation of the GCN2-IMPACT module of translational regulation in a highly controlled step in

115 chemical demonstration, to our knowledge, of translational regulation in a T box riboswitch.

116 a critical process in protein synthesis, but translational regulation in antigen-specific T cells in

117 derstanding of post-transcriptional and post-translational regulation in attaching and effacing patho

118 t al identify MYC as an important target for translational regulation in chronic lymphocytic leukemia

119 Differences in mechanisms of translational regulation in CLL and normal B cells may p

120 les illustrating the critical role played by translational regulation in determining the expression l

121 esults demonstrate a role for 3'UTR mediated translational regulation in fine-tuning the temporal exp

122 SunTag should be broadly applicable to study translational regulation in live single cells.

123 enrichment in P-bodies and eIF4E-binding in translational regulation in mammalian cells.

124 nificance of protein diversification through translational regulation in mammals is largely unexplore

125 ate MNK1 as a key component of BDNF-mediated translational regulation in neurons.

126 To decipher the molecular basis of translational regulation in photomorphogenic Arabidopsis

127 The mechanistic understanding of translational regulation in response to different nutrie

128 ranscriptional coregulation is the selective translational regulation in response to growth condition

129 liver tissues to investigate strain-specific translational regulation in the spontaneously hypertensi

130 To investigate translational regulation in this system, we developed a

131 To understand translational regulation in this system, we systematical

132 The importance of translational regulation in tumour biology is increasing

133 r, these results uncovered critical roles of translational regulations in controlling appropriate gen

134 e monoubiquitination of eS7A was crucial for translational regulation, including the upregulation of

135 This coordinated translational regulation is a universal hallmark across

136 Translational regulation is an essential part of cancer

137 However, to what extent translational regulation is conserved between Arabidopsi

138 eIF2alpha phosphorylation-mediated translational regulation is crucial for global translati

139 FP reporter over-expression show that RNP-4F translational regulation is highly sensitive in the deve

140 This translational regulation is implicated for many key regu

141 circuitry, suggesting that the scheduling of translational regulation is organized by the same cyclic

142 A model for translational regulation is presented whereby in the abs

143 Translational regulation is thus critical for gene expre

144 scriptionally primed to generate neurons but translational regulation maintains these precursors in a

145 ecific transcripts suggests that competitive translational regulation may account for the synthesis o

146 addition to transcriptional regulation, post-translational regulation may also control HSC differenti

147 ther, our results demonstrate a ligand-gated translational regulation mechanism mediated by a non-gen

148 In addition, we characterized a post-translational regulation mechanism of FadD33 by the myco

149 Message-specific translational regulation mechanisms shape the biogenesis

150 t codon are translated, and it suggests that translational regulation might be used by cells to a gre

151 s been learned from bacteria and yeast about translational regulation, much less is known in metazoan

152 d stabilization of MKP1 demonstrate the post-translational regulation of a plant MKP in vivo, adding

153 ses that are fundamental enzymes in the post-translational regulation of ABCG1 and ABCG4 protein leve

154 several studies, and we have also shown that translational regulation of AQP4 by miR-320a could prove

155 is evolutionarily conserved suggesting post-translational regulation of auxin biosynthesis may be a

156 e pathway, and is dependent on S6K1-mediated translational regulation of B7-H1 protein.

157 ave recently identified a novel form of post-translational regulation of BACE1 (beta-site amyloid pre

158 c potential for Alzheimer's disease, via the translational regulation of BACE1.

159 the bone marrow through Rab5-dependent post-translational regulation of beta1/beta2 integrins.

160 We identified translational regulation of BMPRII expression and the co

161 icate that Smt1p is likely to be involved in translational regulation of both mRNAs.

162 ivo translated small ORFs, and to reveal the translational regulation of both small and canonical ORF

163 mRNA levels or protein stability, suggesting translational regulation of C/EBPbeta.

164 es mitotic arrest in male germ cells through translational regulation of cell cycle genes.

165 Here, we elucidate the mechanism of post-translational regulation of cellular HO2 levels by heme.

166 However, post-translational regulation of cGAS remains largely unknown

167 ng of ribosome footprints on RNAs to explore translational regulation of coding and noncoding RNAs in

168 s reveal a critical mechanism underlying the translational regulation of CRC metastatic progression,

169 A, supporting the critical role for the post-translational regulation of cyclin D1 in response to DNA

170 of additional regulatory elements during the translational regulation of DPP.

171 families of lysine deacetylases in the post-translational regulation of DVL, we screened for novel a

172 n, we provide here a novel mechanism of post-translational regulation of dysbindin and hypertrophy vi

173 irst time that WDR77 is directly involved in translational regulation of E2F1/3 mRNAs through their s

174 Transcript-selective translational regulation of epithelial-mesenchymal trans

175 g important roles for translational and post-translational regulation of ESC fate.

176 Post-transcriptional and post-translational regulation of factors that determine skin

177 t encodes a transmembrane receptor, but post-translational regulation of Fat has not been described.

178 However, the post-translational regulation of Fn14 expression has not been

179 In neurons, translational regulation of gene expression has been imp

180 ed polysome profiling by RNA-Seq to quantify translational regulation of gene expression in a recentl

181 probably function in the transcriptional and translational regulation of gene expression in haploid s

182 roRNAs has revealed novel mechanisms of post-translational regulation of gene expression, the implica

183 motifs and miRNA expression associated with translational regulation of gene expression.

184 proteins, contributes along with FsrA to the translational regulation of gene expression.

185 This review will provide an overview of the translational regulation of globin mRNAs and integrated

186 the adult neural stem cell fate through the translational regulation of glycogen synthase kinase 3be

187 n of 14-3-3 is the first description of post-translational regulation of GPSM3 subcellular localizati

188 are established through the localization and translational regulation of gurken (grk) mRNA.

189 ellular labile heme is critical for the post-translational regulation of HAP complex activity, most l

190 bl-1 3'UTR, and involves stage-specific post-translational regulation of HBL-1 nuclear accumulation.

191 CC (R = 0.02), reflecting the primarily post-translational regulation of HIF1alpha.

192 or completely (Hsp33-Y12E) abolish this post-translational regulation of Hsp33 chaperone function.

193 d HSPA5 ubiquitination and suggest that post-translational regulation of HSPA5 protein is critical fo

194 de ribosome profiling, we uncover widespread translational regulation of hundreds of mRNAs serving as

195 The impact of post-translational regulation of HuR and resulting cellular e

196 Translational regulation of IBTKalpha mRNA involves stre

197 en hyper- and hypo-phosphorylated 4E-BP1 and translational regulation of Id1 expression.

198 or the serine-threonine phosphatase PPM1G in translational regulation of Id1 protein expression.

199 Studies on the post-translational regulation of IRF-1 have been hampered by

200 her iron- and oxygen-dependent mechanism for translational regulation of its expression via iron regu

201 Here we report a dynamic, post-translational regulation of its kinase activity that is

202 The experiments revealed extensive translational regulation of key biological processes.

203 ist, Fulvestrant 182,780 suggesting a direct translational regulation of Kir4.1 and glutamate transpo

204 These data show that post-translational regulation of L1 retrotransposons plays a

205 n and cancer, little is known about the post-translational regulation of LGR5.

206 ndrome occur as well - microRNAs involved in translational regulation of major synaptic proteins; sca

207 ding frames of less than 100 codons, and the translational regulation of many genes.

208 Here, we characterize the translational regulation of maternally supplied mom-2 mR

209 This identified unexpected and pervasive translational regulation of most of the core signalling

210 combined with RNA sequencing to characterize translational regulation of mRNAs at early stages of the

211 To gain insight into the translational regulation of mRNAs during nodule formatio

212 regulate sleep by affecting stabilization or translational regulation of mRNAs.

213 ve found that PDHK4 plays a role in the post-translational regulation of mutant KRAS activity.

214 morphogenesis that highlights exquisite post-translational regulation of mVEGFR1 in its role as a mol

215 ssible sites are critically involved in post-translational regulation of N-type Ca(2+) channels by NO

216 Our results imply that translational regulation of nuclear-encoded mitochondria

217 were mediated through transcriptional and/or translational regulation of OPN, smooth muscle cells sti

218 Little is known about post-translational regulation of ORE1 in this process.

219 Thus, translational regulation of p53 mRNA and cellular senesc

220 Translational regulation of PB1-F2 expression was partia

221 y early sleep-wake onset due to altered post-translational regulation of period homolog 2 (PER2).

222 r findings provide new insights into diverse translational regulation of plant immune responses and d

223 ly nothing is presently known about the post-translational regulation of plant MKPs in vivo.

224 Here the authors report that the post-translational regulation of PRC1 components CBX4 and CBX

225 ltransferase (ICMT) plays a key role in post-translational regulation of prenylated proteins.

226 ional proANP, suggesting effects on the post-translational regulation of proBNP.

227 Although its contribution in translational regulation of proline repeat-rich proteins

228 ing evidence is emerging for additional post-translational regulation of proneural protein activity.

229 , we discuss recent advances concerning post-translational regulation of PTEN in general, and in more

230 A striking example is the S phase translational regulation of RICTOR, which is associated

231 urther show that both translational and post-translational regulation of RpoS contribute to peroxide

232 Runx2 during development as well as the post-translational regulation of Runx2 through modification b

233 e data reveal novel mechanisms by which post-translational regulation of Scw can modulate Dpp signali

234 RNA-binding protein that is involved in the translational regulation of several neuronal mRNAs.

235 They also reveal a role for GUN1 in the translational regulation of several PhANGs and highlight

236 However, the post-translational regulation of SNAI2 is less well studied.

237 1 transcription precedes EMT induction, post-translational regulation of Snail1 is also critical for

238 In contrast, post-transcriptional and post-translational regulation of some enzymes appears to cont

239 se of stromal transcriptional and epithelial translational regulation of some SC marker gene expressi

240 However, translational regulation of specific isoforms during neu

241 is a DEAD-box RNA helicase that functions in translational regulation of specific mRNAs.

242 RNA-binding protein that is required for the translational regulation of specific target mRNAs.

243 In addition, transcriptional and post-translational regulation of SsOGT by DNA damage was stud

244 ribosome profiling further reveals potential translational regulation of stress response genes.

245 ependent protein kinase, PKR, is involved in translational regulation of TCTP.

246 Using 3'UTR-luciferase reporter assays, translational regulation of TEX14 was demonstrated to be

247 es primordial follicle formation through the translational regulation of Tex14.

248 ent in the 5' untranslated region allows for translational regulation of TFPIbeta expression.

249 Our findings suggest that post-translational regulation of the BI-1 protein by E3 ligas

250 This unusual poise enables gradual post-translational regulation of the BiP chaperone cycle and

251 ification of the Mdm2 locus or aberrant post-translational regulation of the Mdm2 protein.

252 Together, these findings suggest that post-translational regulation of the Thr(567) in the MT1-MMP

253 Here, we show that post-translational regulation of the transcription factors ET

254 r miR33b, miR96, and miR503 are critical for translational regulation of the transcripts of these two

255 To explore mechanisms involved in the post-translational regulation of the transporter, we have use

256 novel mechanism for mTORC1 kinase-dependent translational regulation of the voltage-gated potassium

257 gged DHCR14 or LBR, we investigated the post-translational regulation of these enzymes.

258 le in Cox1 biogenesis, COX assembly, and the translational regulation of these processes.

259 be an important contributor to Akt-mediated translational regulation of these transcripts in murine

260 The transcriptional and translational regulations of gene expression by the micr

261 le methods for assessing the effects of post-translational regulation on enzymatic activity.

262 structures provide detailed insight into the translational regulation on the bacterial ribosome by mR

263 Translational regulation only occurred in the presence o

264 er RNA levels in young tissue, suggestive of translational regulation or altered protein stability.

265 ve length of the 3'UTR and may be related to translational regulation or ribosome recycling, for whic

266 Coupled with eIF4E translational regulation, our study highlights an import

267 minated the prevalence and dynamic nature of translational regulation pivotal to physiological adapta

268 Post-translational regulation plays a central role in the cir

269 rol of Nrf2 has been largely studied at post-translational regulation points by Keap1.

270 ghout the cell cycle via transcriptional and translational regulation, post-translational modificatio

271 We further show that translational regulation preferentially targets genes in

272 Collectively, our data support a model for translational regulation primarily driven by transitions

273 ochondrial ribosome an intrinsic capacity of translational regulation, probably acquired during evolu

274 nections between the UPR(mt) signaling and a translational regulation program called the 'integrated

275 ition relationships, and transcriptional and translational regulation relationships to identify paths

276 However, its post-translational regulation remains elusive.

277 However, HAdV translational regulation remains relatively uncharacteri

278 nt from the SD region, but how these mediate translational regulation remains unclear.

279 a non-coding RNA that has been implicated in translational regulation, seizure, and anxiety.

280 lation ontology captures transcriptional and translational regulation, substrate-level regulation of

281 chemical network given no transcriptional or translational regulation that can be used to explore the

282 findings provide insights into uORF-mediated translational regulation that can regulate the mammalian

283 these indicate widespread prevalence of post-translational regulation that may segregate the activiti

284 of regulation, including transcriptional and translational regulation, that drive core biological pro

285 the convenience of RNA sequencing has caused translational regulation to be overlooked compared with

286 logical behaviour, and linking rRNA-mediated translational regulation to modulation of lifespan, and

287 t system under anaerobic conditions and adds translational regulation to the ArcA-ArcB regulon.

288 Our results link genome evolution and translational regulation to the long-term persistence of

289 ex, essential networks of small RNA and post-translational regulation to these developmental stages.

290 ome footprints (RFs) on mRNAs to investigate translational regulation under control and sublethal hyp

291 interactions such as signal transduction and translational regulation under physiological conditions.

292 uminate the prevalence and dynamic nature of translational regulation underlying the mammalian cell c

293 Despite high G+C content, translational regulation was not evident by the mammalia

294 to be involved in beta-catenin mRNA (CTNNB1) translational regulation, was controlled by HSF1 repress

295 ve IRESs have created a confusing picture of translational regulation which is not helpful when tryin

296 MRP's canonical functions in RNA binding and translational regulation, which are traditionally associ

297 isoforms there are clear differences in post-translational regulation, which contribute to difference

298 ethylation have opposing effects on in vitro translational regulation, which corroborates well with t

299 hat DHCR14 and LBR undergo differential post-translational regulation, with DHCR14 being rapidly turn

300 for assessing the significance of changes in translational regulation within cells and between condit