ライフサイエンスコーパス: translational repressor

1 argets tested thus far, GLD-1 functions as a translational repressor.

2 and the other as an mRNA-specific autogenous translational repressor.

3 s a sequence-specific RNA-binding autogenous translational repressor.

4 asmic granules and inhibit its activity as a translational repressor.

5 er proteins, such as CYFIP1, which acts as a translational repressor.

6 FMRP controls its function as an RNA-binding translational repressor.

7 response protein1 (IRP1), an iron-dependent translational repressor.

8 tardation protein (FMRP), which functions as translational repressor.

9 1-mediated inhibition of the cellular 4E-BP1 translational repressor.

10 wheat germ extracts confirmed that DCP5 is a translational repressor.

11 a specific inhibitor of mTORC1, is a potent translational repressor.

12 SRC-3(-/-) macrophages implicate SRC-3 as a translational repressor.

13 translation rates, and also by mRNA-specific translational repressors.

14 hat also function as mRNA-binding autogenous translational repressors.

15 by preventing interaction of nanos RNA with translational repressors.

16 naling and the Pumilio (Pum) and Nanos (Nos) translational repressors.

17 translation via convergent regulation of the translational repressor 4E-binding protein 1 (4E-BP1) fo

18 ryotic initiation factor 4E (elF-4E) and the translational repressor 4E-binding protein 1 (4E-BP1) in

19 nslation by activating mTORC1 to inhibit the translational repressor 4E-binding protein 1 (4E-BP1).

20 ctor rpS6, as well as phosphorylation of the translational repressor 4E-binding protein 1.

21 show that the regulation of the TOR effector translational repressor 4E-BP is finely tuned to the nut

22 The translational repressor 4E-BP, the eukaryotic translatio

23 ream phosphorylation and deactivation of the translational repressor 4E-BP1 (eIF4E-binding protein 1)

24 n rapamycin-resistant phosphorylation of the translational repressor 4E-BP1 and phosphorylation of th

25 we demonstrate that PADI4 citrullinates the translational repressor 4E-BP1 and reveal a cross-talk b

26 obese rats increases phosphorylation of the translational repressor 4E-BP1 as well as multiple prote

27 Curiously, inactivating the host translational repressor 4E-BP1 in HCMV-infected cells st

28 orm of RSK1 is present in a complex with the translational repressor 4E-BP1 in IFNlambda-sensitive ce

29 While the translational repressor 4E-BP1 regulates binding of eIF4

30 mechanism that couples the abundance of the translational repressor 4E-BP1 with its target eIF4E via

31 cap binding protein eIF4E, together with the translational repressor 4E-BP1, are both phosphorylated

32 ression of the negative downstream effector, translational repressor 4E-BP1, partially reverses the e

33 tion of the mTORC1 substrate p70 S6K and the translational repressor 4E-BP1.

34 ducing hypophosphorylation/activation of the translational repressor 4E-BP1.

35 Deletion of the translational repressor 4E-BP2 in mice alters excitatory

36 this finding, mice lacking mTORC1 downstream translational repressor 4E-BP2 showed no induction of re

37 diating the interaction between DND1 and the translational repressor 4E-T.

38 tiation factor eIF4F is regulated in part by translational repressors (4E-BPs) that prevent incorpora

39 sed phosphorylation of the mTOR effector and translational repressor, 4E-BP1, in patient focal malfor

40 complex and increases the association of the translational repressor 4EBP1 to the 7-methylguanosine c

41 ered in response to mTOR attenuation via the translational repressor 4EBP1/2 axis.

42 ines of evidence demonstrate that GLD-1 is a translational repressor acting through the TGEs to repre

43 elevated brain protein levels due to loss of translational repressor activity.

44 n of maternal mRNAs, functioning both as the translational repressor and activator during oocyte matu

45 FMRP is most notably a translational repressor and is thought to inhibit transl

46 FMRP is believed to be a translational repressor and may regulate the translation

47 ssary for its in vivo function as a neuronal translational repressor and regulator of synaptic archit

48 le protein complexes and functions both as a translational repressor and splicing regulator for anter

49 activators Dhh1p and Pat1p as functioning as translational repressors and facilitators of P body form

50 arate but overlapping recognition motifs for translational repressors and localization factors provid

51 ates of nontranslating mRNAs associated with translational repressors and the mRNA decapping machiner

52 NAT1 is likely to be a fundamental translational repressor, and its aberrant editing could

53 PUF family translational repressors are conserved developmental reg

54 Remarkably, loss of just the 4E-BP family of translational repressors, arguably the best characterize

55 MOV10--which is the homologue of Drosophila translational repressor Armitage--and proteins of the 60

56 elanogaster, has identified Pumilio (Pum), a translational repressor, as an essential component of on

57 Colocalization with translational repressor BC1 RNA in hippocampal dendrites

58 In Drosophila, the translational repressor Bgcn is required for spermatogon

59 Our analysis shows that translational repressor binding results in self-associat

60 e having a 5' mRNA extension encoding a Nab1 translational repressor binding site in a CAO knockout l

61 t the MEF2A 3' UTR functions as a cis-acting translational repressor both in vitro and in vivo and su

62 Here, we demonstrate that the translational repressor Bruno binds the 3' UTR and inhib

63 optimality to enhanced degradation, and as a translational repressor, but its functions in cells are

64 in, has been implicated in this process as a translational repressor, but the underlying mechanism is

65 lation initiation factors and functions as a translational repressor by targeting assembly of 48S ini

66 ins to a translational activator, GLD2, or a translational repressor, CAF1.

67 lencing by providing an environment in which translational repressors can encounter their mRNA target

68 C. elegans mRNA decay factors, including the translational repressors CAR-1/LSM14 and CGH-1/DDX6, and

69 screen identified components of the Pumilio translational repressor complex (Pumilio, Nanos, and Bra

70 The Nanos-Pumilio translational repressor complex and the miRNA pathway al

71 tions in the expression of the Pumilio (PUM) translational repressor complex enhanced phenotypes due

72 We previously reported that the 4EHP/GIGYF2 translational repressor complex reduces the translation

73 relationship between the Nanos (Nos)-Pumilio translational repressor complex, which promotes GSC self

74 lls lacking the mRNA decapping activator and translational repressor Dhh1.

75 inding protein 1 (4E-BP1) and 2 (4E-BP2) are translational repressors downstream of mTORC1.

76 re present from yeast to mammals, and act as translational repressors during embryo development and c

77 of normal, primary human cells destroys the translational repressor eIF4E binding protein (4E-BP) an

78 ed with inhibition of phosphorylation of the translational repressor eIF4E-binding protein 1 (4E-BP1)

79 mTORC1 directly phosphorylates the translational repressors eIF4E binding proteins (4E-BP)

80 n the signaling that converges onto the RsmA translational repressor either via RetS/LadS or via HptB

81 h the consequence of removing the downstream translational repressor element.

82 he binding affinity between eIF4B and BC RNA translational repressors, enabling the factor to engage

83 mTOR-mediated phosphorylation of both the translational repressor eukaryotic initiation factor 4E

84 everse the CD40-mediated dissociation of the translational repressor eukaryotic initiation factor 4E-

85 essing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-

86 by 58% and increased phosphorylation of the translational repressor, eukaryotic initiation factor (e

87 ative regulatory module, consisting of NOS-3 translational repressor, FEM-CUL-2 (E3 ubiquitin ligase)

88 In fragile X, the loss of the mRNA translational repressor FMRP leads to exaggerated protei

89 ptional silencing of FMR1, which encodes the translational repressor fragile X mental retardation pro

90 large intron of the previously characterized translational repressor gene pumilio (pum).

91 ding the magnesium transporter cnnm2 and the translational repressor gigyf2, and revealed shared anat

92 EDF1 recruits the translational repressors GIGYF2 and EIF4E2 to collided r

93 -3 in the adult germline is regulated by the translational repressor GLD-1: MES-3 is absent from the

94 ls: (1) translation regulation by a specific translational repressor, GLD-1; and (2) uORF elicited re

95 meiotic cell cycle: GLD-1 is a STAR/Quaking translational repressor, GLD-2 is a cytoplasmic poly(A)

96 (eIF4E) binding proteins (4E-BPs), which are translational repressors, have a multifaceted effect on

97 decades, FMRP has been well established as a translational repressor; however, recent whole transcrip

98 ve eIF4F complexes in relation to the 4E-BP1 translational repressor, illustrating a new strategy thr

99 ly, these results point to Puf3p acting as a translational repressor in a manner exceeding the global

100 ) RNA binding proteins function as important translational repressors in multiple biological contexts

101 witch, converting OMA proteins from specific translational repressors in oocytes to global transcript

102 ns from coliphages and yeast can function as translational repressors in plants.

103 ation GNU brings PNG to its initial targets, translational repressors in RNP granules.

104 We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for m

105 Translational repressors, increasing evidence suggests,

106 e show that Pumilio-2 (PUM2), an RNA binding translational repressor, is highly localized at the neur

107 The mRNA encoding the translational repressor Nanos (Nos) forms ribonucleoprot

108 A requirement for the translational repressor Nanos (Nos) in the Drosophila la

109 The translational repressor Nanos (Nos) regulates a single t

110 Here, we show that removing the translational repressor Nanos from either GSCs or their

111 The translational repressor Nanos is expressed in the germli

112 ipts in the fly ovary, including mRNA of the translational repressor Nanos.

113 The translational repressors Nanos (Nos) and Pumilio (Pum) a

114 The translational repressors Nanos and Pumilio act in GSCs t

115 press components of the Dpp cassette and the translational repressors Nanos and Pumilio, whereas cyst

116 this study suggest that TDP-43 represents a translational repressor not only for specific mRNAs but

117 likely acts in cell-fate specification as a translational repressor of APETALA2 in Arabidopsis flowe

118 By contrast, TIA-1 functioned as a translational repressor of cytochrome c, with interventi

119 We propose that dFXR acts as a translational repressor of Futsch to regulate microtubul

120 bacterial small RNA GcvB has been known as a translational repressor of mRNAs encoding amino acid tra

121 otein, Bruno (Bru), has been implicated as a translational repressor of osk mRNA.

122 Thus, Cup is a translational repressor of oskar that is required to ass

123 The R17/MS2 coat protein serves as a translational repressor of replicase by binding to a 19

124 protein also acts as a transcript-selective translational repressor of selenoprotein synthesis durin

125 We demonstrate that Pr76gag acts as a translational repressor of these mRNAs in a dose-depende

126 E-binding) protein (4E-BP) family, which are translational repressors of 5' cap-dependent protein syn

127 made in identifying localization factors and translational repressors of oskar, none of the known com

128 MicroRNAs (miRNAs) function as endogenous translational repressors of protein-coding genes in anim

129 fect of the binding of an RNA stem-loop (the translational repressor) on the association rates of the

130 on, proteomic data further suggests that the translational repressor PDCD4 restrains B cell responses

131 Control of the translational repressor, PHAS-I, was investigated by exp

132 oupled by an interaction between Sqd and the translational repressor protein Bruno.

133 iometry of the complex formed between the T4 translational repressor protein regA and the 16 nt gene

134 control mechanism involving the release of a translational repressor protein that allows the immediat

135 ulatory factors, demonstrated binding of the translational repressor protein TIA-1 to COX-2 mRNA.

136 Thus, CPEB appears to act as a translational repressor protein to control myc translati

137 e RNA-binding studies of the phage RB69 RegA translational repressor protein, regA was configured to

138 each other and associate with Bruno, a known translational repressor protein.

139 These include translational repressor proteins (eukaryotic initiation

140 ith both the scaffold protein, eIF4G and the translational repressor proteins, the eIF4E-binding prot

141 Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of

142 contain putative recognition motifs for the translational repressor, Pumilio, which also exhibits th

143 increased expression of the transcriptional/translational repressor purine-rich element binding prot

144 The T4 translational repressor RegA protein folds into two stru

145 of mid-blastula transition and identify the translational repressor Smaug, a zygotic regulator of ge

146 We report a translational repressor (Smt1p) of the ATP6/8 mRNA that,

147 protein (Orb); this regulation involves the translational repressor Squid (Sqd).

148 hrough the conserved downstream effector and translational repressor, SsdA.

149 SRC-3 may cooperate with other translational repressors such as TIA-1 and TIAR to regul

150 bition of the proteasome causes a buildup of translational repressors, such as polyadenylate-binding

151 Recently, GLD-1 was found to be a translational repressor that acts through regulatory ele

152 Pumilio (Pum) is a translational repressor that binds selectively to target

153 The T4 protein, RegA, is a translational repressor that blocks ribosome binding to

154 es by signalling the degradation of GLD-1, a translational repressor that blocks V-ATPase synthesis.

155 activation of 4E-binding protein (4E-BP1), a translational repressor that inhibits the function of eu

156 om a single operon for which L10(L12) 4 is a translational repressor that recognizes a secondary stru

157 teins from the bacteriophage T4 and RB69 are translational repressors that control the expression of

158 pports a model in which BC1 RNA and FMRP are translational repressors that operate independently.

159 Enforced expression of the cap-dependent translational repressor, the eukaryotic translation init

160 Pat1 in yeast are mRNA decapping activators/translational repressors thought to play key roles in th

161 NF90 and decreased its association with the translational repressors TIAR and TIA-1.

162 idence that bcd also binds RNA and acts as a translational repressor to generate an opposing gradient

163 he rme-2 yolk receptor mRNA, GLD-1 acts as a translational repressor to spatially restrict RME-2 accu

164 Binding of the FMRP translational repressor to UPF1 on NMD targets mainly in

165 ense pulldown identified nucleolysin TIAR, a translational repressor, to bind to a 71-nt hairpin with

166 selective packaging requires the well-known translational repressor (TR) stem-loop, and instead supp

167 3K) class IB and increased expression of the translational repressor translation initiation factor 4E

168 tion, a mutant 4E-BP (eIF4E-binding protein) translational repressor unresponsive to mTORC1 stimulate

169 The pumilio translational repressor was found from both approaches,

170 S6K) (p70) and phosphorylation of the 4E-BP1 translational repressor, we assessed these potential mol

171 , an abundant neuronal granule component and translational repressor, we show that FMRP phase separat

172 levels, suggesting that miR398 can act as a translational repressor when target site complementarity

173 II, autophagy degrades Rim4, an amyloid-like translational repressor whose timed clearance regulates

174 Thus, we establish PML and Z as translational repressors, with potential contributions t

175 , tiRNA(Ala), tiRNA(Cys)) cooperate with the translational repressor Y-box binding protein 1 (YB-1) t

176 rms complexes with the conserved RNA-binding translational repressor, Ybx1.