ライフサイエンスコーパス: translationally

1 Protein folding can begin co-translationally.

2 tructure with two fused rings that form post-translationally.

3 is regulated both transcriptionally and post-translationally.

4 or more ADP-ribose units onto proteins post-translationally.

5 ted process, both transcriptionally and post-translationally.

6 al function, and is aberrantly modified post-translationally.

7 e SRP and are moved through the channel post-translationally(5,6).

8 m folding post-translationally to folding co-translationally--a result consistent with previous exper

9 ferase (NAT) complexes (NatA-NatC), which co-translationally acetylate the N-termini of eukaryotic pr

10 NatA co-translationally acetylates the N termini of a wide varie

11 NatE co-translationally acetylates the N-terminus of half the pr

12 downstream metabolic effects by TH can post-translationally activate other transcription factors.

13 essor to an activator and "seed" for further translationally active aggregation.

14 tion primarily driven by transitions between translationally active and inactive RNA states.

15 size that only a subset of CF microbiota are translationally active and that these activities vary be

16 The phylogenetic identity of translationally active cells can be determined by combin

17 non-canonical amino acid tagging) to measure translationally active cells in soils.

18 Mss51 was enriched in a translationally active form that maintains full Cox1 syn

19 T(EC869) only cleaves tRNA in the context of translationally active GTP.EF-Tu.tRNA ternary complexes.

20 majority of the transcripts contain multiple translationally active ORFs, and also that most isoforms

21 ng duct-derived cysts, displaces miR-17 from translationally active polysomes, and de-represses multi

22 the fraction of HSP90 mRNAs associated with translationally active polysomes, irrespective of unchan

23 S rRNA that allowed the formation of mature, translationally active ribosomes but induced proteotoxic

24 Differentiating translationally active subpopulations adds to our evolvi

25 TTLL glutamylases post-translationally add glutamates to internal glutamates in

26 in formation of the initiation complex were translationally altered during bacterial sepsis.

27 Here, we developed a translationally analogous multistage decision-making (MS

28 Here, we describe a translationally analogous multistage decision-making tas

29 ogenetics, optogenetics, pharmacology, and a translationally analogous Pavlovian-to-instrumental tran

30 ples, constituting the largest single center translationally analyzed osteosarcoma cohort to date, an

31 le MBS homomers are more likely to form post-translationally and rely on more advanced folding-assist

32 Golgi apparatus, most likely occurring post-translationally and specifically facilitating post-trans

33 wall and provide a clinically effective and translationally applicable therapeutic strategy that inv

34 (Sirt1) regulates the production of CRH post-translationally by affecting PC2.

35 ional secretion signal and are modified post-translationally by O-linked glycosylation.

36 Furthermore, Wnt proteins are modified post-translationally by palmitoylation, which is essential fo

37 AIRE is modified post-translationally by phosphorylation and ubiquitylation.

38 l recognition particle (SRP) pathway or post-translationally by the mammalian transmembrane recogniti

39 plasmic reticulum has been shown to occur co-translationally by the signal recognition particle (SRP)

40 of c/EBPbeta in microglia is regulated post-translationally by the ubiquitin ligase COP1 (also calle

41 flammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and

42 delling, oxidative phosphorylation, was post-translationally cleaved generating differential amounts

43 membrane-associated proteins, which are post-translationally cleaved into disulfide-linked polypeptid

44 e-fusion proteins, the spike protein is post-translationally cleaved, in this case by furin, into the

45 Translationally co-regulated mRNA subsets share common u

46 the limitations in creating and maintaining translationally cold samples of trapped ions using neutr

47 cted individuals during suppressive cART are translationally competent and produce the HIV-1 Gag and

48 he incorporation of mt-tRNA(Phe) to generate translationally competent machinery.

49 wn spliced HIV-RNA variants, they maintained translationally competent ORFs, involving elements of ga

50 ombining cell-free synthesis and assembly of translationally competent ribosomes with ribosome displa

51 ated LARP1 scaffolds mTORC1 on the 3'UTRs of translationally-competent RP mRNAs to facilitate mTORC1-

52 odifier (SUMO) is a peptide that can be post-translationally conjugated to ion channels to influence

53 owth, the production of BDSF by RpfF is post-translationally controlled by the RpfR N-terminal FI dom

54 Translationally controlled transcripts are associated wi

55 Translationally controlled tumor protein (TCTP) is a hig

56 Translationally Controlled Tumor Protein (TCTP) is anti-

57 The transcript encoding translationally controlled tumor protein (Tctp), a molec

58 Translationally controlled tumor protein(TCTP) has been

59 ution A6L and I8A (PTD4), derived from human translationally controlled tumor protein, were used as a

60 components of Tor signalling in Drosophila, translationally controlled tumour protein (Tctp) and Rhe

61 eomics analysis of axons reveals 75 proteins translationally controlled via the Sema3A-p-eIF2alpha pa

62 Chemical and optogenetic methods for post-translationally controlling protein function have enable

63 It promotes GSC progeny differentiation by translationally controlling the expression of differenti

64 ng DNA-damage-induced Chk2 activation and by translationally controlling the expression of self-renew

65 used broadband trapping to collect ions and translationally cool along the transmission axis before

66 ancies between model systems and patients to translationally deliver relevant biological insights.

67 nserved signal recognition particle (SRP) co-translationally delivers newly synthesized membrane and

68 TR features distinguish two functionally and translationally distinct subsets of MTOR-sensitive mRNAs

69 nonical messenger ribonucleoproteins by post-translationally down-regulating the eIF4E inhibitory pro

70 Plasmodium berghei gametocytes, is activated translationally during ookinete formation, where the pro

71 ELF1 protein, which itself is regulated post-translationally during the EMT program.

72 Most helical membrane proteins fold co-translationally during unidirectional polypeptide elonga

73 P-mediated protein turnover is markedly post-translationally enhanced by direct protein kinase G (PKG

74 cytosolic (global) and polysome-associated (translationally enhanced) mRNA levels in both subsets.

75 etermining whether a nascent protein will co-translationally fold and function or misfold and malfunc

76 Hypusine is formed post-translationally from lysine and is found in a single cel

77 ressing H(+)-ATPase isoform 2 (AHA2) that is translationally fused with a fluorescent protein and exa

78 Sec is inserted co-translationally in a small fraction of proteins called s

79 regulated post-transcriptionally and/or post-translationally in primary neurons.

80 ion and PER-TIM repression is regulated post-translationally, in part through rhythmic phosphorylatio

81 ent to dimerize 2.5-MDa 70S ribosomes into a translationally inactive 100S complex.

82 The formation of translationally inactive 70S dimers (called 100S ribosom

83 -electron microscopy (cryo-EM) structures of translationally inactive yeast and human ribosomes.

84 dimerization, forming a 100S complex that is translationally inactive.

85 decrease, suggesting that they were rendered translationally incompetent.

86 he genetic code expansion strategy, which co-translationally incorporates ncAAs into specific sites o

87 In creating a circuit with nearly translationally independent behavior, as the RNAs contro

88 several key antibiotic regulatory genes are translationally induced at transition growth phase.

89 on regulators eIF4A and Pabp, which are also translationally-induced despite general translational in

90 RNAs are transcribed earlier and stored in a translationally inert state until needed for translation

91 equired for heat shock response induction in translationally inhibited cells, and specifically affect

92 ) cooperates with the Sec61 translocon to co-translationally insert a transmembrane helix (TMH) of ma

93 tain the amino acid selenocysteine (Sec), co-translationally inserted at a predefined UGA opal codon

94 Tail-anchored (TA) proteins are post-translationally inserted into membranes.

95 y of multi-spanning membrane proteins are co-translationally inserted into the bilayer by the Sec pat

96 in animal bodies, owes its stability to post-translationally installed hydroxyl groups at position 4

97 hich secretory proteins are transported post-translationally into the endoplasmic reticulum (ER) has

98 Tail-anchored (TA) proteins insert post-translationally into the endoplasmic reticulum (ER), the

99 such an approach gives completely misleading translationally invariant, local Hamiltonians on a squar

100 d and polarization in charged systems is not translationally invariant.

101 oscillations, although the quantum liquid is translationally invariant.

102 rconductor was originally conceived as being translationally invariant.

103 es, but how their activity is regulated post-translationally is not well understood.

104 Post-translationally, K48-linked poly-ubiquitination of NUMBL

105 okines and cytokines, underlining the rapid, translationally mediated inflammatory cascade that is in

106 Proteome-wide studies of post-translationally methylated species using mass spectromet

107 a putative ribosomally synthesized and post-translationally modified (RiPP) redox cofactor.

108 loid beta (Abeta) peptides, for example post-translationally modified Abeta peptides with a pyrogluta

109 s/specificities for peptides containing post-translationally modified amino acids.

110 trate that the prosthetic heme group is post-translationally modified and cross-linked with the prote

111 cific biotinylated substrate peptide is post-translationally modified at the cysteine residue, preven

112 Microtubules (MTs) are known to be post-translationally modified at the neuromuscular junction (

113 ytheonamides represent the most heavily post-translationally modified biomolecules that are derived f

114 In this study, we find that PRCD is post-translationally modified by a palmitoyl lipid group at t

115 We clearly demonstrate that RPE65 is post-translationally modified by a palmitoyl moiety, but this

116 al methods, we examined whether PARN is post-translationally modified by acetylation and what effect

117 PfCRT is post-translationally modified by phosphorylation, palmitoylat

118 Collagen is post-translationally modified by prolyl and lysyl hydroxylati

119 ed tyrosine residues, of which some are post-translationally modified by tyrosine O-sulfation and con

120 owed previously that beta1 subunits are post-translationally modified by tyrosine phosphorylation.

121 The dysregulation of heavily post-translationally modified ECM proteins directly contribut

122 e phenomena affect the accessibility of post-translationally modified histone residues that serve as

123 , PHD, bromodomain) that dock to DNA or post-translationally modified histones and a caspase activati

124 tion, proteins in actinobacteria can be post-translationally modified in a process referred to as pup

125 ow that in airway basal cells, SPRY2 is post-translationally modified in response to FGFR1 signaling.

126 This is the first description of a post-translationally modified Mtb-derived protein antigen pre

127 a class of ribosomally synthesized and post-translationally modified natural product which possess a

128 growing family of ribosomally produced, post-translationally modified natural products.

129 cell numbers, especially when studying post-translationally modified or otherwise rare peptide speci

130 The ribosomally synthesized and post-translationally modified peptide (RiPP) bottromycin A2 p

131 Most ribosomally synthesized and post-translationally modified peptide (RiPP) natural products

132 ally unique ribosomally synthesized and post-translationally modified peptide (RiPP) that possesses p

133 omycins are ribosomally synthesized and post-translationally modified peptide natural product antibio

134 owing family of ribosomally encoded and post-translationally modified peptide natural products (RiPPs

135 uced from a ribosomally synthesized and post-translationally modified peptide PqqA via a pathway comp

136 n mode, except for the analysis of some post-translationally modified peptides (e.g., phosphorylation

137 at code for ribosomally synthesized and post-translationally modified peptides (RiPPs) and contain on

138 Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a major cl

139 Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an ascenda

140 Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an emergin

141 a group of ribosomally synthesized and post-translationally modified peptides (RiPPs) exhibiting ant

142 ynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs) proceeds via t

143 Ribosome-synthesized post-translationally modified peptides (RiPPs) represent a ra

144 lusters for ribosomally synthesized and post-translationally modified peptides (RiPPs) that contain a

145 eptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) that display a

146 that act on ribosomally synthesized and post-translationally modified peptides (RiPPs), known as a Ri

147 ides (NRPs) and ribosomally synthesized post-translationally modified peptides (RiPPs), which are imp

148 f bioactive ribosomally synthesized and post-translationally modified peptides (RiPPs), with a thread

149 that encode ribosomally synthesized and post-translationally modified peptides (RiPPs).

150 iscovery of ribosomally synthesized and post-translationally modified peptides (RiPPs).

151 ides called ribosomally synthesized and post-translationally modified peptides (RiPPs).

152 d azoles in ribosomally synthesized and post-translationally modified peptides (RiPPs).

153 ucts called ribosomally synthesized and post-translationally modified peptides (RiPPs).

154 (NRPs), and ribosomally synthesized and post-translationally modified peptides (RiPPs).

155 ew class of ribosomally synthesized and post-translationally modified peptides and thus far are only

156 Post-translationally modified peptides are involved in many a

157 terpene and ribosomally synthesized and post-translationally modified peptides cluster products, repo

158 a family of ribosomally synthesized and post-translationally modified peptides with a highly unusual

159 etides, and ribosomally synthesized and post-translationally modified peptides, from all kingdoms of

160 ut also resulted in the presentation of post-translationally modified peptides, including deamidated

161 erived from ribosomally synthesized and post-translationally modified peptides.

162 actins (Mbns) are ribosomally-produced, post-translationally modified peptidic copper-binding natural

163 h natural, unnatural and CF(2)-labelled post-translationally modified protein substrates via simultan

164 he production of autoantibodies against post-translationally modified proteins (checkpoint 1).

165 th a special focus on the production of post-translationally modified proteins and backbone cyclized

166 functions for quantitative analysis of post-translationally modified proteins and their modification

167 glutathionylated serpins and that these post-translationally modified proteins are candidate biomarke

168 scent polypeptides being translated and post-translationally modified proteins.

169 13 exhibited much lower activity toward post-translationally modified substrates.

170 gnificant support to proposals that the post-translationally modified sulfenato group serves as the n

171 We found that inactivation of YBX1, a post-translationally modified target of JAK2, sensitizes cell

172 med in vitro, will make other elaborate post-translationally modified targets accessible for drug dis

173 eptide is a ribosomally synthesized and post-translationally modified thiopeptide natural product tha

174 peptides; these ribosomal peptides are post-translationally modified to convert serine and cysteine

175 Furthermore, B. subtilis EF-P is post-translationally modified with a 5-aminopentanol group bu

176 els, bound to fly microtubules and were post-translationally modified, hence displaying physiological

177 ad1 is critical for its function and is post-translationally modified.

178 aled low abundance proteoforms that are post-translationally modified.

179 native environment that have been fully post-translationally modified.

180 his superfamily shows the presence of a post-translationally-modified heme with one single covalent e

181 pled receptor kinase-2 (GRK2) that also post-translationally modifies eNOS.

182 inase, type III (PADI3), an enzyme that post-translationally modifies other proteins that are essenti

183 lar evidence that mammalian LC3/GABARAP post-translationally modifies proteins akin to ubiquitination

184 Mechanistically, spermidine post-translationally modifies the translation factor eIF5A, w

185 f MbnH to MauG suggests that MbnH could post-translationally modify a macromolecule, such as internal

186 oxidized GSH, and hydrogen peroxide to post-translationally modify and inhibit the deacylase activit

187 ier by triggering signaling events that post-translationally modify pre-existing components of interc

188 AGA and NuA4 stimulate transcription by post-translationally modifying chromatin.

189 genetically regulate gene expression by post-translationally modifying histones and/or remodeling chr

190 ansferase activity, which is capable of post-translationally modifying lysine residues of the ICDH pr

191 ail a displacement of the repressor from the translationally mute Smt1-ATP8/ATP6 complex by F1, there

192 Identification of post-translationally or chemically modified peptides in mass

193 wild type and gun1, we identified 181 highly translationally or posttranslationally regulated (HiToP)

194 Here, we provide a translationally-oriented review on what is currently kno

195 quired for receptor function, and which post-translationally oxidizes beta2AR cysteine thiols to Cys-

196 Translationally, pregnant women with low or high ACEs we

197 ng the secretory pathway, before MET is post translationally processed by cleavage within its extrace

198 elongated precursor peptides, which are post-translationally processed by proteases to yield the acti

199 nd YnGG enable direct identification of post-translationally processed prenylated peptides, proteome-

200 We translationally profiled the transcriptome of CeA Crh-ex

201 ile tool set will enable researchers to post-translationally program mammalian cellular processes and

202 Ds with insufficient hydrophobicity are post-translationally recognized and retained by the Sec61 tra

203 veal that DSCR6 and Ezh2 critically and post-translationally regulate Stat3 transcriptional activity.

204 e that MbtA activity can be reversibly, post-translationally regulated by acetylation.

205 ranscriptional partner of CBFB, is bound and translationally regulated by CBFB.

206 rotein 2) and Sulf1 (sulfatase 1), which are translationally regulated by EPRS.

207 tochondrially encoded ATP6 and ATP8 genes is translationally regulated by F1 ATPase.

208 Here, we have discovered that moesin is translationally regulated by TGF-beta and is also requir

209 by polysome profiling that inhibin betaA is translationally regulated by TGFbeta via hnRNP E1.

210 transcription factor NAC43 and is also post-translationally regulated by the receptor-like kinase GR

211 lytic activity of metalloproteinases is post-translationally regulated by their endogenous inhibitors

212 We identify a group of ten translationally regulated drivers of EMT sharing a commo

213 Cellular enzymes interact in a post-translationally regulated fashion to govern individual c

214 A subset of Orb2 targets is translationally regulated in cultured S2 cells and fly h

215 such models as proteins associated with post-translationally regulated modes of action.

216 perturbations, and identify many additional translationally regulated mRNAs throughout the yeast gen

217 Of the translationally regulated mRNAs, 30% had one or more ups

218 However, how this protease is post-translationally regulated remains unclear.

219 Translationally regulated secreted proteins included a n

220 Depletion of tyrosine tRNA(GUA) or its translationally regulated targets USP3 and SCD repressed

221 iscovered that specific groups of genes were translationally regulated, mostly in coordination with t

222 tivity of ABI5 is transcriptionally and post-translationally regulated.

223 IRES in the 5' coding sequence of TDP2 that translationally regulates expression of an N-terminally

224 We find that LEP-2 post-translationally regulates LIN-28 by promoting LIN-28 pro

225 We found that CK2alpha post-translationally regulates the ERK-specific phosphatase d

226 This study reveals a novel pathway that post-translationally regulates the general stress response si

227 Our work provides strong evidence that translationally regulating riboswitches also regulate mR

228 Therefore, translationally relevant animal models are required to p

229 Using translationally relevant calcium-alginate hydrogels, we

230 Translationally relevant dietary manipulations may be an

231 ential to normalize the ATME, which might be translationally relevant for cancer prevention and thera

232 Our experimental approach is translationally relevant for developing strategies to pr

233 In addition, promoter methylation of two translationally relevant genes, Schlafen 11 (SLFN11) and

234 lidate the effect of Pim1-modified CSCs in a translationally relevant large animal preclinical model

235 opioid vs. food choice procedures provide a translationally relevant measure (i.e., behavioral alloc

236 isorders like autism and addiction, making a translationally relevant model of empathy extremely impo

237 hether this region also participates in more translationally relevant models of relapse.

238 the impacts of preclinical study design and translationally relevant outcome measures.

239 hophysiology behind these challenges using a translationally relevant strategy.

240 n tissue, but suitable bioinks for producing translationally relevant tissue with complex geometries

241 ective aspects of impaired reward processing translationally relevant to anhedonia, and ketamine's mo

242 this protein splicing activity arose to post-translationally repair proteins that had been inactivate

243 mouse neocortical polysomes, here we report translationally repressed and derepressed mRNA isoforms

244 As a result, target mRNAs are translationally repressed and subsequently deadenylated

245 VAR2CSA is translationally repressed by an upstream open reading fr

246 t polyribosome-associated transcripts can be translationally repressed by RISCs without substantial m

247 DHHC10, translationally repressed in female Plasmodium berghei g

248 ubcellular compartments that are enriched in translationally repressed mRNA.

249 s) are conserved cytoplasmic aggregations of translationally repressed mRNAs assembled with mRNA deca

250 ng bodies and stress granules, which contain translationally repressed mRNAs, these granules harbor t

251 ire Ssp2, a meiosis-specific protein that is translationally repressed until anaphase of MII.

252 tion: Are mRNAs directed to P granules to be translationally repressed, or do they accumulate there a

253 hich determines female physiognomy, but also translationally represses male-specific lethal 2 (msl-2)

254 Mechanistically, miR-15a/16-1 translationally represses pro-angiogenic factors VEGFA,

255 e X mental retardation protein (FMRP), which translationally represses specific messenger RNAs, inclu

256 that BR signaling transcriptionally and post-translationally represses the accumulation of PILS prote

257 egies to prepare for transmission, including translationally repressing and protecting mRNAs needed t

258 od, including whether Plasmodium changes its translationally repressive complexes and mRNA targets in

259 Here we show that STAT3 is post-translationally S-palmitoylated at the SRC homology 2 (S

260 The dimensions of the translationally serviceable locale around synapses have

261 This mRNA is translationally silenced by an antitoxin sRNA, IstR-1, t

262 Genes that are translationally silenced by hnRNP E1 and expressed by it

263 F) homodimerizes the 70S ribosomes to form a translationally silent 100S complex.

264 lso maintain a subset of messenger RNAs in a translationally silent state, which react 'on demand' to

265 cumulate specifically in sperm cells but are translationally silent.

266 rane attack complexes (MAC), ZFYVE21 is post-translationally stabilized on MAC+Rab5+ endosomes in a R

267 This series post-translationally stabilizes the SMN protein, unrelated to

268 substantially elevated mutation rates around translationally stable ('strong') nucleosomes.

269 Stress granules (SGs) harbour translationally stalled messenger ribonucleoproteins and

270 uced accumulation of p-bodies to release the translationally stalled mRNAs for active translation of

271 c analysis of Nedd8-conjugated proteins from translationally stalled ribosomal fractions identified r

272 can be suppressed by proteins that act post-translationally, such as the SOCS (suppressor of cytokin

273 As human trypsins are post-translationally sulfated in the autolysis loop, we also

274 d efficiently only after they have been post-translationally "tagged" with a polyubiquitin chain.

275 ants, where the chloroplast SRP (cpSRP) post-translationally targets light-harvesting chlorophyll a/b

276 Translationally, these findings are predictive of initia

277 Unlike PRC, which was induced post-translationally through increased protein half-life, c-M

278 uited to the Sec71-Sec72 complex either post-translationally through Ssa1 or co-translationally throu

279 ther post-translationally through Ssa1 or co-translationally through Ssb1.

280 expression in higher eukaryotes is regulated translationally through the 5'TOP sequence.

281 nition particle (SRP)(3,4) and then moved co-translationally through the Sec61 or SecY channel by the

282 most secretory proteins are transported post-translationally through the SecY channel by the SecA ATP

283 c proteins such as Hsp20 are maintained post-translationally through their recognition, disassembly,

284 vent-related potentials (ERP) have been used translationally to date but are limited by the significa

285 witch some protein domains from folding post-translationally to folding co-translationally--a result

286 TTLL glycylases add glycines post-translationally to internal glutamates, and we find that

287 antitoxin chemically modifies the toxin post-translationally to neutralize it.

288 gnitive features of depression could be used translationally to predict and evaluate treatment respon

289 The 4.2-A structure of post-translationally unmodified human alpha1A/betaIII microtu

290 e specifically associated with monosomes are translationally up-regulated during seed germination.

291 Among the translationally up-regulated targets of U2AF1-S34F is Nu

292 mRNAs specifically translationally up-regulated with tamoxifen resistance i

293 brown adipose tissue (BAT) and iWAT, and is translationally upregulated by beta3-adrenergic signalin

294 ed that oxidative phosphorylation mRNAs were translationally upregulated during vaccinia virus-induce

295 gene expression; however, specific mRNAs are translationally upregulated in quiescent (G0) mammalian

296 alternative transcript variants identified a translationally upregulated mRNA encoding subunit 3 of t

297 s review aims to provide information that is translationally useful and complementary to pathogenic h

298 Translationally, we show that miR-214 is increased in pl

299 in modifications in eukaryotes and occurs co-translationally when the N-terminus of the nascent polyp

300 These proteins are transported post-translationally with the help of chaperones, meaning tha