ライフサイエンスコーパス: translesion DNA synthesis

1 e associated with homopolymer instability or translesion DNA synthesis.

2 A/FANC pathway, homologous recombination, or translesion DNA synthesis.

3 accounting for polymerase "switching" during translesion DNA synthesis.

4 rmation of the 8-oxo-dG template base during translesion DNA synthesis.

5 h DPCs causes their proteolysis, followed by translesion DNA synthesis.

6 s involved in the tolerance of DNA damage by translesion DNA synthesis.

7 polymerases during replication, repair, and translesion DNA synthesis.

8 the Y family of DNA polymerases involved in translesion DNA synthesis.

9 genome integrity as well as participating in translesion DNA synthesis.

10 in both a DNA damage checkpoint control and translesion DNA synthesis.

11 te in a DNA damage checkpoint control and in translesion DNA synthesis.

12 s and elucidate the interplay between HR and translesion DNA synthesis.

13 vily on hydrogen-bonding interactions during translesion DNA synthesis.

14 ination in response to UV-induced damage for translesion DNA synthesis.

15 equires specialized polymerases that perform translesion DNA synthesis.

16 that PARP10 binding to PCNA is required for translesion DNA synthesis.

17 ro-8-oxo-2'-deoxyguanosine (8-oxo-dG) during translesion DNA synthesis.

18 zeta (Pol zeta) and Rev1 are key players in translesion DNA synthesis.

19 , including T2 amino alcohol (T2AA), inhibit translesion DNA synthesis.

20 amily DNA polymerases play a crucial role in translesion DNA synthesis.

21 atch repair, nucleotide excision repair, and translesion DNA synthesis.

22 ward loop to enhance PCNA ubiquitylation and translesion DNA synthesis.

23 of accessory proteins retained on DNA during translesion DNA synthesis.

24 n DNA damage tolerance through their role in translesion DNA synthesis.

25 oid and induced expression of genes encoding translesion DNA synthesis.

26 A provides a novel biochemical tool to study translesion DNA synthesis.

27 ons coordinates homologous recombination and translesion DNA synthesis.

28 cA nucleoprotein filament (RecA*), catalyses translesion DNA synthesis.

29 lyses indicate that Poltheta is required for translesion DNA synthesis across NO-induced lesions, but

30 To probe the mechanism for in vivo translesion DNA synthesis across this adduct, in vitro p

31 ryonic viability and development through the translesion DNA synthesis activity of Polzeta preserving

32 In addition to translesion DNA synthesis activity, MacDinB-1 synthesize

33 way is believed to be the major mechanism of translesion DNA synthesis and base damage-induced mutage

34 evant platinum-based drugs by promoting both translesion DNA synthesis and DNA repair.

35 n multiple DNA repair pathways, most notably translesion DNA synthesis and double-strand break (DSB)

36 NA repair polymerase theta and uses them for translesion DNA synthesis and double-strand break repair

37 the Y-family of DNA polymerases involved in translesion DNA synthesis and genome mutagenesis.

38 rily conserved Y family members that perform translesion DNA synthesis and have low fidelity, we desc

39 ily of bypass polymerases is responsible for translesion DNA synthesis and includes the human polymer

40 NA polymerase zeta (Polzeta) participates in translesion DNA synthesis and is involved in the generat

41 erase eta (pol eta), an enzyme that performs translesion DNA synthesis and may participate in somatic

42 erences argue against a unified mechanism of translesion DNA synthesis and suggest that polymerases e

43 Acting as a suicide enzyme, HMCES prevents translesion DNA synthesis and the action of endonuclease

44 ucleotide of the ICL, followed by incisions, translesion DNA synthesis, and extension of the nascent

45 epair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination,

46 Mismatched cisplatin adducts could arise by translesion DNA synthesis, and improved repair of such a

47 Polymerase eta (PolH) is necessary for translesion DNA synthesis, and PolH deficiency predispos

48 Nucleotide excision repair and translesion DNA synthesis are two processes that operate

49 of concept for the coordinate inhibition of translesion DNA synthesis as a strategy to improve chemo

50 ve polymerases involved in DNA repair and/or translesion DNA synthesis as anticancer agents are discu

51 hat BRCA1 plays a critical role in promoting translesion DNA synthesis as well as DNA template switch

52 e II appears to be required for the observed translesion DNA synthesis because essentially similar re

53 rthermore, 5-NapITP is a chain terminator of translesion DNA synthesis because the DNA polymerase is

54 the Klenow fragment follows the "A-rule" of translesion DNA synthesis by preferentially incorporatin

55 ur new structures depicting several steps of translesion DNA synthesis by RB69 gp43 exo-, employing a

56 se may play a critical role during mutagenic translesion DNA synthesis bypassing a template AP site i

57 the assessment of the mutagenic profiles of translesion DNA synthesis catalyzed by any error-prone D

58 of metal ion substitution on the dynamics of translesion DNA synthesis catalyzed by the bacteriophage

59 the rate of the conformational change during translesion DNA synthesis depends on pi-electron density

60 cis on a damaged template strand obstructing translesion DNA synthesis despite the absolute requireme

61 It has been suggested that one of these translesion DNA synthesis DNA polymerases, DNA polymeras

62 sults suggest that PolN might play a role in translesion DNA synthesis during ICL repair in human cel

63 he Escherichia coli Klenow fragment performs translesion DNA synthesis during the misreplication of a

64 orporation fidelity, mismatch extension, and translesion DNA synthesis efficiencies were determined u

65 DNA processing (error-free) to low-fidelity translesion DNA synthesis (error-prone) at DNA damage si

66 particularly pol eta, may contribute to the translesion DNA synthesis events observed for 1,N(6)-eth

67 measured include fidelity and efficiency of translesion DNA synthesis, excision repair, and recombin

68 ding and lagging strand abasic sites require translesion DNA synthesis for bypass.

69 in melanoma development besides its bonafide translesion DNA synthesis function, and suggest that tar

70 ure-function analyses for the checkpoint and translesion DNA synthesis functions of the umuDC gene pr

71 Several mutant forms of PCNA that block translesion DNA synthesis have been identified in geneti

72 understand the role of Poleta in error-free translesion DNA synthesis, here we examine the ability o

73 rase switching recently suggested during the translesion DNA synthesis, implies the multiple function

74 ein interactions specific for Rev1's role in translesion DNA synthesis in human cells, and I2 acts as

75 In order to characterize mutagenic translesion DNA synthesis in UVM-induced Escherichia col

76 The close parallels in the efficiency of translesion DNA synthesis in vitro and in vivo for the f

77 monstrate the ability to selectively inhibit translesion DNA synthesis in vitro.

78 s capable of both error-free and error-prone translesion DNA synthesis in vitro.

79 e identify a function of PAF, a component of translesion DNA synthesis, in modulating Wnt signaling.

80 It involves either translesion DNA synthesis initiated by proliferating cel

81 Translesion DNA synthesis is an essential process that h

82 Translesion DNA synthesis is an important branch of the

83 D30, thereby suggesting that Rad30-dependent translesion DNA synthesis is conserved within the eukary

84 e dynamic behavior of DNA polymerases during translesion DNA synthesis is dependent upon the nature o

85 on have direct implications for low-fidelity translesion DNA synthesis, most of which is found to be

86 have been used to study polymerase-mediated translesion DNA synthesis of abasic sites and TT dimers,

87 Some of these polymerases perform such translesion DNA synthesis of specific types of damage wi

88 PolH to translocate to replication foci for translesion DNA synthesis of UV-induced DNA lesions.

89 how that NDP kinase mutants are dependent on translesion DNA synthesis, often a mutagenic form of DNA

90 T2AA significantly inhibited translesion DNA synthesis on a cisplatin-cross-linked te

91 approach, we examined the effect of impaired translesion DNA synthesis on cisplatin response in aggre

92 Nevertheless, translesion DNA synthesis opposite 8-oxoguanine was obse

93 Pol theta has the ability to conduct translesion DNA synthesis opposite an AP site or thymine

94 decade that specialized DNA polymerases for "translesion DNA synthesis" or "TLS" were identified and

95 xide, consistent with a role for DinB(Pa) in translesion DNA synthesis over N2-dG adducts.

96 Because pol beta has been shown to perform translesion DNA synthesis past cisplatin (CP)- and oxali

97 gesting their catalytically limited roles in translesion DNA synthesis past deaminated, oxidized base

98 ependent DPC unfolding is also essential for translesion DNA synthesis past DPCs that cannot be degra

99 and kappa, which have been shown to catalyze translesion DNA synthesis past several DNA lesions.

100 both nucleolytic incisions near the ICL and translesion DNA synthesis past the lesion.

101 hosphates on DNA polymerases when performing translesion DNA synthesis past the pro-mutagenic DNA add

102 llow us to conveniently screen regulators of translesion DNA synthesis pathway and monitor environmen

103 g., REV1, REV3L) involved in the error-prone translesion DNA synthesis pathway can sensitize intrinsi

104 e, the authors present the structures of the translesion DNA synthesis polymerase Rev1 in complex wit

105 is would preserve the substrate for the REV1 translesion DNA synthesis polymerase to incorporate cyto

106 it of DNA polymerase zeta (Polzeta), 1 of 10 translesion DNA synthesis polymerases known in mammals.

107 rs to recruit and coordinate replicative and translesion DNA synthesis polymerases to ensure genome i

108 A, animal cell mitochondria lack specialized translesion DNA synthesis polymerases to tolerate these

109 a ubiquitin-conjugating enzyme critical for translesion DNA synthesis, potentiates B-catenin stabili

110 a ubiquitin-conjugating enzyme critical for translesion DNA synthesis, potentiates beta-catenin stab

111 At the molecular level, the enhancement in translesion DNA synthesis reflects a substantial increas

112 ase that has multiple cellular roles such as translesion DNA synthesis, replication of repetitive seq

113 Translesion DNA synthesis represents the ability of a DN

114 Translesion DNA synthesis represents the ability of a DN

115 seamlessly coordinate both high fidelity and translesion DNA synthesis requires a means to regulate r

116 ity (DNA pol V) that facilitates error-prone translesion DNA synthesis (SOS mutagenesis).

117 These pathways include translesion DNA synthesis, template switching and reprim

118 These pathways broadly include translesion DNA synthesis, template switching, and repli

119 inks (ICLs) are repaired by mechanisms using translesion DNA synthesis that is regulated by monoubiqu

120 Translesion DNA synthesis, the ability of a DNA polymera

121 Due to the critical role of PolH in translesion DNA synthesis, the activity of PolH is tight

122 titude in promoting efficient and error-free translesion DNA synthesis through the diverse array of b

123 irradiation, DNA polymerases specialized in translesion DNA synthesis (TLS) aid DNA replication.

124 Translesion DNA synthesis (TLS) allows bypass of DNA les

125 DNA polymerase V, which participates in both translesion DNA synthesis (TLS) and a DNA damage checkpo

126 which repair is initiated by NER followed by translesion DNA synthesis (TLS) and completed through an

127 Translesion DNA synthesis (TLS) and homologous recombina

128 tochondrial DNA replication by virtue of its translesion DNA synthesis (TLS) and repriming activities

129 served Y family enzyme that is implicated in translesion DNA synthesis (TLS) but whose cellular funct

130 Translesion DNA synthesis (TLS) can use specialized DNA

131 A polymerase zeta (Polzeta) is important for translesion DNA synthesis (TLS) during replication, due

132 Translesion DNA synthesis (TLS) during S-phase uses spec

133 switch from accurate DNA repair to mutagenic translesion DNA synthesis (TLS) during the SOS response

134 In one model pair, up-regulation of translesion DNA synthesis (TLS) enabled tolerance of OT-

135 DNA polymerase eta (Poleta) is a unique translesion DNA synthesis (TLS) enzyme required for the

136 DNA polymerase eta (Poln) is a unique translesion DNA synthesis (TLS) enzyme required for the

137 ored biallelic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as

138 Most translesion DNA synthesis (TLS) in Escherichia coli is d

139 tion in DNA polymerase V- (pol V-) dependent translesion DNA synthesis (TLS) in vivo.

140 zeta (REV3 and REV7) play important roles in translesion DNA synthesis (TLS) in which DNA replication

141 Translesion DNA synthesis (TLS) is a DNA damage toleranc

142 Translesion DNA synthesis (TLS) is a process whereby spe

143 Translesion DNA synthesis (TLS) is the ability of DNA po

144 ions encountered on the template strand, and translesion DNA synthesis (TLS) is used to rescue progre

145 nopus and show that it is dependent upon the translesion DNA synthesis (TLS) master regulator Rad18.

146 Translesion DNA synthesis (TLS) mediated by low-fidelity

147 Translesion DNA synthesis (TLS) of damaged DNA templates

148 -family DNA polymerase capable of catalyzing translesion DNA synthesis (TLS) on certain DNA lesions,

149 Rev1 is a translesion DNA synthesis (TLS) polymerase involved in t

150 the replication of AraC, the lower-fidelity translesion DNA synthesis (TLS) polymerase Poleta is pro

151 s are converted to dsDNA with an appropriate translesion DNA synthesis (TLS) polymerase, followed by

152 l three kingdoms of life possess specialized translesion DNA synthesis (TLS) polymerases (Pols) that

153 randed DNA (dsDNA) form by using appropriate translesion DNA synthesis (TLS) polymerases and then can

154 Screening different translesion DNA synthesis (TLS) polymerases by the use o

155 We propose that NusA recruits translesion DNA synthesis (TLS) polymerases to RNA polym

156 t include mismatch repair (MMR) proteins and translesion DNA synthesis (TLS) polymerases.

157 es the cooperative actions of at least three translesion DNA synthesis (TLS) polymerases: Poleta, REV

158 used attention on the umuD(+)C(+)-dependent, translesion DNA synthesis (TLS) process that is responsi

159 Saccharomyces cerevisiae, Rev1 functions in translesion DNA synthesis (TLS) together with polymerase

160 In translesion DNA synthesis (TLS), a specialized TLS pol i

161 pathways such as nucleotide-excision repair, translesion DNA synthesis (TLS), and homologous recombin

162 r processes, including nucleolytic incision, translesion DNA synthesis (TLS), and homologous recombin

163 ession, promoting replication fork reversal, translesion DNA synthesis (TLS), and repriming.

164 Little is known on how hypoxia affects Translesion DNA Synthesis (TLS), in which error-prone DN

165 The two main tolerance strategies are translesion DNA synthesis (TLS), in which low-fidelity D

166 gene products, all implicated in error-prone translesion DNA synthesis (TLS), mediate mutagenesis in

167 In translesion DNA synthesis (TLS), specialized DNA polymer

168 l of attention due to the roles they play in translesion DNA synthesis (TLS), the potentially mutagen

169 Given the critical role of pol eta during translesion DNA synthesis (TLS), these findings unveil a

170 is specialized for the extension reaction in translesion DNA synthesis (TLS).

171 nit and Rev7 accessory subunit, in promoting translesion DNA synthesis (TLS).

172 bute to the bypassing of DNA lesions, termed translesion DNA synthesis (TLS).

173 ast damaged DNA nucleotides in yeast through translesion DNA synthesis (TLS).

174 ng that CSCs may have intrinsically enhanced translesion DNA synthesis (TLS).

175 s cope with replication-blocking lesions via translesion DNA synthesis (TLS).

176 cialized low fidelity polymerases to perform translesion DNA synthesis (TLS).

177 red during S-phase and may be carried out by translesion DNA synthesis (TLS).

178 haracterized for their ability to facilitate translesion DNA synthesis (TLS).

179 nal modification essential for DNA repair by translesion DNA synthesis (TLS).

180 lerance to DNA damage by replicative bypass [translesion DNA synthesis (TLS)].

181 he replicative bypass of base damage in DNA (translesion DNA synthesis [TLS]) is a ubiquitous mechani

182 fore resorting to mutagenic pathways such as translesion DNA synthesis to bypass these impediments to

183 During translesion DNA synthesis, Ug was bypassed more efficien

184 The mechanism and dynamics of translesion DNA synthesis were evaluated using primer/te

185 NA damage are the consequence of error-prone translesion DNA synthesis, which could be responsible fo

186 V serve dual roles by facilitating efficient translesion DNA synthesis while simultaneously introduci