ライフサイエンスコーパス: translocase

1 a 3' to 5' translocase, and RecD, a 5' to 3' translocase).

2 slpA, cwp66 (adhesin), and secA2 (secretory translocase).

3 d with EcRep and EcUvrD (both 3' to 5' ssDNA translocases).

4 annel to the import motor of the presequence translocase.

5 dria and are translocated by the presequence translocase.

6 gnal peptide-independent assembly of the Tat translocase.

7 ion with the very C-terminus of the FtsK DNA translocase.

8 l process catalyzed predominantly by the Sec translocase.

9 f substepping events in a hexameric helicase/translocase.

10 t these events reflect active pushing by the translocase.

11 gets ribosome-associated proteins to the Sec translocase.

12 ition particle (SRP), an SRP receptor, and a translocase.

13 ated Tha4 entry into the chamber to form the translocase.

14 terminus (FtsKC) is a well characterized DNA translocase.

15 l morphology nor the assembly of the protein translocase.

16 nits a and b and the TatC subunit of the Tat translocase.

17 nerated at least in part by the SMARCAL1 DNA translocase.

18 n factors mtEF-Tu and mtEF-G1, and the Oxa1L translocase.

19 -coupled repair (TCR) is mediated by the Mfd translocase.

20 ing and in triggering assembly of the active translocase.

21 ly through the membrane-embedded SecA-SecYEG translocase.

22 rane and lumen by the SEC1, TAT, or SRP/ALB3 translocases.

23 that TatE-GFP associates with functional Tat translocases.

24 rs ABCA1 and ABCG1, which are membrane lipid translocases.

25 o study more complicated substrates or other translocases.

26 d into mitochondria with the help of protein translocases.

27 is regulated by chaperones and mitochondrial translocases.

28 by a specialized class of ATP-dependent DNA translocases.

29 and that they represent a novel class of DNA translocases.

30 chloroplast envelope membrane by undescribed translocases.

31 Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane p

32 with and dephosphorylate adenine nucleotide translocase 1 (ANT1), a central molecule controlling mit

33 y acid stimulation of the adenine nucleotide translocase 2 (ANT2), an inner mitochondrial membrane pr

34 mics screening identified adenine nucleotide translocase 3 (ANT3) as a previously unknown mortalin su

35 of new glaucoma related candidates, ADP/ATP translocase 3 (ANT3), PC4 and SRFS1-interacting protein

36 e PaoABC, that is co-translocated by the Tat translocase according to a ternary "hitchhiker" mechanis

37 ther with derlin-related proteins, potential translocases across the middle membrane, and an extremel

38 To better understand how translocases act in crowded environments, we used single

39 ATP-independent manner, distinct from a DNA translocase actively threading the downstream DNA in the

40 und that ABCA1's PIP2 and phosphatidylserine translocase activities are independent from each other.

41 ain their ubiquitin ligase, ATPase and dsDNA translocase activities but are impaired in binding to a

42 dicates that RecBCD helicase possesses ssDNA translocase activities in both polarities.

43 inding, PCNA-polyubiquitin-ligase, and dsDNA-translocase activities, respectively.

44 lag in initiating its ATPase as well as the translocase activities.

45 r protein that has ATPase, endonuclease, and translocase activities.

46 solving chromosome bridges requires both DNA translocase activity and ability to bind chromosomal pro

47 Fork reversal in vivo also requires ZRANB3 translocase activity and its interaction with polyubiqui

48 s a previously unrecognized role of the Dna2 translocase activity in DNA break end resection and in t

49 Here we probed the single-stranded DNA translocase activity of Escherichia coli UvrD by single

50 and provides strong structural support for a translocase activity of XPB.

51 fication tag (TAPN-Drs2), retains ATPase and translocase activity, but Drs2p purified using a C-termi

52 scription elongation and, using its helicase/translocase activity, forces RNA polymerase to slide bac

53 ay limits R-loop accumulation requires FANCM translocase activity.

54 ntains an Ssl2-dependent double-stranded DNA translocase activity.

55 sion incision activities, which requires its translocase activity.

56 We show that the FtsK DNA translocase acts differentially at the recombination sit

57 binding, ssDNA endonuclease, 5' to 3' ssDNA translocase and 5' to 3' helicase activity.

58 coli this threat is kept at bay by RecG DNA translocase and by single-strand DNA exonucleases.

59 pTatC is the core component of the thylakoid translocase and coordinates transport through interactio

60 rotated ribosomes favor binding of the eEF2 translocase and disfavor that of the elongation ternary

61 was strongly reduced by inactivation of the translocase and DNA binding activities of the FANCM/MHF

62 iated with the expression of CD36/fatty acid translocase and elevated free fatty acid (FFA) levels.

63 he RAD51 nucleoprotein filament, but not its translocase and helicase activities.

64 Hsp104 is a dynamic ring translocase and hexameric AAA+ protein found in yeast, w

65 ial component of the gating module of the ER translocase and is required to maintain the ER permeabil

66 ex, functions as a gatekeeper of presequence translocase and thereby maintains quality control of inn

67 onsumption independent of adenine nucleotide translocase and uncoupling proteins, decreased mitochond

68 induces transient increase of mitochondrial translocases and a dramatic accumulation of the mitochon

69 rnating active D2 modules are robust protein translocases and function with double the energetic effi

70 Several translocases and insertases have been found in prokaryot

71 ty to engage in intimate collaborations with translocases and other DNA-processing enzymes are far mo

72 ses two superfamily-1 motors, RecB (3' to 5' translocase) and RecD (5' to 3' translocase), that opera

73 ooperates with cochaperones, the presequence translocase, and other chaperone systems.

74 ecBCD possesses two motors (RecB, a 3' to 5' translocase, and RecD, a 5' to 3' translocase).

75 a threonine in motif Ic, widely conserved in translocases, and a family-specific histidine near motif

76 tive to inhibitors of the adenine nucleotide translocase (ANT) and of the voltage-dependent anion cha

77 Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochon

78 Members of the adenine nucleotide translocase (ANT) family exchange ADP for ATP across the

79 nockdown or inhibition of adenine nucleotide translocase (ANT), cyclophilin D (CypD), or mitochondria

80 dentified this protein as adenine nucleotide translocase (ANT), represented by two highly similar iso

81 in the cell, where insertion is assisted by translocase apparatus.

82 Hsp100 polypeptide translocases are conserved members of the AAA+ family (a

83 e substrate receptor complex, and active Tat translocases are formed by the substrate-induced associa

84 Here, using a novel real-time translocase assay, we unexpectedly discovered that Mfd t

85 ucture of the pore complex inform models for translocase assembly and translocation.

86 previously, the sequence and dynamics of Tat translocase assembly remain to be determined.

87 ration: It binds the signal peptide, directs translocase assembly, and may facilitate translocation.

88 The SRP-independent pathway requires the Sec translocase-associated ER membrane protein Sec62 and can

89 rtner protein complexes like the presequence translocase-associated import motor and the respiratory

90 nner membrane is provided by the presequence translocase-associated motor (PAM) which contains the J-

91 t of nascent membrane proteins to the SecYEG translocase at the plasma membrane.

92 ree, indicating the existence of alternative translocases at the inner envelope membrane.

93 mechanism for reorganization is for an ssDNA translocase (ATP-dependent motor) to push the SSB along

94 Furthermore, the stromal domain of the Alb3 translocase binds with high affinity to and regulates GT

95 of the mitochondrial outer membrane protein translocase but not the two receptor subunits, one of wh

96 that is involved in their binding to the Tat translocase, but some facets of this interaction remain

97 nly two nucleotide transporters, the ATP/ADP translocase C. trachomatis Npt1 (Npt1(Ct)) and the nucle

98 We determined that carnitine acyl-carnitine translocase (CACT; Slc25a20) is a direct target of these

99 , which may explain why only a subset of DNA translocases can carry out fork reversal.

100 MraY (phospho-MurNAc-pentapeptide translocase) catalyses the first and an essential membra

101 heterodimer with P4 ATPases to enhance their translocase catalytic activity.

102 es mitophagy independently of its nucleotide translocase catalytic activity.

103 are induced by repression of the fatty acid translocase CD36, which is seen in desmoplastic and dise

104 old, p < 0.001), and, to a lesser degree, FA translocase (CD36) (3.1-fold, p < 0.001) relative to A1A

105 receptor, GPR119] and upstream (a fatty acid translocase, CD36) signaling targets of N-oleoylethanola

106 Here we show that the PA translocase channel has a transport function in which it

107 thrax toxin is composed of three proteins, a translocase channel-forming subunit, called protective a

108 ge, the injectisome, with a cytoplasm-facing translocase channel.

109 Therefore, peptide-clamp sites in translocase channels can sense large steric features (li

110 These translocase channels interact with the substrate protein

111 back to the IMS to integrate with the TIM23 translocase complex and align with the Tim50 protein.

112 Tom40 is the central subunit of the translocase complex and forms a pore in the mitochondria

113 A new study of the bacterial Sec translocase complex reports that ADP/ATP binding to SecA

114 Among these, we identify the protein translocase complex subunit Timm50 as a putative Pptc7 s

115 potential or the structure of the preprotein translocase complexes.

116 n of both the incoming presequence and other translocase components at the translocation contact.

117 We show that a lipid membrane (devoid of translocase components) is sufficient for successful co-

118 ubiquitin E3 ligase SP1, which regulates OEM translocase components.

119 The presequence translocase constituent Pam17 is specifically recruited

120 s spectrometry and identified ROMO1 as a new translocase constituent with an exceptionally short half

121 ring-shaped protein and nucleic acid protein translocases control essential biochemical processes thr

122 te a lipid-dependent dimer formation of MraY translocase correlating with the enzymatic activity.

123 licensed and fired, it is possible that DNA translocases could disrupt pre-replicative complexes (pr

124 Replacement of PICH with its translocase-deficient mutants led to increased SUMO2/3 f

125 ablishing that length has a linear effect on translocase dependence.

126 We also show that translocase depletion in tumor cell lines leads to the a

127 We tested charge density as a translocase determinant and confirmed that the addition

128 have evaluated length and charge density as translocase determinants using model proteins.

129 The protein translocases do not operate as separate entities but are

130 that involves ATP hydrolysis by RIG-I's RNA translocase domain.

131 Bidentate interactions with the Alb3 translocase drive cpSRP43 to a partially inactive state,

132 Two protein translocases drive the import of beta-barrel precursor p

133 approaches to guide studies of the putative translocase EccC, a unique enzyme with three ATPase doma

134 ormed with the Taura syndrome virus IRES and translocase eEF2*GTP bound with sordarin.

135 conserved principles of interaction between translocase/effector and substrate/recipient.

136 the effect of force directionality, and the translocase efficacy.

137 RecG is a DNA translocase encoded by most species of bacteria.

138 ed substrates are chaperone-delivered to the translocase, EscV in enteropathogenic Escherichia coli,

139 eracting checkpoint helicase (PICH) is a DNA translocase essential for chromosome bridge resolution d

140 ave tackled the question of how FtsK/SpoIIIE translocases establish and maintain directional DNA tran

141 ion in a pathway parallel to that of the DNA translocase FANCM.

142 f multiple types of branched DNAs by the DNA translocase FANCM.

143 Fatty acid translocase (FAT/CD36), whose expression is inducible in

144 Lipid translocases (flippases) have been implicated in vesicle

145 agonizing both the FANCM-family DNA helicase/translocase Fml1 and the RecQ-type DNA helicase Rqh1 to

146 the pore-forming component to assemble a new translocase for each substrate.

147 The active translocase for the precursor of periplasmic galactose-b

148 d Hsp104(A503S) can operate as nonprocessive translocases for soluble substrates, indicating a "parti

149 in, each require the concerted action of two translocases for their assembly.

150 e special cases, the divisome-associated DNA translocase FtsK is required.

151 upt RAD51 filaments on DNA through its ssDNA translocase function.

152 The FtsK dsDNA translocase functions in bacterial chromosome unlinking

153 , the known conductance bottleneck in the PA translocase, gates as either a more closed state or a mo

154 It remains unclear how these DNA translocases harness chemical energy (ATP turnover) to p

155 riers, but their association with preprotein translocases has been controversial.

156 o replication stress, the SNF2 family of DNA translocases has emerged as being responsible for remode

157 The RAD54 family DNA translocases have several biochemical activities.

158 factor configuration, without the dedicated translocase/helicase encoding factor TFIIH.

159 responses in humans is the Rad5-related DNA translocase, HLTF.

160 essential, membrane-embedded subunit of the translocase; however, its function is only poorly unders

161 Here, we discuss repurposing AAA+ protein translocases Hsp104 and proteasome-activating nucleotida

162 ntibacterial activity by targeting bacterial translocase I (MraY).

163 Translocase I (MraY/MurX) is an essential enzyme in grow

164 while not affecting the architecture of the translocase, impedes both protein and tRNA import.

165 fe and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized pep

166 TatE being a regular constituent of the Tat translocase in E. coli.

167 long-timescale investigations of the active translocase in near-native conditions and, more generall

168 he respective roles of UvrD helicase and Mfd translocase in repair of UV-induced damage.

169 iver secretory proteins to the Sec61 protein translocase in the endoplasmic reticulum membrane.

170 es evidence for a role of adenine nucleotide translocase in the mechanism underlying altered mitochon

171 with components of the TOM complex, the main translocase in the outer membrane.

172 uctural model for assembly of the active Tat translocase in which substrate binding triggers replacem

173 d PE affect the function of distinct protein translocases in mitochondrial beta-barrel biogenesis.

174 oteins that are imported from the cytosol by translocases in the chloroplast envelope membranes.

175 Using purified proteins we show that DNA translocases, including RNA polymerase, can push budding

176 These FRET spikes result from translocase-induced directional (5' to 3') pushing of th

177 for understanding the integration of protein translocases into a large network that controls organell

178 y apply generally in organizing AAA+ protein translocases into their active conformations.

179 case-like transcription factor (HLTF), a DNA translocase involved in the repair of damaged replicatio

180 Targeting to the translocase is mediated by signal peptides.

181 ulator of chromatin, subfamily A-like 1) DNA translocase is one of several related enzymes, including

182 Proteolytic regulation of the translocases is critically important, but little is know

183 MraY (phospho-MurNAc-pentapeptide translocase) is an integral membrane enzyme that catalyz

184 ana RECG1, an ortholog of the bacterial RecG translocase, is an organellar protein with multiple role

185 The other interacts with the FANCM DNA translocase, is more prominent in late S phase, and favo

186 emonstrated previously for the budding yeast translocases, is ATPase-dependent disruption of RAD51-ds

187 s on the core subunits of the protein import translocase, it does not require the protein import rece

188 D54L and RAD54B, which are Swi2/Snf2-related translocases known to dissociate RAD51 filaments from ds

189 Further study and engineering of AAA+ translocases like Hsp104 and PAN will reveal promising a

190 These data demonstrate that the SEC2 translocase likely integrates a subset of inner envelope

191 e imported by the TIM23 complex (presequence translocase) located in the inner mitochondrial membrane

192 results also suggest that XPB/Ssl2 uses this translocase mechanism during DNA repair rather than phys

193 We determined that the DNA translocase Mfd is an "evolvability factor" that promote

194 the direction for the movement of the dsDNA translocase motor domain for fork reversal.

195 FtsK/SpoIIIE translocases move DNA in a highly processive, directiona

196 Phospho-MurNAc-pentapeptide translocase (MraY) catalyzes the synthesis of Lipid I, a

197 e such target is phospho-MurNAc-pentapeptide translocase (MraY), an essential integral membrane enzym

198 rane protein and core component of the TIM22 translocase of inner membrane, as a protein with cystein

199 ntington's disease (HD), associates with the translocase of mitochondrial inner membrane 23 (TIM23) c

200 The translocase of outer mitochondrial membrane (TOMM) compl

201 consisting of the mitochondrial translocase, translocase of outer mitochondrial membrane 22 (Tom22),

202 Translocase of outer mitochondrial membrane 34 (TOMM34)

203 hepatocyte nuclear factor 4, alpha), TOMM34 (translocase of outer mitochondrial membrane 34) and SRC

204 metric data, the apolipoprotein E (APOE) and translocase of outer mitochondrial membrane 40 homolog (

205 , we identify novel BMI associations in loci translocase of outer mitochondrial membrane 40 homolog (

206 cristae organizing system 60-kD subunit, the translocase of outer mitochondrial membrane 40-kD subuni

207 ria and by ubiquitylation of subunits of the translocase of outer mitochondrial membrane.

208 and Erv1/ALR facilitates import of the small translocase of the inner membrane (Tim) proteins and cys

209 The presequence translocase of the inner membrane (TIM23 complex) mediat

210 matrix, particularly if the function of the translocase of the inner membrane 23 is compromised such

211 There are three isoforms of the TRANSLOCASE OF THE INNER MEMBRANE17 (Tim17).

212 Previously, we characterized the essential translocase of the mitochondrial inner membrane (TIM) co

213 is required for the assembly of the archaic translocase of the outer membrane (ATOM), the functional

214 e domain of the translocase subunit, archaic translocase of the outer membrane (ATOM)14, on the other

215 s into the mitochondrial outer membrane: The translocase of the outer membrane (TOM complex) promotes

216 ority of precursor proteins, the role of the translocase of the outer membrane (TOM) and mechanisms o

217 res two preprotein translocases, the general translocase of the outer membrane (TOM) and the sorting

218 Emc proteins interact with the mitochondrial translocase of the outer membrane (TOM) complex protein

219 translocating precursor proteins through the translocase of the outer membrane (TOM) complex.

220 way, namely transferring substrates from the translocase of the outer membrane complex onto the small

221 must be transported into mitochondria by the translocase of the outer membrane complex.

222 ort and assembly of proteins, including TOM (translocase of the outer membrane) and SAM (sorting and

223 One SNP--rs2075650, located in TOMM40 (translocase of the outer mitochondrial membrane 40 homol

224 and enter the organelle via the TOM complex (translocase of the outer mitochondrial membrane).

225 Furthermore, Tim29 contacts the Translocase of the Outer Mitochondrial Membrane, TOM com

226 gation utilizes highly conserved directional translocases of the SpoIIIE/FtsK family.

227 show that isolated NPH I acts as a 5' to 3' translocase on single-stranded DNA.

228 The mechanisms by which these DNA translocases operate remain largely unknown.

229 y of UvrD when it is functioning either as a translocase or a helicase on DNA in the absence of RecA.

230 istent with EF4 functioning either as a back-translocase or a ribosome sequester.

231 lesion, perhaps by Cockayne syndrome group B translocase, or during the synthesis of a repair patch.

232 p90, and translocated to its interior by the translocase outer membrane (TOM) complex.

233 grated activity of a series of mitochondrial translocases, proteinases, and chaperones.

234 relocate the His-289 residue, such that the translocase reaction can proceed via a nucleophilic atta

235 e imaging to determine how the ATP-dependent translocase RecBCD travels along DNA occupied by tandem

236 e mechanisms by which SMARCAL1 and other DNA translocases repair replication forks are poorly underst

237 smembrane segments of PClep can decrease the translocase requirement for translocation of the peptide

238 Here, we find that the translocase requirements can be altered for PClep in a p

239 SpoIIIE is a homo-hexameric dsDNA translocase responsible for completing chromosome segreg

240 TraB is an FtsK-like DNA translocase responsible for conjugative plasmid transfer

241 charomyces cerevisiae Pif1, a 5' to 3' ssDNA translocase, results in the appearance of isolated, irre

242 pon the adenosine triphosphate-dependent RNA translocase Rho, which binds nascent RNA and dissociates

243 loading of the targeting complex at membrane translocase sites in the post-translational cpSRP pathwa

244 uced stalled forks, the function of the SNF2 translocases (SMARCAL1, ZRANB3, or HLTF), implicated in

245 ivision septum into the forespore by the DNA translocase SpoIIIE.

246 ort intermediates from mitochondrial protein translocases, stabilize protein homeostasis within mitoc

247 vels of the mitochondrial adenine nucleotide translocase stress-sensitive B (SesB), increased adenosi

248 on of TFIIH preparations carrying mutant XPB translocase subunit further indicate that this relief of

249 nits, i.e., Ssl1, Tfb4, and Tfb2, in the DNA translocase subunit Ssl2, and in the kinase module subun

250 dent despite a requirement for the TFIIH DNA translocase subunit Ssl2.

251 eriochlorophyll synthase (BchG), the protein translocase subunit YajC and the YidC membrane protein i

252 ion of the intermembrane space domain of the translocase subunit, archaic translocase of the outer me

253 ASCE ATPases include ring-translocases such as cellular helicases and viral DNA pa

254 Sam37 functions as a coupling factor of the translocase supercomplex of the mitochondrial outer memb

255 Ring-shaped hexameric helicases and translocases support essential DNA-, RNA-, and protein-d

256 The twin-arginine translocase (Tat) transports folded proteins across the

257 The twin-arginine translocase (Tat) transports folded proteins across tigh

258 The twin arginine translocase (Tat) transports folded proteins of widely v

259 In the translocase, Tha4 made an additional contact within the

260 PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs)

261 rsely with the need for Rho activity, an RNA translocase that can bind to emerging transcripts and di

262 flippase trigger expression of an alternate translocase that can resist inhibition.

263 scherichia coli UvrD is an SF1A DNA helicase/translocase that functions in chromosomal DNA repair and

264 richia coli UvrD is a superfamily 1 helicase/translocase that functions in DNA repair, replication, a

265 pA is a hexameric double-ring AAA+ unfoldase/translocase that functions with the ClpP peptidase to de

266 that Msp1 is a robust bidirectional protein translocase that is able to unfold diverse substrates by

267 nation, the activity of an ATP-dependent DNA translocase that is thought to dissociate the elongation

268 SpoIIIE is a membrane-anchored DNA translocase that localizes to the septal midpoint to med

269 FtsK is a bacterial translocase that promotes chromosome dimer resolution an

270 tion by the enzyme Rho, an ATP-dependent RNA translocase that releases RNA by forcing uncharacterized

271 hat depletion of SMARCAL1, a SNF2-family DNA translocase that remodels stalled forks, restores replic

272 coli Rho factor is an exemplar hexameric RNA translocase that terminates transcription in bacteria.

273 ognition that at its core is common to ss/ds translocases that act on DNA or RNA.

274 cB (3' to 5' translocase) and RecD (5' to 3' translocase), that operate on the complementary DNA stra

275 NA-packaging motor, beside the bacterial DNA translocases, that uses a revolving mechanism without ro

276 ences through the TIM23 complex (presequence translocase), the activity of the Hsp70-powered import m

277 nhibitors of Mtb phospho-MurNAc-pentapeptide translocase, the enzyme responsible for the synthesis of

278 beta-barrel proteins requires two preprotein translocases, the general translocase of the outer membr

279 The carrier translocase (TIM22 complex) inserts multispanning protei

280 s required for inhibition of the presequence translocase TIM23, which leads to stabilization of PINK1

281 The presequence translocase (TIM23 complex) sorts precursor proteins wit

282 The ability of translocases to chemo-mechanically push heterologous SSB

283 roteases that collaborate with ATP-dependent translocases to degrade protein substrates.

284 pe III secretion system (T3SS) effectors and translocases to inhibit bacterial invasion of epithelial

285 We report that the mitochondrial translocase Tom22 is essential for metabolic conversion,

286 oteins with the outer mitochondrial membrane translocase, Tom22, to activate metabolic activity in th

287 of a complex consisting of the mitochondrial translocase, translocase of outer mitochondrial membrane

288 Twin-arginine-dependent translocases transport folded proteins across bacterial,

289 Two protein translocases transport precursor proteins into or across

290 lar Cell, Wei et al. (2017) report how a DNA translocase uses SUMO as a cue to save Top2 from ubiquit

291 of the translating ribosome from SecA to the translocase via a concerted mechanism.

292 Hsp104 is a hexameric AAA(+) ring translocase, which drives protein disaggregation in nonm

293 cO supercomplexes is independent of the Bcs1 translocase, which mediates Rip1 translocation during bc

294 uced dysregulation in the adenine nucleotide translocase, which results in a slower rate of ADP or AT

295 ed with diverse cellular activities) protein translocases, which naturally unfold and translocate sub

296 also known as a single-stranded DNA (ssDNA) translocase, while how ScPif1 translocates on ssDNA is u

297 In physiological settings, DNA translocases will encounter DNA-bound proteins, which mu

298 nd to reveal molecular details about the Wzx translocase, Wzy polymerase and O-PS chain-length determ

299 F), and the SWI/SNF catalytic subunit (SNF2) translocase zinc finger ran-binding domain containing 3

300 vitro by multiple enzymes, including the DNA translocase ZRANB3, shown to bind polyubiquitinated PCNA