ライフサイエンスコーパス: transmembrane

1 hange identified that the LBS is composed of transmembrane 3 (TM3) domain and TM7.

2 Studies of lysosome associated protein transmembrane 4B (LAPTM4B) have mainly focused on the 35

3 proteins microsomal TG transfer protein and transmembrane 6 superfamily member 2 (TM6SF2), the latte

4 We show that transmembrane actin nuclear (TAN) lines are induced by s

5 selves and the spatial separation of the key transmembrane adaptor protein LAT from the TCR.

6 ngolipid-enriched microdomains 1 (PAG1) is a transmembrane adaptor protein that affects immune recept

7 The integrin family of transmembrane adhesion receptors coordinates complex sig

8 o confirm its alpha-helical conformation and transmembrane alignment.

9 Here we test whether transmembrane allosteric coupling controls the potassium

10 ity in the activation gate and is subject to transmembrane allostery.

11 GPCRs are characterized by a seven-transmembrane alpha-helical structure, transmitting extr

12 nal prenyl groups (Ypt7-pr) or a recombinant transmembrane anchor (Ypt7-tm).

13 pt7, whether bound to membranes by prenyl or transmembrane anchor.

14 d for pMHC-induced structural changes in the transmembrane and cytoplasmic regions of CD3 subunits.

15 ormation, with or without replacement of its transmembrane and cytoplasmic tail domains with their co

16 omologous crystal structures of the separate transmembrane and dehydrogenase domains, consistent with

17 udy demonstrates that cell adhesion molecule transmembrane and immunoglobulin domain containing 1 (TM

18 selective environment for a large number of transmembrane and membrane-associated proteins.

19 With the view of developing selective transmembrane anion transporters, a series of phosphoniu

20 not previously on the radar-the "nonswapped" transmembrane architecture, an "intrinsic ligand," and h

21 dies showed that AP-4 mediates export of the transmembrane autophagy protein ATG9A from the TGN to pr

22 of regulated secretory cargoes (soluble and transmembrane) away from constitutively secreted protein

23 ATF6 and BBF2H7 are transmembrane basic leucine zipper transcription factors

24 BsYetJ is a bacterial homolog of transmembrane BAX inhibitor-1 motif-containing 6 (TMBIM6

25 e N-domain to the interior of the C-terminal transmembrane beta-barrel (inter-N-C).

26 Using the Yersinia pestis outer transmembrane beta-barrel Ail as a model, we delineated

27 adopt a TpsB fold, containing a 16-stranded transmembrane beta-barrel connected to two periplasmic d

28 and propofol reveal both distinct and common transmembrane binding sites, which are shared in part by

29 erting into the ligand binding pocket at the transmembrane bundle of the receptor, which subsequently

30 amic structural transitions within the seven-transmembrane bundle represent the mechanism by which G-

31 e finger loop of betaarr1 into the M2R seven-transmembrane bundle, which adopts a conformation simila

32 iased screening strategy, we identified five transmembrane C1q signaling/receptor candidates in hNSC

33 igates the role of TRPV4 channels, which are transmembrane calcium channels that can regulate vascula

34 te hydration shell while passing between the transmembrane cavity and cytosol, which must be accommod

35 The sealed transmembrane channel is asymmetric, with one open and o

36 sk is the machinery of the Sec translocon, a transmembrane channel that is involved in both the trans

37 Transmembrane channels and pores have key roles in funda

38 Oligomers of pneumolysin form transmembrane channels in cholesterol-containing lipid b

39 nervous system by forming calcium-permeable transmembrane channels upon binding glutamate and coagon

40 C-X-C chemokine receptor 4 (CXCR4) is a transmembrane chemokine receptor involved in growth, sur

41 ing of HIF-1 to the ATG9A promoter, the only transmembrane component within the autophagy pathway, wa

42 tal cells and frequently coexpressed with CF transmembrane conductance regulator (CFTR) along with tr

43 ssive disease, caused by mutations in the CF transmembrane conductance regulator (CFTR) chloride chan

44 r caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene.

45 binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) have distinct

46 The cystic fibrosis transmembrane conductance regulator (CFTR) is a plasma m

47 es the common human Phe508del (DeltaF508) CF transmembrane conductance regulator (CFTR) mutation, whe

48 ells, motile ciliated cells, cystic fibrosis transmembrane conductance regulator (CFTR)-rich ionocyte

49 cidic pH produced by loss of cystic fibrosis transmembrane conductance regulator anion channels or pr

50 tionale: Enhancing non-CFTR (cystic fibrosis transmembrane conductance regulator)-mediated anion secr

51 o for lumen formation, CFTR (cystic fibrosis transmembrane conductance regulator).

52 ding sites for BODIPY-cyclopamine on the SMO transmembrane core in live cells in real time.

53 This indicates that the rhomboid transmembrane core is intrinsically monomeric.

54 simulations, yields a molecular model of the transmembrane core signalling unit and enables spatial l

55 Modeling results show how changes in cEC transmembrane current densities and gap junctional resis

56 uced cell stretch evoked a rapid increase in transmembrane current that was inhibited by antagonists

57 nd this improved functionality mapped to the transmembrane/cytoplasmic part of alpaca BTN3.

58 positive allosteric modulator binding at the transmembrane dimerization interface.

59 m structure and the drug-binding site of E's transmembrane domain (ETM), determined using solid-state

60 y a global conformational change of all Orai transmembrane domain (TM) helices within the channel com

61 s membrane-related components, including the transmembrane domain (TMD) and cytoplasmic tail (CT), ca

62 d analysis on Pyr, finding that it harbors a transmembrane domain (TMD) and extended C-terminal intra

63 omain (ECD) and allosteric regulation of the transmembrane domain (TMD) from synergistic 5-HT binding

64 subunit: a highly conserved primary site in transmembrane domain (TMD) housing the Zn(2+) substrate;

65 on tau pathology are also confirmed with APP transmembrane domain (TMD) mutant hNPCs, which display d

66 has demonstrated that the carboxyl-terminal transmembrane domain (TMD) of some Bcl-2 protein family

67 At least 25 different, transmembrane domain (TMD)-containing E3s are predicted

68 Transmembrane domain 1 (TMD1) regulates this activity, w

69 A peptide analog of transmembrane domain 2 (TM2) of CXCR4 interfered with PA

70 hese novel findings, we propose alpha(1D-)AR transmembrane domain 2 acts as an ER localization signal

71 es early termination of alpha(1D)-AR between transmembrane domain 2 and 3.

72 infected primary CD4(+) T cells through its transmembrane domain and alters its subcellular localiza

73 Inhibitors that mimic the entire substrate transmembrane domain and engage the active site should p

74 with the loss of part of the alpha1 subunit transmembrane domain and part-replacement with nonsense

75 The sixth transmembrane domain is most frequently disrupted by mis

76 associated with changes in occupancy of the transmembrane domain lipid binding sites.

77 The transmembrane domain of Emc4 tilts away from the main tr

78 of direct ligand interaction within the deep transmembrane domain pocket.

79 ectin has been reported to bind to two seven-transmembrane domain receptors, AdipoR1 and AdipoR2, as

80 ECD is the critical determinant, whereas the transmembrane domain served merely as an anchor.

81 hey are characterized by a single C-terminal transmembrane domain that mediates posttranslational tar

82 king one amino acid (Met-51) near its second transmembrane domain that retained its membrane topology

83 ranslocon-mediated membrane integration of a transmembrane domain upstream from the ribosomal slip si

84 ing conformational rearrangements in the GB2 transmembrane domain via a lever-like mechanism to initi

85 ins are usually composed of two domains: the transmembrane domain, in which the metal cations are tra

86 a largely enclosed binding cavity inside the transmembrane domain.

87 N terminus and the length sensitivity of the transmembrane domain.

88 nt interactions between the C-linker and the transmembrane domain.

89 ain, which is connected to a canonical seven-transmembrane domain.

90 losed and open conformations relative to the transmembrane domain.

91 membrane deformation induced by a non-planar transmembrane domain.

92 SERINC5 is a 10-transmembrane-domain cellular protein that is incorporat

93 the interface between the extracellular and transmembrane domains (ECD and TMD, respectively).

94 Many effectors harbor N-terminal transmembrane domains (TMDs) implicated in effector tran

95 vious work suggested an active role of SNARE transmembrane domains (TMDs) in promoting membrane merge

96 notypes seen in association with variants in transmembrane domains 1 and 2 and the allosteric binding

97 Functional analysis of 4 variants in transmembrane domains 1 or 2 (p.Ile246Thr, p.Pro252Leu,

98 cluster in the extracellular N-terminus and transmembrane domains 1-3, with more severe phenotypes s

99 nd 2 and the allosteric binding site between transmembrane domains 2 and 3.

100 The transmembrane domains adopt a collapsed conformation at

101 nist engagement of the CLR extracellular and transmembrane domains affects transducer recruitment.

102 alpha1 subunit between the third and fourth transmembrane domains and introduced 24 new residues for

103 ions, first rearranging and bringing the two transmembrane domains into close contact along transmemb

104 te proteins implies that signal peptides and transmembrane domains pass through the site occupied by

105 t members of MFS, PIC30 contains 12 putative transmembrane domains, and PIC30-GFP fusion protein sele

106 e emerging sequences tend to encode putative transmembrane domains, and that thymine-rich intergenic

107 ead conformational rearrangements within the transmembrane domains.

108 ons harbor a widespread potential to produce transmembrane domains.

109 pE2TM, both encoding HER2 extracellular and transmembrane domains.

110 We show that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regu

111 During chemiosmosis, a transmembrane electrochemical ion gradient is harnessed

112 ffect of a mitochondrial crista enhances the transmembrane-electrostatically localized proton density

113 area and thus more protonic capacitance for transmembrane-electrostatically localized proton energy

114 erizes the activity of surfactants to induce transmembrane flip-flop of lipids and thus "scramble" th

115 ow that, when expressed in insect cells, the transmembrane form of the 12-helix pore enables the pass

116 d by the peptide hormone glucagon is a seven-transmembrane G protein-coupled receptor (GPCR) that reg

117 Microarrays revealed that the transmembrane glycoprotein Bone marrow stromal antigen 2

118 CD200 is known as an anti-inflammatory transmembrane glycoprotein in the immunoglobulin superfa

119 Each monomer contains nine transmembrane helices (TMs), six of which (TM4-TM9) form

120 amino-acid-binding pocket that is formed by transmembrane helices 1, 6, and 10 and conserved among S

121 h reorganization of extracellular loop 3 and transmembrane helices 6 and 7 manifests independently of

122 te the response of the cytoplasmic region of transmembrane helices 6 and 7 of the beta(1)-adrenergic

123 swap experiments support the hypothesis that transmembrane helices co-evolve with membranes, suggesti

124 ure of how structural rearrangements between transmembrane helices control ligand binding, receptor a

125 We show that 92% of all transmembrane helices have at least one non-canonical H-

126 ion by decreasing the crossing angle between transmembrane helices of integrin alphaIIbbeta3, which e

127 uctures reveal a novel fold comprised of ten transmembrane helices organized into two subdomains and

128 e membrane protein targets with 7, 11 and 16 transmembrane helices provided measures of success.

129 The identified region contains two predicted transmembrane helices that appear to reoccur in a wide r

130 nated by hydrophobic residues of the M and E transmembrane helices that form a binding pocket not pre

131 RocA is a membrane protein containing seven transmembrane helices with an extracytoplasmically locat

132 helical export gate with its four predicted transmembrane helices wrapped around FliPQR/SctRST.

133 Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved s

134 tivity requires Rhs that contains N-terminal transmembrane helices, the PAAR domain, and an intact be

135 ation gate through interactions between both transmembrane helices, the turret, selectivity filter lo

136 ated at the interface of the amphipathic and transmembrane helices.

137 Synaptotagmin-1 contains a single transmembrane helix (TM) and two tandem C2 domains (C2A

138 61 translocon to co-translationally insert a transmembrane helix (TMH) of many multi-pass integral me

139 e transport cycle, conformational changes in transmembrane helix 6 (TM6) alter the glutathione-bindin

140 ansmembrane domains into close contact along transmembrane helix 6 and ultimately inducing conformati

141 trong anchors to two intracellular loops and transmembrane helix 6 of the kappaOR.

142 shows an approximately 10 angstrom shift of transmembrane helix 7 that exposes a large membrane-acce

143 n overall topology to class A GPCRs, but the transmembrane helix H4 is shifted by more than 20 angstr

144 to-pai helical transition in the pore-lining transmembrane helix S6.

145 membrane glycoprotein with an ectodomain, a transmembrane helix, and a short carboxyl-terminal tail,

146 f RPTPs comprises an extracellular region, a transmembrane helix, and two tandem intracellular cataly

147 ar the inserting C-terminal end of the pHLIP transmembrane helix.

148 cellular (ie, NTRK2A203T and NTRK3E176D) and transmembrane (ie, NTRK3L449F) domains increased recepto

149 The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD

150 immunoglobulin tail tyrosine (ITT) motif in transmembrane IgE (mIgE) impairs the memory IgE response

151 n and critically rate-limited by the induced transmembrane influx of [1-(13)C]pyruvate mediated by MC

152 ma HMGIC fusion partner-like 5 (Lhfpl5), and Transmembrane inner ear protein (Tmie).

153 members can modulate apoptosis; however, the transmembrane interactome of the antiapoptotic protein M

154 A unique 'intersubunit latch' within this transmembrane interface maintains the inactive state, an

155 e-embedded motor, which uses energy from the transmembrane ion gradient to generate torque at the int

156 , as well as genes specific to voltage-gated transmembrane ion transporters.

157 showing a decrease in the voltage-dependent transmembrane ionic currents after pulse treatment.

158 attachments between heterochromatin and the transmembrane Lem2-Nur1 complex at the INM are remodeled

159 tesamorelin and palmitylated variants of the transmembrane lipoprotein phospholemman (FXYD1).

160 Leucine rich repeat transmembrane (LRRTM) proteins are synaptic adhesion mol

161 ase CheA, and the coupling protein CheW form transmembrane molecular arrays with remarkable sensing p

162 Transport domains stochastically probe transmembrane motion, and reversible unsuccessful excurs

163 carboxylate transporters MCT1-4 catalyze the transmembrane movement of metabolically essential monoca

164 of the nuclear pore complex scaffold and the transmembrane nucleoporin POM121.

165 ed with hMSCs had a significant elevation in transmembrane oxygenator pressure gradients.

166 ers SELP exon 14 skipping and soluble versus transmembrane P-selectin protein production.

167 units may also contribute, but the nature of transmembrane packing is unclear.

168 ly excluded from bilayer-engaged BRCs than a transmembrane peptide, indicating that mechanisms other

169 odulated by an inhibitory interaction with a transmembrane peptide, phospholamban (PLB).

170 Here, we report transmembrane peptidomimetic inhibitors of the gamma-sec

171 olipid scramblases (CaPLSases) mediate rapid transmembrane phospholipid flip-flop and as such play es

172 d suggest instead that it remains within the transmembrane pore as FeEnt enters the periplasm.

173 lectron microscopy structure of the 16-helix transmembrane pore closely matches the design model.

174 e RCN provides a reliable protocol to assess transmembrane pore formation driven by osmotic pressure

175 On the other hand, the transmembrane pore is occluded in a remarkably similar m

176 bunit interface was associated with a closed transmembrane pore, with resolved monovalent cations int

177 or prolonged exposure induces formation of a transmembrane pore.

178 e structurally and functionally well-defined transmembrane pores opens the door to the creation of de

179 The C-terminal 11 transmembrane portion of PC1 undergoes three cleavage ev

180 f a cryptic epitope on the C terminus of the transmembrane portion of pro-TNF on cleavage.

181 Interactions between the transmembrane portions of the subunits may also contribu

182 haracterized endoplasmic reticulum-localized transmembrane prolyl 4-hydroxylase (P4H-TM)-is found in

183 giotensin-converting enzyme 2), and TMPRSS2 (transmembrane protease serine 2) mediate viral infection

184 g requires the help of another host protein, transmembrane protease serine S1 member 2.

185 , angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2), are modulate

186 ors angiotensin converting enzyme (ACE2) and transmembrane protease/serine subfamily member 2 (TMPRSS

187 n the gene encoding the human Golgi TMEM165 (transmembrane protein 165), belonging to UPF0016 (unchar

188 Transmembrane protein 175 (TMEM175) is a K(+)-selective

189 The present work identifies this gene as transmembrane protein 189 (TMEM189).

190 Mutation of proline-rich transmembrane protein 2 (PRRT2), a regulator of neurotra

191 Transmembrane protein 30A (TMEM30A) maintains the asymme

192 , and TMEM64 (VTT) domain-containing protein transmembrane protein 41B (TMEM41B) for infection by SAR

193 The large isoform of the transmembrane protein angiomotin (AMOT130) controls cell

194 n, implying a role for RPLP1/2 in multi-pass transmembrane protein biogenesis.

195 or both Mpp5a and Rab11a operate through the transmembrane protein Crumbs.

196 Transferrin receptor 2 (TFR2) is a transmembrane protein expressed mainly in hepatocytes an

197 Fatty acid transport protein 4 (FATP4), a transmembrane protein in the endoplasmic reticulum (ER),

198 ne fusion is triggered by synaptotagmin-1, a transmembrane protein in the vesicle membrane (VM), but

199 Megalin is a transmembrane protein involved in clathrin-mediated endo

200 riguingly, there was also association with a transmembrane protein kinase that may function as a rece

201 vel research suggests that disruption to the transmembrane protein linkage between the cytoskeleton a

202 Disruption to the transmembrane protein linkage between the cytoskeleton a

203 Full length TANGO1 is a transmembrane protein localised at endoplasmic reticulum

204 VE-cadherin, occludin and interferon-induced transmembrane protein mRNAs compared to both "low inflam

205 hy with subcortical cysts 1 (Mlc1), an eight-transmembrane protein normally expressed in perivascular

206 biquitin ligase WWP2 and a tumor-suppressing transmembrane protein of unknown biochemical function, T

207 r a number of backbone hydrogen bonds in the transmembrane protein OmpW.

208 domains to interact with Rab7-GTP and the ER transmembrane protein Protrudin and together these compo

209 -14 homologs may also function in regulating transmembrane protein recycling and BMP signaling.

210 how that PINCH-1 interacts with myoferlin, a transmembrane protein that is critical for cancer progre

211 LINGO1 is a transmembrane protein that is up-regulated in the cerebe

212 In the present study, we found that USH2A, a transmembrane protein with a very large extracellular do

213 We identify myristoylation on a transmembrane protein, the microneme protein 7 (MIC7), w

214 -binding Proteins (SMP) domain-containing ER transmembrane protein, utilizes distinct domains to inte

215 hically solved structures of homo-oligomeric transmembrane proteins (HoTPs) and find that ~97% are Cn

216 Both of these single-pass transmembrane proteins are enriched in hair cells and un

217 Accessory and transmembrane proteins assemble in signaling complexes t

218 hese properties enable regulation of certain transmembrane proteins by regulated intramembrane proteo

219 nsgene mRNA, and show that intracellular and transmembrane proteins can be expressed.

220 Tetraspanin (TSPAN) transmembrane proteins control Ca(2+) handling, and thus

221 l that peptidisc peptides can arrange around transmembrane proteins differently, thus revealing the s

222 purified components FtsZ, FtsA and truncated transmembrane proteins essential for cell division.

223 Nevertheless, some multispan helical transmembrane proteins have been proposed to partition i

224 scopy for the analysis of oligomerization of transmembrane proteins in cell-derived lipid membranes.

225 Thylakoid transmembrane proteins in the stroma can interact with C

226 Notably, uropod transmembrane proteins PSGL-1 and CD43 cocluster specifi

227 to the classical pathway of secretion, some transmembrane proteins reach the plasma membrane through

228 Both the lipid molecules and the transmembrane proteins reside on the plasma membranes of

229 ry of a family of endoplasmic reticulum (ER) transmembrane proteins that associate with and modulate

230 uclear membrane is functionalized by diverse transmembrane proteins that associate with nuclear lamin

231 They are heterodimeric transmembrane proteins that bind extracellular matrix (E

232 ensions in studying GABA(A)Rs due to several transmembrane proteins that interact with GABA(A)Rs and

233 ted sodium (Na(V)) channels are pore-forming transmembrane proteins that play essential roles in exci

234 Tetraspanins are a unique family of 4-pass transmembrane proteins that play important roles in a va

235 findings identify the PCDHGs as pro-survival transmembrane proteins that select inhibitory interneuro

236 Starting with an unbiased screen of ~ 1,500 transmembrane proteins using the purified GluN1-NTD prot

237 The TMC genes encode a set of homologous transmembrane proteins whose functions are not well unde

238 Plexins are single-pass transmembrane proteins with multiple domains in both the

239 iors.SIGNIFICANCE STATEMENT Ion channels are transmembrane proteins with selective permeability to sp

240 t droplets can harbor functional soluble and transmembrane proteins, allowing for the colocalization

241 ms, such as the excluded volume of polytopic transmembrane proteins, proximity FRET, and rotational d

242 aperone that improves trafficking of several transmembrane proteins, restored Abeta-induced impaired

243 function of ion channels and other polytopic transmembrane proteins.

244 rse clients, from tail-anchored to polytopic transmembrane proteins.

245 internal vesicular transport of cortex-bound transmembrane proteins.

246 rol-dependent nanoclustering of cell surface transmembrane receptor kinase 1 (TMK1) is critical for t

247 d receptors (GPCRs) are the largest class of transmembrane receptors and serve as signal mediators to

248 ughput technology to interrogate most single transmembrane receptors for binding to 445 IgSF proteins

249 OPA1) and short form (S-OPA1) that lacks the transmembrane region and is generated by cleavage of L-O

250 rane domain of Emc4 tilts away from the main transmembrane region of EMC and is partially mobile.

251 also reveals structural peculiarities at the transmembrane region of IrtAB that result in a partially

252 between the headpiece and the Ca(2+)-binding transmembrane region.

253 d specificity to correct the cystic fibrosis transmembrane regulator (CFTR) function in patient-speci

254 rize recent findings on these novel GABA(A)R transmembrane regulators and highlight a potential avenu

255 ded to mitochondrial pathways; mitochondrial transmembrane resistance (DeltaPsim) was altered and mod

256 GFRalpha1 complex binds to and activates the transmembrane RET tyrosine kinase to signal through intr

257 the extracellular end of the pore lining M2 transmembrane segment (18').

258 es reveal a disruption in the alpha-helix of transmembrane segment 6 (TM6) not observed in family A G

259 GluN1 subunits at the entrance of the first transmembrane segment is shorter and the bilobed cleft o

260 The SLN pentamer was found to interact with transmembrane segment M3 of SERCA, although the interact

261 e of the second extracellular loop and fifth transmembrane segment of the D2R.

262 tional annotations such as domain detection, transmembrane segment prediction, and calculation of ami

263 main (CNBD) connected to the pore-forming S6 transmembrane segment via the C-linker.

264 nv "spike" and the NMR structure of the MPER-transmembrane segment.

265 led the ligand-binding domains from specific transmembrane segments for GluN1 and GluN2A.

266 ducting channels that facilitate movement of transmembrane segments, cytosolic and luminal funnels in

267 Each protomer consists of nine transmembrane segments, which enclose a cytosolic tunnel

268 C-terminus, cytoplasmic loop, and within the transmembrane segments.

269 The type II transmembrane serine protease (TTSP) family encompasses

270 Previous studies have reported that transmembrane serine protease 2 (TMPRSS2) is essential f

271 in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cell

272 l angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2).

273 that, surprisingly, the bulk of two studied transmembrane SG cargoes (phogrin and VMAT2) does not so

274 ucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactio

275 tructure of the full-length receptor and its transmembrane signalling mechanism remain unknown.

276 e N terminus of the G protein-coupling seven-transmembrane-spanning bundle.

277 Binding at this site blocks the transmembrane-spanning sodium ion translocation pathway,

278 ZMPSTE24 has a novel structure, with seven transmembrane spans that form a large water-filled membr

279 nnels in fungi with two pore-loops and eight transmembrane spans.

280 ctions has yielded a consensus alpha-helical transmembrane structure for Pf1 protein.

281 The transmembrane subunit, MlaE, has minimal sequence simila

282 s connecting the quinone-binding site to the transmembrane subunits are found to be responsible for p

283 y designed to monitor osmotic effects during transmembrane tension pore formation by using local mito

284 NA without affecting the expression of other transmembrane TJ proteins.

285 omain, indicating these mutations act on the transmembrane (TM) cytosolic domain.

286 group of splice variants excludes the first transmembrane (TM) domain and contains six TM domains.

287 It is believed that the transmembrane (TM) domain of EphA2 adopts two alternate

288 elical-hairpin construct derived from CFTR's transmembrane (TM) helices 3 and 4 (TM3/4) and their int

289 The seventh member, PC7, is a type-I transmembrane (TM) protein with a 97-residue-long cytoso

290 arge-conductance potassium (BK) channels are transmembrane (TM) proteins that can be synergistically

291 brane nanodomains is thought to exclude many transmembrane (TM) proteins.

292 y six tandem carboxylate residues within the transmembrane (TM)5-6 loop on the intracellular membrane

293 sists of three domains: extracellular (ECD), transmembrane (TMD), and intracellular domain (ICD).

294 generation.SIGNIFICANCE STATEMENT SORLA is a transmembrane trafficking protein previously known to re

295 egulates the expression of genes involved in transmembrane transport and metabolism.

296 OS production, stress response, carbohydrate transmembrane transport, secondary metabolites, etc., wh

297 junctional intercellular communication, and transmembrane transporters, all of which are precursors

298 ents, which enclose a cytosolic tunnel and a transmembrane tunnel that converge at the predicted cata

299 nctional and unable to respond to changes in transmembrane voltage, which is in agreement with previo

300 citability-a threshold-governed transient in transmembrane voltage-is a fundamental physiological pro