ライフサイエンスコーパス: transmembrane domain

1 ar protein of 4249 amino acids with a single transmembrane domain.

2 as well as the transfer of activation to the transmembrane domain.

3 a largely enclosed binding cavity inside the transmembrane domain.

4 of the ligand-binding domain relative to the transmembrane domain.

5 N terminus and the length sensitivity of the transmembrane domain.

6 sequence has also been predicted in the p24 transmembrane domain.

7 in the center of a mobile module within the transmembrane domain.

8 membrane deformation induced by a non-planar transmembrane domain.

9 locations, and the binding of Ca(2+) in the transmembrane domain.

10 of PIRT to PIP(2) and the human TRPM8 S1-S4 transmembrane domain.

11 the previously solved structure of the GCGR transmembrane domain.

12 n to block ATPase activity by binding to the transmembrane domain.

13 nt interactions between the C-linker and the transmembrane domain.

14 uctures, several lipids are bound within the transmembrane domain.

15 ain, which is connected to a canonical seven-transmembrane domain.

16 as metazoan Mitofusins contain only a single transmembrane domain.

17 domain and six alpha-helical segments in the transmembrane domain.

18 mino-acid protein with a putative C-terminal transmembrane domain.

19 ion in trans is abolished by mutation of the transmembrane domain.

20 losed and open conformations relative to the transmembrane domain.

21 bound to the allosteric binding site in the transmembrane domain.

22 tenin, and linking its cytosolic tail to the transmembrane domain.

23 o its monomeric nature in the absence of the transmembrane domain.

24 interactions between the N-terminus and the transmembrane domain.

25 tes signal transmission through the receptor transmembrane domain.

26 dulators (PAMs) to putative sites within the transmembrane domains.

27 e linked by cysteine-rich domains to their 7-transmembrane domains.

28 ead conformational rearrangements within the transmembrane domains.

29 embrane proteins with moderately hydrophobic transmembrane domains.

30 amino-acid mutations, and the orientation of transmembrane domains.

31 mplex by virtue of the proteins' luminal and transmembrane domains.

32 ons harbor a widespread potential to produce transmembrane domains.

33 pE2TM, both encoding HER2 extracellular and transmembrane domains.

34 teins, respectively, some with as many as 19 transmembrane domains.

35 d HCN1 are physiologically relevant and that transmembrane domain 1 (TM1) is essential for the cellul

36 mutations (~25%) within the coding region of transmembrane domain 1 (TMD1) of E protein.

37 Transmembrane domain 1 (TMD1) regulates this activity, w

38 notypes seen in association with variants in transmembrane domains 1 and 2 and the allosteric binding

39 ument proteins, such as substitutions within transmembrane domains 1 and 3 of LMP1, FoP_duplication,

40 Functional analysis of 4 variants in transmembrane domains 1 or 2 (p.Ile246Thr, p.Pro252Leu,

41 cluster in the extracellular N-terminus and transmembrane domains 1-3, with more severe phenotypes s

42 ]F(4)N(3)Bzoxy-AP-binding sites in the nAChR transmembrane domain: 1) in the ion channel, identified

43 ur data indicate that the "extra" residue in transmembrane domain 10 of the GABA transporter GAT-1 pr

44 A peptide analog of transmembrane domain 2 (TM2) of CXCR4 interfered with PA

45 hese novel findings, we propose alpha(1D-)AR transmembrane domain 2 acts as an ER localization signal

46 es early termination of alpha(1D)-AR between transmembrane domain 2 and 3.

47 nd 2 and the allosteric binding site between transmembrane domains 2 and 3.

48 found that paired cysteine substitutions in transmembrane domains 2 and 8 and periplasmic loops of M

49 Furthermore, we identified isoleucine-182 in transmembrane domain 3 of zDHHC3 as a key determinant in

50 formational changes in extracellular loop 2, transmembrane domain 5 (TM5), TM6 and TM7, propagating t

51 c modulator site formed by a crevice between transmembrane domains 5, 7, and 8, and extracellular loo

52 oth carry on one side of their alpha-helical transmembrane domain a conserved amino acid motif.

53 o a single intersubunit site in the GABA(A)R transmembrane domain, a property that may facilitate the

54 The transmembrane domains adopt a collapsed conformation at

55 nist engagement of the CLR extracellular and transmembrane domains affects transducer recruitment.

56 The transmembrane domain allowed MT2 activation after reachi

57 , a descending peptide linker, a seven-helix transmembrane domain and a cytoplasmic tail(15).

58 ion of UL138 activity and determine that its transmembrane domain and acidic cluster dileucine Golgi

59 infected primary CD4(+) T cells through its transmembrane domain and alters its subcellular localiza

60 They essentially consist of a single transmembrane domain and are associated with stress resp

61 EMRE is located at the periphery of the transmembrane domain and associates primarily with the f

62 e also show that MRAP2 dimerizes through its transmembrane domain and can form higher-order oligomers

63 Inhibitors that mimic the entire substrate transmembrane domain and engage the active site should p

64 with the loss of part of the alpha1 subunit transmembrane domain and part-replacement with nonsense

65 cket, inducing conformational changes in the transmembrane domain and receptor activation.

66 g at synapses the receptor is cleaved in its transmembrane domain and releases a protein fragment tha

67 king and interacts with TMD0 of TAPL via its transmembrane domain and that this interaction strongly

68 ns, are located in the interface between the transmembrane domain and the C-terminal nucleotide bindi

69 ealed between the intracellular loops on the transmembrane domain and the NADPH-oxidizing dehydrogena

70 encoding PD-L1, which causes omission of the transmembrane domain and the regulatory sequence in the

71 ses are termed sheddases because they have a transmembrane domain and their catalytic domain on the c

72 hrough a 50-residue region downstream of its transmembrane domain and upstream of the VCPWE motifs.

73 ein 74 (TMEM74), which contains two putative transmembrane domains and exhibits high levels of mRNA i

74 e NADPH-oxidizing flavoenzyme with predicted transmembrane domains and high sequence similarity to gl

75 alpha1 subunit between the third and fourth transmembrane domains and introduced 24 new residues for

76 de evidence that TMEM18 has four, not three, transmembrane domains and that it physically interacts w

77 ween the hydrophobic amino acid sequences of transmembrane domains and their functional interactions

78 ular region with hypervariable Ig domains, a transmembrane domain, and a cytoplasmic tail.

79 n aromatics with hydrophobic residues of the transmembrane domain, and contains the absolutely conser

80 izes COX2 during insertion of its N-proximal transmembrane domain, and subsequently, COX18 transientl

81 nd/or stabilized via interactions within the transmembrane domain, and the p24 transmembrane helix ap

82 ubiquitin ligase containing RING-finger and transmembrane domains, and its expression levels are inc

83 t members of MFS, PIC30 contains 12 putative transmembrane domains, and PIC30-GFP fusion protein sele

84 e emerging sequences tend to encode putative transmembrane domains, and that thymine-rich intergenic

85 We found that both the protease and transmembrane domain are required for the ESX system-spe

86 lysis suggests that the NRP1 cytoplasmic and transmembrane domains are necessary and sufficient to re

87 protein family and reveals how cytosolic and transmembrane domains are strategically positioned for c

88 We mapped two small-XXX-small motifs in the transmembrane domain as potential sites for monomers doc

89 henotype is dependent on the presence of the transmembrane domain, as well as a unique hydrophobic do

90 The I355K substitution in the transmembrane domain associated with cholestasis and ane

91 ding sites in the alpha1beta3gamma2 GABA(A)R transmembrane domain at beta (+)-alpha (-) (beta (+) sit

92 t alleles encode GP130 receptors bearing the transmembrane domain but lacking both the recycling moti

93 The hormones do not directly activate the transmembrane domain but mediate their action via a, thu

94 ubunit steroid-binding sites in the GABA(A)R transmembrane domain, but revealed only little definitio

95 ent of an alpha helix in the periplasmic and transmembrane domains, but it is unknown how the cytopla

96 arges, results in abortive insertion of this transmembrane domain by the Sec pathway and its subseque

97 ified that the tail length of the C-terminal transmembrane domains (C-TMDs) determines efficient inse

98 which, following self-association via their transmembrane domain, can activate MAP kinases in a liga

99 whether a SNARE such as STX11, which lacks a transmembrane domain, can support membrane fusion in viv

100 SERINC5 is a 10-transmembrane-domain cellular protein that is incorporat

101 he 63-amino acid p7 monomer has two putative transmembrane domains connected by a cytosolic loop, and

102 ut otherwise small structural changes in the transmembrane domain, consistent with little changes in

103 elements upstream and downstream of the RodZ transmembrane domain dictate nascent polypeptide selecti

104 the interface between the extracellular and transmembrane domains (ECD and TMD, respectively).

105 these mutations in the sensory and adjacent transmembrane domains emulate the structural changes cau

106 m structure and the drug-binding site of E's transmembrane domain (ETM), determined using solid-state

107 nsmembrane domain topology, with variants in transmembrane domains exhibiting strongly deleterious ef

108 form and only upon binding both agonists the transmembrane domain explores looser packing which would

109 As transmembrane domains followed by cysteine residues are

110 ecognized by direct binding of Asi2 to their transmembrane domains for subsequent ubiquitination by A

111 ns that cleave off the secretion signal, two transmembrane domains forming a translocation pathway, a

112 rgeting not only need to protect the nascent transmembrane domains from improper exposure in the cyto

113 OSIP) and membrane-bound trimers with intact transmembrane domain (gp150) prevented trimer conformati

114 S-acylation adjacent to transmembrane domains has been described in the literatu

115 protomer shows a mirrored arrangement of the transmembrane domains (helices S1-S4) relative to other

116 S binding sites were located in the GABA(A)R transmembrane domain; however the specific localization

117 ary and sufficient for the skipping of L1CAM transmembrane domain in ECs, leading to the release of s

118 ts into the interface between ectodomain and transmembrane domain in the TSHR, as well as the transfe

119 spliced exons in the cytoplasmic tail, with transmembrane domains in exon variants 32.1 and 32.2, an

120 ins are usually composed of two domains: the transmembrane domain, in which the metal cations are tra

121 d degradation of NS4A-NS4B, a region rich in transmembrane domains, in absence of EMC.

122 raps to the G protein-coupling domains-the 7-transmembrane domains-in the membrane.

123 cells particularly depended on the hinge and transmembrane domains included in the CAR design.

124 juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or redu

125 Thus, EMC is a transmembrane domain insertase, a function that may expl

126 systematically study the sequence basis for transmembrane domain interactions.

127 ions, first rearranging and bringing the two transmembrane domains into close contact along transmemb

128 ists as a dimer, with both extracellular and transmembrane domains involved in dimerization.

129 Synaptobrevin-2 transmembrane domain is embedded into the vesicle lipid

130 ry for maximal FERONIA activity, whereas the transmembrane domain is inhibitory.

131 The sixth transmembrane domain is most frequently disrupted by mis

132 isingly, S-acylation of FLS2 adjacent to the transmembrane domain is not required for either FLS2 tra

133 It was found that the 10th transmembrane domain is required for Ser5 stable express

134 Mutations within transmembrane domains IV, V, VI, and VII had no effect o

135 The MacB transmembrane domain lacks a central cavity through whic

136 egrity of the interface between NBD1 and the transmembrane domain leading to its clearance by the qua

137 associated with changes in occupancy of the transmembrane domain lipid binding sites.

138 he results of mutagenesis suggested that the transmembrane domains M1, M3 and M4, which contribute to

139 this report are located in the pre-M1 helix, transmembrane domain M3, and the intracellular carboxyl

140 "unzipping" the extracellular domain and the transmembrane domain, mediated by a unique segment withi

141 ingomyelin and/or cholesterol binding to the transmembrane domain might directly control the oligomer

142 ested a potential activation site within the transmembrane domain, near the A-967079 cavity.

143 where S-acylation of ERECTA adjacent to the transmembrane domain occurs in all ERECTA orthologues bu

144 a common natural helix packing motif to the transmembrane domain of a genetically-encoded and struct

145 creases in membrane thinning/disorder by the transmembrane domain of BamA is greatest in thicker bila

146 cytoplasmic tail and inducing a kink in the transmembrane domain of beta3-integrin.

147 However, replacement of TM2 by the transmembrane domain of CD4, the asialoglycoprotein rece

148 is insensitive to replacement of TM2 by the transmembrane domain of CD74 or by 21 alanines.

149 Replacement of the transmembrane domain of CD74 or the asialoglycoprotein r

150 rved region between this coiled-coil and the transmembrane domain of Coy1.

151 The transmembrane domain of Emc4 tilts away from the main tr

152 t centrally located helices M5 and M6 in the transmembrane domain of flippases has, however, been spa

153 wo putative cholesterol-binding sites in the transmembrane domain of GIRK2.

154 le the unique (14)AxxxxxxxW(22) motif in the transmembrane domain of HIV-1(NL4-3)Vpu was reported to

155 ly incorporated into two residues within the transmembrane domain of KCNE1: F56 and F57.

156 s with LGR4 and LGR5 revealed that the seven-transmembrane domain of LGR4 conferred interaction with

157 hannel motion of both full-length M2 and the transmembrane domain of M2.

158 Upon channel opening, the curved transmembrane domain of MSL1 flattens and expands.

159 oteolytic activation of NOTCH1 to expose the transmembrane domain of NOTCH1.

160 Mutational analyses indicated that the transmembrane domain of sigma1R likely mediated this int

161 Lysine residues within the transmembrane domain of Snc1 are necessary for presentat

162 ime in the ER-PM contact point is due to the transmembrane domain of T95 resulting in an overall tria

163 ary subunits require a shared surface on the transmembrane domain of the AMPAR for their function, bu

164 The familial T43I mutation within the transmembrane domain of the beta-CTF (also referred to a

165 - angstrom solid-state NMR structures of the transmembrane domain of the closed and open BM2 channels

166 on of a racemic peptide corresponding to the transmembrane domain of the influenza A M2 protein (M2-T

167 that the rotational correlation time for the transmembrane domain of the influenza A M2 proton channe

168 acid substitution (p.Trp101Cys) in the first transmembrane domain of the Kir3.4 subunit of the cardia

169 mine the role of S-acylation adjacent to the transmembrane domain of the plant pathogen perceiving re

170 Our data indicate that PES binds to the transmembrane domain of the receptor at a discrete group

171 in the ultra-simple protein itself or in the transmembrane domain of the target receptor, and the eff

172 a homozygous variant Gly399Val in the eighth transmembrane domain of the taurine transporter SLC6A6 w

173 1040Thr, both of which are located in the S6 transmembrane domain of the TRPM4 protein.

174 between TRKB and PTPsigma by binding to the transmembrane domain of TRKB.

175 We also provide evidence that the transmembrane domain of Vpu is required for Tim-3 downre

176 nstructed a structure-based alignment of the transmembrane domains of 120 TRP channel structures.

177 We mutagenized the transmembrane domains of a conserved fungal ABC transpor

178 ng of TAPL and the general function of extra transmembrane domains of ABC transporters.

179 tegrins by disrupting the association of the transmembrane domains of alpha and beta integrins.

180 Here, we show that the isolated transmembrane domains of Bax, Bcl-xL (B-cell lymphoma-ex

181 egion formed by Emc4, Emc5 and Emc6 plus the transmembrane domains of Emc1 and Emc3.

182 erts its transmembrane helix between the two transmembrane domains of LptB(2)FG, which represents a p

183 we present de novo atomic structures of the transmembrane domains of mouse TMEM16A in nanodiscs and

184 indicated that the entire extracellular and transmembrane domains of MT2 are required to correct the

185 CRAC) and CARC-like sequences within the two transmembrane domains of p33.

186 Furthermore, we found that the transmembrane domains of Pmt1 and Pmt2 share a structura

187 l studies have shown that the orientation of transmembrane domains of polytopic membrane proteins wit

188 by a single cleavage between the EGF and the transmembrane domains of pro-EGF.

189 e moieties of GT1b and the juxtamembrane and transmembrane domains of synaptotagmin, respectively.

190 c interactions in both the extracellular and transmembrane domains of the receptor.

191 ether, the data highlight differences in the transmembrane domains of these closely related ion chann

192 , demonstrating that peptidiscs can adapt to transmembrane domains of very different sizes and shapes

193 ase-like enzymes with a predicted C-terminal transmembrane domain, of which five showed GSS activity

194 Mutations to the F protein transmembrane domain or cytoplasmic tail that disrupted

195 te proteins implies that signal peptides and transmembrane domains pass through the site occupied by

196 GPR is 2,115 aa long, with two N-terminal transmembrane domains placing the bulk of the protein in

197 Membrane proteins with multiple transmembrane domains play critical roles in cell physio

198 Membrane proteins with multiple transmembrane domains play essential roles in the cell,

199 c coupling between the extracellular and the transmembrane domains played a key gatekeeper role in th

200 of direct ligand interaction within the deep transmembrane domain pocket.

201 on triggers coupling between cytoplasmic and transmembrane domains, priming the channel for opening.

202 panins (TSPANs) comprise a large family of 4-transmembrane domain proteins.

203 Physical features of the SDC1 transmembrane domain, rather than a specific sequence, c

204 CCRL2 is a 7-transmembrane domain receptor that shares structural and

205 ectin has been reported to bind to two seven-transmembrane domain receptors, AdipoR1 and AdipoR2, as

206 Chemokine receptors are seven transmembrane-domain receptors belonging to class A of G

207 Retro-2 activity resembles disruption of the transmembrane domain recognition complex (TRC) pathway,

208 ng domains to the central ion channel in the transmembrane domain region.

209 The PbgA transmembrane domain (residues 1 to 190) is essential fo

210 Conformational changes in the transmembrane domain result in a sharp kink in the middl

211 5b, d, the arrows showing transmembrane domain rotations were inadvertently pointi

212 hannels reveal a critical role for the fifth transmembrane domain (S5) in sensing anesthetics.

213 the same target and that diversification of transmembrane domain sequences over the course of evolut

214 by their motif organization; each contains a transmembrane domain, serine rich region and a conserved

215 ECD is the critical determinant, whereas the transmembrane domain served merely as an anchor.

216 oforms and mutants that do not have the 10th transmembrane domain show very poor activity.

217 Bcl-2 protein transmembrane domains specifically homooligomerize and h

218 In addition, we observed that the transmembrane domain strongly affects MycP protein level

219 S2-M4 linkers between the ligand-binding and transmembrane domains, suggesting how neurotransmitter b

220 The resulting kink in the inner transmembrane domain swings the aromatic rings from down

221 that physicochemical properties of a protein transmembrane domain that drive lateral heterogeneity of

222 ratable histidine, His-27, in the tetrameric transmembrane domain that forms a reverse WXXXH motif wi

223 oreactivities toward ZnT8 were mapped to its transmembrane domain that is accessible to extracellular

224 ncover an amino acid residue within the NS4A transmembrane domain that is essential for inactivation

225 hey are characterized by a single C-terminal transmembrane domain that mediates posttranslational tar

226 ified a Tyr-16-Phe (Y16F) change in the NS4A transmembrane domain that prevents NS3-NS4A targeting of

227 king one amino acid (Met-51) near its second transmembrane domain that retained its membrane topology

228 ers, in BGCs we found many importer-specific transmembrane domains that co-occur with substrate bindi

229 ins are a family of proteins possessing four transmembrane domains that help in lateral organization

230 (the Pgp engines) lead to changes across Pgp transmembrane domains that result in substrate transloca

231 that occupies the extracellular half of the transmembrane domain, thereby providing a potentially cr

232 A stable homotrimeric structure for the transmembrane domain (TM) also was modeled and supported

233 y a global conformational change of all Orai transmembrane domain (TM) helices within the channel com

234 ed to the membrane of the SR by a C-terminal transmembrane domain (TMD) and bind the T-tubule membran

235 s membrane-related components, including the transmembrane domain (TMD) and cytoplasmic tail (CT), ca

236 d analysis on Pyr, finding that it harbors a transmembrane domain (TMD) and extended C-terminal intra

237 er the lipid embedding of the integrin beta3 transmembrane domain (TMD) and subsequently weaken the a

238 Recent studies showed that its transmembrane domain (TMD) forms a trimer in lipid bilay

239 omain (ECD) and allosteric regulation of the transmembrane domain (TMD) from synergistic 5-HT binding

240 subunit: a highly conserved primary site in transmembrane domain (TMD) housing the Zn(2+) substrate;

241 An unsolved issue is the role of the TRKA transmembrane domain (TMD) in the dimerization of TRKA a

242 he thyrotropin receptor (TSHR) activates the transmembrane domain (TMD) indirectly via an internal ag

243 Previous HeV F studies showed that transmembrane domain (TMD) interactions are important fo

244 uggested that the N-terminal part of the C99 transmembrane domain (TMD) is separated from the C-termi

245 on tau pathology are also confirmed with APP transmembrane domain (TMD) mutant hNPCs, which display d

246 ilibrium binding of the cargo protein to the transmembrane domain (TMD) of a PCAT subsequent to the r

247 ootprints of agonists and antagonists on the transmembrane domain (TMD) of CRF1R and identified numer

248 The single-pass transmembrane domain (TMD) of n-acetylglucosaminyltransf

249 has demonstrated that the carboxyl-terminal transmembrane domain (TMD) of some Bcl-2 protein family

250 We identified lipid-exposed residues in the transmembrane domain (TMD) of the GluA2 subunit of AMPAR

251 The single transmembrane domain (TMD) of the human thrombopoietin r

252 This transmembrane protein binds to the transmembrane domain (TMD) of the platelet-derived growt

253 -terminal fusion peptide (FP) and C-terminal transmembrane domain (TMD) of the protein are challengin

254 n uL23 form a composite binding site for the transmembrane domain (TMD) on the nascent protein.

255 es located in the interfacial regions of the transmembrane domain (TMD) reduce POPG binding, and a su

256 Conformational changes of the transmembrane domain (TMD) underlying ion channel activa

257 the MPER on the lipid bilayer, the adjacent transmembrane domain (TMD) was appended (MPER-TMD) and s

258 However, beyond the need for a transmembrane domain (TMD), little is known about the fe

259 a trimer in which each subunit consists of a transmembrane domain (TMD), which is formed of two helic

260 o terminus inserted deeply into the receptor transmembrane domain (TMD), which leads to partial unwin

261 apidly activated by many stimuli through its transmembrane domain (TMD), with the seven membrane-span

262 At least 25 different, transmembrane domain (TMD)-containing E3s are predicted

263 phobic vestibule that can bind a substrate's transmembrane domain (TMD).

264 rane-proximal external region (MPER) and the transmembrane domain (TMD).

265 Peptides corresponding to transmembrane domain (TMD)1, 2, 3, and 4, but not TMD5,

266 each anchored to a Kir6.2 by its N-terminal transmembrane domain (TMD0).

267 ion of TAPL depends solely on its N-terminal transmembrane domain, TMD0, which lacks conventional tar

268 GluR activation proceeds at the level of the transmembrane domains (TMDs) and how TMD-targeting allos

269 ns are targeted to the ER and how individual transmembrane domains (TMDs) are inserted into the lipid

270 disulfide bonds introduced between the HeV F transmembrane domains (TMDs) block fusion.

271 Transmembrane domains (TMDs) engage in protein-protein i

272 Many effectors harbor N-terminal transmembrane domains (TMDs) implicated in effector tran

273 ns of SNARE proteins but the function of the transmembrane domains (TMDs) in membrane fusion remains

274 vious work suggested an active role of SNARE transmembrane domains (TMDs) in promoting membrane merge

275 at EMC can directly mediate the insertion of transmembrane domains (TMDs) into the lipid bilayer.

276 We demonstrate that the isolated transmembrane domains (TMDs) of fusion proteins such as

277 f respiratory complexes, with the metastable transmembrane domains (TMDs) of rhomboid substrates prot

278 using coarse-grained molecular dynamics, the transmembrane domains (TMDs) of t-SNARE complexes are sh

279 The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity

280 of nucleotide binding domains (NBDs) to the transmembrane domains (TMDs), which switch between inwar

281 ownstream of sequences encoding two adjacent transmembrane domains (TMDs).

282 formed by TMEM206 proteins which display two transmembrane domains (TMs) and are expressed at the pla

283 s to be limited by the propensity of a polar transmembrane domain to achieve its correct topological

284 s phospholipids that are embedded within the transmembrane domains to maintain receptor integrity and

285 lutionary coupling analysis, supports a four transmembrane domain topology, with variants in transmem

286 ranslocon-mediated membrane integration of a transmembrane domain upstream from the ribosomal slip si

287 ing conformational rearrangements in the GB2 transmembrane domain via a lever-like mechanism to initi

288 h respect to the membrane hosting syntaxin's transmembrane domain was investigated with nanometer pre

289 llographic studies have focused on conserved transmembrane domains, where multiple substrate binding

290 t fungal Fzo1 proteins exhibit two predicted transmembrane domains, whereas metazoan Mitofusins conta

291 CFTR, involving detachment of NBD1 from the transmembrane domain, which contrast with the compact as

292 ssing the SPT subunit LCB1 lacking its first transmembrane domain, which is critical for ORM-mediated

293 differences occur at the start of the second transmembrane domain, which is destabilized in the 5a is

294 specificity features, inside and outside the transmembrane domain, which we used to develop a couplin

295 enable the rigid-body repositioning of the 7-transmembrane domains, which come into contact with each

296 uter membrane through a conserved N-terminal transmembrane domain, while the C-terminal region is cyt

297 L) subunit residue substitutions were all in transmembrane domains, while the alpha1(R112Q and N115R)

298 es (TMHs) 6 and 12 of human P-gp connect the transmembrane domains with its nucleotide-binding domain

299 eir structure which contains seven predicted transmembrane domains with two internal triple-helix bun

300 has an N-out C-in topology and contains four transmembrane domains, with the fourth forming a re-entr