ライフサイエンスコーパス: transmembrane helices

1 wn to involve tilting and bending of various transmembrane helices.

2 raction networks as well as the movements of transmembrane helices.

3 f a large interior chamber that is formed by transmembrane helices.

4 ," located at the extracellular interface of transmembrane helices.

5 between the extensions to the 10th and 12th transmembrane helices.

6 s of the transporter and even within certain transmembrane helices.

7 CrgA is predicted to have two transmembrane helices.

8 is an important factor in the association of transmembrane helices.

9 t accompanied by concerted rearrangements of transmembrane helices.

10 s) sandwiched between each alphabeta pair of transmembrane helices.

11 the midmembrane breaks in two corresponding transmembrane helices.

12 nsert between the second and third predicted transmembrane helices.

13 erted-topology repeats, each comprising five transmembrane helices.

14 urn, may coordinate the rearrangement of the transmembrane helices.

15 dissociation of, the integrin alpha and beta transmembrane helices.

16 via the lipid membrane by going between the transmembrane helices.

17 issue for lysines and arginines in designed transmembrane helices.

18 rst (Leu22-Lys30) and fourth (Phe131-Thr137) transmembrane helices.

19 lic cavity surrounded by 12 mostly irregular transmembrane helices.

20 ive site but causes only minor shifts in the transmembrane helices.

21 a channel formed by a twisted bundle of six transmembrane helices.

22 rnal milieu by means of gaps between splayed transmembrane helices.

23 rising one nucleotide-binding domain and six transmembrane helices.

24 vation through N-terminal association of the transmembrane helices.

25 membrane proteins below 60 kDa with up to 8 transmembrane helices.

26 PCPs) anchored in the inner membrane by two transmembrane helices.

27 ends or breaks that are remarkably common in transmembrane helices.

28 bound cholesterol molecules to the receptor transmembrane helices.

29 d by single-residue changes that destabilize transmembrane helices.

30 pore by way of an iris-like expansion of the transmembrane helices.

31 etermined to be 15.8 kDa with four predicted transmembrane helices.

32 pied a space between the slide helix and two transmembrane helices.

33 in and the cytosolic ends of 5 of SERCA's 10 transmembrane helices.

34 rotective paralogs with different numbers of transmembrane helices.

35 ated at the interface of the amphipathic and transmembrane helices.

36 rich loop that connects the fourth and fifth transmembrane helices.

37 s of the individual complexes, including 132 transmembrane helices.

38 gest that membrane-exposed polar residues in transmembrane helices 1 and 2 of BR may provide the mole

39 hi-values occurs at the cytosolic termini of transmembrane helices 1 and 2, which we identify as a co

40 eling studies and 2-DOG uptake revealed that transmembrane helices 1 and 5 contain amino acid residue

41 m their unexpected inability to dimerize via transmembrane helices 1 and 5.

42 rge conformational changes in their adjacent transmembrane helices 1 and 6.

43 in related transporters, is located between transmembrane helices 1 and 8 of the FIRL-fold; here, we

44 rough a direct interaction between Na(+) and transmembrane helices 1 and 8, whereas Na(+) binding at

45 suggested that aromatic residues present in transmembrane helices 1, 2, and 7 interact to form an ex

46 nformation with nortriptyline wedged between transmembrane helices 1, 3, 6 and 8, blocking the transp

47 in the central binding site, located between transmembrane helices 1, 3, 6, 8 and 10, directly blocki

48 osed between extracellular loops 4 and 6 and transmembrane helices 1, 6, 10 and 11.

49 amino-acid-binding pocket that is formed by transmembrane helices 1, 6, and 10 and conserved among S

50 E14 leads to extensive rotation and tilt of transmembrane helices 1-3 in conjunction with repacking

51 inside the channel and seems to be closer to transmembrane helices 1-4.

52 ol molecule wedged within a groove formed by transmembrane helices 1a, 5 and 7.

53 alyzed using principal component analysis of transmembrane helices 1b and 6a.

54 -linking experiments established the role of transmembrane helices 2 and 6 in the putative dimer inte

55 ggered by the rotation of the kink angles of transmembrane helices 2 and 7 and is mediated by large c

56 iously unknown heterodimer interface between transmembrane helices 3 and 5 of both subunits, which se

57 imity between two conserved amino acids from transmembrane helices 3 and 7 interacting through sulfur

58 for the ATP derivatives that is bordered by transmembrane helices 3, 5, 6, and 7 in human P2Y(12,) w

59 Mutations in transmembrane helices 3-6 yielded predominantly varphi-v

60 and Sav1866 from Staphylococcus aureus, two transmembrane helices (3 and 4) in the membrane domains

61 tructured cytoplasmic loop region connecting transmembrane helices 5 and 6 (CL3) and show how each pr

62 Synthetic peptides with the sequence of transmembrane helices 5 and 6 of CB1R, fused to a cell-p

63 icinity of the large lumenal loop connecting transmembrane helices 5 and 6 of CP43.

64 , located near the pore-forming loop between transmembrane helices 5 and 6, prevented glycosylation,

65 pecific high-affinity sites located near the transmembrane helices 5-7 of the receptor.

66 f transmembrane helix 2 (TM2) and the top of transmembrane helices 6 and 7 (TM6-TM7) form the core of

67 discs by monitoring the spatial positions of transmembrane helices 6 and 7 at the cytoplasmic surface

68 h reorganization of extracellular loop 3 and transmembrane helices 6 and 7 manifests independently of

69 te the response of the cytoplasmic region of transmembrane helices 6 and 7 of the beta(1)-adrenergic

70 ment of extracellular loop 3 and the tops of transmembrane helices 6 and 7, an inward movement of tra

71 utward movement of the extracellular ends of transmembrane helices 6 and 7.

72 hydrophobic pore in the luminal side of the transmembrane helices 6, 8, and 9.

73 buted to the two large loops of SecY linking transmembrane helices 6-7 and 8-9.

74 n of both the nucleotide binding domains and transmembrane helices 6.

75 We also show that the large loop between transmembrane helices 7 and 8 of FtsW is important for t

76 ognized cytoplasmic site in the loop between transmembrane helices 8 and 9, which influences the elec

77 -terminal pore-forming domain comprising six transmembrane helices, a pore helix, and a selectivity f

78 toplasmic extensions to the fourth and sixth transmembrane helices; a secondary, functionally less re

79 Only when all the transmembrane helices adopt a counterclockwise rotation,

80 hermal motion; (iii) transient separation of transmembrane helices allowed penetration of detergent m

81 substituents fine tune the configuration of transmembrane helices alphaM1-2.

82 Here we show that the 12 transmembrane helices and 2 cytosolic nucleotide-binding

83 es 16 different subunits, with a total of 64 transmembrane helices and 9 iron-sulphur clusters.

84 t charged segment that are predicted to form transmembrane helices and a cytosolic loop, respectively

85 The Fo motor comprises of seven transmembrane helices and a decameric c-ring and invagin

86 nterior for cotranslational insertion of the transmembrane helices and a fluidic surface for proper a

87 neless version of ArnT support a model of 13 transmembrane helices and a large C-terminal region expo

88 ution, showing that each subunit contains 11 transmembrane helices and a lumenal beta-trefoil fold te

89 on of the hydrophobic interactions among the transmembrane helices and a pair of hydrophobic patches

90 ane topology and the new model predicts four transmembrane helices and a potential re-entrant loop on

91 reveals a horseshoe-shaped arrangement of 19 transmembrane helices and an extracellular domain positi

92 The structures reveal nine transmembrane helices and an extramembrane cap domain th

93 odimer, with each protomer consisting of six transmembrane helices and an N-terminal cytosolic domain

94 ge and diverse family of proteins with seven transmembrane helices and common topology and, most like

95 All models revealed 12 transmembrane helices and connecting loops and represent

96 strate preference, and the importance of its transmembrane helices and disulfide bond.

97 e beta1AR define ligand-binding sites in the transmembrane helices and effector docking sites at the

98 It contains four transmembrane helices and forms a functional dimer.

99 dulate the proton transfer dynamics, and how transmembrane helices and gating residues control the hy

100 matching of hydrophobic regions on rhodopsin transmembrane helices and hydrophobic thickness of lipid

101 s (GPCRs) have mostly focused on the role of transmembrane helices and intracellular loop regions.

102 l uncharacterized protein with two predicted transmembrane helices and is localized at the endoplasmi

103 otting, we demonstrate that GOAT contains 11 transmembrane helices and one reentrant loop.

104 zobenzene pushes apart the outer ends of the transmembrane helices and opens the channel in a light-d

105 usly, but it also interacts with most of the transmembrane helices and periplasmic regions of SecY, w

106 gs accurately reproduced the orientations of transmembrane helices and showed a significant degree of

107 While elements in the receptor's transmembrane helices and the C-terminal alpha5 helix of

108 hannel is regulated by interplay between the transmembrane helices and the termini.

109 vity: this pulls apart the outer ends of the transmembrane helices and thereby opens an aperture, or

110 All four proteins include transmembrane helices and together form the membrane anc

111 ach subunit of the transporter contains nine transmembrane helices and two hairpins that suggest a pl

112 Scap has eight transmembrane helices and two large luminal loops, desig

113 Each subunit of the transporter contains 12 transmembrane helices and two periplasmic loops that sug

114 s demonstrated using two proteins: CrgA (two transmembrane helices) and Rv1861 (three transmembrane h

115 to the extracellular surface in cells), two transmembrane helices, and a large C-terminal lumenal do

116 smembrane helices, identify 18 supernumerary transmembrane helices, and assign and model 14 supernume

117 Subunit c typically comprises two transmembrane helices, and the c ring features an ion-bi

118 t binding domain immediately adjacent to the transmembrane helices appear to control selectivity of Q

119 we lower the force to initiate folding while transmembrane helices are aligned in a zigzag manner wit

120 rules governing direct interactions between transmembrane helices are complex and not restricted to

121 investigated whether prolines in or near the transmembrane helices are essential for BCRP function.

122 The packing structures of transmembrane helices are traditionally attributed to pa

123 r, including membrane proteins with multiple transmembrane helices, are enriched and recovered in the

124 with two inverted structural repeats of five transmembrane helices arranged, unusually, face-to-back.

125 t M2 is tightly associated with the adjacent transmembrane helices at the intracellular end but is mo

126 interaction of the two crossed C-terminal M4 transmembrane helices at the vestibule entrance.

127 icelles, YgaP forms a homodimer with the two transmembrane helices being the dimer interface, whereas

128 two transmembrane helices) and Rv1861 (three transmembrane helices), both from Mycobacterium tubercul

129 tibodies act by conformationally locking the transmembrane helices by means of restraining the exoloo

130 yl acceptors are frequently observed between transmembrane helices (Calpha-H...O=C).

131 osed, indicating that local movements of the transmembrane helices can control ion access to the pore

132 structure shows a novel fold comprising four transmembrane helices capped by a cytosolic domain, and

133 swap experiments support the hypothesis that transmembrane helices co-evolve with membranes, suggesti

134 The seven-transmembrane helices, conformationally distinct from th

135 There, the conformation of transmembrane helices constituting a membrane-spanning f

136 es located in a periplasmic loop between two transmembrane helices contain conserved charged residues

137 Many transmembrane helices contain serine and/or threonine re

138 ure of how structural rearrangements between transmembrane helices control ligand binding, receptor a

139 Residue-residue contacts across the transmembrane helices dictate the three-dimensional topo

140 c architecture, with each subunit forming 12 transmembrane helices divided into structurally similar

141 in the crystal structure, the outer ring of transmembrane helices do not pack against the pore-formi

142 rangement of three distinct domains: a seven-transmembrane helices domain (TMD), a hinge domain (HD)

143 echnique to measure pulling forces acting on transmembrane helices during their cotranslational inser

144 d MFS fold, that is, with two domains of six transmembrane helices each which are related by twofold

145 amily fold; that is, with two domains of six transmembrane helices each, related by 2-fold pseudosymm

146 t proteins, which contain two domains of six transmembrane helices each.

147 Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved s

148 by the ligand-ectodomain interactions to the transmembrane helices either through direct hormonal con

149 Four beta4, each containing two transmembrane helices, encircle Slo1, contacting it thro

150 The Ste24p core structure is a ring of seven transmembrane helices enclosing a voluminous cavity cont

151 sm in the AM2 transmembrane domain; the four transmembrane helices flanking the channel lumen alone s

152 eticulum membrane protein that contains four transmembrane helices followed by a cytoplasmic ligand-b

153 Barttin consists of two transmembrane helices followed by a long intracellular c

154 ces the challenge of chaperoning hydrophobic transmembrane helices for faithful membrane insertion.

155 e and a membrane protein that contains eight transmembrane helices form a complex that may function a

156 The two transmembrane helices form a left-handed packing arrange

157 he slipknot loop seems to strap together the transmembrane helices forming the channel.

158 s on tight coupling between movements of the transmembrane helices forming the two Ca(2+)-binding sit

159 g function is mediated by the interaction of transmembrane helices from both proteins.

160 ace of Ste2 is formed by the N terminus, the transmembrane helices H1, H2 and H7, and the first extra

161 nteractions between its beta-ionone ring and transmembrane helices H5 and H6, while deprotonation of

162 We show that 92% of all transmembrane helices have at least one non-canonical H-

163 erol concentration, an increased presence of transmembrane helices I and II, but a reduced presence o

164 is a small cytosolic domain inserted between transmembrane helices I and II.

165 t contain eight iron-sulphur clusters and 60 transmembrane helices, identify 18 supernumerary transme

166 mutagenesis of aromatic residues located in transmembrane helices II, IV, and V of subunit B, near g

167 short intracellular linker-helix IIS4-S5 and transmembrane helices IIS5 and IIIS6.

168 in) binds between the linker helix IIL45 and transmembrane helices IIS5, IIS6, and IIIS6 with its dib

169 STRA6 has one intramembrane and nine transmembrane helices in an intricate dimeric assembly.

170 res similar and substantial movements of the transmembrane helices in both P2X receptors and ASICs, a

171 encephalitis virus and dengue virus revealed transmembrane helices in lipid bilayers, receptor-bindin

172 y mutations altering either LPS structure or transmembrane helices in LptG.

173 functional studies to probe the movement of transmembrane helices in NorM from Neiserria gonorrheae

174 concerted fluctuations of retinal ligand and transmembrane helices in rhodopsin.

175 rted disulfide bridges linking the M1 and M3 transmembrane helices in the alpha and gamma subunits.

176 imulations were conducted of the TRPV1 S1-S4 transmembrane helices in the presence of capsaicin place

177 The pore-forming transmembrane helices in these channels are linked by sh

178 The identification of transmembrane helices in transmembrane proteins is cruci

179 The predicted transmembrane helices in XA23 also overlap with those of

180 re consisting of a tetramer composed of four transmembrane helices, in which two opposing helices are

181 Upon activation, the transmembrane helices increase the tilt angle by 6 degre

182 domain inserted between the second and third transmembrane helices interacts intimately with paired E

183 o-EM), which show novel assembly of the four transmembrane helices into channels of octamers and unde

184 protein is the insertion of its hydrophobic transmembrane helices into the lipid bilayer.

185 l attributes describing secondary structure, transmembrane helices, intrinsically disordered regions,

186 ffer in ligand orientation and the number of transmembrane helices involved.

187 refore, that the relative positioning of the transmembrane helices is preserved in mimics of the cell

188 oop 2, leaving only a narrow channel between transmembrane helices IV and V that connects it to the l

189 instead favor C-terminal dimerization of the transmembrane helices, juxtamembrane segment dissociatio

190 ific conformational changes within the seven transmembrane helices, leading to the coupling and activ

191 esidues and stabilized by one or both of the transmembrane helices linked by the loop.

192 rsity originates from differences within the transmembrane helices (M1 and M2) of both channel famili

193 t the canonical PLB-binding site (comprising transmembrane helices M2, M4, and M9) is the preferred s

194 revealed that the iris-like expansion of the transmembrane helices mainly results from interchain mot

195 aggregation because of the hydrophobicity of transmembrane helices, making them difficult to study us

196 tramolecular interactions so that individual transmembrane helices manifest different properties.

197 n transfer, and the membrane arm contains 78 transmembrane helices, mostly contributed by antiporter-

198 data also implied that the substrate-binding transmembrane helices move up to 10 A in NorM-NG during

199 e conformations favoring dimerization of the transmembrane helices near their N termini, dimerization

200 in bilayers stretched to match the length of transmembrane helices observed as increase of sn-1 chain

201 the chemokine-binding pocket formed by seven transmembrane helices of CCR5, and the N terminus of CCR

202 All six transmembrane helices of CmTMEM175 are tightly packed wi

203 ed the IC pocket-located in-between the four transmembrane helices of each human Cx26 (hCx26) monomer

204 We hypothesize that the transmembrane helices of FtsB form a stable dimeric core

205 ion by decreasing the crossing angle between transmembrane helices of integrin alphaIIbbeta3, which e

206 induces an inward rotation and shift of the transmembrane helices of LptFG and LptC to tighten the c

207 ure of three serines on the same side of the transmembrane helices of MS-DesK, triggering a switching

208 wo glutamic residues located in the adjacent transmembrane helices of NuoK are important for the ener

209 d prolines located at loops of discontinuous transmembrane helices of NuoL, NuoM, and NuoN were shown

210 wn K(+) coordination sites buried within the transmembrane helices of the enzyme.

211 Molecular dynamics of the S1-S4 transmembrane helices of the TRPV1 in a lipid bilayer co

212 dylcholine bilayer and with the target S1-S4 transmembrane helices of TRPV1.

213 The transmembrane helices of US28 adopt an active-state-like

214 elix on the intracellular side, and by S4-S6 transmembrane helices on the lateral sides.

215 uctures reveal a novel fold comprised of ten transmembrane helices organized into two subdomains and

216 er containing eight distinct subunits and 26 transmembrane helices per monomer, catalyzes proton-coup

217 transmembrane region containing at least 26 transmembrane helices per protomer.

218 thic helix extends outwards from the ring of transmembrane helices, permitting assembly of complexes

219 e membrane protein targets with 7, 11 and 16 transmembrane helices provided measures of success.

220 , only one porelike structure containing two transmembrane helices remained at 26 mus, and none of th

221 lic cavity surrounded by 12 mostly irregular transmembrane helices represents a common structural fea

222 The arrangement of the transmembrane helices reveals hallmarks of an active con

223 or is formed by a linker-helix L45 and three transmembrane helices (S5 and two S6s); 2) IIS6 contains

224 d GlpG, it has been proposed that one of the transmembrane helices (S5) of the protease can rotate to

225 We find that Panx1 protomers harbor four transmembrane helices similar in arrangement to other la

226 pontaneous global conformation change of the transmembrane helices, similar to the motion involved in

227 aposed to membrane-anchoring domains such as transmembrane helices, sites of irreversible lipid modif

228 e protein that are allosterically coupled to transmembrane helices so as to expose ion binding sites

229 on process specific interactions between the transmembrane helices start to form.

230 nal domains, each with six largely irregular transmembrane helices surrounding an aqueous cavity open

231 cal catalytic cap domain that sits atop four transmembrane helices that anchor the enzyme in the endo

232 The identified region contains two predicted transmembrane helices that appear to reoccur in a wide r

233 onsisting of a Pro-rich motif flanked by two transmembrane helices that are conserved among members o

234 ified conserved charged residues within TMD0 transmembrane helices that are essential for individual

235 ootprinting reveal ordered waters within Rho transmembrane helices that are located close to highly c

236 ue substrates evolved intrinsically-unstable transmembrane helices that both become unstructured when

237 a homodimer with each subunit containing 12 transmembrane helices that can be divided into two struc

238 -facing allosteric binding sites outside the transmembrane helices that can only be reached via lipid

239 nated by hydrophobic residues of the M and E transmembrane helices that form a binding pocket not pre

240 en conformation by altering the structure of transmembrane helices that line the cavity.

241 ontains a nucleotide-binding domain and four transmembrane helices that protrude in the periplasm int

242 the mutual interplay of interactions between transmembrane helices, the cytoplasmic talin protein, an

243 imers, by holding apart the N termini of the transmembrane helices, the extracellular domains instead

244 tivity requires Rhs that contains N-terminal transmembrane helices, the PAAR domain, and an intact be

245 ation gate through interactions between both transmembrane helices, the turret, selectivity filter lo

246 Containing 10 transmembrane helices, the two halves of NCX_Mj share a

247 c methods used to assign the topology of the transmembrane helices, these two types of structure pred

248 s intramolecular signaling chain through the transmembrane helices; this chain connects chemokine bin

249 Many transmembrane helices tilt and shift positions, and the

250 Scap has eight transmembrane helices (TM) joined by four small hydrophi

251 t Na,K-ATPase activity, whereas mutations in transmembrane helices (TM), alphaTM2 and alphaTM4, aboli

252 During the gating process, both the transmembrane helices TM1 and TM2 cooperatively rotate i

253 r, in homodimeric configurations with either transmembrane helices TM1/H8 or TM4/3 at the interface,

254 domain containing the ATP binding site and 2 transmembrane helices (TM1 and TM2) that form a cation p

255 ane topology with an intracellular loop, two transmembrane helices (TM1 and TM2), and extracellular N

256 te homotrimers, with each subunit having two transmembrane helices, TM1 and TM2.

257 Here, we propose nine residues in transmembrane helices (TM2, TM3, and TM5) that potential

258 d interactions between the cytosolic ends of transmembrane helices TM3 and TM6 of class-A (rhodopsin-

259 o three prolines located in the odd-numbered transmembrane helices (TMH), Pro-27, Pro-132, and Pro-22

260 xperiments with synthetic peptides mimicking transmembrane helices (TMH), we show that such superpote

261 Homologous transmembrane helices (TMHs) 6 and 12 of human P-gp conn

262 The CbuD1884 protein contains two transmembrane helices (TMHs) and a coiled-coil domain pr

263 Ag(+)(Cd(+2))-sensitive Cys extends from the transmembrane helices (TMHs) of subunits a and c into cy

264 in (Cdr1p) that correspond to each of the 12 transmembrane helices (TMHs) of the two transmembrane do

265 ting of an N-terminal domain containing four transmembrane helices (TMHs), a large central periplasmi

266 lerae, reveals a protein fold composed of 12 transmembrane helices (TMHs), confirming hydropathy anal

267 rotations about the axis (eta) of all seven transmembrane helices (TMHs), showing that the experimen

268 ed in the transport mechanism, in particular transmembrane helices (TMs) 1a and 7 as well as extracel

269 acing state involves rigid body movements of transmembrane helices (TMs) 2-6 and 8-12 to form an inve

270 nn-Pick C1 (NPC1), a lysosomal protein of 13 transmembrane helices (TMs) and three lumenal domains, e

271 ns (NBDs) with conformational changes in its transmembrane helices (TMs) is poorly defined.

272 mologues-including LeuT-have shown how their transmembrane helices (TMs) undergo conformational chang

273 ucture of NhaA, solved at pH 4, comprises 12 transmembrane helices (TMs), arranged in two domains, wi

274 Each monomer contains nine transmembrane helices (TMs), six of which (TM4-TM9) form

275 30-residue TEB4-Doa10 domain, includes three transmembrane helices (TMs).

276 EBP adopts an unreported fold involving five transmembrane-helices (TMs) that creates a membrane cavi

277 (secondary structure, solvent accessibility, transmembrane helices (TMSEG) and strands, coiled-coil r

278 cellular ligand binding events through their transmembrane helices to activate intracellular G protei

279 We propose that this transition enables the transmembrane helices to adopt a distinct conformation t

280 utilize the expanded model encompassing six transmembrane helices to calculate the RyR1 pore region

281 l constraint is released that allows the two transmembrane helices to come together to facilitate act

282 embrane (the turret) and that joins with the transmembrane helices to form the ion permeation pathway

283 ake advantage of hydrophobic interactions of transmembrane helices to manipulate the assembly of ssMP

284 iston-like or rotational displacement of the transmembrane helices to modulate activity of the linked

285 nformation and structure predictions for the transmembrane helices to the amino acid sequence we iden

286 ated sensory input domain of PA1396 has five transmembrane helices, two of which are required for DSF

287 ered potential rearrangement of at least two transmembrane helices upon Na(+)-induced drug export.

288 ocket was narrowed down to the upper part of transmembrane helices V, VI, VII and the extracellular l

289 large-scale structural rearrangements of the transmembrane helices via dynamic hydrogen bond and salt

290 switch between alternative crossings of the transmembrane helices, which form dimeric structures.

291 a closely packed bundle of mutually aligned transmembrane helices, which is further stabilized by a

292 quires an N-terminal interaction between the transmembrane helices, which promotes an antiparallel in

293 se transporter FucP and have identified four transmembrane helices whose ends close to form a predict

294 tached to lipid bilayers through hydrophobic transmembrane helices, whose topogenesis requires sophis

295 RocA is a membrane protein containing seven transmembrane helices with an extracytoplasmically locat

296 and AdipoR2 were predicted to contain seven transmembrane helices with the opposite topology to G-pr

297 s) are a family of proteins containing seven transmembrane helices, with the N- and C-terminus of the

298 AREpins simultaneously zippering their SNARE transmembrane helices within the freshly fused bilayers

299 edge of the topological organization of Hhat transmembrane helices would enhance our understanding of

300 helical export gate with its four predicted transmembrane helices wrapped around FliPQR/SctRST.