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1 oupled receptors (GPCRs, also known as seven-transmembrane receptors).
2 the neuropeptide sensitivity of the neuronal transmembrane receptor.
3 ai signaling module by a cell surface, seven-transmembrane receptor.
4 NA injection by T5 phage upon binding to its transmembrane receptor.
5 i) signaling module by a cell surface, seven-transmembrane receptor.
6 y similar defects as the knockout of the Dcc transmembrane receptor.
7 function are G proteins controlled by seven transmembrane receptors.
8 receptors (GPCRs) are the largest family of transmembrane receptors.
9 (Galpha), most notably by G protein-coupled transmembrane receptors.
10 g pathways initiated by specific nuclear and transmembrane receptors.
11 stributed in the cytoplasmic domains of many transmembrane receptors.
12 tein that connects the actin cytoskeleton to transmembrane receptors.
13 connections by anchoring actin filaments to transmembrane receptors.
14 ptor tyrosine kinase, and the Frizzled seven-transmembrane receptors.
15 c lipids may modulate ectodomain shedding of transmembrane receptors.
16 nly at the carboxyl tails of GPCRs and other transmembrane receptors.
17 with the same charge density but no specific transmembrane receptors.
18 tch family consists of four highly conserved transmembrane receptors.
19 lowing their recruitment to signal-activated transmembrane receptors.
20 degradation, a pathway usually reserved for transmembrane receptors.
21 mains in extracytoplasmic regions in several transmembrane receptors.
27 estin-mediated signaling downstream of seven transmembrane receptors (7TMRs) is a relatively new para
30 upled receptors (GPCRs), also known as seven-transmembrane receptors (7TMRs), both by inhibiting clas
34 ated G protein-coupled receptors, (aka seven-transmembrane receptors, 7TMRs) also mediate 7TMR intern
36 e first to reveal, we believe, for any seven-transmembrane receptor, a functional role of ubiquitinat
37 s, and our findings suggest that single pass transmembrane receptors act as GPCRs in plants, challeng
38 , for spatiotemporal control over endogenous transmembrane receptor activation, enabled through the o
39 talin are key steps to initiate the integrin transmembrane receptors' activation, which mediates many
40 med "energy taxis." In Escherichia coli, the transmembrane receptor Aer is the primary energy sensor
41 inducing peptide (AIP) signal to its cognate transmembrane receptor (AgrC) is responsible for control
44 that netrin-1 also interacts with the orphan transmembrane receptor amyloid precursor protein (APP).
45 ing cellular cytoprotective functions by a 7-transmembrane receptor and define the biochemical pathwa
46 bilical cord vascular endothelial cells as a transmembrane receptor and may recognize certain bacteri
48 otein expression and activation of NOTCH2, a transmembrane receptor and transcriptional regulator kno
49 structural and signaling scaffold that binds transmembrane receptors and a wide variety of intracellu
50 nctions through binding to ligand-stimulated transmembrane receptors and activating their kinase doma
51 located within the cytoplasmic tails of many transmembrane receptors and associated adaptor proteins
57 d receptors (GPCRs) are the largest class of transmembrane receptors and serve as signal mediators to
58 Rs) represent one of the largest families of transmembrane receptors and the most common drug target.
59 manner that required selective activation of transmembrane receptors and was distinct from VEGF-A-ind
60 ure accurate trafficking and distribution of transmembrane receptors and/or proteins and their ligand
62 e last 20 years support the notion that some transmembrane receptors are activated not only by their
65 oupled receptors (GPCRs, also known as seven-transmembrane receptors) are typically found at the cell
66 TLRs), widely expressed and highly conserved transmembrane receptors, are at the intersection of diet
70 ance of C5a receptor [(C5aR)2/C5L2], a seven-transmembrane receptor binding C5a and C5adesArg, remain
72 etween extracellular signaling molecules and transmembrane receptors, but how appropriate context-dep
74 esicles maintain the structural integrity of transmembrane receptors by keeping them in their physiol
75 ation of heterodimeric (alpha/beta) integrin transmembrane receptors by the 270 kDa cytoskeletal prot
76 echanism by which an anti-inflammatory seven-transmembrane receptor can negatively regulate JAK/STAT
77 e recent discoveries reveal the existence of transmembrane receptors capable of responding to steroid
78 rotein is necessary for transit of selective transmembrane receptor cargo by the COPII coat for anter
80 d for several genes, including those for the transmembrane receptor CD44 (CD44 [rs507230]; P = 3.98 x
81 ar carbohydrate-binding domain of the Type I transmembrane receptor CD44 is known to undergo affinity
82 nce suggests that interactions involving the transmembrane receptor CD44 may play an important role i
83 MIF (which largely functions via the type II transmembrane receptor CD74) in prostate, bladder and ki
86 netic disorder, is caused by mutations of CF transmembrane receptor (CFTR) - a chloride channel prese
87 way as a result of defective cystic fibrosis transmembrane receptor (CFTR) expression and function.
88 d for inferring the functional properties of transmembrane receptor clusters from their structure.
89 ndothelial growth factor receptor, Flt1 is a transmembrane receptor co-expressed with an alternate tr
93 e multiple physiologic systems by activating transmembrane receptors containing intracellular guanyly
94 and detect their concentration via the AgrC transmembrane receptor, coordinating local bacterial pop
100 norhabditis elegans through the leucine-rich transmembrane receptor DMA-1/LRR-TM expressed on PVD neu
101 peptide ligand that binds and activates the transmembrane receptor domain, eliciting a cellular casc
103 ues, we developed a phenotyping asssay named Transmembrane Receptor Dynamics (TReD), studied the dyna
108 iate many of their physiological effects via transmembrane receptors expressed in the plasma membrane
109 eptors (MORs) are members of the large seven-transmembrane receptor family which transduce the effect
112 ved signaling node comprising a prototypical transmembrane receptor for c-di-GMP, LapD, and a cognate
116 or-like tyrosine kinase (RYK) functions as a transmembrane receptor for the Wnt family of secreted pr
117 The activin receptor type IIB (ActRIIB) is a transmembrane receptor for transforming growth factor-be
118 ughput technology to interrogate most single transmembrane receptors for binding to 445 IgSF proteins
121 Mammalian plexins constitute a family of transmembrane receptors for semaphorins and represent cr
126 results provide atomic insight into a type I transmembrane receptor heterocomplex and the mechanism o
127 ggest entry into neuronal stem cells through transmembrane receptors, hijacking cellular signaling to
128 s to reveal the arrangement of the component transmembrane receptors, histidine kinases (CheA) and Ch
129 The repeating ternary units are composed of transmembrane receptors, histidine-kinase CheA, and coup
130 Classic IL-6 signaling is conditioned by the transmembrane receptor (IL-6R) and homodimerization of g
131 ycation end products (RAGE) is a multiligand transmembrane receptor implicated in a number of disease
134 ch encodes an emerging positive regulator of transmembrane receptors in plants, suppressed the effect
135 show that somatodendritic sorting of various transmembrane receptors in rat hippocampal neurons is me
136 eriments, we investigated the roles of three transmembrane receptors in regulating dorsolateral pathf
137 Members of the plexin family are unique transmembrane receptors in that they interact directly w
139 t spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and in
140 le photocontrol of the clustering of diverse transmembrane receptors including fibroblast growth fact
141 onse to the triggering of a diverse array of transmembrane receptors, including antigen receptors.
142 l lamina is linked to the sarcolemma through transmembrane receptors, including integrins and dystrog
145 ase (ILK) plays a pivotal role in connecting transmembrane receptor integrin to the actin cytoskeleto
147 arge class of soluble proteins that dimerize transmembrane receptors into precise signaling topologie
149 which signals through cAMP, is a melanocytic transmembrane receptor involved in pigmentation, adaptiv
150 ceptor CXC-chemokine receptor 4 (CXCR4) is a transmembrane receptor involved in survival, proliferati
152 c embryogenesis receptor kinases (SERKs) are transmembrane receptors involved in plant immunity.
154 ession requires the RNase activity of the ER transmembrane receptor IRE-1, we developed a potent IRE-
157 In nonneuronal cells, CME of the majority of transmembrane receptors is either directly or indirectly
158 FR trafficking, as the localization of other transmembrane receptors is unaltered in chp-1(lf) mutant
160 rol-dependent nanoclustering of cell surface transmembrane receptor kinase 1 (TMK1) is critical for t
162 n AvrPto does so by directly targeting plant transmembrane receptor kinases involved in bacterial per
165 plasmic levels of cyclic-di-GMP activate the transmembrane receptor LapD that in turn recruits the pe
172 Mutations in the gene encoding the single transmembrane receptor multiple epidermal growth factor-
173 to heightened inflammatory responses from CF transmembrane receptor mutant cells and highlight autoph
174 or complex of distinct Lys motif (LysM)-type transmembrane receptors named NOD FACTOR RECEPTOR1 (LjNF
179 microvessels to show that activation of the transmembrane receptor NOTCH1 directly regulates vascula
181 Deleted in colorectal cancer (DCC), a large transmembrane receptor of netrin-1, is critical for medi
184 The vibrio autoinducer molecules bind to transmembrane receptors of the two-component histidine s
187 where raft compartmentalization can promote transmembrane receptor oligomerization, shield proteins
188 specific GAG sulfation patterns and involve transmembrane receptors or extracellular matrix-associat
189 otile bacteria sense chemical gradients with transmembrane receptors organised in supramolecular sign
191 (mRNA) expression of Indian Hh, a ligand of transmembrane receptor patched 1, was 184x higher in BE
192 d in a non-redundant fashion with the Draper transmembrane receptor pathway: loss of either pathway f
194 ted semaphorin 2b (Sema-2b) acts through its transmembrane receptor Plexin B (PlexB) to locally attra
195 , renal tubular epithelial cells lacking the transmembrane receptor Plexin-B2 or its semaphorin ligan
196 orin 3E (Sema3E), acts through a single-pass transmembrane receptor, plexin D1, to provide a repulsiv
199 learning rate, of the collagen formation and transmembrane receptor protein tyrosine kinase activity
200 positional cloning and report it to encode a transmembrane receptor protein with two hypervariable ex
202 erial chemotaxis signaling cluster, in which transmembrane receptors regulate CheA autokinase activit
203 homodimerization and heterodimerization of 7-transmembrane receptors regulate processes including spe
205 RIIa) has been identified as an ITAM-bearing transmembrane receptor responsible for mediating "outsid
209 ted neurorepellent Slit2, acting through its transmembrane receptor, Roundabout (Robo)-1, inhibits ch
210 discovery over 20 years ago, eukaryotic-like transmembrane receptor Ser/Thr protein kinases (STPKs) h
211 ondins (TSP or THBS) and the Notch family of transmembrane receptors share a role in multiple, overla
212 Members of the Frizzled family of sevenpass transmembrane receptors signal via the canonical Wnt pat
215 overed for their role in desensitizing seven-transmembrane receptor signaling via the heterotrimeric
216 how membrane nanoscale organization controls transmembrane receptors signaling activity remains a cha
217 ted that these glycoproteins would influence transmembrane receptor spatial organization and function
221 pattern recognition receptors-which include transmembrane receptors such as toll-like receptors (TLR
222 " Their receptors are part of a larger seven-transmembrane receptor superfamily, commonly referred to
224 nd colleagues have identified a novel 17-kDa transmembrane receptor, termed Plg-R(KT), that binds pla
225 are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR
227 ycation end products (RAGE) is a multiligand transmembrane receptor that can undergo proteolysis at t
233 (Spz) into the activating ligand for Toll, a transmembrane receptor that is distributed throughout th
235 ate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is expressed on epithelial c
237 umor necrosis factor receptor 2 (TNFR2) is a transmembrane receptor that is linked to immune modulati
238 ial cells, guanylyl cyclase 2C (GUCY2C) is a transmembrane receptor that makes cGMP in response to th
240 AIL-R1; also known as death receptor 4) is a transmembrane receptor that mediates TRAIL-induced apopt
243 eceptor 5 (DR5) is a death domain-containing transmembrane receptor that triggers apoptosis upon bind
244 eptor (LIMR)-type proteins are putative nine-transmembrane receptors that are evolutionarily conserve
252 egrins comprise a family of 24 heterodimeric transmembrane receptors that mediate cell attachment to
254 TPsigma) and its subfamily member LAR act as transmembrane receptors that mediate growth inhibition o
256 Integrins are bidirectional, allosteric transmembrane receptors that play a central role in hemo
260 dulators is controlled by endocytosis of the transmembrane receptors that transduce their effects.
261 are made possible by integrins, a family of transmembrane receptors that, upon binding to the extrac
262 otective signaling stimulated by a typical 7-transmembrane receptor the angiotensin ATII 1A receptor,
263 l lattice formed from three core proteins: a transmembrane receptor, the His kinase CheA, and the ada
264 in is one of the most mechanistically direct transmembrane receptors-the intracellular domain contain
265 aling proteins, cytoskeletal components, and transmembrane receptors, thereby serving as a scaffold t
266 The primary initiator of coagulation, the transmembrane receptor tissue factor (TF), has gained co
268 nteractions that promoted the endocytosis of transmembrane receptors, TLR4 was selected as cargo for
271 s relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules
272 s of studies, namely the propensity of seven transmembrane receptors to form dimers and thus demonstr
276 rom the cytosol, including cell division and transmembrane receptor trafficking and degradation.
281 ms was observed for NTRK2, which encodes the transmembrane receptor tropomyosin-related kinase B, bin
289 Epidermal growth factor receptor (EGFR) is a transmembrane receptor-tyrosine kinase that is associate
292 RDC3 and ARRDC4 upon activation of the seven transmembrane receptors vasopressin 2 and beta adrenergi
293 pression of Notch3, a member of Notch family transmembrane receptors, was elevated in human cells dur
297 gene encodes an approximately 50 kDa type I transmembrane receptor with an ectodomain containing thr
299 human cytomegalovirus (HCMV)-encoded type I transmembrane receptors with Fcgamma-binding properties
300 herefore hypothesized that preorganizing the transmembrane receptors would potentiate local TGF-beta