ライフサイエンスコーパス: transmissibility

1 jor determinant of infectivity and therefore transmissibility.

2 cond wave, while accounting for its relative transmissibility.

3 compatibility and in vivo pathogenicity and transmissibility.

4 uitable for transmission and the duration of transmissibility.

5 ese viruses acquire efficient human-to-human transmissibility.

6 bal public health concern, given its ease of transmissibility.

7 SIV 1145-N66S displayed poor infectivity and transmissibility.

8 s prevent definitive classification of human transmissibility.

9 cs in real time only provides a glimpse into transmissibility.

10 iotic resistance, colonization potential, or transmissibility.

11 rom somatic mutations that must drive clonal transmissibility.

12 that may represent key initiators of clonal transmissibility.

13 ntly of great interest for determining virus transmissibility.

14 nt can generate novel viruses with increased transmissibility.

15 ough this mechanism, have a potent effect on transmissibility.

16 are likely to be major determinants of virus transmissibility.

17 ns are subject to enhanced susceptibility or transmissibility.

18 wind speed was correlated with decreased RSV transmissibility.

19 by zoonotic viruses that acquired efficient transmissibility.

20 romoting influenza A virus pathogenicity and transmissibility.

21 in the flea foregut, which greatly increased transmissibility.

22 identify certain viral factors that enhance transmissibility.

23 asmid combinations that optimize fitness and transmissibility.

24 ighlighting its potential for human-to-human transmissibility.

25 f the influenza M segment to influence virus transmissibility.

26 us (MRSA) epidemiology is complicated by its transmissibility.

27 igs, acquired greatly enhanced virulence and transmissibility.

28 members reporting swine contact to estimate transmissibility.

29 t a role of HSV-2 infection in enhancing HIV transmissibility.

30 ner that is favorable to its survival and/or transmissibility.

31 nhancing their persistence and surprisingly, transmissibility.

32 eorological drivers were associated with RSV transmissibility.

33 explain a further 15% of the variance in RSV transmissibility.

34 ersion of the traA mutation restored plasmid transmissibility.

35 or trade-offs between pathogen virulence and transmissibility.

36 es of the outbreak: high covertness and high transmissibility.

37 at SARS-CoV-2 may be evolving towards higher transmissibility.

38 o artefenomel dosing to investigate parasite transmissibility.

39 rvention effectiveness, and reduction in HIV transmissibility.

40 is complex (MTBC) that vary in virulence and transmissibility.

41 hould be tested for changes in virulence and transmissibility.

42 apenemase-positive isolates have the highest transmissibility.

43 er-defining SNPs potentially contributing to transmissibility.

44 ins which exhibit increased virulence and/or transmissibility.

45 on, and limited (0 < R0 <= 1) human-to-human transmissibility.

46 asymptomatic individuals and their relative transmissibility.

47 the virus mutates to increase human-to-human transmissibility.

48 entified mutations associated with increased transmissibility.

49 model with two possible values for intrinsic transmissibility across three epochs.

50 ess the brain, initiate feed-forward amyloid transmissibility among cells of the blood-brain barrier

51 of shigellosis infection, including seasonal transmissibilities and basic reproductive number (R0).

52 ourse of an epidemic) with various levels of transmissibility and 5-fold fractional-dose vaccine effi

53 ynamics, especially if the disease shows low transmissibility and a long infectious period, and when

54 y sensitive to model parameters defining the transmissibility and clinical severity of the pandemic s

55 nd mucus may be an important factor in viral transmissibility and could be a barrier for interspecies

56 nd mucus may be an important factor in viral transmissibility and could be a species barrier between

57 l framework to deal with such path-dependent transmissibility and demonstrate the nontrivial interpla

58 eling the mechanisms causing increased viral transmissibility and disease severity requires experimen

59 The transmissibility and duration of ESBL-E carriage was qua

60 Transmissibility and duration of ESBL-E carriage was qua

61 future outbreaks are likely dependent on the transmissibility and evolutionary dynamics of circulatin

62 out how the disease spreads, such as uniform transmissibility and homogeneous mixing within a populat

63 es, with particular focus on influenza virus transmissibility and host-range specificity.

64 ed to understand the differences in parasite transmissibility and immunity to different genotypes.

65 s therefore the primary determinant of viral transmissibility and immunogenicity.

66 increasing prevalence worldwide, its sexual transmissibility and its facilitation of human immunodef

67 er, important questions remain regarding its transmissibility and pathogenesis.

68 viral drug susceptibility, vaccine efficacy, transmissibility and pathogenicity studies.

69 o-animal adaptation for establishing mucosal transmissibility and pathogenicity.

70 also found a significant association between transmissibility and population density, illiteracy, and

71 ick-borne equine pathogens, emphasizing tick transmissibility and potential control strategies to pre

72 ch outbreaks are driven by inherent pathogen transmissibility and pre-existing population immunity, a

73 The molecular mechanisms determining the transmissibility and prevalence of drug-resistant tuberc

74 rovides mechanistic insights into horizontal transmissibility and puts forward a dual chemo-immunothe

75 The high transmissibility and rapid evolutionary rate of noroviru

76 demic in Morocco during 2009-2010, including transmissibility and risk factors associated with fatal

77 genuine prion disease characterized by both transmissibility and strain variation.

78 t identifying adaptations required for virus transmissibility and systems-level analyses of influenza

79 al genetic markers associated with increased transmissibility and to examine whether these markers le

80 which indicates the potential for changes in transmissibility and virulence and could render current

81 e in Bamako remains worrying, given its high transmissibility and virulence.

82 onal programs mechanistically links parasite transmissibility and virulence.

83 -CoV-2 spike protein, a major determinant of transmissibility, and discuss key molecular aspects that

84 but may impact in vivo infectivity, mucosal transmissibility, and early infection events.

85 uction number (R(t)), a real-time measure of transmissibility, and examined its relationship with env

86 ociated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influen

87 viral drug susceptibility, vaccine efficacy, transmissibility, and pathogenesis.

88 sk, indicated sequence type heterogeneity in transmissibility, and showed that within-ward transmissi

89 ule production in emm87 GAS did not increase transmissibility, and the absence of capsule enhanced pe

90 tory of the infectious disease, its inherent transmissibility, and the intervention feasibility in th

91 of molecular determinants of pathogenicity, transmissibility, and tropism.

92 e history with immunity, pathogen diversity, transmissibility, and zoonotic risk, and critical data g

93 offs between toxicity, relative fitness, and transmissibility are critical for understanding the mult

94 wever, viral properties that determine HIV-1 transmissibility are not fully elucidated.

95 osocomial transmission, and changes in viral transmissibility, as well as diagnostic laboratory artif

96 nship between prion strains and interspecies transmissibility barriers.

97 Method 4 assesses transmissibility before public health interventions, by

98 ighest before symptom onset, suggesting high transmissibility before symptoms.

99 rrets is considered a surrogate indicator of transmissibility between humans, these studies raised co

100 luenza viruses is a key determinant of their transmissibility, both from avian and animal species to

101 shedding is a determinant of infectivity and transmissibility, but few data exist about oseltamivir's

102 ve contact animals, and demonstrated limited transmissibility by respiratory droplets.

103 poorly understood phenomenon of AIV airborne transmissibility by revealing a role for NS1 and charact

104 rtant (HA1-H17Y/HA2-R106K) regained airborne transmissibility by stabilizing HA to an activation pH o

105 es probably contribute to the acquisition of transmissibility by this mutant virus.

106 between the number of acquired pathogens and transmissibility by ticks.

107 Tick transmissibility can be lost with attenuation, but when

108 Transmissibility can be measured by the reproduction num

109 ansmitted viruses, suggesting that mammalian transmissibility can evolve through multiple genetic pat

110 phenotypes, phenotypes associated with viral transmissibility, cell or tissue tropism phenotypes, and

111 Joint estimates of severity and transmissibility clustered within a relatively small reg

112 double mutant had virus shedding titers and transmissibility comparable to those of the wild type, i

113 owed that the rF257C virus exhibited reduced transmissibility compared to that of wild-type FMDV in t

114 This high transmissibility could be due to both high infectiousnes

115 ximate Bayesian computation to assess strain transmissibility, dependence of present season influenza

116 The quantification of transmissibility during epidemics is essential to design

117 the bacterium, finding significantly higher transmissibility during the cooler and drier months.

118 indications of increased HIV-1 virulence and transmissibility during the course of the epidemic and a

119 We illustrate this by deriving transmissibility estimates for the H3N2v-M virus, an imp

120 reservoir, quantification of uncertainty in transmissibility estimates, and provision of the first e

121 ems where heterogeneity between serotypes in transmissibility facilitates competitive exclusion, here

122 hypothesis, social-motivational and cultural transmissibility factors can provide foundations for usi

123 An increasing temporal trend in transmissibility ([Formula: see text], p-value: 0.013) d

124 ined source was within 5 years, and assessed transmissibility from forward transmissions resulting in

125 estigation data, we sought to estimate H3N2v transmissibility from swine to humans.

126 effect of multiple exposures to fly bites on transmissibility has not been addressed.

127 pts an alternative conformation and acquires transmissibility; hence, it becomes a prion.

128 of disease due to recent transmission and in transmissibility (highest for lineage-2 and lowest for l

129 r in pathogenesis that may affect virulence, transmissibility, host response and emergence of drug re

130 istidine kinase ComD significantly decreased transmissibility in a mouse model, further validating th

131 ssociated with viral fitness, virulence, and transmissibility in a natural host.

132 s in human airway cells and pathogenesis and transmissibility in animal models were also assessed.

133 f replicative ability in vivo, virulence and transmissibility in animal studies (mouse, ferret, and g

134 V627 genotype with uncompromised fitness and transmissibility in both avian and mammalian species.

135 s of the outbreak had higher infectivity and transmissibility in chickens than the wild bird index H5

136 ce in vitro, and increased pathogenicity and transmissibility in chickens.

137 their zoonotic infection characteristics and transmissibility in chickens.

138 nerated reassorted viruses conferred aerosol transmissibility in ferrets (a property shared by human

139 plicate efficiently in mammals, show limited transmissibility in ferrets and guinea pigs, and possess

140 1 influenza virus pathogenicity and airborne transmissibility in ferrets and is associated with pande

141 The H7N8 LPAI virus displayed limited transmissibility in ferrets placed in direct contact wit

142 us did not prevent influenza replication and transmissibility in ferrets, but did attenuate influenza

143 atic properties, replication efficiency, and transmissibility in ferrets.

144 NEP T48N) were identified as determinants of transmissibility in guinea pigs.

145 n opportunity to understand the evolution of transmissibility in guinea pigs.

146 man respiratory cells, virulence in mice and transmissibility in guinea pigs.

147 led to genomic changes that increased viral transmissibility in humans.

148 ns are assumed to lead to a 20% reduction in transmissibility in intervention facilities, prevalent c

149 ve were assessed for their pathogenicity and transmissibility in mammalian models, as well as their a

150 tal finding that a mutant avian virus gained transmissibility in mammals despite the mutations confer

151 tability to H5N1 influenza virus fitness and transmissibility in mammals in the background of a non-l

152 in particular its relative pathogenicity and transmissibility in mammals, are not known.

153 H5N1 viruses with the potential for aerosol transmissibility in mammals.

154 eceptor-binding affinity, pathogenicity, and transmissibility in mice and ferrets of four H5N6 isolat

155 ssortant viruses with enhanced virulence and transmissibility in mice and guinea pig models.

156 ween viral genetic diversity, virulence, and transmissibility in natural hosts.

157 tants demonstrated increased replication and transmissibility in pig, but were still inefficient when

158 and enhanced replication, pathogenicity, and transmissibility in pigs, guinea pigs, and ferrets in vi

159 N9) shows modest replication, virulence, and transmissibility in pigs, suggesting that it is not well

160 dm09 genes is responsible for less efficient transmissibility in pigs.

161 he values of R and Rindex and an increase in transmissibility in recent years were noted with all met

162 ycans are key determinants of host range and transmissibility in several pathogens.

163 versity is important for viral virulence and transmissibility in susceptible animals.

164 ariants of the prion protein (PrP) determine transmissibility in the hosts, as has been shown for cla

165 viruses revealed genetic markers of airborne transmissibility in the Polymerase Basic 2 (PB2), PB1, P

166 , replicative efficiency, pathogenicity, and transmissibility in vitro and in vivo.

167 evolution of M. tuberculosis toward enhanced transmissibility in vivo that are associated with altere

168 determine the likelihood of interhuman viral transmissibility, in turn enabling general predictions o

169 us could mutate to have increased interhuman transmissibility, increasing its pandemic potential.

170 ich could be due to their high virulence and transmissibility induced by high genetic diversity.

171 In addition to enhancing transmissibility, induction of the PhoP-PhoQ system in t

172 between parasite clearance following ACT and transmissibility is currently unknown.

173 model prediction for SCLs of varying oxygen transmissibility is in good agreement with available the

174 ch as symptoms or demographics, in norovirus transmissibility is poorly understood.

175 ines influenza A virus fitness and therefore transmissibility is the interaction of the surface glyco

176 hat the frequency of antigenic variation and transmissibility may be linked, antigen switching being

177 ve implications for understanding how dengue transmissibility may depend on the immune status of infe

178 However, we find that transmissibility may increase substantially if vaccine c

179 udies to assess the safety, infectivity, and transmissibility of a new P. vivax isolate.

180 the first quantitative evidence of enhanced transmissibility of a pandemic MRSA lineage, and highlig

181 novel infection depends on both the inherent transmissibility of a pathogen, and the level of suscept

182 ological characteristics, pathogenicity, and transmissibility of A/Anhui/1/2013 (H7N9) virus and vari

183 The transmissibility of AHC is high in small-scale outbreaks

184 However, the transmissibility of AHC remains unclear.

185 Studies in experimental animals show transmissibility of amyloidogenic proteins associated wi

186 g to the 'prion behaviour', that implies the transmissibility of an aberrant fold.

187 unity (which affects both infection risk and transmissibility of any resulting infection), age-mediat

188 ur findings suggest that for a high relative transmissibility of asymptomatic hosts, Zika virus shows

189 We found that, as the relative transmissibility of asymptomatic infection increases, a

190 analyses underscore the need to quantify the transmissibility of asymptomatic infections, without whi

191 The restrictions to transmissibility of avian influenza viruses in mammals a

192 ue opportunity to study the pathogenesis and transmissibility of bacterial vaginosis (BV) because it

193 Studies have demonstrated the transmissibility of both rickettsial pathogens and novel

194 of mouse models for assessing the potential transmissibility of common neurodegenerative diseases.

195 We studied the transmissibility of community-associated methicillin-res

196 ntact rates, and their correlations with the transmissibility of COVID-19, using mobility data collec

197 tanding of where transmission occurs and the transmissibility of drug-resistant strains, and estimate

198 NA-directed DNA methylation; but the meiotic transmissibility of graft-mediated epigenetic changes re

199 ar transmission properties, we estimated the transmissibility of H3N2v from swine to humans and the b

200 ains, we compared the relative virulence and transmissibility of H7N9 viruses isolated during the sec

201 ity and viral replication, pathogenicity and transmissibility of H7N9 viruses.

202 We also compared the transmissibility of H9N2:pH1N1 (P0), H9N2:pH1N1 (P7) and

203 lly acquired mutations known to increase the transmissibility of highly pathogenic H5N1 influenza vir

204 The variable infectivity and transmissibility of HIV/SHIV has been recently associate

205 ture residues are involved in increasing the transmissibility of infecting viruses; therefore, they a

206 We determined the pathogenicity and transmissibility of influenza A/Italy/3/2013 virus in mo

207 ect pigs under experimental conditions, with transmissibility of influenza B/Victoria lineage virus a

208 is a key determinant for the host range and transmissibility of influenza viruses.

209 The bites of uninfected sand flies favor the transmissibility of L. donovani by infected hosts, owing

210 ates were most sensitive to estimates of the transmissibility of MDR strains, the probability of acqu

211 se introductions rather than a change in the transmissibility of measles.

212 plications for our understanding of the high transmissibility of measles.

213 This study hence demonstrates epigenetic transmissibility of metabolic and inflammatory traits re

214 l variations in mRNA editing and the genetic transmissibility of mRNA editing are equivocal.

215 Transmissibility of neoplasia was preventable by prior n

216 s, lessen unwarranted apprehension about the transmissibility of noninfectious proteopathies, and pro

217 racterizing the amplitude and variability in transmissibility of novel human influenza strains as the

218 provide insights into the pathogenicity and transmissibility of novel reassortant H3N2 viruses in pi

219 We further evaluated transmissibility of oral microbiomes from parents and du

220 ging in mammals owing to the relative tissue transmissibility of orange-red light, but their dependen

221 ent failures after ACT and the viability and transmissibility of persisting ring stage parasites rema

222 of infection mimics the prolonged cough and transmissibility of pertussis, and we hypothesized that

223 ular prion protein (PrP) function(s) and the transmissibility of prion protein neurodegenerative dise

224 cosylation and GPI anchoring, can affect the transmissibility of prions as well as the biochemical pr

225 etic approaches to estimate the variation in transmissibility of rapidly-evolving viral epidemics.

226 Meteorological drivers are known to affect transmissibility of respiratory viruses including respir

227 that are only slightly asymmetric, increased transmissibility of secondary infections through immune

228 that directly test the in vivo cross-species transmissibility of SIVcpz strains to humans.

229 SARS-CoV-2 transmission, particularly if the transmissibility of subclinical infections is low.

230 We apply it to assess the transmissibility of swine-origin influenza A H3N2v-M vir

231 Transmissibility of TB is high; therefore, transplant te

232 However, transmissibility of the Congo Basin clade was slightly g

233 This study aimed to calculate the transmissibility of the disease with and without interve

234 on in endemic states, where small changes in transmissibility of the diseases can lead to explosive o

235 re bred with wild-type SD mates and germline transmissibility of the ES cell line was confirmed by id

236 model for examining the genetics underlying transmissibility of the Eurasian avian-like swine lineag

237 We find that substantially increased transmissibility of the H1N1pdm09 virus is required to r

238 es, then were added to target cells, and the transmissibility of the HK2 Bogota reporter was tracked

239 ion decisions will be determined by both the transmissibility of the novel strain (measured by the ba

240 in animal models, and the pathogenicity and transmissibility of the other seven genotype viruses rem

241 itness costs' that impair the replication or transmissibility of the pathogen.

242 on and tumorigenesis, as demonstrated by the transmissibility of the phenotype and protection conferr

243 Because of the high transmissibility of the virus and the high rate of morbi

244 ability to control an Ebola outbreak include transmissibility of the virus and the proportion of tran

245 as raised great concerns about the potential transmissibility of the virus in humans.

246 the morphology of the influenza A virion and transmissibility of the virus in the guinea pig model.

247 Transmissibility of the virus was comparable to observat

248 y and less appropriately-to characterize the transmissibility of the virus, hides the fact that trans

249 t position 228 in the HA is critical for the transmissibility of these reassortant H3N2 viruses.

250 The transmissibility of these viruses further highlights the

251 d to better understand the pathogenicity and transmissibility of these viruses in mammals.

252 me tantalizing clues on the pathogenesis and transmissibility of this pandemic virus.

253 ls, which may underlie the highly contagious transmissibility of this virus among humans.

254 tudy was undertaken to quantify variation in transmissibility of TSWV isolates by T. tabaci, in the a

255 fection, we determined the pathogenicity and transmissibility of two Asian-origin H5Nx viruses in mam

256 Our results suggest that an increase in the transmissibility of typhoid due to the emergence of drug

257 st range, tissue tropism, pathogenicity, and transmissibility of viruses.

258 Data were limited on the component-specific transmissibility of Zika and long-term sequelae of infec

259 131) are undefined, but may include enhanced transmissibility or ability to colonize the intestine co

260 -infection does not significantly affect the transmissibility or the mutation rate of Mtb within pati

261 our study was robust to the removal of high transmissibility outliers and to the removal of the smal

262 aracterized by the layer-wise path-dependent transmissibility over a contact, that is dynamically det

263 ing the viral infection dynamics reveals two transmissibility parameters influenced by the management

264 rring variation in clinical isolates affects transmissibility, pathogenesis, immune modulation, and d

265 fecting begomoviruses, including lack of sap transmissibility, phloem limitation, a resistance phenot

266 of resistance, 10-year trend of resistance, transmissibility, preventability in the community settin

267 pt to the environment, yielding cell-to-cell transmissibility, prion infectivity and toxicity.

268 rated model to investigate human-to-mosquito transmissibility, providing a method to link within-huma

269 adaptation is required for a virus to attain transmissibility, providing an opportunity to understand

270 We infer the viral transmissibility, rate of waning natural immunity and ra

271 s, but its effects on viral pathogenesis and transmissibility remain unclear.

272 However, the mechanism of IsaB on host transmissibility remains unclear.

273 Assessment of transmissibility requires tools that can accurately iden

274 sults provide evidence that not only is tick transmissibility retained by the attenuated T2Bo strain,

275 waning immunity rates and oral polio vaccine transmissibility reveals that higher waning immunity rat

276 resistance without compromising fitness and transmissibility, showing that, in addition to weaknesse

277 A suggested increase in measles transmissibility since elimination warrants continued mo

278 ely identify critical determinants for viral transmissibility since they were transmitted under simil

279 to new infectious PrP(Sc) Interspecies prion transmissibility studies performed by experimental chall

280 In a household-based TB transmissibility study in Peru, we identified a large MI

281 e epidemic depends critically on the disease transmissibility, suggesting that for a sufficiently hig

282 ture influenza A(H5N1) mutants with airborne transmissibility, suggesting that human influenza pandem

283 A(H1N1)pdm09 genes displayed less efficient transmissibility than the endemic and reassortant H3N2 v

284 vert to neurovirulence and reacquire greater transmissibility that could potentially result in the re

285 ly, we test whether EVD strains have uniform transmissibility through a novel statistical test, and f

286 ype O FMDV could increase both virulence and transmissibility, thus leading to their dominance in the

287 HA segments are required to provide optimal transmissibility to an influenza virus.

288 e and evolution of scrapie strains and their transmissibility to other species, including humans.

289 To probe the structural features that confer transmissibility to prion protein (PrP) fibrils, we have

290 elded a virus with indistinguishable contact transmissibility to the wild-type pandemic strain.

291 ective regarding the mechanism of Leishmania transmissibility to vector sand flies.

292 ecological traits, including human-to-human transmissibility, transmission routes, tissue tropisms,

293 We sought to assess the risk of its human transmissibility using two complementary approaches.

294 ity, suggesting that for a sufficiently high transmissibility, vaccine delivery after the onset of ep

295 Measles transmissibility was assessed by estimation of the repro

296 lls, and in vivo mammalian pathogenicity and transmissibility were investigated.

297 lity, ease of contact transmission, and seed transmissibility, which are typical tobamovirus characte

298 humidity were associated with increased RSV transmissibility, while higher value of maximum wind spe

299 are permissive for infection and sustainable transmissibility with the 2014 initial wild bird-adapted

300 nce plasmids can mediate their retention and transmissibility, worsening the trajectory for antimicro