ライフサイエンスコーパス: transplantable

1 em/progenitor compartments, and are serially transplantable.

2 resemble human uterine adenosarcoma and are transplantable.

3 -like features and subsequently AML that was transplantable.

4 Tumors express T-cell markers and are transplantable.

5 onocytic leukemia (CMML), which was serially transplantable.

6 in the initiation of an aggressive and fully transplantable acute leukaemia.

7 sing multiple murine tumor models, including transplantable adenocarcinoma, melanoma, sarcoma, and th

8 to develop the use of isolated human GPCs as transplantable agents both for mediating enzymatic resto

9 ressing wild-type N-Myc developed clonal and transplantable AML after approximately 1 month; those tr

10 iquid culture, generated fully penetrant and transplantable AML in BM transplant recipients, and disp

11 ed in 90% of patients with AML and induces a transplantable AML in murine models provides an alternat

12 In 45% of animals, a transplantable AML of relatively short latency and frequ

13 imals, which died of a highly aggressive and transplantable AML within 3 to 5 months.

14 Moreover, the disease was easily transplantable and allowed different therapeutic options

15 pha-null cells for months that were serially transplantable and contributed to all lineages in second

16 Two tumors were transplantable and established as stable cell lines.

17 icent mice, HSCs from these animals were not transplantable and even selected against.

18 MML providing the first examples of serially transplantable and genetically accurate models of CMML.

19 significantly suppressed the growth of both transplantable and inducible melanoma.

20 The disease was transplantable and maintained expression of mutant IDH1.

21 Lymphomas were transplantable and of clonal origin and were characteriz

22 The disease was not transplantable and prolonged observation showed normaliz

23 clude that NKG2C(+) memory-like NK cells are transplantable and require active or latent (subclinical

24 Moreover, Smo/Smo medulloblastomas were transplantable and serially passaged in vivo, demonstrat

25 y, these cells are altered at these sites in transplantable and spontaneous mouse models of cancer-in

26 therapeutic settings by taking advantage of transplantable and spontaneous mouse tumor models.

27 on, have variable clinical presentation, are transplantable, and develop oligo/monoclonal expansion.

28 were obtained in a transgenic mouse model of transplantable APL, and in the RA response of leukemic c

29 ke cartilage constructs from MSCs for future transplantable articular cartilage regeneration therapie

30 body blockade of DC-HIL delays the growth of transplantable B16 melanoma in syngeneic mice, which is

31 We have used the preclinical transplantable B16 melanoma model to profile chemokines

32 its potential to prevent melanoma using both transplantable B16 tumor and autochthonous melanoma mode

33 We also demonstrate in a transplantable BALB/c mouse tumor model that treatment w

34 c effects against established M/D-driven and transplantable BC, largely reflecting increased type I i

35 which may one day alleviate the scarcity of transplantable beta cells for the treatment of diabetes.

36 -cell mass is limited by the availability of transplantable beta-cells and the need for chronic immun

37 , notochord and neural tube, and is serially transplantable between embryos.

38 ponents of cell-laden artificial tissues and transplantable biosensors.

39 ncing of normal, chronic phase, and serially transplantable blast crisis chronic myeloid leukemia (CM

40 cally organized, rapidly fatal, and serially transplantable blast population, phenotypically and tran

41 Transplantable bone marrow-derived endothelial progenito

42 s significantly reduced tumor growth in both transplantable breast and lung cancer models.

43 of these observations, we used two different transplantable breast cancer models, yielding results th

44 ouse models of breast cancer and against 4T1 transplantable breast tumors in BALB/c mice.

45 limited tumor growth in several human, solid transplantable cancers.

46 effectively controls the growth of distinct (transplantable, carcinogen- or oncogene induced) orthoto

47 Neoplasia manifested as transplantable CD8+ lymphoma or leukemia, indicating tha

48 ant melanoma is the lack of mouse models and transplantable cell lines.

49 Truly endothelial, BOEC are progeny of a transplantable cell that originates in bone marrow, a pu

50 stage for more applied pursuits to generate transplantable cells for treating blood disorders.

51 stem cells (hESCs) are a potential source of transplantable cells for treating diabetes and are curre

52 antagonist, AGN 193109, on the generation of transplantable cells, including pre-CFU-S, short-term re

53 led recipients to resist growth of malignant transplantable cells.

54 to both ascites and solid cancers induced by transplantable cells.

55 lly reduce the mass of viable and functional transplantable cells.

56 tocytes could provide an unlimited supply of transplantable cells.

57 higher in primary tumors than in a derived, transplantable cholangiocarcinoma serially-propagated in

58 -2 double KO mutants spontaneously developed transplantable CML-like myeloproliferative disease due t

59 Using a transplantable colon carcinoma model, we found that CD8(

60 helial cells (CEnC) has provided a source of transplantable corneal endothelium, with a significant p

61 tocol for the generation of a functional and transplantable corneal epithelium derived from human ind

62 ischemic injury could be discriminated from 'transplantable' DCD livers.

63 c system in Saccharomyces cerevisiae using a transplantable degron, CL1 (1).

64 AKT-initiated tumors were serially transplantable, demonstrating permanent genetic changes

65 There is a huge need for the availability of transplantable donor corneas worldwide to reduce the bur

66 responsible led to the discovery of serially transplantable, donor-derived, macroscopic, multilineage

67 hly efficient and reproducible production of transplantable dopamine progenitors from hESCs.

68 library of shRNAs into individual mice using transplantable Emu-myc lymphoma cells.

69 is protein interaction domain functions as a transplantable endocytic sorting signal that is sufficie

70 essive, highly aneuploid, heterogeneous, and transplantable epithelial cancers in mice.

71 a et al. (2013) report a potential source of transplantable epithelial cells from fetal gut that can

72 se in transplanted mice, but caused a fatal, transplantable erythroleukemia instead.

73 CALR(del/+) mice develop a transplantable ET-like disease with marked thrombocytosi

74 The creation of a transplantable graft to permanently replace kidney funct

75 ermine whether in vitro vessel maturation in transplantable grafts can accelerate vascular integratio

76 Consecutive LR for transplantable HCC between 2000 and 2015 were studied.

77 In initially transplantable HCC-cirr patients, ITT survival was bette

78 has moved the field closer to creation of a transplantable heart.

79 choice and preferable to (68)Ga-DOTA-JR11 in transplantable HEK293-hsst(2) tumors in mice.

80 emonstrated that expression of the G-CSFR on transplantable hematopoietic cells but not stromal cells

81 in telomere elongation and the formation of transplantable hematopoietic malignancies.

82 genomic instability, and the development of transplantable hematopoietic neoplasms with myeloprolife

83 uniparental ES cells can differentiate into transplantable hematopoietic progenitors in vitro that c

84 v (CCN3) increases the frequency of serially transplantable hematopoietic stem cells (HSCs) 6-fold.

85 For decades, in vitro expansion of transplantable hematopoietic stem cells (HSCs) has been

86 y marrow of adult zebrafish harbors about 10 transplantable hematopoietic stem cells; this tissue als

87 zaD) and trichostatin A (TSA), which expands transplantable HSC 7- to 10-fold.

88 hat CD41-KO-associated defects are long-term transplantable, HSC-derived and, in part, mediated throu

89 hematopoiesis in adult axolotls and contain transplantable HSCs capable of long-term multilineage bl

90 The cells mature into transplantable HSCs in culture.

91 epresent an important step toward generating transplantable HSCs in vitro that are needed for autolog

92 lture enabled more than 12-fold expansion of transplantable HSCs that provided balanced multilineage

93 utility of the human placenta as a source of transplantable HSCs.

94 e the value of ESCs as a potential source of transplantable HSCs.

95 ferentiation protocols for the generation of transplantable HSCs.

96 n in air, resulting in increased recovery of transplantable HSCs.

97 orting the self-renewal and proliferation of transplantable human cord blood hematopoietic stem cells

98 letion of MLLT3 prevented the maintenance of transplantable human haematopoietic stem or progenitor c

99 Transplantable human haemopoietic cells could serve as a

100 al can be exploited to increase expansion of transplantable human HSCs and points to broader implicat

101 system that facilitates ex vivo expansion of transplantable human HSCs.

102 This need for transplantable human islets has stimulated efforts to ex

103 lly help to overcome the chronic shortage of transplantable human livers.

104 ll, differentiation, and near elimination of transplantable human LSCs in mice, while sparing normal

105 gate LHRH receptors in MRI-H255 and MRI-H187 transplantable human melanoma tumor lines.

106 ew medical interventions, such as generating transplantable human organs in livestock.

107 igation of mesodermal development to produce transplantable human tissue progenitors and uncover deve

108 The present study aims to develop transplantable hyaline-like cartilage constructs by stim

109 IBC phenotype by establishing a unique human transplantable IBC xenograft, MARY-X, which manifests fl

110 t, we report here that in a well-established transplantable (ID8 cell line) model of peritoneal/ovari

111 The YOVAL1.1 melanoma model is transplantable, immunogenic and sensitive to clinical th

112 In addition, the tumors are serially transplantable in irradiated wild-type mice, underlying

113 lymphoproliferative disorder, which was not transplantable in late-stage disease into secondary reci

114 0%) developed AML resembling M2-AML that was transplantable in secondary recipients.

115 Generation of transplantable insulin-producing cells from human embryo

116 , but the myeloproliferative disease was not transplantable into secondary recipients.

117 Disease was transplantable into secondary recipients.

118 The tumors were transplantable into syngeneic immunocompetent mice.

119 eveloping mouse embryo the first definitive (transplantable-into-the-adult) haematopoietic stem cells

120 utic opportunity to improve the viability of transplantable islets.

121 of this study was to increase the number of transplantable kidneys and lungs by implementing a uDCD

122 A significant increase in transplantable kidneys could be achieved by extension of

123 d should compensation increase the number of transplantable kidneys, laws and regulations prohibiting

124 ten pumping less-than-ideal, yet potentially transplantable kidneys, may help reverse the trend.

125 ng seems a promising approach to produce new transplantable kidneys.

126 stnatal progenitor cell-based technology for transplantable large tissue-engineered constructs.

127 haracteristics, and can initiate serially re-transplantable leukaemia and survive chemotherapy in pat

128 o myeloproliferative disease within days and transplantable leukaemias within weeks.

129 se that developed was shown to be a uniform, transplantable leukemia with both erythroid and megakary

130 p16/p19(-/-) bone marrow cells, we generated transplantable leukemia-initiating cells that rapidly in

131 liferative disorder (MPD) that progresses to transplantable leukemia.

132 disease progression culminating in serially transplantable leukemia.

133 Several transplantable lines were obtained from the RCCs, and on

134 In this study we show that the MinD MTS is a transplantable lipid-binding motif that can effectively

135 Tissue engineering of a transplantable liver could provide an alternative to don

136 a proof of principle for the generation of a transplantable liver graft as a potential treatment for

137 we demonstrate a novel approach to generate transplantable liver grafts using decellularized liver m

138 eria in a clinical trial (n = 6) to identify transplantable liver grafts with low BDI.

139 the challenges of creating fully functional transplantable liver grafts with this whole liver engine

140 duct epithelial phenotypes in vitro, and (5) transplantable liver-repopulating cells.

141 nor livers, thereby increasing the number of transplantable livers by 20%.

142 in homing efficiency, 3.8-fold reduction in transplantable long-term hematopoietic stem cells (LT-HS

143 inst an inducible genetic melanoma model and transplantable lung and ovarian tumors, demonstrating po

144 ealthy syngeneic mice induces rapidly fatal, transplantable lymphoblastic leukemias that resist imati

145 When inoculated with a transplantable lymphoma cell line, EL4, the treated old

146 JAK3A572V induces an aggressive, fatal, and transplantable lymphoproliferative disorder characterize

147 -isoleucine signal acts in an autonomous and transplantable manner.

148 ssay in mice, we show here that gene-marked, transplantable marrow cells from the plastic-nonadherent

149 rom cultures of blood is mostly derived from transplantable marrow-derived cells.

150 binding sites for LHRH were detected in both transplantable melanoma tumor lines.

151 The helix also acts as an autonomous transplantable membrane binding domain capable of direct

152 al and spatial experimental designs and to a transplantable metastasis model derived from human cance

153 This study establishes a novel, transplantable model of murine histiocytic/myeloid sarco

154 xome sequencing of ID8, the most widely used transplantable model of ovarian cancer, covering 194,000

155 metastatic niche formation, we established a transplantable model of spontaneous melanoma brain metas

156 sion protein (Fc:TbetaRII) on transgenic and transplantable models of breast cancer metastases.

157 Using transplantable models of lung tumors in mice, we found t

158 e (restricted to BM and lymphoid tissues) to transplantable monoclonal T-cell leukemia/lymphoma scatt

159 (relative to the rapid growth rates of other transplantable mouse kidney tumors), propensity for lung

160 We tested this hypothesis using a transplantable mouse mammary tumor model.

161 In experiments using the B16 transplantable mouse melanoma, tumor-expressed chemerin

162 In a transplantable mouse model based on the EmuTCL1 transgen

163 A transplantable mouse MPNST-like melanoma cell line recap

164 s in all 10 mammary glands, and also using a transplantable mouse tumor model.

165 dings were further validated in mice bearing transplantable MT-RET-1 melanoma, in which L-NIL normali

166 in a reduction of hematopoietic clusters and transplantable murine HSCs.

167 Using B16/BL6, a transplantable murine melanoma model, we show a dichotom

168 Transplantable murine models of ovarian high grade serou

169 There is a need for transplantable murine models of ovarian high-grade serou

170 he basis for defective TIL lytic function in transplantable murine tumor models.

171 The most used models include transplantable murine tumors grown in syngeneic hosts an

172 Transplantable, myelo-lymphoid hematopoietic stem/progen

173 125b alone in mice causes a very aggressive, transplantable myeloid leukemia.

174 Dnmt3a+/- mice also spontaneously developed transplantable myeloid malignancies after a long latent

175 lesterolemic mice, displayed leukocytosis, a transplantable myeloproliferative disorder, and a dramat

176 s the result of genetic knockdown, develop a transplantable myeloproliferative phenotype that closely

177 results depict human ES cells as a source of transplantable neural precursors for possible nervous sy

178 A possible source for transplantable neurons in Parkinson's disease are adult

179 population defined in these studies includes transplantable, non-self-renewing B lymphocyte progenito

180 hanical properties promoted formation of 3D, transplantable organ buds from tissues including kidney,

181 at high risk of discard, though potentially transplantable organs are still being discarded.

182 It is important to identify new sources of transplantable organs because of the critical shortage o

183 The critical shortage of transplantable organs has resulted in the use of extende

184 urce utilization required for procurement of transplantable organs in an organ procurement organizati

185 As the need for transplantable organs increases, waiting lists of patien

186 The shortage of transplantable organs provides an impetus to develop tis

187 There is an ever-growing demand for transplantable organs to replace acute and chronically d

188 and for development of a renewable source of transplantable organs via modified xenotransplantation.

189 nsplantation, given the critical shortage of transplantable organs, maximal benefit may be achieved b

190 T3/T4 therapy results in more transplantable organs, with no detriment to posttranspla

191 trics as a means of increasing the supply of transplantable organs.

192 bowel donation was lower than for the other transplantable organs.

193 goal by increasing the number and quality of transplantable organs.

194 on to prevent perioperative tissue injury to transplantable organs.

195 rscores the need to identify all potentially transplantable organs.

196 will save lives by increasing the number of transplantable organs.

197 thical framework to guide the procurement of transplantable organs.

198 tential solution to the critical shortage of transplantable organs.

199 an development, and to the creation of human transplantable organs.

200 f donor livers and improving the function of transplantable organs.

201 g viral infections are a potential source of transplantable organs.

202 th is seriously limited by acute shortage of transplantable organs.

203 claim warm ischemic livers that would not be transplantable otherwise.

204 from aggressive mammary tumors derived from transplantable p53 null mouse mammary outgrowth lines re

205 bA1c levels between 3.5 and 6.2 in otherwise transplantable pancreata are not associated with differe

206 ous injection of either 250,000 cells of the transplantable pancreatic adenocarcinoma cell line Pan02

207 and wild type (WT) mice were injected with a transplantable pancreatic adenocarcinoma cell line.

208 We established a bank of transplantable patient-derived prostate cancer xenograft

209 ces regeneration of high-risk MM in serially transplantable patient-derived xenografts.

210 cancer models are thought to be provided by transplantable, patient-derived tumor xenografts (PDX).

211 cancer models are thought to be provided by transplantable, patient-derived xenografts (PDXs).

212 allowed obtaining an increase of potentially transplantable patients (+8.9% in training set and 24.6%

213 rcinoma (HCC) as the first-line treatment in transplantable patients followed by "salvage transplanta

214 8 months of age, over half developed readily transplantable PCT in lymph nodes, Peyer's patches, and

215 MSCV-Myc-induced AML was polyclonal, readily transplantable, possessed an intact Arf-p53 pathway, and

216 eminated lymphoma characterized by a clonal, transplantable pre-B-cell population of neoplastic lymph

217 Arf in mice triggers a highly aggressive and transplantable precursor B-ALL.

218 indings demonstrate that MDS originates in a transplantable, premalignant, long-term repopulating, MD

219 Using a two-compartment transplantable prostate tumor model in which survival of

220 s, Flt3-L treatment of mice with preexisting transplantable prostate tumors results in tumor regressi

221 ill also lead to improved disease models and transplantable prototypes with adult-like physiological

222 y was conceived for initially resectable and transplantable (R&T) hepatocellular carcinoma (HCC) pati

223 is a hallmark of epithelial cells from model transplantable rat prostate tumors that progress to mali

224 s to identify preoperative predictors of non transplantable recurrence (NTR) to improve patient selec

225 We identify a transplantable recycling sequence that is both necessary

226 Using transgenic and transplantable Rgnef knockout mouse models, we find that

227 s, MIF deficiency confers protection against transplantable s.c. melanoma outgrowth and melanoma lung

228 ed the first immortal cell line (SPARKY) and transplantable scid mouse xenograft (Sparky-X) from a ma

229 These observations define a transplantable signal mediating rapid recycling of a het

230 effective expansion of HCEC monolayers to a transplantable size with a normal HCEC density, through

231 id hormone receptors (SMRT(mRID)) produced a transplantable skeletal syndrome that reduced radial bon

232 iation-induced SJL acute myeloid leukemia, a transplantable spontaneous SJL lymphoma, and the C57BL/6

233 abeta T cells, we examined the growth of the transplantable squamous cell carcinoma (SCC) line, PDV,

234 hese findings are relevant for generation of transplantable stem cell-derived beta-cells.

235 ells of both parental origins can form adult-transplantable stem cells and can repopulate an adult or

236 We also observe that transplantable stem cells are largely quiescent during o

237 gramming may be a strategy for derivation of transplantable stem cells for clinical application.

238 hese results offer the opportunity to expand transplantable stem cells to improve outcomes in patient

239 ividing tumors; however, neither ascitic nor transplantable subcutaneous tumors are predictive of act

240 rved in PLCgamma2(-/-) and Lyn(-/-) mice was transplantable, suggesting the involvement of an immune

241 ntileukemia activity induced by CpG ODN in a transplantable syngeneic pre-B ALL model.

242 ile PDXs and PDOs may serve as tractable and transplantable systems for probing the molecular propert

243 essing JAK3 mutants developed a long-latency transplantable T-ALL-like disease, characterized by an a

244 A-binding mutant developed an aggressive and transplantable T-cell lymphoma 4 to 10 months after tran

245 Different strategies to generate transplantable tissue grafts in vitro and harness host r

246 ing experts in their attempt to create thick transplantable tissues and organs.

247 sue engineering involves the construction of transplantable tissues in which bone marrow aspirates ma

248 This leukemia was transplantable to conditioned wild-type recipients.

249 The sarcomas are transplantable to immunologically compromised hosts, sho

250 the bone marrow (BM) stroma since it is not transplantable to irradiated wild-type recipients.

251 The MPN phenotype is transplantable to secondary recipient mice.

252 The leukemia is transplantable to secondary recipients and is ATRA respo

253 developed acute myeloid leukemias that were transplantable to wild-type recipients.

254 diseases in humans because they solely used transplantable tumor lines, and instead of true tumor an

255 ults suggest the possibility of developing a transplantable tumor model in this large-animal system.

256 With a transplantable tumor model, we compared the efficacy of

257 Using the A20 B cell lymphoma as a transplantable tumor model, we demonstrate that this tum

258 al tumor models, Apc(Min/+) mice and an MC38 transplantable tumor model.

259 ad statistically reduced tumor onset in both transplantable tumor models (FVB/n and BALB/c) and signi

260 ng cells in the tumor microenvironment using transplantable tumor models in mice.

261 restriction reduces prostate tumor growth in transplantable tumor models in rodents, which suggests t

262 In transplantable tumor models such as P1.HTR, tumors grow

263 etastatic effect than does wtIL-2 in several transplantable tumor models: the experimental metastasis

264 3 oncoprotein from its signaling function, a transplantable tumor system was developed.

265 ouse 4T1 mammary carcinoma, a BALB/c-derived transplantable tumor that shares many characteristics wi

266 A transplantable tumor was established after the transfer

267 both T cells participated in resistance to a transplantable tumor.

268 od preparations of tumor cells and eradicate transplantable tumor.

269 Transplantable tumors are an accepted gold standard in c

270 t tumor growth and metastasis in the form of transplantable tumors derived directly from individuals

271 Furthermore, transplantable tumors derived from NAG-1 transfected HCT

272 First, transplantable tumors developing in a mouse expressing g

273 Second, transplantable tumors developing in chimeric mice recons

274 plete regression of primary, metastatic, and transplantable tumors following the ablation of c-Myc, s

275 The lack of transplantable tumors has limited assessment of graft-ve

276 e requirement of cathelicidin in controlling transplantable tumors in mice.

277 developing methods to screen chemicals using transplantable tumors in rodents.

278 Overall, this panel of transplantable tumors provides a resource for detailed e

279 The spectrum of transplantable tumors that were initially induced and ma

280 d to either enhance or inhibit the growth of transplantable tumors, depending on the system.

281 d against the transplant antigens present on transplantable tumors, not against the tumor-specific an

282 )Stro-1(+) cells efficiently formed serially transplantable tumors, whereas CD117(-)Stro-1(-) cells r

283 CD4(+) and CD8(+) T cells in three distinct transplantable tumors.

284 ased survival from and clearance of multiple transplantable tumors.

285 n stem-like cells that can initiate serially transplantable tumors.

286 es against carcinogen-induced neoplasias and transplantable tumors.

287 the growth of primary carcinogen-induced and transplantable tumors.

288 ity of DC, and their impact on the growth of transplantable tumors.

289 dered mice more susceptible to the growth of transplantable tumors.

290 We present a transplantable tumour line, maintained in immune-comprom

291 approach using CRISPR-Cas9 genome editing in transplantable tumours in mice treated with immunotherap

292 7/pT46 are remarkably stable and function as transplantable units for phospho-regulation of stability

293 o bioengineered mini-organs in vitro yielded transplantable units that also suppressed hyperglycemia

294 Transgenerational effects were transplantable using diet-associated bacteria communitie

295 Transplantable vascularized bioengineered intestine coul

296 Overall, 32 stably transplantable xenograft lines were established, represe

297 Transgenic spontaneously occurring and transplantable xenograft models of adenocarcinoma of the

298 Both models yielded stably transplantable xenografts at comparably high rates ( app

299 xpressed MCSC-specific markers and generated transplantable xenografts in nude mice.

300 TN aggressive human breast tumors as well as transplantable xenografts obtained from SKBR3 expressed