ライフサイエンスコーパス: transplantation tolerance

1 minireview provides an overview of clinical transplantation tolerance.

2 eral and a well established model of central transplantation tolerance.

3 innate immune signaling in the induction of transplantation tolerance.

4 , but can also be major players in mediating transplantation tolerance.

5 , clinically relevant strategy to facilitate transplantation tolerance.

6 lymphoid compartments play critical roles in transplantation tolerance.

7 otective role against allograft rejection in transplantation tolerance.

8 rologous immunity is considered a barrier to transplantation tolerance.

9 trategies to induce durable and reproducible transplantation tolerance.

10 whether testicular immune privilege promotes transplantation tolerance.

11 T cells by Foxp3 gene transfer could induce transplantation tolerance.

12 autoimmune disorders as well as induction of transplantation tolerance.

13 ctions, autoimmune disease, and induction of transplantation tolerance.

14 n models and implicated strategies to induce transplantation tolerance.

15 o prevent autoimmune disorders and establish transplantation tolerance.

16 ount for the antigen specificity of dominant transplantation tolerance.

17 he response to allogeneic tissues to promote transplantation tolerance.

18 sed in this study resulted in development of transplantation tolerance.

19 zed thymokidney transplantation that induced transplantation tolerance.

20 d signaling uniformly induces donor-specific transplantation tolerance.

21 le that may be required for the induction of transplantation tolerance.

22 is an emerging strategy for inducing robust transplantation tolerance.

23 may play a critical role in the induction of transplantation tolerance.

24 ncipal regulators of both self-tolerance and transplantation tolerance.

25 vances in the use of immunotherapy to induce transplantation tolerance.

26 -LFA therapy uniquely resulted in "dominant" transplantation tolerance.

27 austed T cells that could in fact facilitate transplantation tolerance.

28 ents of strategies being developed to induce transplantation tolerance.

29 irculation to the thymus in the induction of transplantation tolerance.

30 ti-CD154 mAb induces a state of "functional" transplantation tolerance.

31 ion of T-cell division by rapamycin promotes transplantation tolerance.

32 regimen for induction of mixed chimerism and transplantation tolerance.

33 r the inhibition of these pathways to induce transplantation tolerance.

34 presentation may have an adjunctive role in transplantation tolerance.

35 graft acceptance and, in certain situations, transplantation tolerance.

36 otic pathways were resistant to induction of transplantation tolerance.

37 conditioning regimen leads to donor-specific transplantation tolerance.

38 in cancers and possibly for the induction of transplantation tolerance.

39 t rejection and in some circumstances induce transplantation tolerance.

40 dult rats is capable of mediating long-lived transplantation tolerance.

41 iod interrupts sensitization and may produce transplantation tolerance.

42 agonism as a promising target for promoting transplantation tolerance.

43 n the development of strategies for specific transplantation tolerance.

44 e expression and facilitate the emergence of transplantation tolerance.

45 en is a suitable target for the induction of transplantation tolerance.

46 approach for the induction of donor-specific transplantation tolerance.

47 novel strategy to promote graft survival and transplantation tolerance.

48 costimulatory blockade to promote a state of transplantation tolerance.

49 shown their therapeutic efficacy in inducing transplantation tolerance.

50 myeloid cells as a therapeutic strategy for transplantation tolerance.

51 nal development of therapeutics that promote transplantation tolerance.

52 required for costimulatory blockade-induced transplantation tolerance.

53 y which TLI/ATS/CTX conditioning may augment transplantation tolerance.

54 a novel means to promote graft survival and transplantation tolerance.

55 ing CD40-CD40L costimulatory signals induces transplantation tolerance.

56 Tregs may not have a central role in kidney transplantation tolerance.

57 us (CMV) infection disrupts the induction of transplantation tolerance.

58 iate both induction and adoptive transfer of transplantation tolerance.

59 ritical for the induction and maintenance of transplantation tolerance.

60 gulator, BLyS, may be effective in promoting transplantation tolerance.

61 4Ig is a well-established strategy to induce transplantation tolerance.

62 a clinically relevant strategy to facilitate transplantation tolerance.

63 lls, B cells can mediate graft rejection and transplantation tolerance.

64 it these populations may be key to achieving transplantation tolerance.

65 ly regulate alloimmune responses and promote transplantation tolerance.

66 nd offer therapeutic potential for achieving transplantation tolerance.

67 ental models in which to study resistance to transplantation tolerance.

68 e control of autoimmunity and maintenance of transplantation tolerance.

69 T17 alloreactivity constitutes a barrier to transplantation tolerance.

70 transplantation can prevent the induction of transplantation tolerance.

71 her IL-6 and TNF-alpha promote resistance to transplantation tolerance.

72 thways may have therapeutic value to promote transplantation tolerance.

73 present general conditions for Treg-mediated transplantation tolerance.

74 nd may provide a novel approach to promoting transplantation tolerance.

75 ms used by B lymphocytes in the induction of transplantation tolerance.

76 onor-reactive Treg cells during induction of transplantation tolerance.

77 he absence of alloantibodies is a feature of transplantation tolerance.

78 rce of hematopoietic cells that could induce transplantation tolerance.

79 ation of anti-LFA/anti-ICAM reliably induced transplantation tolerance.

80 oci were not beneficial for the induction of transplantation tolerance.

81 ection and that their activation can prevent transplantation tolerance.

82 reagents for the induction of donor-specific transplantation tolerance.

83 vate adaptive immune responses that abrogate transplantation tolerance.

84 Ags by the mother is a physiologic model of transplantation tolerance.

85 s the detrimental effects of TLR agonists on transplantation tolerance.

86 question: is B cell tolerance essential for transplantation tolerance?

87 of allochimeric protein with FTY720 induces transplantation tolerance, a state that may be associate

88 ote allogeneic SC engraftment with resulting transplantation tolerance across complete MHC barriers w

89 logeneic chimerism can induce donor-specific transplantation tolerance across full MHC barriers.

90 llografts to support thymopoiesis and induce transplantation tolerance across fully MHC-mismatched ba

91 tional vascularized thymic grafts can induce transplantation tolerance across fully MHC-mismatched ba

92 reconstitution and results in donor-specific transplantation tolerance across MHC disparities, withou

93 ore transplantation, could induce allogeneic transplantation tolerance across two-haplotype fully maj

94 suggest that regulatory T cells maintaining transplantation tolerance after CD4 Ab blockade can be i

95 nipulate thymic function in adults to induce transplantation tolerance after the age of thymic involu

96 as been hypothesized that regimens to induce transplantation tolerance and long-term hematopoietic ch

97 ripts shared with Th2 cells, suggesting that transplantation tolerance and normal immunoregulation ma

98 regulatory functions, and they contribute to transplantation tolerance and operational tolerance in b

99 of innate immunity prevents the induction of transplantation tolerance and shortens skin allograft su

100 l production is critical in the induction of transplantation tolerance and the maintenance of durable

101 mechanisms explains the difficulty to induce transplantation tolerance and to develop reliable biomar

102 velopment of new strategies for induction of transplantation tolerance and treatment of cancer, chron

103 y cells (Tregs) are important in maintaining transplantation tolerance, and FoxP3 is the protoypic Tr

104 roliferation can present to the induction of transplantation tolerance, and have important implicatio

105 rgets to prevent allograft rejection, induce transplantation tolerance, and inhibit autoimmune diseas

106 ter understanding of B cell contributions to transplantation tolerance, and may inform the developmen

107 asis, steering protective immunity, inducing transplantation tolerance, and treating diverse immune-r

108 tailor Treg cells for cell therapy to induce transplantation tolerance are highlighted.

109 It appears that skin and islet transplantation tolerance are mediated by different CD4

110 e T cells persist after induction of cardiac transplantation tolerance, but fail to acquire a memory

111 nnate immune system impairs the induction of transplantation tolerance, but the responsible inflammat

112 st that Idd loci can facilitate induction of transplantation tolerance by costimulation blockade and

113 the efferocytic receptor MerTK in mediating transplantation tolerance by donor apoptotic cells and i

114 tolerant alloreactive B cells contribute to transplantation tolerance by foregoing germinal center r

115 for induction and maintenance of peripheral transplantation tolerance by its ability to alter the ba

116 We sought to identify different mediators of transplantation tolerance by performing single-cell RNA

117 immune regulatory functions, with a focus on transplantation tolerance, by analyzing their mechanisms

118 These data suggest that transplantation tolerance can be achieved by reducing th

119 hat durable hemopoietic chimerism and robust transplantation tolerance can be achieved without cytoto

120 Transplantation tolerance can be induced in animals and

121 Transplantation tolerance can be induced in mice by graf

122 i-CD154 mAb uniformly induces donor-specific transplantation tolerance characterized by the deletion

123 at the genetic threshold for normalizing the transplantation tolerance defect is higher than that for

124 Transplantation tolerance, defined as acceptance of a gr

125 Transplantation tolerance, defined as allograft acceptan

126 Transplantation tolerance depends on the right balance b

127 tivated T cells is one critical mechanism of transplantation tolerance, drugs such as ciclosporin tha

128 onstrated that acute CMV infection abrogated transplantation tolerance during the maintenance stage i

129 infection on: (a) disruption of established transplantation tolerance during tolerance maintenance;

130 induced antibodies, but not B cells, impeded transplantation tolerance elicited by costimulation bloc

131 ft-versus-host disease (GVHD) protection and transplantation tolerance following allogeneic bone marr

132 use) results in donor-specific cross-species transplantation tolerance for subsequent nonvascularized

133 allografts, whereas a 90-day therapy induced transplantation tolerance (>200 days).

134 ft rejection can occur long after a state of transplantation tolerance has been acquired.

135 role of CD4(+) T regulatory cells (Treg) in transplantation tolerance has been established, putative

136 and alloantibodies on the ability to induce transplantation tolerance has not been elucidated.

137 assuming that autoimmunity and resistance to transplantation tolerance have a common basis.

138 Recent investigations using animal models of transplantation tolerance have demonstrated that immunor

139 Prior experimental strategies to induce transplantation tolerance have focused largely on modify

140 Transplantation tolerance holds promise to reduce compli

141 chimerism is a promising approach for organ transplantation tolerance; however, human leukocyte anti

142 Agents that interfere with peripheral transplantation tolerance impair establishment of chimer

143 20 previously described biomarkers for liver transplantation tolerance in a cohort of 17 liver transp

144 n indirectly presented donor peptide induces transplantation tolerance in a transiently immunosuppres

145 rompted this study to achieve donor-specific transplantation tolerance in adult recipients using a no

146 t rejection in one mouse strain, and achieve transplantation tolerance in another.

147 oward understanding the mechanistic basis of transplantation tolerance in experimental models, which

148 ould be generated in vitro and could promote transplantation tolerance in immunocompetent recipient m

149 nale for a safe approach for inducing robust transplantation tolerance in large animals and humans.

150 rived suppressor cells, for the induction of transplantation tolerance in light of new clinical trial

151 s has been shown to prevent the induction of transplantation tolerance in mice via the generation of

152 lass II molecules are effective in promoting transplantation tolerance in mice, which suggests that s

153 mune activation via TLRs is known to prevent transplantation tolerance in multiple animal models.

154 he early 1950s that it is possible to induce transplantation tolerance in neonates, immune tolerance

155 The inability to induce transplantation tolerance in NOD (H2g7) mice was associa

156 pothesis that autoimmunity and resistance to transplantation tolerance in NOD mice are distinct pheno

157 that mechanisms controlling autoimmunity and transplantation tolerance in NOD mice are not completely

158 f autoimmune diabetes and induction of islet transplantation tolerance in nonobese diabetic (NOD) mic

159 persistent gene expression and long-lasting transplantation tolerance in recipients of genetically m

160 is a powerful and effective means to achieve transplantation tolerance in rodent models.

161 lonal antibody therapy can be used to induce transplantation tolerance in rodent models.

162 gand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates.

163 of costimulatory signal 2 may induce a true transplantation tolerance in sensitized rats, as documen

164 Antigen-specific transplantation tolerance in the absence of immunosuppre

165 portant for the induction and maintenance of transplantation tolerance in the CTLA4-Ig plus bone marr

166 mit clinical SC engraftment and induction of transplantation tolerance in the future.

167 cyclosporine (CsA) has been shown to induce transplantation tolerance in the nonfunctional rat heter

168 to induce mixed hematopoietic chimerism and transplantation tolerance in the pig-to-primate model, w

169 on the recipient RT1.Aa background to induce transplantation tolerance in the rat cardiac transplant

170 Transplantation tolerance in this model developed within

171 identify a role for LIF in the regulation of transplantation tolerance in vivo.

172 e immunomodulatory effect of DST in inducing transplantation tolerance in vivo.

173 eraction with LFA-1 form a central aspect of transplantation tolerance induced by anti-CD45RB therapy

174 n self-tolerance, NOD mice resist peripheral transplantation tolerance induced by costimulation block

175 ency do not correct resistance to peripheral transplantation tolerance induced by costimulation block

176 e diabetic mice and prevented acquisition of transplantation tolerance induced by costimulation block

177 lls exported from the thymus are critical to transplantation tolerance induced by intrathymic Ag inoc

178 or role in both the early and late phases of transplantation tolerance induced by the ALS, sirolimus,

179 ipient phagocytes is a critical mediator for transplantation tolerance induced by this strategy.

180 of activated T cells (NFAT) pathway impairs transplantation tolerance induced with anti-CD154 antibo

181 Our results support the notion that transplantation tolerance, induced by class II gene tran

182 mportant implications for the development of transplantation tolerance-inducing strategies in primate

183 eic hematopoietic stem cells (HSCs) on organ transplantation tolerance induction and immune reconstit

184 , therefore can alter host susceptibility to transplantation tolerance induction as well as impair th

185 Specifically, islet transplantation tolerance induction holds out the promis

186 We conclude that transplantation tolerance induction in mice treated with

187 The data suggest that transplantation tolerance induction protocols that incor

188 ic murine skin transplant model that resists transplantation tolerance induction when innate immunity

189 d exhibit genetically dominant resistance to transplantation tolerance induction.

190 new generation of immunomodulating agents in transplantation tolerance induction.

191 remains the most promising strategy to bring transplantation tolerance into clinical routine.

192 the H2g7 MHC, and precludes the induction of transplantation tolerance irrespective of MHC haplotype.

193 Overall, our study reveals that transplantation tolerance is associated with Tconvs' sus

194 In parallel, induction of transplantation tolerance is dependent on the presence o

195 Transplantation tolerance is facilitated by activation-i

196 correlated with Th1 differentiation, whereas transplantation tolerance is frequently associated with

197 A major obstacle to transplantation tolerance is humoral immunity.

198 Transplantation tolerance is induced by perioperative ad

199 Transplantation tolerance is induced reliably in experim

200 A reliable, nontoxic method of inducing transplantation tolerance is needed to overcome the prob

201 The induction of transplantation tolerance is one of the primary goals fo

202 The state of transplantation tolerance is these hosts was documented

203 ulating alloimmune responses but its role in transplantation tolerance is unknown.

204 In experimental organ transplantation, tolerance is induced by administration

205 In studies of transplantation tolerance it appears that regulatory T c

206 Such signals may also provide a barrier to transplantation tolerance mediated by Tregs.

207 Here we used an allogeneic murine islet transplantation tolerance model to examine the impact of

208 e investigated the role of chimerism in this transplantation tolerance model.

209 In transplantation tolerance, numerous regulatory populatio

210 ve T cells may be partly responsible for the transplantation tolerance observed in mice with defectiv

211 rior review has focused on the immunology of transplantation tolerance or development of phase 3 auto

212 -2 pathway to treat autoimmunity, facilitate transplantation tolerance, or potentiate tumor immunothe

213 resistance to costimulation blockade-induced transplantation tolerance phenotypes in NOD mice can be

214 The ability to induce durable transplantation tolerance predictably and consistently i

215 yeloablative conditioning using a peripheral transplantation tolerance protocol.

216 Clinical application of transplantation tolerance protocols may require patient

217 ll depletion is a critical component of many transplantation tolerance protocols.

218 Research in transplantation tolerance relies on application of succe

219 ve macrophages that mediate the induction of transplantation tolerance remain elusive.

220 Achieving transplantation tolerance remains an unresolved clinical

221 ntation have any effect on the generation of transplantation tolerance remains to be established.

222 I and class II matching for the induction of transplantation tolerance remains unclear.

223 Thus, transplantation tolerance requires both costimulatory bl

224 cal application of mixed chimerism to induce transplantation tolerance requires novel approaches to s

225 D25(+) T cells do have a suppressive role in transplantation tolerance, so do CD4(+)CD25(-) T cells,

226 oid or lymphoid dendritic cells (DC) induces transplantation tolerance suggests that adoptive transfe

227 recipitates acute rejection, thus abrogating transplantation tolerance, the donor-specific tolerant s

228 MT) induces mixed chimerism that establishes transplantation tolerance, the preconditioning regimens

229 dictive strength of SENP6 and FEM1C in liver transplantation tolerance, there are also risks in estab

230 potential of experimental protocols inducing transplantation tolerance through mixed chimerism.

231 Induction of transplantation tolerance to alloantigens without genera

232 ar immune privilege fosters the induction of transplantation tolerance to allografts in both immunolo

233 c chimerism carries with it the induction of transplantation tolerance to any other tissue or organ f

234 tional vascularized thymic grafts permitting transplantation tolerance to be induced in a large anima

235 s studies showed the feasibility of inducing transplantation tolerance to cadaveric renal allografts

236 indings to the generation and maintenance of transplantation tolerance to extrathymic tissue allograf

237 d anti-CD40L) to produce mixed chimerism and transplantation tolerance to fully major histocompatibil

238 lone, can successfully induce donor-specific transplantation tolerance to fully mismatched cardiac al

239 D8, and CD154 (CD40 ligand) induces dominant transplantation tolerance to fully mismatched skin allog

240 matopoietic chimerism induces donor-specific transplantation tolerance to lung allografts.

241 Although transplantation tolerance to organ allografts has been a

242 ame target Ag (OVA) achieves Foxp3-dependent transplantation tolerance to OVA-expressing skin grafts,

243 apies targeting CD154 and LFA-1 for inducing transplantation tolerance to pancreatic islet allografts

244 pproach both issues by establishing specific transplantation tolerance to pig organ grafts.

245 imeric administration induced donor-specific transplantation tolerance to rat cardiac allografts.

246 rized thymic lobe (VTL) allografts to induce transplantation tolerance to renal allografts across a f

247 or bone marrow (DBM) infusion induces robust transplantation tolerance to skin allografts in mice.

248 (DCs) that might facilitate the induction of transplantation tolerance to the replacement tissues.

249 ligands CD80 and CD86, can be used to induce transplantation tolerance to vascularized allografts.

250 f 10 microg of alpha1h u70-77-RT1.Aa induced transplantation tolerance toward WF grafts in four of si

251 e treated with a protocol designed to induce transplantation tolerance toward WF heart allografts: a

252 the translation of strategies for promoting transplantation tolerance towards a new clinical era.

253 the contribution of alloreactive B cells to transplantation tolerance using a mouse cardiac transpla

254 Donor-specific transplantation tolerance was induced by administration

255 When transplantation tolerance was induced to grafts mismatch

256 ism in the establishment of CTLA4-Ig-induced transplantation tolerance was investigated using reverse

257 In the context of transplantation tolerance, we present a hypothesis that

258 on of regulatory cells to the development of transplantation tolerance, we suggest the possibility th

259 ly study the role of Fas in the induction of transplantation tolerance, we used Fas mutant B6.MRL-lpr

260 onor hematopoietic repopulation and specific transplantation tolerance were achieved in mice treated

261 ecipient-type sequences were shown to induce transplantation tolerance when administered at the time

262 applicable approach for induction of "true" transplantation tolerance where chronic rejection is con

263 when perturbed, results in the induction of transplantation tolerance while maintaining anti-microbi

264 for robustly inducing and stably maintaining transplantation tolerance while preserving host anti-pat

265 Therefore, the achievement of transplantation tolerance will likely require induction

266 Induction of transplantation tolerance with certain therapeutic nonde

267 ods for inducing hematopoietic chimerism and transplantation tolerance, with a special emphasis on re

268 ta demonstrating the effect of infections on transplantation tolerance, with particular emphasis on t

269 w chimerism reliably produces donor-specific transplantation tolerance without immunosuppressive drug

270 Induction of islet transplantation tolerance would be far preferable.