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1 ncodes a major facilitator superfamily (MFS) transporter.
2 x interacted more efficiently with the YecSC transporter.
3 ATPase that represents a candidate polyamine transporter.
4 envelope and functioned as a low-affinity Pi transporter.
5 substrates that are translocated by the MmpL transporter.
6 ated with down-regulation of the host SLC7A2 transporter.
7 addition, GltS was identified as a glutamate transporter.
8 ty of dedicated cholesterol and phospholipid transporters.
9 elices 1, 6, and 10 and conserved among SLC7 transporters.
10 esign based on knockout metabolomics of drug transporters.
11 and translocation by WzmWzt and related ABC transporters.
12 neurons express vesicular glutamate or GABA transporters.
13 repressing the transcription of zinc uptake transporters.
14 specific to voltage-gated transmembrane ion transporters.
15 e-forming proteins, such as porins and ionic transporters.
16 not reduce the transport rate of individual transporters.
17 the 'credit card swipe' model of other lipid transporters.
18 utionary origins of widespread Na(+)-coupled transporters.
19 logies within the KDELR-family of retrograde transporters.
20 achieved through the function of SUT sucrose transporters.
21 d explaining the number and diversity of ABC transporters.
22 yeast mitochondria lacking endogenous NAD(+) transporters.
23 tein family 0016), a family of secondary ion transporters.
24 involve presynaptic component vesicular GABA transporters.
25 plasms identified rice Lysine-Histidine-type Transporter 1 (OsLHT1) as a candidate gene associated wi
26 inase 1 (TK-1), and equilibrative nucleoside transporter 1 (SLC29A1) in HCC compared with liver tissu
27 and that pharmacologic inhibition of glucose transporter 1 and PRC1 synergistically promoted ER stres
28 nistically, glucose uptake via GLUT (glucose transporter)-1 and enhanced glycolysis in neutrophils pr
29 evious expression of the vesicular glutamate transporter 2 (Vglut2) gene, coupled with immunofluoresc
30 P neurons expressing the vesicular glutamate transporter 2 (VP(VGluT2))], whose activation generates
31 owering blood sugar by the sodium-glucose co-transporter 2 inhibitor empagliflozin provides cardiac p
33 s, despite dual inhibition of sodium-glucose transporter-2 and the renin-angiotensin system, remains
35 de-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors as combination therapy for type
36 is composed of transient vesicular glutamate transporter 3 (tVGLUT3) neurons, which convey primarily
37 o be required for insulin-stimulated glucose transporter 4 translocation in mouse skeletal muscle.
38 ells in vitro, reducing the abundance of ABC transporter A1 (ABCA1) and thus cholesterol efflux and i
41 th reduced placental glutamine and glutamate transporter activity and expression, and propose the mam
42 diated histidine uptake, system L amino acid transporter activity and Na(+) K(+) -ATPase activity usi
45 uggest that abnormal glutamine and glutamate transporter activity is part of the spectrum of placenta
46 into three classes and, though the regulated transporter activity of class I proteins is becoming bet
49 ted histidine uptake and system L amino acid transporter activity were similar in sarcolemmal membran
50 importance of key coordinating residues for transporter activity, and provide a structural explanati
52 tercellular communication, and transmembrane transporters, all of which are precursors for impaired g
53 and C-terminal halves in many eukaryotic ABC transporters, allowing all four consensus functional dom
56 usal relationship between amygdala serotonin transporter and an animal's sensitivity to threat by rev
57 bundle protein that acts as an intracellular transporter and buffer for fatty-acyl-CoA and is active
58 lowly than the constitutively secreted GLUT1 transporter and localize CHC22 to the ER-to-Golgi interm
59 he CD147-Ig1 domain, displaces CAIX from the transporter and suppresses CAIX-mediated facilitation of
60 e induced by ligand binding to the serotonin transporter and to the glycine transporters (GlyT1 and G
61 se compounds were in vitro substrates of the transporter and validated the differences observed betwe
63 O, there was significant dysregulation of BA transporters and BA detoxification/synthesis enzymes in
64 ved in cellular transport, including calcium transporters and cytoskeletal regulators, that are assoc
66 Deepened eisosomes are able to trap nutrient transporters and protect them from rapid endocytosis.
67 sis, genes encoding ferritin, flavodoxin, Fe transporters and siderophore uptake genes were more abun
68 LTP-triggered PAP withdrawal involves NKCC1 transporters and the actin-controlling protein cofilin b
69 e global structural similarity of homologous transporters and the enormous diversity of their substra
70 ly needed to understand these novel membrane transporters and their contributions to health and disea
71 ide insight into the assembly of PACE family transporters and their regulation via LTTR proteins on d
72 chitecture of several medically relevant ABC transporters and their supramolecular assemblies, includ
73 attributed to disruption of one of two d-Ser transporters and/or activation of a previously nonfuncti
74 he two CRM1 similarly, NESs from Mek1, eIF4E-transporter, and RPS2 showed >10-fold affinity differenc
75 tivating enzymes, ATP binding cassette (ABC) transporters, and central carbon metabolic proteins) wer
76 aE, has minimal sequence similarity to other transporters, and the structure of the entire inner-memb
82 synaptic dopamine autoreceptors and dopamine transporters-as well as heterosynaptic mechanisms, such
83 is caused by variation in type and number of transporters, assimilation machinery, and anatomical fea
84 ansporter TmrAB, a functional homolog of the transporter associated with antigen processing (TAP) by
85 mplex, a scaffold for signaling proteins and transporters at the cell membrane; MLXIP that, with the
86 revealed that specific localization of auxin transporters at the different membranes of these young c
87 ycogen synthase (glys), atp-binding cassette transporter (atp), and low-density lipoprotein receptor
88 cently revealed that the late endo-lysosomal transporter ATP13A2 pumps polyamines like spermine into
90 lular auxin receptor - rather than the auxin transporter AUXIN RESISTANT 1 (AUX1) - was considered to
91 ch include tracers of bacterial maltodextrin transporter, bacterial thymidine kinase, antibiotics, an
92 RS) working in a sensory complex with an ABC-transporter (BceAB), together acting as a flux-sensor wh
94 is a prototypical H(+) -dependent multidrug transporter belonging to the Major Facilitator Superfami
95 tition between two carbon sources for shared transporters, between transcription factors for binding
96 n MGAS5005, the annotated beta-glucoside PTS transporter (bglP) was found to be crucial for GAS growt
97 terest in using endogenous compounds as drug transporter biomarkers to facilitate drug-drug interacti
98 mpts spatial retreat of astroglial glutamate transporters, boosting glutamate spillover and NMDA-rece
99 ikely compensated for by the related SLC20A1 transporter, but strongly decreased XPR1-mediated phosph
100 native function of Esbp6 revealed that this transporter can excrete fusel acids (byproducts of aroma
101 Determining drug interactions with these transporters can be useful in identifying and predicting
103 se findings identify SLC25A51 as a mammalian transporter capable of importing NAD(+) into mitochondri
104 bly affect transport rates of NBCe1 or other transporters carrying HCO3- , CO3= , or NaCO3- ion pairs
105 5 (SLC7A5) gene, which encodes an amino acid transporter cause microcephaly and seizures, yet the mec
109 ity was unsurprising, disruption of a single transporter, CycA, was sufficient to completely overcome
110 utations in CTNS-a gene encoding the cystine transporter cystinosin-cause the rare, autosomal, recess
111 orphisms reducing expression of the dopamine transporter (DAT) are associated with some conditions.
112 dopamine D(2/3) receptor (D2/3R) or dopamine transporter (DAT) availabilities, or synaptic dopamine l
114 ined by its capacity to inhibit the dopamine transporter (DAT), and emerging evidence suggests that d
116 r magnesium and that down-regulation of this transporter decreases glucose-stimulated insulin secreti
118 rve choline and phosphatidylcholine, choline transporter deficiency was implicated in impaired membra
119 set neurometabolic disease caused by choline transporter deficiency with autosomal recessive inherita
120 nce of this transport system was verified in transporter-deficient rats as a secondary model organism
121 MB-231 breast cancer cells, the cell-surface transporter density (n) may decay with cell radius (r) f
124 l themes including up-regulation of nutrient transporters, down-regulation of adhesion molecules and
125 odegenerative diseases, the contributions of transporter dysfunction to disease pathophysiology remai
126 hat, although CAs could stimulate non- HCO3- transporters (e.g. Na-H exchangers) by accelerating CO(2
127 ghtly controlled by the astrocytic glutamate transporter EAAT2, influencing synaptic functioning and
129 g interactions with equilibrative nucleoside transporter (ENT) 1 and ENT2 using Bayesian modeling.
130 JNK, inhibits expression of the gemcitabine transporter ENT1, so that cells take up smaller amounts
131 NK), inhibited expression of the gemcitabine transporter ENT1, which reduced gemcitabine uptake by pa
135 any of the targeted brain regions, serotonin transporter expression, specifically within the right ve
136 Several missense mutations in the orphan transporter FLVCR2 have been reported in Fowler syndrome
140 azoans and utilizes a wide array of nutrient transporters found on the absorptive enterocytes of the
142 istribution across H4c domain controls slc13 transporter function and is utilized by slc13-interactin
145 be determined by plasma membrane GABA uptake transporters (GATs) located on astrocytes and neurons.
146 on protein between LPL and its physiological transporter GBIHBP1 that is highly active and largely re
147 n emotion regulation revealed that serotonin transporter gene expression in the ventrolateral prefron
149 y increasing the transcript level of silicon transporter genes (EcLsi1, EcLsi2 and EcLsi6) as well as
151 ts show that consideration of BGC-associated transporter genes can inform predictions of specialized
153 oot anatomy, up-regulation of Si channel and transporter genes, ascorbate-glutathione cycle and nutri
154 he expression of mitochondrial influx Ca(2+) transporter genes, but upregulation in the genes related
155 ated the expression of Si channel and efflux transporter genes- Lsi1 and Lsi2 while the addition of S
156 assessed surface expression of the glutamate transporter GLT-1 and glutamate efflux in the nucleus ac
158 .026) placental mRNA expression of a glucose transporter (GLUT-3) and increased (P = 0.037) placental
159 eletion of only one highly expressed glucose transporter, Glut1 or Glut3, in cancer cells does not im
163 or both flagellar trafficking of the glucose transporter GT1 and for successful cytokinesis and survi
164 ein (Rh) family of ammonia (NH(3)/NH(4) (+)) transporters has been identified in organisms from all d
167 r from previous observations for similar ABC transporters, highlighting the extent of mechanistic div
168 ence imaging of the archaeal model glutamate transporter homologue Glt(Ph) from Pyrococcus horikoshii
169 in vivo functionality of the chlamydial Opp transporter in C. trachomatis Importantly, we found that
171 Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LP
172 a membrane localization of the GLUT4 glucose transporter in skeletal muscle, but are not deficient in
173 e will discuss the role played by nucleoside transporters in human health and disease, with emphasis
174 macrophages have focused on the role of ABC transporters in moving cholesterol onto high-density lip
176 he involvement of these mitochondrial Ca(2+) transporters in supporting the CRAC current (I(CRAC) ) u
177 cose lowering properties by inhibiting sugar transporters in the small intestine and improving insuli
178 entified in other CAX homologs and/or Ca(2+) transporters, including the mammalian Na(+)/Ca(2+) excha
179 lar cholesterol levels mediated by the ABCG1 transporter increase ATP release by volume-regulated ani
180 gh levels of the membrane transporter, using transporter inhibition assays and transient knockdown of
181 te commonly used in high-throughput in vitro transporter inhibition assays in the early ADME profilin
182 tion and provide the first example of an ECF-transporter involved in overcoming host-induced nutritio
183 nputs to regulate different ion channels and transporters involved in the control of K(+) fluxes by p
184 cytoplasm by the ATP binding cassette (ABC) transporter IrtAB(4), which features an additional cytop
187 nderstanding of substrate selectivity by SMR transporters is needed to identify the types of selectiv
188 T (SLC13A5; mINDY), a sodium-coupled citrate transporter, is the mammalian ortholog of Drosophila IND
189 expression of GABA(A)R or of the chloride co-transporter KCC2, but rather with inhibition of KCC2 dim
190 olvement in the regulation of ATPase, cation transporter, kinase and UDP-glycosyltransferases genes.
193 this process, and mutations in these sterol transporters lead to disorders such as Tangier disease a
194 o an increase in insulin-independent glucose transporter levels, enhanced cellular glucose uptake, hi
196 this system, the ATP-binding cassette (ABC) transporter LptB(2) FGC extracts LPS from the inner memb
198 is due to acid inhibition of monocarboxylate transporters (MCTs), resulting in a negative feedback on
199 tons, which are exported via monocarboxylate transporters (MCTs), supporting the formation of an acid
201 al change - which occurs in all conventional transporter mechanisms - has not been observed in any hi
204 We developed a novel protocol to measure transporter-mediated histidine uptake, system L amino ac
206 compounds, which are oftentimes subjected to transporter-mediated uptake, are challenging in drug dis
207 confirmed that (i) genes encoding methionine transporter (metP) and manganese transporter (mtsA) are
208 methionine transporter (metP) and manganese transporter (mtsA) are crucial for GBS survival in whole
210 he expression of the plasma membrane citrate transporter NaCT in HepG2 cells and decreases cellular l
212 the human SLC4A7 gene encoding the Na/HCO(3) transporter NBCn1 suggest that this pH-regulating protei
213 d heme transport system containing near-iron transporter (NEAT) domains and its efficacy as a vaccine
216 ab) immunized against a bacterial 14TM helix transporter, NorC, from Staphylococcus aureus We identif
219 We recently identified MmpL11 as a conserved transporter of mycolic acid-containing lipids including
220 that increase the expression of cholesterol transporters on atheroma macrophages leading to increase
221 alizations between pSTAT5 and vesicular GABA transporter or vasopressin were observed, whereas approx
222 signaling pathways, surface markers, efflux transporters, or components of complex tumor microenviro
225 pression of GLUT4, the high capacity glucose transporter, partially rescues viral replication in the
226 vered and validated the plasmodial l-lactate transporter, PfFNT, as a novel antimalarial drug target.
228 nstrated that knockdown of XPR1, a phosphate transporter present in MIN6m9 cells and pancreatic islet
230 ere, we report the black flying fox receptor transporter protein 4 (RTP4) as a potent interferon (IFN
231 = 1.1 x 10-14), the SLC19A1/(ABCC1 + ABCC4) transporter ratio (P = 3.6 x 10-4), the MTX infusion tim
233 otential application as long-range molecular transporters, responsive surfaces, and (bio)sensors.
234 We further show that inhibitors of glucose transporters selectively kill SLC7A11(high) cancer cells
236 D(2)/D(3), 5-HT(1A), 5-HT(2A) and serotonin transporter (SERT) occupancies of brexpiprazole in adult
237 bound at the dimer interface in the leucine transporter show decreased k(off) rates in molecular dyn
239 d mRNA-seq analysis identified the glutamine transporter SLC1A5 as an FTO target that promotes metabo
241 GWAS is a missense mutation in the manganese transporter SLC39A8, which is associated with altered gl
243 derophores as pathogenicity factors, we used transporters specific for siderophore BGCs to identify b
245 are often protected from treatment by efflux transporters, such as P-glycoprotein (P-gp) at the blood
248 lacentas with reduced activity of amino acid transporter systems A and L, thought to contribute to po
249 e was identified that is a NRT2-type nitrate transporter TaNRT2.5 with a key role in seed vigour.
250 ause p53 regulates expression of the peptide transporter Tap1 and the aminopeptidase Erap1, which are
252 opsis root epidermal cells requires the IRT1 transporter that also allows the entry of certain non-ir
253 R1 and STK39 kinases, and the SLC12A2 ion co-transporter that are required for post-transcriptional u
255 s as a chloroplast-localized low-affinity Pi transporter that mediates UV tolerance and rice yields a
257 ort is mediated by the ubiquitous Amt/Mep/Rh transporters that includes the human Rhesus factors.
259 ecular identification of vesicular glutamate transporter three and cholecystokinin expressing cortica
260 istic understanding of the heterodimeric ABC transporter TmrAB, a functional homolog of the transport
261 l binding and facilitate return of the empty transporter to an outward-open state upon metal release.
262 ggest that Chlamydia evolved an oligopeptide transporter to facilitate the acquisition of oligopeptid
263 d its putative ligand-binding sites face the transporter to likely modulate ATPase activity upon O an
264 via trafficking to the vacuole, heterologous transporters to facilitate intracellular routing, and st
265 nterfaced with biological systems can act as transporters to move cargo such as hydrogel alginate cap
268 e use tripartite ATP-independent periplasmic transporters (TRAPs) to scavenge sialic acid from host t
273 proposed to function in delivery of glucose transporter type 4 (GLUT4)-containing vesicles to the pl
275 ltidrug resistance protein 1 (MDR1) membrane transporter up-regulation in both the mouse astrocytes a
276 we review recent studies of diverse membrane transporters using computational methods, with an emphas
277 which expresses high levels of the membrane transporter, using transporter inhibition assays and tra
278 served that both systems, the sensor and the transporter, utilize galactose-binding proteins that als
280 neurons that express ESR1 and vesicular GABA transporter (VGAT) (MPOA(ESR1 VGAT) neurons) robustly pr
281 ing the vesicular glutamate (vGLUT2) or GABA transporter (vGAT), then determined whether TH-ir neuron
283 chinery mediated through vesicular glutamate transporters (VGLUTs) that ultimately dictate glutamater
284 ter NES binding weaker to CRM1(E571K), eIF4E-transporter was mislocalized in tumor cells carrying CRM
286 ition, Slc30a10, encoding a manganese efflux transporter, was one of the genes most induced by 1,25(O
289 s that support the normal functioning of the transporter, when reconstituted in vesicles of defined l
291 al information on ATP binding cassette (ABC) transporters, which are expressed in the human liver.
292 rmal proximal tubules through P-glycoprotein transporter while being retained in cancerous kidney tis
293 , we summarize the RND superfamily of efflux transporters with a primary focus on the assembly and fu
295 ive transcript abundance patterns of various transporters with known functions in salinity tolerance.
298 on and subsequent loading onto the dedicated transporter Wntless/evenness interrupted (WLS/Evi).