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2 detail: the highly effective inhibitor 1,3,5-tri-[5-(1-quinolinum)-pent-1-yn-1-yl]-benzene tribromide
3 tPyQB) and the less potent antagonist 1,3,5,-tri-{5-[1-(2-picolinium)]-pent-1-yn-1-yl}benzene tribrom
4 at the designed alpha-helical peptide family TRI [(Ac-G(LKALEEK)4G-CONH2)], containing single site su
7 ed for the regioselective synthesis of 1,3,5-tri- and 1,3,4,5-tetrasubstituted pyrazoles by the react
10 successive action of exo-peptidases, mainly, tri- and di-peptidylpeptidases, aminopeptidases and carb
11 successive action of exo-peptidases (mainly, tri- and di-peptidylpeptidases, aminopeptidases and carb
16 thylation of chlorosilanes is reported using tri- and difluoromethyl sulfides, sulfoxides, and sulfon
17 nes using magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes is reporte
18 and efficient method for the preparation of tri- and difluoromethylsilanes using magnesium metal-med
19 detected in both the presence and absence of tri- and dihydroxy bile salts in rats, WT mice, and CELK
21 both parental alleles had similar levels of tri- and dimethylated H3K4 within the Gsalpha first exon
22 n containing 2A), which is selective towards tri- and dimethylated histone H3 lysyl residues 9 and 36
23 lso called JARID1A or KDM5A) can demethylate tri- and dimethylated lysine 4 in histone H3, which are
25 g oxygenase JMJD2A specifically demethylates tri- and dimethylated lysine-9 and lysine-36 of histone
26 KDM4 subfamily of demethylases removes H3K9 tri- and dimethylation and contributes to the regulation
27 KDM4A is a histone demethylase that targets tri- and dimethylation marks on histone H3 lysines 9 and
29 Orf153 (ymfB) is a nonspecific nucleoside tri- and diphosphatase and atypically releases inorganic
31 ng stimulates self-association of NrdR, with tri- and diphosphates stimulating oligomerization more e
32 lyzes the phosphodiester bonds of nucleoside tri- and diphosphates, but not monophosphates, thus disp
33 pyrase, an enzyme that hydrolyzes nucleoside tri- and diphosphates, each normalized ischemic leukoseq
34 ase that hydrolyzes extracellular nucleoside tri- and diphosphates, has seven potential N-glycosylati
38 n the same way, suggesting binding modes for tri- and hexanucleotide-repeat RNAs in two neurodegenera
40 shed and are illustrated by the formation of tri- and pentablock and scarf architectures with cylinde
42 Methods have been developed to synthesize tri- and pentapeptide thioesters containing one or more
43 r carry out the total syntheses of heparosan tri- and pentasaccharides and heparin di-, tetra-, hexa-
44 have previously investigated the binding of tri- and pentasaccharides of N-glycan with a GlcNAc at t
46 optimized in order to generate arsanes from tri- and pentavalent inorganic arsenic species (iAs(III)
47 on of plasmids with loxP sites: a model with tri- and possibly multimeric co-integrates comprising th
50 4,4'-)-dicarbomethoxydibenzo-27-crown-9 with tri- and tetra-(ethyleneoxy) linkages transposed were sy
52 hown to be correlated with the expression of tri- and tetra-antennary beta1,6-N-acetylglucosamine (be
53 he high-pI fractions, nor were predominantly tri- and tetra-antennary glycans associated with low-pI
54 MALDI-MS data revealed several fucosylated tri- and tetra-antennary glycans which were significantl
55 reduced content and structural diversity of tri- and tetra-antennary N-glycans and of O-glycans, 2)
56 pecificity and activity of human FUT8 toward tri- and tetra-antennary N-glycans in the forms of glyco
59 ized acyl chains, phosphatidic acids (PAs)), tri- and tetra-galactosyldiacylglycerols (TrGDGs and TeG
60 s efficient preparation of hindered biaryls (tri- and tetra-ortho-substituted), functions effectively
61 played high activity in the hydrogenation of tri- and tetra-substituted alkenes with TON > 8000 for t
63 relative amount of biantennary glycan versus tri- and tetraantennary glycans was different at separat
65 iantennary glycans, N83 containing primarily tri- and tetraantennary glycans, and N247 containing exc
66 entified carry more biantennary glycans than tri- and tetraantennary glycans, and the relative amount
67 a decrease in the amount of highly branched tri- and tetraantennary N-glycans, whereas monoantennary
69 rtho PCBs [OR = 4.55 (95% CI: 1.48, 13.95)], tri- and tetrachloro PCBs [OR = 3.66 (95% CI: 1.37, -9.7
70 A computational analysis of the reaction of tri- and tetracoordinate boron azides R2BN3 (R = H, Me,
74 ased hepatic BA hydrophilicity by increasing tri- and tetrahydroxylated and decreasing the dihydroxyl
75 ed the ability of these proteins to generate tri- and tetraketide lactone products using N-acetylcyst
76 e potent inhibitors, monosulfated benzofuran tri- and tetrameric homologues of the parent designed di
78 to Plasmodium chitinases: the enzymes cleave tri- and tetramers of GlcNAc from penta- and hexameric o
82 t base-stacking interactions; analyses of 62 tri- and tetranucleotide repeat-containing genes associa
86 wall but not the wall of S. aureus contained tri- and tetrapeptide units, suggesting the presence of
89 recovered support was utilized to synthesize tri- and tetrapeptides that contain amino acids other th
91 he oxygen- and novel carbon-linked adenosine tri- and tetraphosphate analogues are stable from pH 3 t
94 re mono-, 20% di-, and approximately 1% were tri- and tetraphosphopeptides, and 78 novel phosphorylat
95 conciled this issue using a panel of minimal tri- and tetrasaccharide sequences of variable but well
96 text] Syntheses of fluorinated mucin core 2 tri- and tetrasaccharides modified at the C-3 or C-4 pos
97 urves were generated for a series of related tri- and tetrasaccharides to evaluate their relative eff
101 electrophiles, a broad range of mono-, di-, tri- and tetrasubstituted alkenes are compatible in thes
102 f terminal, geminal, disubstituted internal, tri- and tetrasubstituted alkenes using pinacolborane (H
106 ocess is the ability to directly couple di-, tri- and tetrasubstituted alkenyl cyanohydrin pronucleop
108 odology for the stereoselective synthesis of tri- and tetrasubstituted allylic amines based on Pd-cat
109 A selective and convenient synthesis of tri- and tetrasubstituted alpha,beta-unsaturated ketones
110 ntioselective syntheses of challenging alpha-tri- and tetrasubstituted alpha-amino acids including an
112 chemo- and stereoselective access to various tri- and tetrasubstituted conjugated alkenones and alken
113 vertheless, a diverse range of unsymmetrical tri- and tetrasubstituted cyclobutane structures can be
114 of these reactions which form unsymmetrical tri- and tetrasubstituted cyclobutanes through a heterod
115 roalkenes, giving access to the synthesis of tri- and tetrasubstituted double bonds in Rauhut-Currier
116 yl amides to form nonpropenyl disubstituted, tri- and tetrasubstituted enamides with excellent geomet
117 A Bronsted acid-catalyzed method to prepare tri- and tetrasubstituted furans efficiently from cycloi
120 lysis and proceeds using sterically hindered tri- and tetrasubstituted olefins to give products conta
122 , thus bestowing a powerful avenue to access tri- and tetrasubstituted pyridines including carbo- and
123 uide, analogues were synthesized in both the tri- and tetrasubstituted pyrrolidine series by means of
125 the cascade reactions of naturally occurring tri- and tetrasubstituted tetraenes (in agreement with c
126 component synthesis of highly functionalized tri- and tetrasubstituted thiophenes has been reported i
127 electivity and syn-stereoselectivity to form tri- and tetrasubstituted vinylboronic esters from comme
128 0' interprotomer cross-links, including di-, tri- and tetrasulfide bonds, which allosterically inhibi
130 ses that convert these diphosphates into the tri- and tetraterpene precursors of sterols, hopanoids,
132 ding, the binding of a series of mono-, bi-, tri- and tetravalent carboxylate ligands to Ca(II) was e
134 (4)L(6) through self-assembly reactions with tri- and tetravalent metal ions such as Ga(III), Fe(III)
135 rentiate HPAEC peak fractions containing the tri- and tri'-antennary branching isomers and two tetraa
136 e salts (TAA), benzylamines (mono-, di-, and tri-), and illicit drugs (MA, MDEA, and haloperidol).
137 he addition of dialkylzincs and (E)-di-, (E)-tri-, and (Z)-disubstituted vinylzinc reagents to alpha-
138 lpha-casein sample, while 19 mono-, 8 di-, 4 tri-, and 3 tetraphosphopeptides were identified in the
140 R screening of a comprehensive panel of di-, tri-, and high-mannose oligosaccharides establish that h
142 nt and selective (>or=98%) syntheses of di-, tri-, and oligoenes containing regio- and stereodefined
143 train synthesizing cross-bridges with mono-, tri-, and pentaglycyl as well as tetraglycyl-monoseryl,
145 allows for synthesizing both mono- and di-, tri-, and poly( p-carboxyphenyl)siloxanes with p-carboxy
146 everal unique LOS glycoforms containing di-, tri-, and poly-N-acetyllactosamine repeats added to the
148 e, and outer arm), and galactosylation (di-, tri-, and tetra-) between striatum and SN N-glycans with
149 ional ensembles of unacetylated, mono-, di-, tri-, and tetra-acetylated H4 histone tails using Replic
150 can reach a tetra-anionic state, mono-, di-, tri-, and tetra-anionic complexes likely dominate as the
151 ble, for the first time, to prepare any bi-, tri-, and tetra-antennary asymmetric N-glycan from a sin
152 nt strategy for the rapid production of bi-, tri-, and tetra-antennary complex type N-glycans with an
153 t of fully galactosylated or sialylated bi-, tri-, and tetra-antennary N-glycans was largely equivale
155 are common building blocks, a family of di-, tri-, and tetra-histidine-catecholic adducts, that were
156 he Sir proteins to reconstituted mono-, di-, tri-, and tetra-nucleosomal chromatin templates and show
161 Et2N:BH3 (10) and representative mono-, di-, tri-, and tetra-substituted olefins were carried out at
163 ul chemoselectivity in the synthesis of di-, tri-, and tetraamines (62 examples) by use of Buchwald-H
167 wenty-amino acid PSA fragments carrying di-, tri-, and tetrabranched complex-type glycans were prepar
169 ation intermediates and accumulation of bi-, tri-, and tetracyclic sesterterpenes, revealing the cycl
171 l alpha-D-mannopyranoside residues, and di-, tri-, and tetrameric analogs possessing terminal 3, 6-di
172 -(1->3)-glucan mimetics and synthesized di-, tri-, and tetramers in an enantiomerically pure form by
173 A series of three short oligomers (di-, tri-, and tetramers) of cis-2-(aminomethyl)cyclobutane c
174 All members of this library of mono-, di-, tri-, and tetramethyl-substituted derivatives were chara
175 Applications to four different sets of di-, tri-, and tetranucleotide loci from a number of human po
176 the repeat structure including abundant di-, tri-, and tetranucleotide microsatellite loci yielded ac
177 is model and use it to fit DNA data for di-, tri-, and tetranucleotide repeats in humans, mice, fruit
179 howed that the mutation rate differs in di-, tri-, and tetranucleotide repeats, how mutation rate dis
180 g SSRs composed of iterations of mono-, di-, tri-, and tetranucleotides are mostly restricted to host
181 imple sequences consisting of repeating di-, tri-, and tetranucleotides, which allow the maximum reso
183 ))-H bonds of N-terminal amino acids in di-, tri-, and tetrapeptides without installing a directing g
184 had a narrow substrate specificity with di-, tri-, and tetrapeptides, and it hydrolyzed only basic N-
186 chsticks" self-assemble into multipods (bi-, tri-, and tetrapods) of varying coordination number and
187 nditions, regioselective methylation of di-, tri-, and tetrasaccharide substrates proceeded in isolat
188 vels of elongation of fucose-O-Thr61 to di-, tri-, and tetrasaccharides, not previously observed in r
191 broad range of N-allyl amides to form Z-di-, tri-, and tetrasubstituted enamides with exceptional geo
193 ocess shows functional group tolerance; di-, tri-, and tetrasubstituted N-vinylazoles were obtained i
194 regioselective incorporation of mono-, di-, tri-, and tetrasubstituted olefins at the alpha-carbon o
195 nversion of structurally diverse mono-, di-, tri-, and tetrasubstituted olefins to N-H aziridines usi
197 the desired product, including isomeric di-, tri-, and tetrasubstituted species previously believed t
198 sts for the asymmetric hydrogenation of di-, tri-, and tetrasubstituted unfunctionalized alkenes.
199 quent MS(2) and MS(3) spectra of mono-, di-, tri-, and tetrasulfated KS oligosaccharides and sialylat
200 lorimetry (ITC) data for the binding of di-, tri-, and tetravalent carbohydrate analogues possessing
201 from our previous report for binding of di-, tri-, and tetravalent carbohydrate analogues possessing
202 ever, Hill plots for the binding of the di-, tri-, and tetravalent trimannoside analogues to both lec
204 8 for monomethylated lysine, and 84 for di-, tri-, and unmethylated lysine) have been effectively use
207 reveal a "trans-tail" regulation of H3-Lys-4 tri- but not dimethylation by H2B-Lys-123 ubiquitination
208 tion (mono-, di-, and tetra-), fucosylation (tri-, core, and outer arm), and galactosylation (di-, tr
209 A-Ni(II)-Zn(II) inhibitor complexes bound to tri-, di- and monomethyl forms of H3K9 and the trimethyl
210 osine-based nucleotides, including adenosine tri-, di-, and mono-phosphate, are controlled through th
212 in fatty acid uptake, lipid droplet size, or tri-, di-, or monoacylglycerol levels when compared with
214 our peptide nomenclature, the prefixes di-, tri-, etc. refer to the number of amino acid residues in
216 und throughout the genome, di- (H3K4me2) and tri- (H3K4me3) methylated H3K4 are enriched at specific
218 tial histone H3 methylation (mono-, di-, and tri-) is still not understood, and the involvement of do
219 ed unique mono- (K16Ac), di- (K12Ac, K16Ac), tri- (K8Ac, K12Ac, K16Ac), and tetra-acetylated (K5Ac, K
223 being a pyranopyran nitrile synthesized from tri- O-acetyl-d-galactal by Ferrier cyanoglycosidation,
224 rmed in eight individuals with CAS affecting tri- or bileaflet aortic valves revealed considerable ol
226 a its chromodomain, binds histone H3 peptide tri- or di-methylated at lysine 9 (H3K9me3/H3K9me2) in s
227 innate immune sensor RIG-I distinguishes 5' tri- or diphosphate containing viral double-stranded (ds
228 d primers produced products with 5'-terminal tri- or diphosphate groups, indicating that genuine unpr
229 pin ribozyme appears to take up at least one tri- or divalent cation or two monovalent cations upon l
231 utinin is a homotrimeric receptor, and thus, tri- or oligovalent ligands should have a high binding a
232 ritical in the oxidative process involving a tri- or tetra-coordinate gold(I) with the oxidizing reag
233 t the accessibility of the gold(I) center to tri- or tetra-coordination is critical in the oxidative
234 ed on 3,5-dihydroxybenzyl alcohol containing tri- or tetrafunctional chiral central cores and allyl e
237 their ability to promote selective ethylene tri- or tetramerization in combination with chromium.
240 ts do not contain any particular unique di-, tri- or tetranucleotide sequences, but are frequently co
241 tion mutations lacking either the C-terminal tri- or tetrapeptide exhibit apparent size increases of
244 process gave access to highly functionalized tri- or tetrasubstituted dihydropyranones featuring an u
246 itopic 2-pyridinyl aromatic carboxylates and tri- or tetratopic phenols gave the corresponding ester-
248 ng different glycine branch lengths (penta-, tri-, or monoglycine), while PBP2a can only cross-link p
255 letions (genetic instabilities) of repeating tri-, tetra- and pentanucleotide repeating sequences ass
256 Macrocyclization of suitably functionalized tri-, tetra- and pentapeptides via Suzuki-Miyaura cross-
257 that the major N-glycans were monosialylated tri-, tetra-, and penta-antennary oligosaccharides conta
258 classical methods, giving a wide variety of tri-, tetra-, and penta-substituted pyridines in high, o
260 In this way, selectively substituted di-, tri-, tetra-, and pentachloro-BODIPYs 2-5 were prepared.
262 iana yielded fungal-type sesterterpenes with tri-, tetra-, and pentacyclic scaffolds, and notably (-)
264 is enzymatic synthesis yielded predominantly tri-, tetra-, and pentaglutamyl species for the [(3)H]fo
266 the early PGC-LC elution of smaller glycans (tri-, tetra-, and pentasaccharides) at low organic solve
267 elevant noncovalent interactions stabilizing tri-, tetra-, hexa-, and octameric cyclic peptoids (as f
268 sulfane ring structure predominates, and the tri-, tetra-, hexa-, hepta-, and nonasulfanes were prese
269 that differ in the length of their peptides (tri-, tetra-, or pentapeptides with or without mono- or
270 nthesized having hydrophilic spacers of di-, tri-, tetra-, penta(ethylene glycol) and tri(propylene g
271 ns, all types of microsatellite (mono-, di-, tri-, tetra-, penta-, and hexanucleotide repeats) are fo
272 tellite mutations involving the expansion of tri-, tetra-, penta-, or hexanucleotide repeats cause mo
273 The separation of myo-inositol mono-, di-, tri-, tetra-, pentakis-, and hexakisphosphate (InsP1, In
274 the native epitope becomes larger across the tri-, tetra-, pentasaccharide series, entropy contributi
275 inhibition of PPE can be effected by simple tri-, tetra-and pentapeptides terminating in a carboxyli
279 and analyzed using GC-negative ion MS for 26 tri- to decabromodiphenyl ethers (BDEs), as well as othe
281 he 5' end of transcribed genes in a 5'-to-3' tri- to di- to monomethyl gradient and promotes associat
282 roximal tubules there was a greater ratio of tri- to dimethylated H3K4 of Gsalpha exon 1 in the more
284 abetic db/m mice) and increased the ratio of tri- to disulfated disaccharides in hepatic HSPGs (P < 0
286 h-resolution mass spectrometry to measure 10 tri- to heptabrominated diphenyl eithers in serum sample
287 the arithmetic mean serum concentrations of tri- to hexaBDEs were lower in NHANES 2007/08 than in 20
288 ion contributed to the body burden of mostly tri- to hexachlorobiphenyls and produced a distinct prof
291 ified highly polymorphic BES-SSRs containing tri- to hexanucleotides motifs and bringing together rel
292 cases significantly correlated (P < 0.05) to tri- to nona-BDE homologues, and the strength of the cor
293 up to 52% and the aqueous concentrations of tri- to nonachlorobiphenyl PCB congeners by as much as 9
294 leven standard oligosaccharides ranging from tri- to nonasaccharide (3'-sialyllactose, 6'-sialyllacto
295 ngeners of 2,3,7- and 2,3,7,8-Br-substituted tri- to octabromodibenzo-p-dioxins and -furans, and all
296 attached support has been used to synthesize tri- to octapeptides in 28 to 97% yields using only 1.2
297 ibrary of 31 free HMOs, ranging in size from tri- to octasaccharide, was screened against three human
298 entic oligosaccharide standards ranging from tri- to octasaccharides, and their identities were confi
299 ermodynamic data demonstrate that the native tri- to pentasaccharides have free energies of binding i