ライフサイエンスコーパス: triazole

1 iazo compound lying ca. 5 kcal/mol above the triazole.

2 e and benzimidazole substitution of the aryl-triazole.

3 ituted furan/pyrrole derivative and a stable triazole.

4 enable the direct synthesis of alpha-chiral triazoles.

5 bonds originating from the cage's six 1,2,3-triazoles.

6 n yielded the corresponding 5-aryl-4-ethynyl triazoles.

7 promising alternative method for analysis of triazoles.

8 oles, and 5-alkynylated 1,4,5-trisubstituted triazoles.

9 indolin-2-imines instead of 1-sulfonyl-1,2,3-triazoles.

10 n with organic azides, yielding the expected triazoles.

11 cluding saccharin, pyridones, pyrazoles, and triazoles.

12 een reported with long-term use of the other triazoles.

13 esis of carboxylated 1,4-disubstituted 1,2,3-triazoles (1,4-cDTs) has been accomplished.

14 the alkylation of archetypal ambident 1,2,4-triazole, 1,2,3-triazole, and their anions, analyzed by

15 leged heterocycle triazole to provide 2-(1 H-triazole-1-yl)-3-arylthio indole, which is an analogue o

16 xyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazole ((11)C-PS13), a COX-1 PET neuroimaging radiopha

17 he EAE model, the secondary amine 12 and the triazole 14 were able to ameliorate disease severity and

18 e types, such as 1H-benzotriazoles, 1H-1,2,3-triazoles, 1H-1,2,4-triazoles, 1H-tetrazoles, 1H-pyrazol

19 benzotriazoles, 1H-1,2,3-triazoles, 1H-1,2,4-triazoles, 1H-tetrazoles, 1H-pyrazoles, and 1H-benzimida

20 C(50) ~ 20 nM at hP2Y(14)R/mP2Y(14)R), or of triazole 2, preserved affinity.

21 3,5-Dinitrimino-1,2,4-triazole (2) with three protons has the potential of dep

22 ng N(6)-dicyclobutylmethyl-adenine and 1,2,4-triazole-3-carboxamide (40, MRS7451) nucleobases.

23 Poly(1H-1,2,4-triazole-3-thiol) (poly(T3T)) conductive film was coated

24 f vanillin (VAN) was studied on the 1H-1,2,4-triazole-3-thiol-Au (T3T-Au) electrode.

25 tuted 4-alkyl-5-(3,5-dinitrophenyl)-4H-1,2,4-triazole-3-thiols and their 3-nitro-5-(trifluoromethyl)p

26 ting in the formation of 5-sulfonamido-1,2,3-triazole-4-carbothioamide sodium salts as the only produ

27 nce of alkali to afford 1-aryl-5-amino-1,2,3-triazole-4-carbothioamides 11.

28 ,2,3-thiadiazol-4-carbimidamides 5 and 1,2,3-triazole-4-carbothioamides 4.

29 identify a novel hit series of 5-amino-1,2,3-triazole-4-carboxamides (ATC).

30 um cation, [1-(2-(18)F-fluoroethyl),1H[1,2,3]triazole-4-ethylene]triphenylphosphonium bromide ((18)F-

31 es 3a-c into the relevant 2-phenyl-2 H-1,2,3-triazoles (4a-c) have been measured in dioxane/water at

32 Thereby, we accessed 1,4-disubstituted triazoles, 5-iodo-1,4,5-trisubstituted triazoles, and 5-

33 esponding 1- and 4-(1H-pyrrol-3-yl)-1H-1,2,4-triazole-5(4H)-thiones are formed in high yields.

34 ]benzothiadiazole, 5,6-dicyanobenzo[d][1,2,3]triazole, 6,7-dicyanoquinoxaline, and 6,7-dinitroquinoxa

35 rformed, which identified fragment hit 1,2,3-triazole 7 as an attractive starting point for a structu

36 ydrophilic spacer, and either an alkyne (6), triazole (7), or piperazine (8) link to the PBD.

37 ford bicyclic 1,2,3-thiadiazoles 8 and 1,2,3-triazoles 9 connected via a 1,1'-piperazinyl linker.

38 2O2 insult, cells treated with 3-amino-1,2,4-triazole (a catalase inhibitor) were the most sensitive.

39 In the case of O-linked triazoles, a cascade sequence consisting of intramolecul

40 alogues bearing a 1,4,5-trisubstituted-1,2,3-triazole aglycone was synthesized using a straightforwar

41 Here we show that posaconazole, another triazole, also blocks cholesterol export from lysosomes.

42 tinib and showed that modifying the 1H-1,2,3-triazole altered complex I inhibition, identifying the h

43 Using electrospray ionization, oligo(triazole amide)s were best ionized as protonated molecul

44 Here, we report a class of biphenyl triazoles among which stands out a lead compound, 34, th

45 the differences between imidazole and 1,2,4-triazole analogues.

46 Tertiary homoallylic alcohols containing a triazole and a halomethyl moiety, structural units relev

47 impair the copying process, yet some radical triazole and amide DNA backbones perform surprisingly we

48 An alternating motif of glucose and triazole and aryl groups was shown to have the right mix

49 ation of an appropriate linker between 1,2,4-triazole and benzimidazolone moieties, whereby a cyclobu

50 of the Southern Asian lineage by exposure to triazole and echinocandin antifungals but not by exposur

51 es) generate N,N-di-Boc imide-functionalized triazole and isoxazole heterocycles.

52 ion of two types of peptides, one containing triazole and the other with native peptide bonds, on a g

53 An NMR comparative study of 1,2,3-triazole and triazolium anion recognition units containi

54 ant 1,4-disubstituted-5-arylthiomethyl-1,2,3-triazoles and 1,5-disubstituted-4-arylthio-1,2,3-triazol

55 se include the preparation of a few glycosyl triazoles and aryl triazoles and isoxazoles.

56 zoles as well as C-beta-d-glucosaminyl 1,2,4-triazoles and imidazoles were synthesized and tested as

57 aration of a few glycosyl triazoles and aryl triazoles and isoxazoles.

58 ion indicated the necessity of unsubstituted triazoles and leucine linker to obtain maximal growth in

59 functionalization of a broad range of 1,2,3-triazoles and pyrazoles in excellent yields and selectiv

60 ses, including organophosphates, carbamates, triazoles and pyrethroids from fruits and vegetables, wi

61 The triazoles and terbinafine exhibited low MICs against all

62 inear relationships between concentration of triazoles and their HPLC peak areas in the range of 0.5-

63 tudies of 3,5-dinitrophenyl-containing 1,2,4-triazoles and their trifluoromethyl analogues revealed t

64 sistance to multiple drug classes, including triazoles and/or echinocandins.

65 ed O- and N-enediynes fused to indole, 1,2,3-triazole, and isocoumarin was investigated.

66 of archetypal ambident 1,2,4-triazole, 1,2,3-triazole, and their anions, analyzed by in situ (1)H/(19

67 llest stabilizing effect is seen for the 1,5-triazole, and this is attributed to the triazole group b

68 tuted triazoles, 5-iodo-1,4,5-trisubstituted triazoles, and 5-alkynylated 1,4,5-trisubstituted triazo

69 o afford high-molecular-weight polymers with triazole- and urea-type interchain links, respectively.

70 solution retain the reactivity of liberated triazole anions but, by virtue of highly regioselective

71 in the direct N-alkylation of unsubstituted triazole anions.

72 uconazole (ISAV) is a novel, broad-spectrum, triazole antifungal agent (IV and by mouth [PO]) develop

73 ncentrations (MFCs), with higher MFCs of the triazole antifungal agents being seen for the South Afri

74 Triazole antifungal resistance in A. fumigatus has becom

75 scopy of oligonucleotides spin-labelled with triazole-appended nitroxides at the 2' position offers a

76 ed in the para-position, the 1,4 and the 2,4-triazoles are cation-stabilizing, whereas the 1,5-triazo

77 Three series of biarylpyrazole imidazole and triazoles are described, which vary in the linker betwee

78 Halo-triazoles are known XB donors, yet few examples detail t

79 Unsubstituted triazoles are particularly challenging, often requiring

80 nimines, and cyclization products, and 1,2,4-triazoles are precursors of nitrile ylides.

81 Triazoles are privileged heterocycles for a variety of a

82 Both triazoles are strongly recommended salvage treatments.

83 Triazoles are the mainstay of therapy against Aspergillu

84 xchange (SuTEx) chemistry to demonstrate the triazole as an effective LG for activating nucleophilic

85 insertion of single 1,4-disubstituted 1,2,3-triazoles as metabolically stable bioisosteres of trans-

86 We introduced 1,4-disubstituted 1,2,3-triazoles as metabolically stable bioisosteres to replac

87 yl substituted 1-(beta-d-glucosaminyl)-1,2,3-triazoles as well as C-beta-d-glucosaminyl 1,2,4-triazol

88 he key cyclometalated iron species active in triazole-assisted iron-catalyzed C-H activation.

89 ulting click-linked iLOV gene contains eight triazoles at the sites of chemical ligation, and yet is

90 Rotation of previously identified 1,2,3-triazole attached to the central m-benzoic acid core (25

91 n this class, leading to highly potent 1,2,3-triazole based infectivity inhibitors (EC50 </= 20 nM).

92 lecular assemblies formed by synthetic alkyl triazole-based amphiphiles against interfaces of thermot

93 e inhibitors (GSIs), we screened a series of triazole-based compounds for their potential to bind gam

94 Triazole-based deubiquitylase (DUB)-resistant ubiquitin

95 rk, we evaluate the inhibition of InhA by 14 triazole-based diphenyl ethers and use a combination of

96 Triazole-based IL moieties were synthesized using click

97 ide-N-ethylated Ub probes may complement the triazole-based probes in the study of Ub interactome.

98 g results promote further development of our triazole-based S1R antagonists as novel treatments for p

99 and biologically evaluated a series of novel triazole-based S1R antagonists.

100 ctron-withdrawing in character, with the 1,5-triazole being the most electron-withdrawing.

101 We reported a series of triazole bisphosphonate GGDPS inhibitors, of which the m

102 One of the analogues, containing a B26-B29 triazole bridge, was highly active in binding to both IR

103 odologies for the synthesis of different BCP triazole building blocks from one precursor, 1-azido-3-i

104 ighly regioselective functionally rich 1,2,3-triazoles by discriminating their reactivities.

105 from 5-alkoxyisoxazoles and 1-sulfonyl-1,2,3-triazoles by tuning the Rh(II) catalyst and the reaction

106 The synthesis of 1H-triazoles can be accomplished by the Banert cascade from

107 rsion of bis-azides to the corresponding bis-triazoles can be readily achieved in the presence of cop

108 N2 elimination from monocyclic 1,2,3-triazoles can generate iminocarbenes, 1H-azirines, keten

109 n, we explore the 5-(methylchalcogeno)-1,2,3-triazole (chalcogen = Se, Te) motif as a novel ChB donor

110 side-chain orientations of a novel hydantoin triazole chemotype (1) to protein-protein interfaces rev

111 4-triazole) or substantially enhanced (1,2,3-triazole) compared to the parent anions.

112 methoxyphenyl)-5-(N-methyl-3'-indolyl)-1,2,4-triazole compound (also known as NMK-T-057) can bind to

113 optimization of a synthetic route to access triazole-containing DBOs and biological evaluation of a

114 This led to the discovery of a triazole-containing diphenyl ether with an increased res

115 The present study has characterized a triazole-containing inducer of NRF2 and elucidated the m

116 ion of the two IGF-1 precursor chains by the triazole-containing moieties, and variation of its neigh

117 or thiosemicarbazone moiety, while VIM-2 by triazole-containing molecules.

118 on demonstrated that the introduction of the triazole core in the scaffold of nonsteroidal antiandrog

119 benzofurans, while, in the case of N-linked triazoles, cyclopropa[cd]indole-carbaldehydes were isola

120 riazole, with systemic treatment using known triazoles demonstrated synergistic antifungal effects ag

121 omeric forms of [1,2,4]triazolo[3,2-c][1,2,4]triazole derivatives in acidic conditions has been achie

122 4) is the most effective chiral catalyst for triazole-derived carbene transformations, whereas Rh(2)

123 Furthermore, the feasibility of triazole dose escalation, combination therapy, and proph

124 ugs clotrimazole and tioconazole, and to the triazole drugs fluconazole and voriconazole.

125 We recently introduced sulfur-triazole exchange (SuTEx) chemistry to demonstrate the t

126 dipeptide surrogates in the form of Xaa-psi[triazole]-F2Gly building blocks were established, and se

127 f compounds belonging to the 5-alkynyl-1,2,3-triazole family that exhibits potent antileukemic effect

128 we report the synthesis of the 5-iodo-1,2,3-triazole (FITI) analog of the PET tracer [(18)F]ICMT11 a

129 panded the armamentarium of reactions beyond triazole formation and two new examples of in cellulo KT

130 cases, C-O bond cleavage occurred via either triazole formation and/or hydrolysis of the ester bond i

131 The extent of triazole formation correlated with ribosome affinity for

132 The extent of triazole formation depends upon leaving group ability.

133 -functionalized 1,2,3-thiadiazoles and 1,2,3-triazoles from 2-cyanothioacetamides and sulfonyl azides

134 applied for extraction and determination of triazoles from natural water, some juices and it represe

135 Our overall results suggest that the triazole functionality is required for ITZ-mediated inhi

136 ene oxide for solid-phase microextraction of triazole fungicides from natural water and juices is int

137 Thus, agricultural use of triazole fungicides may put bees at risk of being unable

138 rcetin-metabolizing activity, identified six triazole fungicides, all fungal P450 inhibitors, that do

139 For 1,2,3-triazole-fused analogues, using NH-Ts as a nucleophilic

140 metal free DBU catalyzed synthesis of 1,2,3-triazole-fused dihydrobenzoxazinone derivatives by tande

141 ynes resulted in unsymmetrically substituted triazole-fused enediyne systems, while the Suzuki reacti

142 An efficient direct approach to triazole-fused sultams has been developed.

143 lated cyclohexa 2,5-dienones, giving new cis-triazole-fused tricyclic scaffolds.

144 1,5-triazole, and this is attributed to the triazole group being twisted out of conjugation in the d

145 These studies all suggest that the 1,5-triazole group exerts a strong electron-withdrawing effe

146 gamma(+) values indicate that the 1,4 triazole group is cation-stabilizing relative to the phe

147 Finally, the anionic triazole group is the most effective radical-stabilizing

148 er between the biaryl pyrazole and imidazole/triazole group.

149 The three triazole groups all enhance the methylenecyclopropane re

150 Computational studies indicate that these triazole groups all stabilize benzylic radicals by a spi

151 nd (19)F chemical shifts indicate that these triazole groups are all inductively electron-withdrawing

152 Three fluorobenzenes substituted with meta-triazole groups have been prepared, and (19)F chemical s

153 Specifically, 1,2,3-triazole groups, when incorporated onto polypeptide side

154 ve Zn(OAc)2-mediated method toward propargyl triazoles has been developed for the first time from com

155 ,2-diaryl-2 H-azirines with 1-sulfonyl-1,2,3-triazoles has been developed.

156 ethod for the synthesis of substituted 1,2,3-triazoles has been developed.

157 of furazan-functionalized 5-nitroimino-1,2,4-triazoles has been explored.

158 sigma(+) values for these three triazoles have also been determined from solvolysis rate

159 e E-CuAAC can directly generate alpha-chiral triazoles in a complex molecular environment.

160 ith clinical and environmental resistance to triazoles in A. fumigatus.

161 ess to 4-, 1,4-, 1,5-, and 1,4,5-substituted triazoles in excellent yield.

162 Controls verified the additional role of triazoles in rigidifying the three-dimensional structure

163 he presence of CO and1-aryl-(1H)-benzo-1,2,3-triazoles in the absence of CO through a common intermed

164 hemical families, oxazoles, strobilurins and triazoles, in water and fruit samples, using dispersive

165 -ray structure of the highly efficient 1,2,3-triazole inhibitor MMG-0358.

166 irst time a linear peptidomimetic with three triazole insertions in its backbone and maintained biolo

167 oles are cation-stabilizing, whereas the 1,5-triazole is carbocation-destabilizing.

168 relative to the phenyl group, albeit the 1,5 triazole is significantly destabilizing relative to phen

169 sign, synthesis, and evaluation of novel des-triazole ITZ analogues that incorporate modifications to

170 f the five different azine-substituted 1,2,4-triazole ligands employed, L(azine) = 4-(4-methylphenyl)

171 of c-MYC and BCL2 G-quadruplex selective bis-triazole ligands that specifically target promoter G-qua

172 f the two components generates an artificial triazole linkage that is tolerated in functionally criti

173 ion yields glassy polymers composed of rigid triazole linkages with enhanced toughness, the RAFT moie

174 ol (vitamin E) in blends with the cellobiose-triazole-linked atactic poly(4-methyl-1-pentene) (CB-aPM

175 e cycloaddition (TAAC) polymerization to 1,4-triazole-linked oligopeptides.

176 (C(5)) on the Calpha side chain through the triazole linker was achieved by solid phase synthesis wi

177 base at Calpha through a spacer chain with a triazole linker.

178 xycoumarin-derived antennae attached through triazole linkers were modest sensitizers for Eu(III) and

179 e bonds' rich proteins with intra main-chain triazole links.

180 Animal models confirmed that a high triazole minimal inhibitory concentration corresponded w

181 rigid spatial arrangement of the quaternized triazole moieties above and below the Pc core, as confir

182 The triazole moieties thus formed two "cationic donuts" that

183 backbone-fluorinated 1,4-disubstituted 1,2,3-triazole moieties.

184 olyheterocycles containing pyrrole and 1,2,4-triazole moieties.

185 veloped tankyrase inhibitors bearing a 1,2,4-triazole moiety and binding predominantly to the adenosi

186 e analogues designed using the hydroxy-1,2,3-triazole moiety as a bioisostere for the distal carboxyl

187 The 1,2,3-triazole moiety can be incorporated as a peptide bond bi

188 Aspartate analogue 8 with the hydroxy-1,2,3-triazole moiety directly attached to glycine was unexpec

189 The copolymer was covalently modified with triazole moiety to fortify the antimicrobial and antibio

190 ional cation-pai interaction of the aromatic triazole moiety with the Arg(356) residue of the recepto

191 resent between the cyclohexadienone unit and triazole moiety.

192 We show that the triazole motif slows the rate of formation for the final

193 adults fed combinations of quercetin and the triazole myclobutanil, the expression of five of six mit

194 1,2,4-triazoles was first accomplished under triazole-NHC control to give unknown fused heterocyclic

195 he synthetic application of 5-iodo-4-ethynyl triazoles obtained was also evaluated: the Sonogashira c

196 to the synthesis of multiply substituted BCP triazoles on either a modular or a one-pot basis.

197 tivities that are completely inverted (1,2,4-triazole) or substantially enhanced (1,2,3-triazole) com

198 st appealing series contain imidazole, 1,2,4-triazole, or benzimidazole rings fused to the 2,3-positi

199 Here, the authors design a triazole peptide that self-replicates and then self-asse

200 The conformational change of triazole polypeptides in response to the donor-acceptor

201 highly optimised topical triazole with oral triazoles potentially induces synergistic effects agains

202 o precursors have linear geometries, and the triazole product is a flat heterocycle.

203 ich N(2) is extruded on the way to the 1,2,3-triazole product to give instead acrylamide rotaxanes.

204 Organophosphates, triazoles, pyrethroids and triazines compounds showed go

205 bond (ChB) donors integrated into a 3,5-bis-triazole pyridine structure covalently linked to benzo-1

206 and treatment outcomes using oral antifungal triazoles remain suboptimal.

207 y reactive with azides, and the formation of triazole required many days compared to a few hours for

208 This review will provide an overview of triazole resistance as it is currently understood, as we

209 It could promptly detect triazole resistance in a panel of 30 clinical strains of

210 The development of multiple triazole resistance in pathogenic filamentous fungi has

211 Triazole resistance is an increasing problem in invasive

212 candins, was not affected by the presence of triazole resistance mutations.

213 aled assorted underlying mechanisms enabling triazole resistance within individual clinical and envir

214 including three that exhibited environmental triazole resistance).

215 haracteristics, day 42 and day 90 mortality, triazole-resistance profiles, and antifungal treatments

216 alleles, even in mixtures containing only 1% triazole-resistant A. fumigatus strains.

217 Samples of plant bulbs were positive for triazole-resistant A. fumigatus with CYP51A mutations.

218 s is the occurrence of mixed infections with triazole-resistant and -susceptible A. fumigatus strains

219 he triazole-resistant strains in mixtures of triazole-resistant and -susceptible strains of A. fumiga

220 strains of A. fumigatus, even in mixtures of triazole-resistant and -susceptible strains of A. fumiga

221 iated resistance alleles even in mixtures of triazole-resistant and -susceptible strains of A. fumiga

222 Infections caused by triazole-resistant Aspergillus fumigatus are associated

223 ates of 50%-100% in patients infected with a triazole-resistant Aspergillus fumigatus, but a direct c

224 to Ireland from the Netherlands might harbor triazole-resistant Aspergillus fumigatus.

225 We used this method to detect triazole-resistant clinical strains of A. fumigatus with

226 p guide treatment decisions in patients with triazole-resistant invasive aspergillosis.

227 ety of cyp51A gene mutations, as well as the triazole-resistant strains in mixtures of triazole-resis

228 rucial to develop robust methods to identify triazole-resistant strains of A. fumigatus, even in mixt

229 Invasive aspergillosis caused by triazole-resistant strains of Aspergillus fumigatus is a

230 zoles and 1,5-disubstituted-4-arylthio-1,2,3-triazoles, respectively, in a regioselective manner with

231 , subsequent reduction to N-tetrafluoroethyl triazoles, rhodium-catalyzed transannulation with nitril

232 An insight into the mechanism of the triazole ring cleavage was achieved by performing a DFT

233 [3,4-a]isoquinolines, in good yields without triazole ring cleavage.

234 ion starts with a hydrolytic cleavage of the triazole ring followed by oxidative cyclization.

235 beta-lactam ring of carbapenems and that the triazole ring generated by this reaction is well tolerat

236 ence of sulfur as a trap, the opening of the triazole ring occurs with the formation of derivatives o

237 The primary products underwent a triazole ring opening under the basic arylation conditio

238 lo[3,4-a]isoquinolines involves, besides the triazole ring opening, the unusual migration of the cyan

239 The annulation of the sultam fragment to the triazole ring proceeds smoothly under transition-metal-f

240 le ring but not by those tested containing a triazole ring.

241 earing either CF(3) or (t)Bu moieties on the triazole rings along with triphenylpnictogens (PnPh(3))

242 dology allows direct access to 4-alkyl-1,2,4-triazoles ( rr up to 94:6) and 1-alkyl-1,2,3-triazoles (

243 triazoles ( rr up to 94:6) and 1-alkyl-1,2,3-triazoles ( rr up to 99:1) in one step.

244 in the interaction of another inhibitor, the triazole (S)-seviteronel (VT-464), with P450 17A1.

245 inverse agonists of GHSR based on the 1,2,4-triazole scaffold.

246 The "triazole scan" yielded peptidomimetics with improved res

247 ly stable bioisosteres of trans-amide bonds (triazole scan) was recently applied to the (177)Lu-label

248 ld the corresponding 1-aryl-(1H)-benzo-1,2,3-triazoles selectively in good yields.

249 The imidazole and triazole series with the short -CH2- linker displayed pr

250 ravenous solutions of both second-generation triazoles showed characteristics that were suitable for

251 Both triazoles showed favorable characteristics for aerosol d

252 While the N-beta-d-glucosaminyl 1,2,3-triazoles showed weak or no inhibition, the C-beta-d-glu

253 cloaddition to N-bromotetrafluoroethyl 1,2,3-triazoles, subsequent reduction to N-tetrafluoroethyl tr

254 by additional interactions involving certain triazole substituents.

255 Gram-negative pathogens with N-linked 1,2,4-triazoles substituted on the 5-position provides the mos

256 We show for the first time that the amide-to-triazole substitution strategy offers new opportunities

257 we studied conjugates with multiple amide-to-triazole substitutions for additive or synergistic effec

258 llus fumigatus, but a direct comparison with triazole-susceptible IA is lacking.

259 or oxidative N-N bond formation in the 1,2,4-triazole synthesis.

260 splayed higher persistence (e.g., terbutryn, triazoles: T1/2 >> 120 days).

261 The central 1,2,4-triazole template and trans-cyclobutyl linker of the lea

262 genative transannulation of N-sulfonyl-1,2,3-triazole-tethered cyclohexadienones has been achieved fo

263 ffinity thyrointegrin alphavbeta3 antagonist triazole tetraiodothyroacetic acid, TAT, via noncleavabl

264 ons of the benzyl azide products into amine, triazole, tetrazole, and pyrrole functional groups highl

265 t is reportedly inhibited by itraconazole, a triazole that is used as an antifungal drug.

266 thod results in densely functionalised 1,2,3-triazoles that remain challenging to prepare by azide-al

267 obal insurgence of isolates resistant to the triazoles, the frontline antifungal class used in medici

268 With limited options for standard triazole therapy, aerosolized delivery with one of the s

269 thly diversified with privileged heterocycle triazole to provide 2-(1 H-triazole-1-yl)-3-arylthio ind

270 that of other dibenzocyclooctynes, fusion of triazole to the dibenzocyclooctyne system in 3 results i

271 pplied to alkenyl imidazoles, pyrazoles, and triazoles to provide products with nitrogen incorporated

272 2,4,6-trifluorophenoxy]propan-2-yl]-4H-1,2,4-triazole) to image 11beta-HSD1 availability in the human

273 l inhibitory concentration corresponded with triazole treatment failure and that the efficacy of othe

274 the donor-acceptor properties of side-chain triazole units via protonation-deprotonation.

275 TZ2PA6 and TZ2PA5 inhibitors, forming a syn-triazole upon cycloaddition within the gorge from alkyne

276 ity (pK(a)) of heterocyclic leaving group of triazole urea derivatives as diacylglycerol lipase (DAGL

277 We screened a 1,2,3-triazole urea library to identify selective inhibitors o

278 We have previously reported that triazole ureas can act as selective and CNS-active inhib

279 Triazole ureas constitute a versatile class of irreversi

280 does not inhibit DAGL), which indicates the triazole ureas may affect the energy balance in mice thr

281 We found that 2,4-substituted triazole ureas with a biphenylmethanol group provided th

282 ree synthesis of any 1,4-disubstituted 1,2,3-triazole using the cycloaddition reactions of an appropr

283 cyclization of (2-bromophenyl)pyrrolyl-1,2,4-triazoles via copper-mediated intramolecular direct C-ar

284 SN(3) led to the chemoselective formation of triazoles via Cu(I)-catalyzed cycloaddition or vinyl azi

285 d delivery with one of the second-generation triazoles was considered.

286 d intramolecular direct C-arylation of 1,2,4-triazoles was first accomplished under triazole-NHC cont

287 A series of new 4,5-dihydro-1H-1,2,4-triazoles was synthesized from amidrazones and acetylene

288 s, pre-concentration factors and LOQ for all triazoles were 95.2-98.0%, about 200 and 0.2-0.4 ug L(-1

289 s with three, four, and six arms of glycosyl triazoles were designed, synthesized, and characterized.

290 action using alkyl azides, and the resulting triazoles were quaternized providing well-defined multit

291 4-(4-methylphenyl)-3-phenyl-5-(azine)-1,2,4-triazole, where azine = pyridine, pyridazine, 4-pyrimidi

292 ization of sulfonamide-tethered 5-iodo-1,2,3-triazoles which are readily available via an improved pr

293 It features arylation of a click triazole with a diaryliodonium salt in the presence of a

294 he combination of a highly optimised topical triazole with oral triazoles potentially induces synergi

295 mediated transannulation of N-sulfonyl-1,2,3-triazoles with a Michael acceptor-tethered indole deriva

296 of a small library of novel 1,4-substituted triazoles with AR antagonistic activity.

297 ein the discovery of 3,5-dinitrophenyl 1,2,4-triazoles with excellent and selective antimycobacterial

298 cyclization of (2-bromophenyl)pyrrolyl-1,2,4-triazoles with TTMSS/AIBN under neutral conditions allow

299 pical treatment using PC945, a novel inhaled triazole, with systemic treatment using known triazoles

300 readily derivatized to the corresponding ETP-triazoles without compromising anticancer activity.