ライフサイエンスコーパス: tricarboxylic acid

1 I fatty acid synthesis and elongation (FAE), tricarboxylic acid, amino sugar, heme, lipoate, and shik

2 iate metabolism, especially reactions in the tricarboxylic acid and the urea cycles.

3 as identified as benzene dicarboxylic acids, tricarboxylic acids, and tetracarboxylic acid isomers, c

4 AtGA2ox9 oxidizes carbon-20 to form tricarboxylic acid C(20)-GAs, whereas AtGA2ox10 produces

5 and upregulation of molecules linked to the tricarboxylic acid cycle (eg, aspartate aminotransferase

6 ssumed to be burned fully by tissues via the tricarboxylic acid cycle (TCA cycle) to carbon dioxide.

7 sis of organic acids, including those of the tricarboxylic acid cycle (TCA cycle), by mixed-mode reve

8 rom patients with recessive mutations in the tricarboxylic acid cycle (TCA) gene succinyl-CoA ligase

9 sumption has been linked to replenishment of tricarboxylic acid cycle (TCA) intermediates and synthes

10 IRT3 deacetylase activates the rate-limiting tricarboxylic acid cycle (TCA) isocitrate dehydrogenase

11 ynthase (Ccar_06155) was a key enzyme in its tricarboxylic acid cycle (TCA) pathway.

12 -accumulation of metabolites involved in the tricarboxylic acid cycle (TCA), and have abnormal mitoch

13 AGI-6780 combination significantly decreased tricarboxylic acid cycle activity and adenosine triphosp

14 hese compounds involving deregulation of the tricarboxylic acid cycle activity and suppression of mit

15 We link mitochondrial tricarboxylic acid cycle activity to IDH2-mediated produ

16 P/O2 kidneys inferring relative increases in tricarboxylic acid cycle activity versus HMP/Air kidneys

17 abolism, photosynthesis, remobilization, and tricarboxylic acid cycle activity) allow to refix 79% of

18 amage to enzymes involved in glycolysis, the tricarboxylic acid cycle and ATP biosynthesis.

19 flux of glutamine-derived carbon through the tricarboxylic acid cycle and by concurrently activating

20 TFAM augmented the muscle tricarboxylic acid cycle and citrate synthase facilitati

21 MmOGOR from its native role in the reductive tricarboxylic acid cycle and drive it directly with ligh

22 chondrial functional pathways, including the tricarboxylic acid cycle and electron transport chain.

23 at impaired the routing of pyruvate into the tricarboxylic acid cycle and established a metabolic sta

24 flux to glutamate both from glucose via the tricarboxylic acid cycle and from glutamine were increas

25 mine to alpha-ketoglutarate to replenish the tricarboxylic acid cycle and generate ATP.

26 ling of glucose-derived metabolites into the tricarboxylic acid cycle and glutathione biosynthesis, r

27 that genes encoding proteins involved in the tricarboxylic acid cycle and glycolysis pathways were hi

28 examination of significant compounds in the tricarboxylic acid cycle and glycolysis reveals that tre

29 d effects, promoting pyruvate entry into the tricarboxylic acid cycle and inhibiting terminal effecto

30 BACH1 decreases glucose utilization in the tricarboxylic acid cycle and negatively regulates transc

31 The tricarboxylic acid cycle and nucleic acid metabolism pat

32 , this limits glutamate availability for the tricarboxylic acid cycle and other biosynthetic reaction

33 atively more prominent at the expense of the tricarboxylic acid cycle and oxidative metabolism in gen

34 y mitochondria to fuel ATP production by the tricarboxylic acid cycle and oxidative phosphorylation (

35 wnregulation of enzymes participating in the tricarboxylic acid cycle and oxidative phosphorylation.

36 ycolysis, whereas M2 macrophages rely on the tricarboxylic acid cycle and oxidative phosphorylation;

37 o mitochondria is also known to activate the tricarboxylic acid cycle and seems to be crucial for mat

38 enzyme complex that is involved in both the tricarboxylic acid cycle and the electron transport chai

39 tion of fatty acids to supply carbon for the tricarboxylic acid cycle as well as production of sucros

40 ic flux of benzoate-derived carbons from the tricarboxylic acid cycle did not reach the upper Embden-

41 is made by diverting aconitate away from the tricarboxylic acid cycle during inflammatory macrophage

42 The tricarboxylic acid cycle enzyme 2-oxoglutarate dehydroge

43 ubunit I relative to actin; in cortex, lower tricarboxylic acid cycle enzyme aconitase and higher pro

44 Loss of the tricarboxylic acid cycle enzyme fumarate hydratase (FH)

45 ctivating mutations of the gene encoding the tricarboxylic acid cycle enzyme fumarate hydratase (FH)

46 (HLRCC), a disease in which mutation of the tricarboxylic acid cycle enzyme fumarate hydratase (FH)

47 Mutations of the tricarboxylic acid cycle enzyme fumarate hydratase cause

48 chondrial isocitrate dehydrogenase (IDH)2, a tricarboxylic acid cycle enzyme mutated in subsets of ac

49 Interestingly, deficiency for the tricarboxylic acid cycle enzyme succinate dehydrogenase

50 labeling data suggest the inhibition of the tricarboxylic acid cycle enzyme succinate dehydrogenase,

51 te dehydrogenase complex, a rate-controlling tricarboxylic acid cycle enzyme.

52 ctokinase, glucokinase, pyruvate kinase, and tricarboxylic acid cycle enzymes, indicating ATP product

53 anced mitochondrial function and accelerated tricarboxylic acid cycle flux coupled with reduced fat c

54 lutamine uptake was approximately 50% of the tricarboxylic acid cycle flux, the rate of ATP productio

55 acid production was approximately 6% of the tricarboxylic acid cycle flux.

56 to glucose as the carbon source to fuel the tricarboxylic acid cycle for vaccinia virus replication.

57 strocytes, and alternations in mitochondrial tricarboxylic acid cycle function.

58 s of TRIM24 iHMECs revealed a glycolytic and tricarboxylic acid cycle gene signature, alongside incre

59 in cohesive operation of glycolysis and the tricarboxylic acid cycle in a normal glucose-replete mil

60 m through the IRG1/itaconate axis within the tricarboxylic acid cycle in activated macrophages.

61 involvement of the increased activity of the tricarboxylic acid cycle in carbon repartitioning.

62 arbon metabolism, sucrose synthesis, and the tricarboxylic acid cycle in leaves and oil synthesis in

63 decreased flux from glycolysis entering the tricarboxylic acid cycle in Muller cells accompanied by

64 ssion and covalent regulation, and hence the tricarboxylic acid cycle influx of pyruvate-derived acet

65 A recent study shows that the tricarboxylic acid cycle intermediate alpha-ketoglutarat

66 The generated tricarboxylic acid cycle intermediate alpha-ketoglutarat

67 showed that substantial accumulation of the tricarboxylic acid cycle intermediate alpha-ketoglutaric

68 ize heme from the amino acid glycine and the tricarboxylic acid cycle intermediate succinyl CoA for i

69 show that alpha-ketoglutarate (alpha-KG), a tricarboxylic acid cycle intermediate, extends the lifes

70 esting that glutamine's ability to replenish tricarboxylic acid cycle intermediates (anaplerosis) is

71 Seven tricarboxylic acid cycle intermediates (citrate, isocitr

72 (N2,N2-dimethylguanosine, N1-methylinosine), tricarboxylic acid cycle intermediates (malate, fumarate

73 tal nitrogen added as N2O and large pools of tricarboxylic acid cycle intermediates and amino acids.

74 ts of perfusion and (11)C incorporation into tricarboxylic acid cycle intermediates and bicarbonate a

75 The kinetics of acetate incorporation into tricarboxylic acid cycle intermediates and into lipids s

76 response is concurrent with rapid changes in tricarboxylic acid cycle intermediates and large changes

77 Tricarboxylic acid cycle intermediates are decreased dur

78 d for the conversion of 4-hydroxybenzoate to tricarboxylic acid cycle intermediates as well as the ma

79 equires fatty acid oxidation and shunting of tricarboxylic acid cycle intermediates for de novo lipid

80 xpression increased anaplerotic refilling of tricarboxylic acid cycle intermediates in mouse brain du

81 (13)C-Labeling of tricarboxylic acid cycle intermediates originating from

82 re metabolism, leading to elevated levels of tricarboxylic acid cycle intermediates, amino acids, sug

83 respiration rates, changes in the levels of tricarboxylic acid cycle intermediates, and accumulation

84 oenergetics as measured by altered levels of tricarboxylic acid cycle intermediates, NAD(+)/NADH, and

85 8 production is attributable to depletion of tricarboxylic acid cycle intermediates.

86 considered incapable of de novo synthesis of tricarboxylic acid cycle intermediates; therefore they r

87 We find that the tricarboxylic acid cycle is required for the terminal ef

88 wed enhanced glycolysis, glutaminolysis, and tricarboxylic acid cycle metabolism with high alpha-keto

89 TLR-induced hexokinase activity and perturb tricarboxylic acid cycle metabolism.

90 Fumarate is a tricarboxylic acid cycle metabolite whose intracellular

91 succinate, fumarate and total 2HG) and other tricarboxylic acid cycle metabolites (alpha-ketoglutarat

92 idopsis are differentially fine-regulated by tricarboxylic acid cycle metabolites (most likely depend

93 lipophilic methyl-conjugates of pyruvate and tricarboxylic acid cycle metabolites bypassed the gateke

94 nd the global declines in the glycolytic and tricarboxylic acid cycle metabolites characteristic of n

95 Glycolytic and tricarboxylic acid cycle metabolites revealed bottleneck

96 diture were associated with PC6, PC9 (AA and tricarboxylic acid cycle metabolites), and PC10.

97 dance of dipeptide metabolites, depleted key tricarboxylic acid cycle metabolites, and slowed progres

98 decreased cellular ATP and depleted critical tricarboxylic acid cycle metabolites, leading to suppres

99 ed photosynthesis, hormone biosynthesis, and tricarboxylic acid cycle metabolites.

100 biopsies revealed a glutamate metabolism and tricarboxylic acid cycle node that was specific to prost

101 ntermediates derived from the glycolysis and tricarboxylic acid cycle pathways.

102 and metabolism of [U-(13)C3]glycerol in the tricarboxylic acid cycle prior to gluconeogenesis or gly

103 Moreover, ineffective tricarboxylic acid cycle replenishment, disturbed carboh

104 s chosen for further studies for its role in tricarboxylic acid cycle replenishment.

105 bundance plots of selected analytes from the tricarboxylic acid cycle revealed differences between he

106 HFD-fed SIRT3 knockout (KO) mice showed that tricarboxylic acid cycle substrate-based respiration is

107 eviously suggested that, during hypoxia, the tricarboxylic acid cycle switches to a noncyclic operati

108 r- and redox-driven variant of the reductive tricarboxylic acid cycle that is capable of producing li

109 at mediates pyruvate oxidation and fuels the tricarboxylic acid cycle to meet energy demand.

110 ng cells shifted their metabolism to use the tricarboxylic acid cycle to metabolize acetate in contra

111 otoxic extracellular Glu through a truncated tricarboxylic acid cycle under hypoglycemic conditions.

112 Levels of the intermediates of the tricarboxylic acid cycle were altered, and increases in

113 Nucleotide metabolism and the tricarboxylic acid cycle were among the pathways perturb

114 in ndufv1, fluxes through glycolysis and the tricarboxylic acid cycle were dramatically increased com

115 iling suggested that both glycolysis and the tricarboxylic acid cycle were suppressed in a similar ma

116 lex (PDHc) activation to maintain TCA cycle (tricarboxylic acid cycle) and promotes cancer metastasis

117 gy metabolism pathways (e.g., glycolysis and tricarboxylic acid cycle).

118 ive pentose phosphate pathway, Calvin cycle, tricarboxylic acid cycle, and amino acid biosynthetic pa

119 ehydrogenase glutathionylation, impaired the tricarboxylic acid cycle, and depleted ATP in leukemia s

120 energy metabolism, including glycolysis, the tricarboxylic acid cycle, and electron transport chain,

121 esis, ascorbate and aldarate metabolism, the tricarboxylic acid cycle, and glycolysis-diverting pathw

122 rmediates of glycolysis/gluconeogenesis, the tricarboxylic acid cycle, and monosaccharide and disacch

123 metabolic processes, such as glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation.

124 , and proline), sugars, intermediates of the tricarboxylic acid cycle, and polyamines and lower level

125 components of the electron transport chain, tricarboxylic acid cycle, and protein import apparatus.

126 ut also through metabolites generated in the tricarboxylic acid cycle, as well as mitochondria-nuclea

127 f the leg; and released intermediates of the tricarboxylic acid cycle, balancing anaplerosis from ami

128 unt generates catabolites that may enter the tricarboxylic acid cycle, but it is unknown whether cata

129 abolites including amino acids, fatty acids, tricarboxylic acid cycle, carbohydrates and associated i

130 ght-modulated metabolites participate in the tricarboxylic acid cycle, carbon balance, phytohormone b

131 rate that is associated with reversal of the tricarboxylic acid cycle, coupled with increased ketogen

132 nses a blockage at the aconitase step of the tricarboxylic acid cycle, either through elevated citrat

133 the expression of genes encoding enzymes of tricarboxylic acid cycle, electron transport chain, oxid

134 performed to compare metabolism through the tricarboxylic acid cycle, fermentation, alanine metaboli

135 arbon and nitrogen metabolism, including the tricarboxylic acid cycle, glycolysis, respiration, and t

136 ate dehydrogenase (MDH), a key enzyme in the tricarboxylic acid cycle, has been identified to be acet

137 lytic pathway and decreased flux through the tricarboxylic acid cycle, in order to decrease mitochond

138 ral key mitochondrial functions, such as the tricarboxylic acid cycle, mitochondrial electron transfe

139 ed in fermentation, hydrogen production, the tricarboxylic acid cycle, NAD biosynthesis, nitrate and

140 genes and pathways of immunity, glycolysis, tricarboxylic acid cycle, OX-PHOS, nicotinamide dinucleo

141 , there is a metabolic remodelling involving tricarboxylic acid cycle, polyol and pentose phosphate p

142 photosynthetic light and dark reactions, the tricarboxylic acid cycle, protein metabolism, and redox

143 ong been known to act as an inhibitor of the tricarboxylic acid cycle, the fate of the amino acid flu

144 erse reaction, supporting anaplerosis of the tricarboxylic acid cycle, under conditions leading to sl

145 ites decreases citrate oxidation through the tricarboxylic acid cycle, whereas increased glutamine up

146 etone body production and breakdown, and the tricarboxylic acid cycle, which inversely correlated wit

147 Ketoglutarate (AKG) is a key intermediate of tricarboxylic acid cycle, which is generated during endu

148 reased expression of genes that regulate the tricarboxylic acid cycle, which resulted from microbe pr

149 ase fatty acid uptake and oxidation into the tricarboxylic acid cycle, while reducing glucose and lac

150 oxoglutarate dehydrogenase-an enzyme of the tricarboxylic acid cycle-specifically results in increas

151 C), fatty acid beta-oxidation (FAO), and the tricarboxylic acid cycle.

152 ue to diminished entry of glutamate into the tricarboxylic acid cycle.

153 ycolytic intermediates and components of the tricarboxylic acid cycle.

154 te dehydrogenase) and pyruvate flux into the tricarboxylic acid cycle.

155 y acid synthesis and pyruvate entry into the tricarboxylic acid cycle.

156 ose catabolism through glycolysis versus the tricarboxylic acid cycle.

157 olved in cell growth, RNA metabolism and the tricarboxylic acid cycle.

158 ith suppression of glucose metabolism in the tricarboxylic acid cycle.

159 undance in controlling the flux-modus of the tricarboxylic acid cycle.

160 conversion of malate and oxaloacetate in the tricarboxylic acid cycle.

161 ce defenses to substrates that can enter the tricarboxylic acid cycle.

162 ssroads of oxidative phosphorylation and the tricarboxylic acid cycle.

163 ate pathway, and gluconeogenesis through the tricarboxylic acid cycle.

164 rs of an enzyme involved in the operation of tricarboxylic acid cycle.

165 t increase in pyruvate oxidation through the tricarboxylic acid cycle.

166 nicotine, oxidative phosphorylation, and the tricarboxylic acid cycle.

167 ase complex is missing in the cyanobacterial tricarboxylic acid cycle.

168 earts were mitochondrial dysfunction and the tricarboxylic acid cycle.

169 (CcpE) that functions as a regulator of the tricarboxylic acid cycle.

170 ns involved in the respiratory chain and the tricarboxylic acid cycle.

171 uctions in enzymes of beta-oxidation and the tricarboxylic acid cycle.

172 Carbon may be fixed via the reductive tricarboxylic acid cycle.

173 otein 2) is required for the activity of the tricarboxylic acid cycle.

174 tic apparatus, the ability to fix C, and the tricarboxylic acid cycle.

175 the produced acetyl-CoA channelled into the tricarboxylic acid cycle.

176 dation and carbon fixation via the reductive tricarboxylic acid cycle.

177 d by a decreased glycolysis and an increased tricarboxylic acid cycle/oxidative pathway, preceded the

178 by attenuating mitochondrial respiration and tricarboxylic acid cycling.

179 R-beta-selective ligand increased markers of tricarboxylic acid-dependent and -independent energy bio

180 rioxo-2, 5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid)), have demonstrated promising result

181 2 (also known as HKUST-1; BTC, benzene-1,3,5-tricarboxylic acid) infiltrated with the molecule 7,7,8,

182 was associated with decreased levels of some tricarboxylic acid intermediates and amino acids, wherea

183 IDO)-dependent tryptophan metabolites (TMs), tricarboxylic acid intermediates, and purine metabolites

184 requirements and anaplerotically generating tricarboxylic acid intermediates.

185 1-mutant cells exhibited increased oxidative tricarboxylic acid metabolism along with decreased reduc

186 expends glucose through enhanced glycolysis, tricarboxylic acid metabolism and pyruvate dehydrogenase

187 In the presence of slow reacting di- and tricarboxylic acids (oxalic, malonic, succinic, and citr

188 e isomers of pyridine dicarboxylic acids and tricarboxylic acids (PCAs).

189 sm of amino acids, nucleotides, fatty acids, tricarboxylic acids, photosynthesis and photorespiration

190 quantify the melanin biomarker pyrrole-2,3,5-tricarboxylic acid (PTCA) was evaluated as a means of no

191 rdial metabolic networks such as the reverse tricarboxylic acid (rTCA) cycle and clay mineral catalys

192 imordial nature of the non-enzymatic reverse tricarboxylic acid (rTCA) cycle and describe a modeling

193 The reverse tricarboxylic acid (rTCA) cycle has been explored from v

194 ne, associated to accumulation of glutamate, tricarboxylic acid (TCA) anaplerotic intermediates and G

195 ), amino acid synthesis (four genes) and the tricarboxylic acid (TCA) cycle (five genes), and four ge

196 n and iron limitation dramatically decreased tricarboxylic acid (TCA) cycle activity, creating a meta

197 e remodeling of ketogenic flux and sustained tricarboxylic acid (TCA) cycle activity, which are concu

198 d oxidation, an effect linked to a defect in tricarboxylic acid (TCA) cycle activity.

199 did not cause energy distress, but impaired tricarboxylic acid (TCA) cycle anaplerosis, macromolecul

200 ncover a previously unknown link between the tricarboxylic acid (TCA) cycle and cell cycle progressio

201 stimulates glutamine catabolism through the tricarboxylic acid (TCA) cycle and consequently lowers i

202 (Fh1), a key component of the mitochondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate me

203 e cells and by reducing carbon flux into the tricarboxylic acid (TCA) cycle and de novo lipid biosynt

204 cose deprivation stimulated re-wiring of the tricarboxylic acid (TCA) cycle and early steps of glucon

205 tbeats to stimulate metabolic enzymes in the tricarboxylic acid (TCA) cycle and electron transport ch

206 at steady induction of hepatic mitochondrial tricarboxylic acid (TCA) cycle and lipogenesis are centr

207 include mitochondrial genes involved in the tricarboxylic acid (TCA) cycle and other nuclear-encoded

208 expression of genes encoding enzymes of the tricarboxylic acid (TCA) cycle and oxidative phosphoryla

209 wo essential energy-producing processes, the tricarboxylic acid (TCA) cycle and oxidative phosphoryla

210 hird, the relative flux through the complete tricarboxylic acid (TCA) cycle and succinate dehydrogena

211 zymes in key metabolic pathways, such as the tricarboxylic acid (TCA) cycle and the pentose phosphate

212 rient metabolic pathways like amino acid and tricarboxylic acid (TCA) cycle are also profoundly pertu

213 y regulated in BMSCs from T2D mice, with the tricarboxylic acid (TCA) cycle being one of the primary

214 pening of the gateway from glycolysis to the tricarboxylic acid (TCA) cycle by producing acetyl coenz

215 The tricarboxylic acid (TCA) cycle converts the end products

216 tation, we capture decreased flux toward the tricarboxylic acid (TCA) cycle during the metabolism of

217 glycolysis enzyme abundance and decreases in tricarboxylic acid (TCA) cycle enzyme abundance with inc

218 Germ line mutations of the gene encoding the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase

219 Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase

220 te, decreases lactate and key glycolytic and tricarboxylic acid (TCA) cycle enzyme levels, and trigge

221 ars, inherited and acquired mutations in the tricarboxylic acid (TCA) cycle enzymes have been reporte

222 cation of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydr

223 e mutations in nuclear-encoded mitochondrial tricarboxylic acid (TCA) cycle enzymes that produce onco

224 elevated activity of complex II, and certain tricarboxylic acid (TCA) cycle enzymes, which led to mit

225 n (pyruvate and oxaloacetate) must enter the tricarboxylic acid (TCA) cycle first and then use phosph

226 accelerated one carbon metabolism, abnormal tricarboxylic acid (TCA) cycle flux and glutamate metabo

227 (leuZ) prevents sRNA-dependent remodeling of tricarboxylic acid (TCA) cycle fluxes and decreases anti

228 cells attempt to direct acetyl-CoA into the tricarboxylic acid (TCA) cycle for ATP production rather

229 tabolic quiescence, associated with impaired tricarboxylic acid (TCA) cycle function and metabolite i

230 f succinate and other TCA metabolites in the tricarboxylic acid (TCA) cycle in mediating lipid accumu

231 Typhimurium undergoes an incomplete tricarboxylic acid (TCA) cycle in the anaerobic mammalia

232 nd functionally, to specifically bind to the tricarboxylic acid (TCA) cycle intermediate succinate.

233 was partially rescued by the addition of the tricarboxylic acid (TCA) cycle intermediate, alpha-ketog

234 abolyzed to alpha-ketoglutarate (alphaKG), a tricarboxylic acid (TCA) cycle intermediate, through two

235 significant alterations in the levels of key tricarboxylic acid (TCA) cycle intermediates and amino a

236 r treatment revealed increased quantities of tricarboxylic acid (TCA) cycle intermediates and increas

237 Altered levels of tricarboxylic acid (TCA) cycle intermediates and the ass

238 ding to less glucose carbons contributing to tricarboxylic acid (TCA) cycle intermediates and the pen

239 sed anabolic demands, wherein glycolytic and tricarboxylic acid (TCA) cycle intermediates are shunted

240 ine as an anaplerotic substrate to replenish tricarboxylic acid (TCA) cycle intermediates that have b

241 ve oxygen species with oxidative stress, and tricarboxylic acid (TCA) cycle intermediates were quanti

242 emical compound classes such as amino acids, tricarboxylic acid (TCA) cycle intermediates, fatty acid

243 icularly pentose phosphate pathway (PPP) and tricarboxylic acid (TCA) cycle intermediates.

244 ge of the pathway and coordinately decreases tricarboxylic acid (TCA) cycle intermediates.

245 mulation of organic acids that are primarily tricarboxylic acid (TCA) cycle intermediates.

246 rther, GCBCs did not metabolize glucose into tricarboxylic acid (TCA) cycle intermediates.

247 13)C]acetyl-CoA and M2 and M4 isotopomers of tricarboxylic acid (TCA) cycle intermediates.

248 The tricarboxylic acid (TCA) cycle is a central metabolic pa

249 The tricarboxylic acid (TCA) cycle is an interface among gly

250 The tricarboxylic acid (TCA) cycle is central to energy prod

251 ational modeling, we identify alterations in Tricarboxylic Acid (TCA) cycle metabolism following even

252 Specifically, we demonstrated that tricarboxylic acid (TCA) cycle metabolites are more abun

253 For example, tricarboxylic acid (TCA) cycle metabolites generated and

254 Glycolysis/gluconeogenesis and tricarboxylic acid (TCA) cycle metabolites have been ass

255 Fatty acid oxidation activity and tricarboxylic acid (TCA) cycle metabolites were measured

256 epigenetic changes directed by mitochondrial tricarboxylic acid (TCA) cycle metabolites.

257 nveiled an aberrant glutamate metabolism and tricarboxylic acid (TCA) cycle node in prostate cancer-d

258 d to changes in the levels of glycolysis and tricarboxylic acid (TCA) cycle pathway intermediates.

259 tive phosphorylation pathway proteins and 18 tricarboxylic acid (TCA) cycle proteins compared to CsP

260 s for respiratory chain flavoproteins or for tricarboxylic acid (TCA) cycle resulted in increased res

261 sed longevity suggesting that anaplerosis of tricarboxylic acid (TCA) cycle substrates likely plays a

262 V. cholerae genes that encode enzymes of the tricarboxylic acid (TCA) cycle that contain iron-sulfur

263 Plant mitochondria have a fully operational tricarboxylic acid (TCA) cycle that plays a central role

264 Tumor cells utilize Gln in the tricarboxylic acid (TCA) cycle to maintain sufficient po

265 multiple anaplerotic routes into a canonical tricarboxylic acid (TCA) cycle to satisfy their energy r

266 vation, macrophages increased glycolysis and tricarboxylic acid (TCA) cycle volume.

267 s, including important intermediaries of the tricarboxylic acid (TCA) cycle, amino acids including pr

268 , including glycolysis, gluconeogenesis, the tricarboxylic acid (TCA) cycle, and amino acid synthesis

269 s, including conspicuous cristae, mtDNA, the tricarboxylic acid (TCA) cycle, and ATP synthesis powere

270 L-malic acid in mitochondria as part of the tricarboxylic acid (TCA) cycle, and in the cytosol/nucle

271 and pathways, including Pyruvate Metabolism, Tricarboxylic acid (TCA) cycle, and Oxidative Phosphoryl

272 te available energy, such as glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphoryl

273 e components of mitochondrialbeta-oxidation, tricarboxylic acid (TCA) cycle, and respiratory chain.

274 at the level of pyruvate metabolism and the tricarboxylic acid (TCA) cycle, and these perturbations

275 ent assimilation of these compounds into the tricarboxylic acid (TCA) cycle, and, correspondingly, th

276 scription of HAP4 and genes required for the tricarboxylic acid (TCA) cycle, electron transport chain

277 rboxykinase (PCK2), the hub molecule linking tricarboxylic acid (TCA) cycle, glycolysis and gluconeog

278 otal role regulating carbon flux between the tricarboxylic acid (TCA) cycle, glyoxylate shunt and met

279 marate hydratase, an essential enzyme in the tricarboxylic acid (TCA) cycle, has been identified as o

280 ine-derived metabolic intermediates into the Tricarboxylic Acid (TCA) cycle, leading to reduced citra

281 several multienzyme systems involved in the tricarboxylic acid (TCA) cycle, photorespiration, and th

282 rossroad of the electron transport chain and tricarboxylic acid (TCA) cycle, two central bioenergetic

283 in kinase in coordinating glycolysis and the tricarboxylic acid (TCA) cycle, which is instrumental in

284 X controls central carbon metabolism via the tricarboxylic acid (TCA) cycle, while PtsN controls nitr

285 s glycolysis and regulates the expression of tricarboxylic acid (TCA) cycle-related genes.

286 lyses from these mouse studies revealed that tricarboxylic acid (TCA) cycle-related urinary metabolit

287 ne's superiority over glucose in feeding the tricarboxylic acid (TCA) cycle.

288 tions of the proteins constituting the plant tricarboxylic acid (TCA) cycle.

289 lung cancers (NSCLCs) oxidize glucose in the tricarboxylic acid (TCA) cycle.

290 or synthesis, and decreased flux through the tricarboxylic acid (TCA) cycle.

291 te and disrupted metabolites involved in the tricarboxylic acid (TCA) cycle.

292 , the pentose phosphate (PP) pathway and the tricarboxylic acid (TCA) cycle.

293 ion and the production of metabolites by the tricarboxylic acid (TCA) cycle.

294 iratory chain and each enzymatic step of the tricarboxylic acid (TCA) cycle.

295 alphaKG) is an essential intermediate in the tricarboxylic acid (TCA) cycle.

296 continued oxidation of substrates within the tricarboxylic acid (TCA) cycle.

297 CDAB-sucABCD operon, encoding enzymes of the tricarboxylic acid (TCA) cycle.

298 ly half of these genes encode members of the tricarboxylic acid (TCA) cycle.

299 ng the utilization of glucose to support the tricarboxylic acid (TCA) cycle.

300 the reaction of the dianion of pyrrole-1,2,5-tricarboxylic acid tert-butyl ester dimethyl ester with