ライフサイエンスコーパス: trisaccharide

1 al domain N of the lyase was found to bind a trisaccharide.

2 ansferase2 (B3GALNT2) to form the O-mannosyl trisaccharide.

3 in the assembly of a protected S. pneumoniae trisaccharide.

4 protein and with one repeat of the terminal trisaccharide.

5 activity reduced the prevalence of the O-Fuc trisaccharide.

6 unsymmetrical urea-linked disaccharides and trisaccharide.

7 e to initiate construction of the side-chain trisaccharide.

8 in concurrence with the lowest K(m) for the trisaccharide.

9 (Gal) and 3 (GlcNAc, GalNAc) of the terminal trisaccharide.

10 nity binding to glycans bearing the Lewis(x) trisaccharide.

11 d core structure and a nonrepeating terminal trisaccharide.

12 oluble in diethyl ether, because of the free trisaccharide.

13 eta-Gal-(1,3)-alpha-GalNAc-(1,3)-beta-GalNAc trisaccharide.

14 f this glycopeptide with an N-bromoacetamido trisaccharide.

15 1,3Galbeta1,4GlcNAc; and the type B branched trisaccharide.

16 n blastose in 43.2% molar yield based on the trisaccharide.

17 hydrophobic cleft interacting with the core trisaccharide.

18 is exemplified in the one-pot synthesis of a trisaccharide.

19 ing-end mannoses are different from the free trisaccharide.

20 ylated allowing the purification of the main trisaccharide.

21 mono-cultures grew very efficiently on this trisaccharide.

22 l bromide, gave exclusively the alpha-linked trisaccharide.

23 d pentasaccharide that contains the Lewis(x) trisaccharide.

24 ing may require engagement of more than four trisaccharides.

25 one-pot syntheses of chondroitin and heparin trisaccharides.

26 a block route involving the coupling of two trisaccharides.

27 olyM, which were further degraded to di- and trisaccharides.

28 oxin serotype A when expressed as individual trisaccharides.

29 lycosyl fluoride donors to yield the derived trisaccharides.

30 the binding domains alone and with purified trisaccharides.

31 of the TES ether of disaccharide 16a, while trisaccharide 18a results from a glycosidation of in sit

32 Trisaccharide 2 is a derivative of 1, in which the hydro

33 f 20 and a 43:27:30 mixture of regioisomeric trisaccharides 29 and 30 and tetrasaccharide 31 from the

34 ing domain for fucose (460 muM) and H type 2 trisaccharide (390 muM), an HBGA shown previously to be

35 same GalNAc-4-SO4- and GalNAc-3-SO4-bearing trisaccharides (6.7 mol of trisaccharide/mol of bovine s

36 ATCC 10543 capable of liberating both the A trisaccharide (A-Tri; GalNAcalpha1-->3(Fucalpha1-->2)Gal

37 ed more challenging, particularly with bulky trisaccharide acceptors.

38 GlcpNAc(1 -->3)]alpha-L-Rhap or the branched trisaccharide alpha-L-Rhap(1-->2)[beta-D-GlcpNAc(1-->3)]

39 iselase digestion of the products released a trisaccharide (alpha-[(3)H]xylosyl-isoprimeverose), indi

40 O-), di- (beta-Gal-1,3-alpha-GalNAc-O-), and trisaccharide (alpha-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-O

41 The di- and trisaccharide analogues were found to be slightly less e

42 The epitope consists of a trisaccharide anchored to the antibody via the O- and N-

43 near rhamnose-containing oligosaccharides, a trisaccharide and a pentasaccharide.

44 tuted at position 3 with an arabinose di- or trisaccharide and at position 6 with glucuronic acid or

45 abilized by several interactions between the trisaccharide and CD1d residues.

46 the 3'-O-sulfated form of Lewis A (suLe(A)) trisaccharide and sialylated Lewis A and that fluorescei

47 ctures of the NV P domain with and without A trisaccharide and the NV P polypeptide revealed no major

48 he synthetic ligand, relative to the natural trisaccharide, and that the entropic component does not

49 etic efforts also provided a reduced phospho-trisaccharide, and the NMR data of this derivative confi

50 ose), the universal fucosyl donor, the Le(x) trisaccharide, and their C-5 substituted derivatives can

51 assing hexoses, pentoses, disaccharides, and trisaccharides, and is able to oxidize glucose to glucon

52 f germ-line residues to recognize the entire trisaccharide antigen and so confer strict specificity.

53 mplex with the Chlamydiaceae family-specific trisaccharide antigen Kdo(2-->8)Kdo(2-->4)Kdo (Kdo = 3-d

54 erance to GM3, an important tumor-associated trisaccharide antigen, seriously hinders its usage in ca

55 lera toxin subunit B, R-phycoerythrin, and B-trisaccharide antigen, with dissociation constants up to

56 d strict specificity for the family-specific trisaccharide antigen; however, only the related antibod

57 (Sp3GH98), which cleaves the entire terminal trisaccharide antigenic determinants of both A- and B-an

58 Data from synthetic trisaccharide antigens 2 and 3 and tetrasaccharide antig

59 stacked" conformation known for the isolated trisaccharide antigens.

60 +1 subsite and 6-O-SO(3)(-) at -2 subsite of trisaccharides are critical for heparanase recognition,

61 Galactose alpha1-3 galactose (Gal) trisaccharides are present on the surface of wild-type p

62 approximately 4 ion pairs for the reference trisaccharide, are formed in the interaction.

63 idase sensitivity defined a novel glucuronyl trisaccharide as GlcNAcbeta1-3(GlcAbeta1-4)fucitol.

64 f the additional sugar-MBP interactions in a trisaccharide as opposed to a monosaccharide are offset

65 peat covalently modified by a full O-glucose trisaccharide at 2.2 A resolution.

66 complex with the pentasaccharide and various trisaccharides at 1.9-2.0A resolution showed that beta4G

67 20 CBMs was synthesized with mono-, di-, or trisaccharides at each site for comparison of binding af

68 binant Glt1 strongly preferred the full core trisaccharide attached to Skp1 and labeled only Skp1 in

69 i; GalNAcalpha1-->3(Fucalpha1-->2)Gal) and B trisaccharide (B-Tri; Galalpha1-->3(Fucalpha1-->2)Gal) f

70 f a repeating unit consisting of a HexNAc(3) trisaccharide backbone in which two of the three HexNAc

71 2, the disaccharide beta-maltose, 3, and the trisaccharide beta-maltotriose, 4) were synthesized, pur

72 njugated to the fungal cell wall beta-mannan trisaccharide [beta-(Man)(3)] by novel saccharide-peptid

73 Glycopeptide 1 with the fucosylated trisaccharide, beta-d-GlcNAc(1-->4)[alpha-l-Fuc(1-->6)]-

74 These three features favorable to trisaccharide binding are consistent with the observatio

75 The A-trisaccharide binding mode seen in the NV P domain compl

76 2.3-A cocrystal structure reveals that the A trisaccharide binds to the NV P domain through interacti

77 pocket, unlike in the structures of A and B trisaccharides bound to VA387 P domain, where the alpha-

78 inoglycoside antibiotic isepamicin, a psuedo-trisaccharide, bound to aminoglycoside nucleotidyltransf

79 re employed for the assembly of the L-rhamno-trisaccharide building block.

80 glucose moiety was converted into a di- and trisaccharide by following the protection and deprotecti

81 d but not alpha/beta-(1-->3)-linked glucosyl trisaccharides can be bound by their internal glucosyl r

82 The anomeric aminooxy GM3 trisaccharide cancer antigen (Neu5Acalpha2,3Galbeta1,4Gl

83 nthracycline subgroup that contains a C(7)-O-trisaccharide chain composed of L-2-deoxysugars.

84 analogue with a modified or even incomplete trisaccharide chain.

85 N-Glycopeptides containing 1 to 4 trisaccharide chains, with the carbohydrates vicinal to

86 previously reported for the VA387 P-domain-A-trisaccharide complex.

87 t a minimum binding sequence is a disulfated trisaccharide comprised of an internal iduronate flanked

88 y, incubation of T3SA+ with sialyllactose, a trisaccharide comprised of lactose and sialic acid, bloc

89 s with conjugates containing disaccharide or trisaccharide conjugated to immunogenic proteins followe

90 with a six-membered lactone) and digoxin (a trisaccharide-conjugated CTS with a five-membered lacton

91 5 capsular polysaccharide repeating unit, a trisaccharide consisting of two FucNAc units, is describ

92 f many Gram-negative bacteria is composed of trisaccharides containing 4-O-phosphorylated L-glycero-D

93 ofuranosidase capable of hydrolyzing di- and trisaccharides containing a terminal, non-reducing fruct

94 kes an LOS that consists only of the heptose trisaccharide core and 2-keto-deoxyoctulosonic acid (KDO

95 sugar moieties extending beyond the heptose trisaccharide core is not required for pustule formation

96 ccessfully utilized for the synthesis of the trisaccharide core of complex N-linked glycans.

97 1,6-arm mannose residues generates a linear trisaccharide core structure and resulted in a significa

98 noethyl glycosides of selectively O-sulfated trisaccharide corresponding to the HNK-1 antigen, its no

99 s two-step activation, trans-trans-patterned trisaccharides could be assembled in a highly efficient

100 mer of the H-type II blood group determinant trisaccharide (D-Fuc-(alpha1-->2)-L-Gal-(beta1-->4)-L-Gl

101 ely 10.7 microM) comparable to the reference trisaccharide DEF ( approximately 4.5 microM), it accele

102 cent to the binding domain for the reference trisaccharide DEF.

103 geometry and interaction profile for ECS and trisaccharide DEF.

104 the (1-->5)-beta-d-galactofuranosyl di- and trisaccharide derivatives 12 and 13.

105 , a variety of selectively protected di- and trisaccharide derivatives can be accessed in an operatio

106 menable to the stereocontrolled syntheses of trisaccharide diastereomers, and a tetrasaccharide.

107 s were applied to the synthesis of a Lewis X trisaccharide displaying a propargyl group at the anomer

108 We found that the entire branched trisaccharide domain of QS-21 is dispensable for adjuvan

109 rough derivatizing at the west wing branched trisaccharide domain.

110 a Galbeta(1,3)[Neu5Acalpha(2,6)]GalNAc-based trisaccharide donor and a Gb3 acceptor.

111 ycosylation procedures, and a novel Lewis(x) trisaccharide donor, 7, was prepared and utilized as a k

112 odipeptide, a 6-deoxy-L-talosyl dipeptide, a trisaccharide donor, and a 3-hydroxyalkanoic acid.

113 eation of the glycosidic linkage between the trisaccharide donor, used as a pentenyl glycoside, and t

114 ome egg antigens, which contain the Lewis(x) trisaccharide, drive alternative activation of APCs and

115 tic immmunoaffinity columns, the immobilized trisaccharide (DSG-Sepharose) eliminates anti-GQ1b antib

116 This antibody optimally binds di- and trisaccharide epitopes, whereas larger oligomers bind wi

117 ride and low levels of a fully reconstituted trisaccharide form of aclacinomycin are observed.

118 [(3)H]glucose from UDP-[(3)H]glucose to the trisaccharide form of Skp1 in a glt1-dependent fashion.

119 sulfur analogues of derivatives of branched trisaccharides found in natural polysaccharides.

120 hrough either an alpha- or beta-linkage to a trisaccharide fragment of mycobacterial arabinan.

121 y occurring carbohydrate motifs, including a trisaccharide fragment of the naturally occurring marine

122 ed, spacer-equipped, phosphorylated upstream trisaccharide fragment of the O-PS of V. cholerae O139.

123 entasaccharides, two tetrasaccharides, and a trisaccharide fragment of the O-specific antigen of Vibr

124 exasaccharides, the Le(x) and Le(a) branched trisaccharide fragments adopt the rigid "stacked" confor

125 The conformational properties of di- and trisaccharide fragments of the polysialic acid O-antigen

126 production of singly charged mono-, di-, and trisaccharide fragments.

127 lex, VLR RBC36 in complex with the H-antigen trisaccharide from human blood type O erythrocytes, at 1

128 ycosyltransferase reactions to build di- and trisaccharides from the virus surface.

129 ctions of residual dipolar couplings for the trisaccharide fucosyllactose.

130 and leukocytes, and to the Gal alpha 1-3Gal trisaccharide (Gal) antigen.

131 The trisaccharide, Gal beta 4GlcNAc beta 3Fuc, is the minima

132 The fucose moiety of the blood group B trisaccharide Galalpha1-3(Fucalpha1-2)Gal also binds to

133 define the binding epitope for BDCA-2 as the trisaccharide Galbeta1-3/4GlcNAcbeta1-2Man.

134 ted that this adhesin specifically binds the trisaccharide Galbeta1-4(Fucalpha1-3)GlcNAc, also known

135 Hep4P and Hep-(1-->7)-Hep4P and the branched trisaccharide Glc-(1-->3)-[Hep-(1-->7)]-Hep4P, respectiv

136 analpha1,3-Manbeta-OR (1,4-1,3-arm); and the trisaccharide GlcNAcbeta1,4-GlcNAcbeta1,4-GlcNAc (chitot

137 (GlcNAcbeta1,2-Manalpha1,3)Man; the 1,6-arm trisaccharide, GlcNAcbeta1,2-Manalpha1,6-Manbeta-OR (1,2

138 galactosyltransferase much like the acceptor trisaccharide, GlcNAcbeta1-2Manbeta1-6Man, which is pres

139 pha1,6-Manbeta-OR (1,2-1,6-arm); the 1,3-arm trisaccharides, GlcNAcbeta1,2-Manalpha1,3-Manbeta-OR (1,

140 ta-2S-iduronate to expose the fully sulfated trisaccharide (GlcNS(6S)-IdoUA(2S)-GlcNS(6S)) does initi

141 streamline the synthesis of the globo series trisaccharides (globotriaose and isoglobotriaose) and al

142 sfully applied to the synthesis of digitoxin trisaccharide glycal for the direct synthesis of digitox

143 ltransferase, we prepared a library of Le(x) trisaccharide glycans bearing a wide variety of function

144 olyclonal sera from rabbits immunized with a trisaccharide glycoconjugate.

145 aride attachments perform better than di- or trisaccharide glycosides.

146 It was further observed that the trisaccharide GPI analogues 5 and 6 were better SrtA sub

147 studies of a set of eight synthetic HEP-like trisaccharides harboring different sulfation patterns de

148 zed side chain incorporated in the west wing trisaccharide have been synthesized.

149 Our study also illustrates that the alpha-trisaccharide having N- and 6-O-SO(3)(-) at -2 and +1 su

150 OS with one to five repeats of the terminal trisaccharide, having at the nonreducing end a GlcNAc or

151 orcing the proximal beta-linked sugar of the trisaccharide head group to adopt the typical binding or

152 Incorporation of GalNAc Gb3 trisaccharide in a heterobifunctional ligand with an att

153 glycosyltransferases assemble a similar core trisaccharide in both organisms, and a bifunctional alph

154 highly specific TFF2 binding to the 6-linked trisaccharide in GlcNAcalpha1-4Galbeta1-4GlcNAcbeta1-6(F

155 x), and the Le(a) trisaccharide to the Le(x) trisaccharide in Le(a)Le(x), was found to be very flexib

156 The decrease in yield after the trisaccharide in the (1-->2)-mannan synthesis is attribu

157 t monosaccharides, six disaccharides and two trisaccharides in (0.25, 0.50, 1.00 and 1.50)molkg(-1) a

158 glycosidic bond that connects the two Le(x) trisaccharides in dimLe(x), and the Le(a) trisaccharide

159 nked glycan trimannoside and Le(X) and Le(A) trisaccharides in very good yield (76%, 62%, and 59% yie

160 Con A with a synthetic analog of the natural trisaccharide, in which a hydroxyethyl side chain replac

161 he synthesis of two Streptococcus pneumoniae trisaccharides, in which the applicability of the two si

162 Here, we use this technique to show that trisaccharides increase the apparent thermodynamic bindi

163 >4)-, and alpha/beta-(1-->6)-linked glucosyl trisaccharides into the SP-D carbohydrate recognition do

164 This linear B trisaccharide is a component of porcine tissues and orga

165 The alpha-GalNAc residue unique to the A trisaccharide is buried deeply in the NV binding pocket,

166 The modified trisaccharide is more buried and fits more snugly than t

167 of any of the Stx forms, indicating that the trisaccharide is necessary for binding.

168 ide of the Salmonella anatum group E(1) core trisaccharide is presented in which all three glycosidic

169 Antibody recognition of the di- and trisaccharide is primarily dependent on the mannose unit

170 In the second step, the trisaccharide is specifically hydrolyzed by trehalase, t

171 A new cyclic trisaccharide is synthesized by cycloglycosylation of a

172 residues, in alpha-linkages to the Skp1 core trisaccharide, is unexpectedly critical for oxygen-depen

173 alactosyldiacylglycerol) and the beta-linked trisaccharide (isoglobotriaosylceramide), is unclear.

174 to form beta-(1 --> 2),beta-(1 --> 3)-linked trisaccharides, isolated in excellent 95% yield.

175 For a complex trisaccharide isomer mixture, HRdm was able to resolve 5

176 e state of substance P as well as individual trisaccharide isomers from a mixture of melezitose and r

177 s paper, we focus on the conformation of the trisaccharide Le(x) (Gal[Fucalpha(1-3)]beta(1-4)GlcNAc).

178 endent and inhibitable by fucose and Lewis-x trisaccharides (Le(x)).

179 13C-1H couplings for a bound trisaccharide ligand, methyl 3,6-di-O-(alpha-D-mannopyra

180 abeled Manalpha(1-2)Manalpha(1-2)ManalphaOMe trisaccharide ligand, when bound to cyanovirin-N (CV-N),

181 ide bound to the enzyme, and the 1,2-1,6-arm trisaccharide makes the maximum number of interactions w

182 at this receptor has a high affinity for the trisaccharide maltotriose (K(d)<1 microM) but little aff

183 ecies that selectively binds and engulfs the trisaccharide Manalpha1-3(Manalpha1-6)Man over mannose o

184 le to discriminate between the three related trisaccharides methyl Manalpha(1-2)Manalpha(1-2)Man, met

185 binding to biantennary glycans expressing Pk trisaccharide mimics immobilized on streptavidin, result

186 saccharide, N-acetylneuraminic acid, and the trisaccharide mixture, neuraminyl lactoses, disrupted hu

187 ould readily be prepared by employing a core trisaccharide modified by the orthogonal protecting grou

188 ynthesized by cycloglycosylation of a linear trisaccharide, modified with hydroxymethyl moiety at C4

189 NAc-3-SO4-bearing trisaccharides (6.7 mol of trisaccharide/mol of bovine serum albumin) have K(i) val

190 the terminal branch of GD1a as well as this trisaccharide motif alone, corresponding to the sialyl-T

191 ink within the central GlcNS-GlcA/IdoA-GlcNS trisaccharide motif.

192 Phosphorylated O-mannosyl trisaccharide [N-acetylgalactosamine-beta3-N-acetylgluco

193 nantioselective and straightforward route to trisaccharide natural products digoxose and digitoxin ha

194 calpha2-6, as well as the affinities for the trisaccharide Neu5Acalpha2-8Neu5Acalpha2-8Neu5Ac versus

195 We thus synthesized the terminal trisaccharide, NeuAc(alpha2-8)NeuAc(alpha2-3)Gal common

196 ly, nanodiscs containing the optimal A and B trisaccharide NGLs, as well as the corresponding NGLs of

197 tegy consisted first in the synthesis of the trisaccharide O-beta-d-Fruf-(2<-->6)-O-alpha-d-Glcp-(1<-

198 The resulting trisaccharide obtained in 23% molar yield based on treha

199 e with laminaritetraose and the other with a trisaccharide of 1,3-1,4-beta-d-glucan, have been determ

200 This study shows: (i) that the non-terminal trisaccharide of heparin is sufficient to initiate the s

201 Stx1 preferred the Pk trisaccharide of its native receptor, globotriaosylceram

202 Mutations affecting the terminal trisaccharide of lipopolysaccharide resulted in reduced

203 inia enterocolitica O:50 strain 3229 and the trisaccharide of Pseudomonas chlororaphis subsp. aureofa

204 of H type 1 and Globo H and of the terminal trisaccharides of A type 1 and Globo A.

205 ng the non-reducing terminal mono-, di-, and trisaccharides of Skp1 revealed, surprisingly, that the

206 RBC36 binds the H-trisaccharide on the concave surface of the LRR modules

207 he alpha chain required a terminal Gal and a trisaccharide or longer oligosaccharide to serve as an a

208 finity ligand (the terminally phosphorylated trisaccharide P-Man(alpha1,2)Man(alpha1,2)Man-O-(CH(2))(

209 n streptavidin, resulting in display of four trisaccharides per streptavidin face.

210 Stx1 primarily recognizes the Pk-trisaccharide portion and has three Pk binding sites per

211 The cyclic trisaccharide possesses a rarely observed perfect trigon

212 The trisaccharides prepared from (13)C6(glc) sucrose and lac

213 entasaccharide and several GlcNAc-containing trisaccharides present in N-glycans.

214 o confirmed the absence of a possible pseudo-trisaccharide product.

215 We conclude that the terminal trisaccharide protects Bordetella species from the bacte

216 ccharide composition with preference for the trisaccharides raffinose and panose.

217 gentiobiose nigerose, and kojibiose), and 7 trisaccharides (raffinose, isomaltotriose, erlose, melez

218 nteracts preferentially with the 1,2-1,6-arm trisaccharide rather than with the 1,2-1,3-arm or 1,4-1,

219 branched core structure with a nonrepeating trisaccharide, rather than a long-chain repeating O-Ag.

220 ent forms of these 4-sulfated and 3-sulfated trisaccharides reflects a difference in the impact of co

221 heteropolysaccharide chains comprised of the trisaccharide repeat unit Fuc4NAc-ManNAcA-GlcNAc, where

222 al common antigen (ECA) are comprised of the trisaccharide repeat unit Fuc4NAc-ManNAcA-GlcNAc, where

223 P-undecaprenol (lipid III), the donor of the trisaccharide repeat unit in the biosynthesis of enterob

224 tion of undecaprenylpyrophosphate-linked ECA trisaccharide repeat units and the polymerization of tri

225 Individual trisaccharide repeat units are assembled as undecaprenyl

226 In contrast, WbdA(O8) polymerizes trisaccharide repeat units containing single alpha-(1-->

227 phorylundecaprenol (lipid III), the donor of trisaccharide repeat units for ECA polysaccharide chain

228 nalyses and show for the first time that the trisaccharide repeat units of ECA(CYC) and ECA(PG) are a

229 ecules lacked an aglycone and contained four trisaccharide repeat units that were nonstoichiometrical

230 revealed that they uniformly contained four trisaccharide repeat units, and they were substituted wi

231 aride repeat units and the polymerization of trisaccharide repeat units, respectively.

232 a fucosyl residue in one of the five O-chain trisaccharide repeat units.

233 Ac transferase involved in the synthesis ECA trisaccharide repeat units.

234 The O-PS of strain CU1000 consisted of a trisaccharide repeating unit composed of L-rhamnose and

235 e preparation of structural analogues of the trisaccharide repeating unit from Streptococcus pneumoni

236 rst total synthesis of the conjugation-ready trisaccharide repeating unit of Pseudomonas aeruginosa O

237 synthesis of an aminopropyl linker-attached trisaccharide repeating unit of Staphylococcus aureus ca

238 ruginosa O11 lipopolysaccharide, which has a trisaccharide repeating unit similar to that of the S. a

239 ECA, a heteropolysaccharide built from the trisaccharide repeating unit, -->3)-alpha-D-Fucp4NAc-(1-

240 rom S. haemolyticus strain JCSC1435 showed a trisaccharide repeating unit: -3-alpha-L-FucNAc-3-(2-NAc

241 Since CP5 and CP8 have similar trisaccharide repeating units, it is important to identi

242 As in our previous syntheses of trisaccharide repeating units, the potential propagation

243 ess the structurally complex linker-attached trisaccharide repeating units, which are valuable tools

244 nd ITC the binding of CVN to three synthetic trisaccharides representing the full-length D1, D2 and D

245 galactosyltransferase required to extend the trisaccharide, require elevated O(2) as for P4H1-null ce

246 A hetero-trisaccharide resin glycoside of jalapinolic acid known

247 synthesis, makes use of the coupling of two trisaccharides, resulting in a shorter sequence and an o

248 but bind monosaccharides, disaccharides, or trisaccharides reveals the presence of four subsites tha

249 A-Rha B-Rha C-GlcNAc D-Rha A' and a modified trisaccharide Rha B-Rha C-GlcNAc D in which Rha C* is mi

250 The clicked mannose, lactose, and alpha-Gal trisaccharide SAMs were used in the analysis of specific

251 Modification of the acyl chain domain in the trisaccharide series revealed that a terminal carboxylic

252 Multiple pentasaccharide and trisaccharide side chains are O linked to BclA.

253 This ability extends from a small trisaccharide species to larger biantennary systems and

254 of donor and acceptor performance up to the trisaccharide stage in solution and on the solid support

255 f His(6)-HFR1 to Manalpha1-6(Manalpha1-3)Man trisaccharide structures.

256 s to the naturally occurring mono-, di-, and trisaccharide substructures.

257 rasaccharide structure, all disaccharide and trisaccharide subunits of the GPI backbone have been stu

258 tB resulted in BclA being replaced with only trisaccharides, suggesting that the enzyme encoded by th

259 The trisaccharide sulfate IdoA2S-GlcNS6S-IdoA2S was found to

260 he observation of a tighter complex with the trisaccharide than the pentasaccharide.

261 is a pentasaccharide containing the Lewis(x) trisaccharide that is found on schistosome eggs and in b

262 1-->4)-beta-ManNAc-(1-->4)-beta-GlcNAc-(1--> trisaccharide that is substituted with beta-Gal at O3 of

263 We have synthesized 11 trisaccharides that are highly tunable in structure and

264 ptica core oligosaccharide with one terminal trisaccharide to aminooxylated BSA via their terminal ke

265 x) trisaccharides in dimLe(x), and the Le(a) trisaccharide to the Le(x) trisaccharide in Le(a)Le(x),

266 d 6-O-sulfated oligosaccharides ranging from trisaccharides to nonasaccharides.

267 g five isomeric disaccharides, four isomeric trisaccharides, two isomeric pentasaccharides, and two i

268 were more stable to heat treatment than were trisaccharides under all of the conditions tested.

269 ), was designed to mimic the nonreducing end trisaccharide unit DEF of the sequence specific heparin

270 osa PAO1 (serotype O5) comprises a repeating trisaccharide unit that is critical for virulence and pr

271 skali is composed of the following repeating trisaccharide unit: --> 3)GalNAcbeta4,6S(1 --> 4) [Fucal

272 e that MLG in brown algae solely consists of trisaccharide units of contiguous (1 --> 4)-beta-linked

273 inear tetrasaccharide domain revealed that a trisaccharide variant is equipotent to QS-21, while the

274 Thus, after the trisaccharide was prepared and linked to Asn, the carboh

275 The fully deprotected anomeric aminooxy GM3 trisaccharide was then conjugated to the immunologically

276 A third fraction containing trisaccharides was acetylated allowing the purification

277 Finally, in contrast to the small trisaccharides, we demonstrated that a longer HEP-like h

278 utants of either strain lacking the terminal trisaccharide were aggregated and permeabilized by SP-D.

279 cking even one of the sugars in the terminal trisaccharide were bound and aggregated by SP-A.

280 A; however, LPS mutants lacking the terminal trisaccharide were susceptible to SP-A.

281 The NMR spectra of the three trisaccharides were fully assigned, and their structures

282 ty to discriminate 13 underivatized isomeric trisaccharides were reported using electrospray ionizati

283 lginate tetrasaccharide and K143A/M171A with trisaccharide) were solved.

284 demonstrated by the synthesis of the Galili trisaccharide, which has been identified as an epitope t

285 se SRCL are highly specific for the Lewis(x) trisaccharide, which is commonly found on the surfaces o

286 . bronchiseptica mutant lacking the terminal trisaccharide, while wild-type B. bronchiseptica and mut

287 Elongation of the trisaccharide with PglH results in a hexasaccharide reve

288 lly relevant variant, Stx2, preferred the Pk trisaccharide with the terminal galactose replaced with

289 also shares carbohydrate recognition of this trisaccharide with toxin A elaborated by Clostridium dif

290 ongated with high efficiency, both contain a trisaccharide with two glucuronic acid residues that ena

291 donors to prepare various disaccharides and trisaccharides with good to excellent beta-selectivity.

292 with remarkable selectivity, and binds these trisaccharides with K(A) values ranging from 8.1x10(3)M(

293 Seven trisaccharides with relative content varying from 1.5 to

294 is less selective in that it binds all three trisaccharides with similar K(A) values ranging from 1.7

295 th disaccharides were identified as branched trisaccharides, with a glucosyl residue alpha-(1 --> 2)-

296 f NGLs based on the blood group type A and B trisaccharides, with three different lipid head groups b

297 at all sites is efficiently elongated to the trisaccharide Xyl-Xyl-Glc.

298 O-Glucose can be elongated by xylose to the trisaccharide, Xylalpha1-3Xylalpha1-3Glcbeta1-O-Ser, who

299 elongating the glycan to generate the final trisaccharide xylose-xylose-glucose, however, remained u

300 allenging Gal-alpha-(1-4)-Gal linkage in Gb3 trisaccharide yielded the desired alpha linkage almost e