ライフサイエンスコーパス: triterpene

1 re accumulate abnormally high levels of this triterpene.

2 ctra even allowed for the discovery of a new triterpene.

3 resulting in production of species-specific triterpenes.

4 glycosylates flavonoids, isoflavonoids, and triterpenes.

5 ubsequent conversion of PSPP to a mixture of triterpenes.

6 y improved the production of 3-O-glucuronide triterpenes.

7 at reflected the content of phytosterols and triterpenes.

8 8-fold) and was a good source of pentacyclic triterpenes.

9 nt ursane-type and oleanane-type pentacyclic triterpenes.

10 a hydroxylation of oleanane- and ursane-type triterpenes.

11 egies for enhanced production of pentacyclic triterpenes.

12 The chromium-catalyzed allylic oxidation of triterpene 1 with O2 and N-hydroxyphthalimide (NHPI, 5 e

13 non-amorphadiene sesquiterpene, monoterpene, triterpene, 2-C-methyl-D-erythritol 4-phosphate and meva

14 Therefore, a chemical triterpene 3-O-glucuronidation was conducted in this stu

15 ing 6 phytosterols (34.73-59.48 mg/100 g), 6 triterpenes (30.56-57.47 mg/100 g), and 5 other unsaponi

16 glucuronyl imidate donors and oleanane-type triterpene acceptors were synthesized, and the relative

17 and transgenic lines selected for high-level triterpene accumulation.

18 Ursolic acid, a pentacyclic triterpene acid, has been shown to suppress the expressi

19 /100g), tocopherols (8.83mg/100g), and three triterpene acids (mangiferolic, isomangiferolic and mang

20 focusing on acyl groups, squalene, sterols, triterpene acids/esters, fatty alcohols, wax esters and

21 e presence of 0.5% of lignin, flavonoid, and triterpene additives in the heated mixtures resulted in

22 s putatively encoding three early enzymes of triterpene aglycone formation: squalene synthase (SS), s

23 la are glycosides of at least five different triterpene aglycones: soyasapogenol B, soyasapogenol E,

24 30 different saponins based on at least five triterpene aglycones; soyasapogenols B and E, medicageni

25 osperm and the embryo had similar sterol and triterpene alcohol contents and compositions.

26 sociated with the biosynthesis of polycyclic triterpenes, although there have been suggestions that i

27 a previously undescribed xanthone and three triterpenes: ambonic acid, mangiferonic acid and a mixtu

28 racteristics of celastrol, a quinone methide triterpene and an active component from Chinese herbal m

29 able rich in phytochemicals mainly including triterpenes and caffeoylquinic acids.

30 method enabled a precise estimation of major triterpenes and chlorogenic acid in C. asiatica in a sho

31 micals including phenolic acids, flavonoids, triterpenes and other common dietary phytochemicals, as

32 ased on their bioactive components including triterpenes and polysaccharides by using chromatographic

33 pands the accessible stereochemical space of triterpenes and represents the first step to the develop

34 welve fatty acids and their conjugates, five triterpenes and steroids, two sesquiterpenes, and six co

35 linear precursor for the biosynthesis of C30 triterpenes and sterols across plant, animal and fungal

36 corresponding 50% increase in the levels of triterpenes and the main storage carbohydrate, inulin.

37 rce of different secondary metabolites, i.e. triterpenes and their derivates, which possess not only

38 Triterpenes are among the most diverse plant natural pro

39 Pentacyclic triterpenes are minor, but very relevant compounds found

40 3-O-beta-Glucuronide triterpenes are plant-derived compounds.

41 Triterpenes are structurally complex natural products wi

42 Triterpenes are structurally complex plant natural produ

43 of bitter and highly oxygenated tetracyclic triterpenes, are mainly produced by the plant family Cuc

44 This represents as many triterpenes as have been reported for all other Arabidop

45 tective chemicals (glycosylated steroids and triterpenes) as part of their innate immune system.

46 (Avena spp.) make root-derived antimicrobial triterpenes (avenacins) that provide protection against

47 synthesis of a cyclopropane ring in certain triterpene backbones.

48 A series of triterpene-based gamma-secretase modulators is optimized

49 er the acidic conditions and yielded unusual triterpenes bearing a bicyclo[4.3.1]decane fragment (22)

50 e cyclization products, including the simple triterpene beta-amyrin.

51 Avenacins are synthesized from the simple triterpene, beta-amyrin.

52 roduction, and the capacity to produce novel triterpenes beyond squalene.

53 trol, a potent anti-inflammatory pentacyclic triterpene, binds Nur77 to inhibit inflammation and indu

54 Limonin, a highly oxygenated triterpene biomolecule of citrus fruits is responsible f

55 ble genome sequence resources to investigate triterpene biosynthesis across the Brassicaceae.

56 and MAKIBISHI1, the rate-limiting enzyme for triterpene biosynthesis and an E3 ubiquitin ligase that

57 an important advance in the understanding of triterpene biosynthesis and paves the way for engineerin

58 hat mechanistic diversity is the default for triterpene biosynthesis and that product accuracy result

59 the spatiotemporal regulation of pentacyclic triterpene biosynthesis in sweet basil.

60 ms (C31 and C32) by cotargeting the TMTs and triterpene biosynthesis to the chloroplasts, whereas onl

61 the JA signaling pathway, leads to enhanced triterpene biosynthesis, in particular of the thalianol

62 ty and mechanisms underlying B,C-ring-opened triterpene biosynthesis, opening avenues towards accessi

63 is incompatible with prevailing concepts of triterpene biosynthesis, which posit tight control over

64 , 2,3-oxidosqualene cyclases (OSCs) in plant triterpene biosynthesis.

65 (OSCs) catalyze the first committed step in triterpene biosynthesis.

66 nary relationships of the numerous candidate triterpene biosynthetic gene clusters (BGCs) observed.

67 B-family transcription factors, and specific triterpene biosynthetic genes.

68 We discovered a triterpene biosynthetic network in the roots of the smal

69 template for discovery and reconstitution of triterpene biosynthetic pathways in plants that require

70 ngal compound peplusol is another linear C30 triterpene, but has only been reported in the genus Euph

71 ed a cytochrome P450 enzyme AsCYP72A475 as a triterpene C-21beta hydroxylase, and showed that express

72 the total squalene was methylated, and total triterpene (C30+C31+C32) content was elevated 7-fold.

73 The quinone methide triterpene celastrol, derived from a traditional Chinese

74 -oic acid), a cell-permeable dienonephenolic triterpene compound, revealed its potent inhibitory acti

75 ed by benzoate and cinnamate derivatives and triterpenes consistent with a styrax-type resin (Styrax

76 Up to 91% of the total triterpene contents could be converted to methylated for

77 indicator for estimation of phytosterol and triterpene contents in Djulis hull.

78 To test if methylated triterpenes could be produced in tobacco, we also engine

79 s of friedelin production by friedelane-type triterpene cyclases have not yet been fully elucidated.

80 ino acids that are unique to friedelane-type triterpene cyclases may lead to variations in catalytic

81 acted on these OSCs, and the friedelane-type triterpene cyclases may undergo weaker selective restric

82 tional characterization, the friedelane-type triterpene cyclases were separately verified in the four

83 angements being catalyzed by friedelane-type triterpene cyclases.

84 Our discoveries provide new insights into triterpene cyclization, revealing hidden functional dive

85 of this residue results in a major change in triterpene cyclization, with production of tetracyclic r

86 xidation-rearrangement biosynthetic logic of triterpene cyclizations for modifying the tirucallane sc

87 evidence for volatile compound formation via triterpene degradation in plants.

88 In our continuing study of triterpene derivatives as potent anti-HIV agents, differ

89 p study of potent anti-HIV agents, seven new triterpene derivatives were designed, synthesized, and e

90 he structure-activity relationships (SAR) of triterpene-derived anti-HIV agents and led to the design

91 The sterols and triterpene dialcohols composition is an important parame

92 ed by polymeric SPE and then the sterols and triterpene dialcohols were isolated by an in-house packe

93 of VOO (including quality indices, sterols, triterpene dialcohols, waxes and diacylglycerols) were f

94 ynthesize DMNT by the degradation of the C30 triterpene diol, arabidiol.

95 Results demonstrated that sterols and triterpene diols can be used as indicators of variety an

96 Sterols and triterpene diols in olive oil as indicators of variety a

97 uffling the genes encoding a core palette of triterpene-diversifying enzymes, presumably in response

98 xamined for its mechanism, we found that the triterpene down-regulated the expression of cell surviva

99 icins are proapoptotic and anti-inflammatory triterpene electrophiles isolated from an Australian des

100 te to the development of phytosterols and/or triterpenes enriched functional foods.

101 we discovered that Celastrol, a pentacyclic triterpene extracted from the roots of Tripterygium Wilf

102 entical to those previously reported for the triterpenes extracted from the algae.

103 Bioactive triterpenes feature complex fused-ring structures, prima

104 indings can be attributed to the presence of triterpenes, flavonoids and sterols in Z. album, which a

105 be functionally conserved and OSCs producing triterpenes for which no enzymatic source was known.

106 The distinction of oxidized di- and triterpenes, for example, is hindered by the superpositi

107 ng a conserved mechanism for B,C-ring-opened triterpene formation in plants.

108 mediate carbocations towards B,C-ring-opened triterpene formation.

109 UA is a pentacyclic triterpene found too in several traditional plants, and

110 Maslinic acid, a pentacyclic triterpene from Olea europaea L., exerts hypoglycemic, a

111 Whether celastrol, a triterpene from traditional Chinese medicine, can modula

112 aneous determination of the main pentacyclic triterpenes from Olea europaea L. in rat plasma.

113 ients, was used to identify phytosterols and triterpenes from seven inbred lines of Djulis hull using

114 Using the triterpenes from various Actaea (syn.

115 Lupeol, a pentacyclic triterpene, from the hexane extract of Solanum melongena

116 synthesis in land plants via the assembly of triterpene gene clusters and present biochemical and gen

117 diate 2 for the synthesis of the pentacyclic triterpene germanicol 1 have been developed.

118 oots also synthesize the beta-amyrin-derived triterpene glycoside avenacin A-1, which provides protec

119 eptor activity-modifying protein (RAMP)-like triterpene glycoside receptor (RL-TGR), a novel corecept

120 eptor activity modifying protein (RAMP)-like triterpene glycoside receptor (RL-TGR), was previously f

121 d the early pathway steps needed to make the triterpene glycoside scaffold; however, the biosynthetic

122 l as well as the binding properties of three triterpene glycosides (cimicifugoside, cimiracemoside F,

123 e needed to fully characterize whether these triterpene glycosides as well as other components of bla

124 ntermediate in the synthesis of more complex triterpene glycosides associated with plant defense.

125 and modifies its pharmacology to respond to triterpene glycosides found in sponges that serve as a p

126 were then employed to show that neither the triterpene glycosides nor their enzymatically prepared a

127 ously found to be involved in recognition of triterpene glycosides, a family of naturally occurring c

128 eceptor involved in signaling in response to triterpene glycosides.

129 d targeted metabolite profiling, to identify triterpene glycosyltransferases (GTs) from among the mor

130 sent crystal structures of the UDP flavonoid/triterpene GT UGT71G1 from Medicago truncatula bound to

131 Celastroid natural products, triterpenes, have been and continue to be investigated i

132 avonol quercetin with higher efficiency than triterpenes; however, integrated transcript and metaboli

133 e in the absence of NADPH gives a mixture of triterpene hydrocarbons and alcohols, including botryoco

134 es allowed in silico identification of known triterpenes in enriched fractions obtained from an extra

135 presence of phenolic compounds, tannins, and triterpenes in L. alba aqueous infusion and stem, flower

136 ed OSC capable of generating B,C-ring-opened triterpenes, including camelliol A and B and the novel (

137 Linear, branch-chained triterpenes, including squalene (C30), botryococcene (C3

138 ompounds-namely, flavonoids, diterpenes, and triterpenes, including the defense-related compound ella

139 st drastically rearranged of the pentacyclic triterpenes, involves a complex nonstop process, with no

140 Celastrol, a pentacyclic triterpene, is the most potent antiobesity agent that ha

141 Lupeol, a triterpene, is the principal constituent of common fruit

142 Betulinic acid (BA), a pentacyclic triterpene isolated from the bark of the white birch tre

143 steroid sulfatase (STS) inhibiting lanostane triterpenes (LTTs) from a complex extract of the polypor

144 Triterpenes lupeol and lupeol acetate (1, 2) were isolat

145 gions of structure-activity relationship for triterpene maslinic acid and its analogs.

146 Together these findings suggest that simple triterpenes may have widespread and as yet largely unrec

147 r specific role as regulators of specialized triterpene metabolism in M. truncatula.

148 xidosqualene to a diverse array of secondary triterpene metabolites in plants.

149 -18-en-3beta-ol methyl ether), a pentacyclic triterpene methyl ether that is enriched in grains of co

150 Miliacin, a pentacyclic triterpene methyl ether uniquely abundant in broomcorn m

151 d be produced in tobacco, we also engineered triterpene methyltransferases (TMTs) from B. braunii int

152 s screened computationally assuming that the triterpene methyltransferases (TMTs) might resemble the

153 The availability of closely related triterpene methyltransferases exhibiting distinct substr

154 This study examines the effect of a triterpene mixture (F094) and a single molecular species

155 nthesis (for the triterpene synthase SAD1, a triterpene-modifying cytochrome P450 SAD2, and the serin

156 ergent pathways for the biosynthesis of root triterpenes, namely thalianin (seven steps), thalianyl m

157 We found that (20S)-Rg3, a triterpene natural compound known as ginsenoside, reduce

158 Betulinic acid is a pentacyclic triterpene natural product initially identified as a mel

159 axanes, epothilones, statins, retinoids, di-/triterpenes, noviose deoxysugar, and antibiotics derived

160 commonly used to identify and quantify major triterpenes of C. asiatica extracts, but associated with

161 and evolved interdependently for specialized triterpene oil production greater than 500 MYA.

162 The triterpene oil squalene is an essential component of nan

163 colony-forming, green algae that accumulates triterpene oils in excess of 30% of its dry weight.

164 The composition of the triterpene oils is dominated by dimethylated to tetramet

165 lts support the advantages of yeast produced triterpene oils to include completely controlled growth

166 tion platform to generate squalene and novel triterpene oils, all of which are equally as efficacious

167 cid contents, and specifically the effect of triterpenes on endothelial function.

168 investigate the effect of lupeol, a dietary triterpene, on (a) apoptosis of tumor necrosis factor-re

169 es (e.g., artemisinin), 26 monoterpenes, two triterpenes, one diterpene and 38 other non-polar metabo

170 Phenolic compounds, sterols, triterpenes, organic acids, fatty acids and volatiles pr

171 Molecular verification of induction of the triterpene pathway in a cell culture system provides a n

172 epresentative BGCs was carried out and their triterpene pathway products were elucidated.

173 Among the latter, the group of pentacyclic triterpenes (PcTr) is the least studied.

174 Previous studies suggest that pentacyclic triterpenes (PCTs), a class of plant-derived bioactive p

175 The occurrence of triterpene pentacyclic acids in plants is extensive, but

176 -Delta(1,4)-cyclohexadien-3-one A-rings from triterpene precursors has been demonstrated beginning wi

177 ffect and associated mechanisms of Lupeol, a triterpene present in fruits and vegetables, in androgen

178 Triterpenes remained unchanged, while ellagic acid deriv

179 Triterpene resin has also been deployed for defense of l

180 of oleanane-type and ursane-type pentacyclic triterpenes, respectively.

181 Unique quercetin-rich (QAE) and triterpene-rich (TAE) apple peel extracts, their constit

182 lidated concept was then exemplified using a triterpene-rich Eriobotrya japonica leaf extract.

183 ogy platform for the production of bioactive triterpene sapo(ge)nins.

184 us nonvolatile hydrophobic terpenes, such as triterpene sapogenins, from engineered yeast cells into

185 on of the seed-specific transcription factor TRITERPENE SAPONIN ACTIVATION REGULATOR3 (TSAR3), which

186 actors of the basic helix-loop-helix family, TRITERPENE SAPONIN BIOSYNTHESIS ACTIVATING REGULATOR1 (T

187 G REGULATOR1 (TSAR1) and TSAR2, which direct triterpene saponin biosynthesis in Medicago truncatula.

188 cytochromes P450 and glycosyltransferases in triterpene saponin biosynthesis in Medicago.

189 pathways including isoflavonoid, lignin and triterpene saponin biosynthesis were modified or added b

190 ulted in elevated transcript levels of known triterpene saponin biosynthetic genes and strongly incre

191 nt patterns of transactivation of downstream triterpene saponin biosynthetic genes, hinting at distin

192 time, we assessed the non-toxic doses of the triterpene saponins (ginsenoside-Rb3 and ginsenoside-Rd)

193 instead have two divergent OSCs that produce triterpene saponins and that are likely to have evolved

194 Triterpene saponins are important bioactive constituents

195 Here, we profiled triterpene saponins from the skin and flesh of red beetr

196 The biosynthesis of triterpene saponins is poorly characterized in spite of

197 f the steps specific for the biosynthesis of triterpene saponins remain uncharacterized at the molecu

198 osaponins comprise oleanane- and ursane-type triterpene saponins that are abundantly present in the r

199 ichome numbers, accumulation of a variety of triterpene saponins, and extensive but differential ecto

200 We tentatively identified 44 triterpene saponins, of which 37 had not been detected p

201 evels of salicylic acid, and lower levels of triterpene saponins.

202 s and strongly increased the accumulation of triterpene saponins.

203 AS) required for the production of the major triterpene scaffold beta-amyrin, the precursor of erythr

204 is postulated to be formed from a 30-carbon triterpene scaffold by loss of 4 carbons with associated

205 tructure of QS-21 consists of a glycosylated triterpene scaffold coupled to a complex glycosylated 18

206 lase able to produce the potential 30-carbon triterpene scaffold precursor tirucalla-7,24-dien-3beta-

207 ng both the C and D rings of the pentacyclic triterpene scaffold to give 12,13beta-epoxy-3beta,16beta

208 re acylated at the carbon-21 position of the triterpene scaffold, a modification critical for antifun

209 p opportunities to engineer novel oxygenated triterpene scaffolds by manipulating the precursor suppl

210 a oxidation of the oleanane- and ursane-type triterpene scaffolds to produce maslinic and corosolic a

211 e enzyme(s) responsible for decorating these triterpene scaffolds with methyl substituents were unkno

212 tion of mono- and dimethylated forms of both triterpene scaffolds.

213 n precursor 2,3-oxidosqualene into different triterpene scaffolds.

214 Our findings shed light on quinoa triterpene skeletal diversity and mechanisms underlying

215 ion, hydroxylation, and glycosylation of the triterpene skeleton in the model legume Medicago truncat

216 In addition, another triterpene skeleton, moronic acid (MA, 3), was also empl

217 ridgehead double bonds (anti-Bredt) within a triterpene skeleton.

218 heir diversity is closely related to various triterpene skeletons catalyzed by different 2,3-oxidosqu

219 Triterpene skeletons, catalyzing by 2,3-oxidosqualene cy

220 ree produced rare or previously inaccessible triterpene stereoisomers, namely, (3S,13S)-malabarica-17

221 al oxidosqualene cyclases that might produce triterpene stereoisomers.

222 s now make it possible to access and harness triterpene structural diversity using engineering biolog

223 fects of the yeast-derived squalene or novel triterpenes, suggesting their safety in adjuvant formula

224 amyrin synthase (CqbAS1) and B,C-ring-opened triterpene synthase CqQS.

225 al, the metabolic fate for most of the major triterpene synthase products in Arabidopsis is now at le

226 three genes for avenacin synthesis (for the triterpene synthase SAD1, a triterpene-modifying cytochr

227 esearch explored the functional diversity of triterpene synthases from a multispecies perspective.

228 sidue that determines product specificity in triterpene synthases from diverse plant species.

229 likely progenitor to the other Botryococcus triterpene synthases, catalyzes a two-step reaction with

230 mic region that includes two S. lycopersicum triterpene synthases.

231 ights into the phylogenetic relationships of triterpene synthases.

232 revealing hidden functional diversity within triterpene synthases.

233 oids, and carotenoids; the betagamma di- and triterpene synthases; the zeta head-to-tail cis-prenyl t

234 nt Arabidopsis thaliana that is required for triterpene synthesis (the thalianol pathway).

235 nt assembly of operon-like gene clusters for triterpene synthesis has occurred independently in diver

236 otective groups afforded compounds useful in triterpene synthesis, especially in the preparation of p

237 overning the regio- and stereospecificity of triterpene synthesis.

238 eptors' reactivities on 3-O-beta-glucuronide triterpenes synthesis, and this knowledge would help to

239 a general hub of carotenoids and polycyclic triterpenes synthesis.

240 Oats produce avenacins, antifungal triterpenes that are synthesized in the roots and provid

241 Three additional triterpenes, the allylic isomers of HSQ and HBO, and an

242 his genus were isolated from this extract (a triterpene, two furanonaphtoquinones, a furanochromone,

243 ely induced, associated with accumulation of triterpenes, upon exposure of M. truncatula cell suspens

244 ormation of the fatty acid moiety and of the triterpene via the mevalonate route.

245 n that of OA, and consumption of pentacyclic triterpenes was associated with improved endothelial fun

246 hloroplasts, whereas only 4% to 14% of total triterpenes were methylated when this metabolism was dir

247 Six novel oxasqualenoids (polyether triterpenes) were isolated from the red alga Laurencia v

248 ng artificially mixed samples of pentacyclic triterpenes which were screened for modulatory activitie

249 ning bioactive compounds, mainly phenols and triterpenes, which could be potentially isolated for fur

250 Celastrol, a friedelane-type triterpene with significant bioactivities, is specifical

251 a family of naturally occurring glycosylated triterpenes with a molecular weight > 2,000, exhibit ski

252 Triterpenes with B,C-ring-opened skeletons are extremely

253 Triterpenes with complex scaffold modifications are wide

254 es, finding ways to produce stereoisomers of triterpenes would be highly desirable to open new avenue