ライフサイエンスコーパス: tropism

1 IV-target cell fusion independently of viral tropism.

2 eric glycoprotein complex thus limiting cell tropism.

3 mbinant vectors with tailored properties and tropism.

4 echanism of plasmid-transferable animal host tropism.

5 e long-term expression, and selective tissue tropism.

6 ied CDC-exosomes demonstrate limited cardiac tropism.

7 le species, which permits a broad vertebrate tropism.

8 host range expansion or alteration in tissue tropism.

9 desirable safety profile and strong neuronal tropism.

10 the field of poxvirus binding and infection tropism.

11 s a short fiber and a so-far-unknown natural tropism.

12 sociations between IGVL gene usage and organ tropism.

13 ly to AAV vector transduction efficiency and tropism.

14 ng titer, transduction efficiency, or tissue tropism.

15 n mouse kidneys and its association with MSC tropism.

16 than a viral surface protein, determines IEC tropism.

17 menting its biogeography and putative tissue tropism.

18 al changes and evidence of SARS-CoV-2 tissue tropism.

19 mouse where pFUS was unable to increase MSC tropism.

20 n prion uptake could contribute to host cell tropism.

21 for metalloprotease use in strain-dependent tropism.

22 arly ubiquitous and display species-specific tropism.

23 ssues of humans and camels reflects MERS-CoV tropism.

24 cular integrity and modulating T cell tissue tropism.

25 n of rAAV produces unique patterns of tissue tropism.

26 ed molecular changes and inhibited renal MSC tropism.

27 ing of basic norovirus pathogenesis and cell tropism.

28 ues about disease pathophysiology and tissue tropism.

29 rculating antibodies and might affect tissue tropism.

30 rotein sequences of known viruses with human tropism.

31 31, and this can impact infectivity and cell tropism.

32 ld contribute to H5N1 virus pathogenesis and tropism.

33 c ECM proteins may be involved in metastatic tropism.

34 s allele affect peripheral prion replication/tropism.

35 g pathogens' ability to infect new hosts and tropism.

36 unknown consequences for virulence and host tropism.

37 immune evasion and regulation of viral cell tropism.

38 ates ABA in the regulation of their relevant tropisms.

39 rface of the culture with different cellular tropisms.

40 r, natural serotypes display a finite set of tropisms.

41 relevant to the CMVs which have broad tissue tropisms.

42 in spike from two IBV strains with different tropisms.

43 rated simultaneously 66 parameters: parasite tropism (7 parameters), organ and immune responses (loca

44 l experiments, another virus with retrograde tropism, a canine adenovirus expressing Cre recombinase,

45 dapted rhesus CMV vector with limited tissue tropism; a repaired vector with normal tropism elicited

46 of erythrocyte receptors defines target cell tropism, activating downstream events and resulting in t

47 cohort of 19 environmental lytic phages with tropism against E. faecalis, we found that these phages

48 ignature sequences in HIV-gp120 that predict tropism also predict PAH.

49 l RNA, we identify molecular determinants of tropism among circulating immune cells and examine tempo

50 rus envelope is a key determinant of species tropism and a primary target of the host humoral immune

51 ques, and investigated their effects on cell tropism and activation, especially their potential to re

52 t recapitulates key features of HIV-1 entry, tropism and antibody sensitivity.

53 to characterize HBoV determinants of tissue tropism and antigenicity in future experiments.

54 The tropism and characteristics of the brain-derived Envs we

55 essary for GPCMV epithelial cell/trophoblast tropism and congenital infection and is a potentially im

56 renal micro-environmental changes induce MSC tropism and could influence the therapeutic efficacy of

57 y viruses is a critical determinant of viral tropism and disease.

58 rated in the capsid displayed a reduced lung tropism and efficiently retargeted gene expression to va

59 mbinant herpes viral vectors with retrograde tropism and expressing different fluorophores were injec

60 dney tissue was harvested to determine viral tropism and for transcriptomic and proteomic analysis.

61 ocyte-priming underlies TGLI1-mediated brain tropism and found that TGLI1-positive CSCs strongly acti

62 ilarities in 19 genes associated with tissue tropism and immunomodulation.

63 the key determinants of host range and cell tropism and is subjected to the control of host innate a

64 t-reactive Th17 cells are imprinted with gut tropism and migrate to the inflamed gut.

65 e no RHV in vitro systems available to study tropism and molecular virology.

66 rus (HCV) displays a restricted host species tropism and only humans and chimpanzees are susceptible

67 tors and receptors are determinants of viral tropism and pathogenesis, understanding these virus-host

68 rtant for deeper understanding of SARS-CoV-2 tropism and pathogenesis.

69 is an important determinant of virus entry, tropism and pathogenesis.

70 teractions and mechanisms that determine its tropism and pathogenicity in the nervous system, which a

71 Unexpectedly, ZIKV exhibits a broad tropism and persistence in body tissues and fluids, whic

72 , NS1 and IFN-lambda interactions govern IEC tropism and persistence of MNoV.

73 labelling that obviates dependence on viral tropism and promoter penetration, particularly in non-ro

74 ubstantially illuminate the interesting ZIKV tropism and provide insights into pathogenesis.

75 in the RRV VP4 gene influences cholangiocyte tropism and reduces pathogenicity in mice.IMPORTANCE Rot

76 Both tuft-cell tropism and resistance to interferon-lambda (IFN-lambda)

77 and the degree of the virus' nervous tissue tropism and should be examined in future studies.

78 RNA viruses with poorly understood cellular tropism and species selectivity.

79 The broader tissue tropism and the increased post-transmission replication

80 important step toward understanding cellular tropism and the mechanisms of influenza virus infection

81 omical compartment they reside, their tissue tropism and the molecular and immunological processes re

82 CMV host receptor associated with epithelial tropism and the role of the adenylate cyclase/PKA/AKT-me

83 g systems have been modified to change their tropism and to display proteins or peptides, billions of

84 Viral tropism and transmission of herpesviruses are best studi

85 d during infection, but its in vivo cellular tropism and tropism determinants remain unidentified.

86 ites of EAV persistence, the viral host cell tropism and whether viral replication in carrier stallio

87 /or cellular factors involved in OvHV-2 cell tropism and will advance investigation of cellular facto

88 t influenza A virus haemagglutinin means the tropism and zoonotic potential of these viruses has not

89 ucture, yet they present with diverse tissue tropisms and disease presentations.

90 serve critical functions in cell and tissue tropism, and are often targeted by the neutralizing anti

91 ence, but retained the CNS infectivity, cell tropism, and neuropathology of the parental virus.

92 the major determinant of host range, tissue tropism, and pathogenesis of coronaviruses.

93 at can be used to further study replication, tropism, and pathogenesis of IDV.IMPORTANCE Influenza D

94 ferences in host dietary nutrition, cellular tropism, and pathogenesis.

95 ms that drive high infectivity, broad tissue tropism, and severe pathology.

96 r understanding of ZIKV pathogenesis, tissue tropism, and the resulting pathology and discuss areas f

97 er-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of rese

98 ic CD4(+) lymphocytes acquire extracutaneous tropism, and with disease progression, they disseminate

99 ransmissibility, transmission routes, tissue tropisms, and host range.

100 Salmonella AB toxins, their cell and tissue tropisms, and the design for improved typhoid vaccines a

101 , but the cellular dynamics that direct this tropism are unknown.

102 ells, and displays a similar pattern of cell tropism as KoRV-A and GALV.

103 MCPyV oncogenic mechanism and host cellular tropism, as well as the molecular events occurring in th

104 Ct, at the whole-genome level and in tissue tropism-associated genes.

105 uman fetal brain tissues and that the tissue tropism broadens with the progression of gestation.

106 rotein did not alter virus (TC-PC177) tissue tropism but reduced the virulence of the highly virulent

107 viruses (HIV and SIV), irrespective of virus tropism, but not hepatitis C virus, adenovirus 5 (ADV5),

108 re, we elucidate the determinants for kidney tropism by studying interactions between the receptor-bi

109 We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associate

110 ising vector for gene therapy, but its broad tropism can be detrimental if the transgene being delive

111 udies we showed that corneal epithelial cell tropism can be predicted by the presence of a lysine or

112 ies, such as AAV capsid antibody evasion and tropism, can be coevolved by combining rational design a

113 s genome editing and evolution for microbial tropism changes and expands the scope of biological C1 c

114 tionary selection experiments, we found that tropism could be redirected to different miRNAs.

115 sful therapy, which indicates a preferential tropism-dependent provirus elimination in the immunocomp

116 have distinct, S-dependent organ and tissue tropisms despite using a common receptor, suggesting tha

117 ster cells and, thus, may serve as a species tropism determinant.

118 ection, but its in vivo cellular tropism and tropism determinants remain unidentified.

119 Here we asked if this tropism difference affects the MPyV-specific CD8 T cell

120 disease included having neural and/or renal tropism, direct contact or respiratory transmission, and

121 l for research on viral pathogenesis, tissue tropism, dissemination, and therapy.

122 Cellular tropism during persistent viral infection is commonly co

123 important determinants of dissemination and tropism during reovirus-induced disease.

124 e fully in line with this gradual loss of X4 tropism during therapy.

125 Replication kinetics, cell tropism, effect on tissue integrity, and cytokine secret

126 l as aspects of host genetics, age, cellular tropisms, elevated Th1 cytokines, and loss of surfactant

127 issue tropism; a repaired vector with normal tropism elicited conventional responses.

128 her known polyomaviruses concerning its cell tropism, entry receptor requirements, and infection kine

129 The absence of a significant tropism for any of the 3 genetically distinct bat ACE2 p

130 pstein-Barr virus (EBV) has a well-described tropism for B cells and epithelial cells.

131 EBV is a common gammaherpes virus with tropism for B lymphocytes and infection in immunocompete

132 M expression did not affect gammaherpesvirus tropism for B-1 B cells, B cell-specific ATM expression

133 an liver xenograft mouse model with expanded tropism for both murine and human hepatocytes.

134 ter lethargy and mortality, with an extended tropism for brain tissues in both ferret and mouse model

135 is in a wide variety of mammals, with strong tropism for cattle and eventually humans.

136 nic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, af

137 udovirus and live virus to demonstrate viral tropism for choroid plexus epithelial cells but little t

138 n-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8

139 MYXV tropism for human cancer cells is largely mediated by in

140 al surface loops that simultaneously display tropism for human hepatocytes, increased gene transfer e

141 (PCR) analysis, but tissue location and cell tropism for KSHV infection has not been established.

142 glycoprotein of SARS-CoV-2 has a broad host tropism for mammalian ACE2 receptors, despite divergence

143 enhanced virulence in mice, although primary tropism for musculoskeletal tissues was maintained.

144 is an oncolytic picornavirus with selective tropism for neuroendocrine cancers.

145 ions confer species-specific recognition and tropism for particular host tissues and represent attrac

146 y serves as an important determinant of HCMV tropism for select subsets of hematopoietic cells.

147 ravital imaging of the spleen, we identify a tropism for Streptococcus pneumoniae in this organ media

148 Follistatin gene delivery intervention with tropism for striated muscle reduced the serum concentrat

149 ermore, we demonstrate that EAV has specific tropism for stromal cells (fibrocytes and possibly tissu

150 s (AAV) vectors has demonstrated appropriate tropism for target tissues, including the liver, heart a

151 ovarian cancer possesses specific metastatic tropism for the adipose-rich omentum, which has a pivota

152 ctions in young children and has a selective tropism for the apical surface of well-differentiated hu

153 Viral tropism for the decidua and placenta is then dependent o

154 of ovarian cancer metastasis and metastatic tropism for the omentum.

155 fection of female animals, C. burnetii shows tropism for the placenta and is associated with late-ter

156 Some of these pathogens also have a tropism for the reproductive system, thereby increasing

157 BCoV also has a dual tropism for the respiratory and gastrointestinal tracts.

158 PRCV has a tissue tropism for the upper and lower respiratory tracts and a

159 o and inside cells and displays preferential tropism for their progenitor cells.

160 sets of CPSs, we show that CPSs dictate host tropism for these phages and that expression of non-perm

161 and lower respiratory tracts and a cellular tropism for type 1 and 2 pneumocytes in lung but is gene

162 P(C) also failed to infect TgEq but retained tropism for wild-type mice.

163 ) , efforts to define in vivo norovirus cell tropism have generated conflicting results.

164 irus capsids, which display different tissue tropisms, have features in common with other parvoviruse

165 ope and plays key roles in LASV growth, cell tropism, host range, and pathogenicity.

166 nalyses, this study suggests that the tissue tropisms (i.e., in swine upper respiratory tracts) of av

167 ir natural hosts have provided insights into tropism, identifying the cells and tissues that support

168 tested, roles for NSP1-1 in RVB host species tropism, immune evasion, and pathogenesis.

169 yet untested roles for NSP1-1 in RVB species tropism, immune evasion, and pathogenesis.IMPORTANCE Whi

170 eractions that underlie IAV pathogenesis and tropism.IMPORTANCE Many zoonotic avian influenza A virus

171 not been tested for their virulence or organ tropism in ferrets.

172 urthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogen

173 To identify host factors relevant for MYXV tropism in human cancer cells, we performed a small inte

174 To investigate IAV tropism in human cells, we evaluated the replication of

175 Mouse papillomavirus has shown broad tissue tropism in nude mice.

176 e analyses to date of in vivo norovirus cell tropism in orally inoculated, immunocompetent hosts at t

177 HCMV and POka VZV strains to evaluate virus tropism in skin organ culture (SOC) and skin xenograft m

178 ific transcriptional responses indicative of tropism in the coordination of host's immune tissue resp

179 uorescent protein (ZsG), we visualized virus tropism in the Syrian hamster model.

180 d by arthropod vectors with a broad cellular tropism in vitro as well as in vivo Both AKAV and SBV ca

181 Our findings support a model for GAS skin tropism in which GAS generates an anoxic niche to evade

182 e results suggest that SARS-CoV-2 has kidney tropism, including the ability to replicate in kidney ce

183 dge in vivo and in vitro studies of cellular tropism, infectivity, and pathogenesis of influenza viru

184 may not explain all aspects of DBA erythroid tropism, involvement of GATA1/HSP70 and globin/heme imba

185 ends on a number of factors, of which tissue tropism is among the most important.

186 For many viruses, tissue tropism is determined by the availability of virus recep

187 EBV tropism is dictated by gp42 levels in the virion, as it

188 VSV tumor tropism is generally dependent on the permissiveness of

189 Tissue and cellular tropism is one key to understanding the pathogenesis of

190 minantly in the lung(2,4); the same receptor tropism is thought to have determined the pathogenicity-

191 The mechanism of strain-specific cell tropism is unknown.

192 of selective factors, except for coreceptor tropism, is consistent with others' findings in male-to-

193 GPs in osmosensing or gravisensing and other tropisms, leading us yet further towards the Holy Grail

194 pi)mutagens that, thanks to marked chromatin tropisms, limit the mutation load and increase the poten

195 Recent work led us to hypothesize that this tropism may reflect pathogenic interactions between RAGE

196 Although this metastatic tropism may reflect the mechanical trapping of circulati

197 on of RFO utilization to pneumococcal tissue tropism may, in fact, be due to the essential role the A

198 d capsid holds the promise of in vivo vector tropism modification and targeting.

199 vitro systems will be useful for studies of tropism, molecular virology, and characterization of vir

200 [ATRU-4] [EMPA-TROPISM]; NCT03485222).

201 presented neither the characteristic in vivo tropism nor symptoms.

202 A strong tropism of A. nasoniae to the N. vitripennis ovipositor

203 of these subjects involved the study of cell tropism of circulating virus, evidence for HIV superinfe

204 O locus genes have been linked to the tissue tropism of clinical pneumococcal isolates.

205 aspects of the metastatic cascade and organ tropism of disseminating cancer cells.

206 recise identification of tissue and cellular tropism of EAV is critical for understanding the molecul

207 The tropism of EBV for B cells and epithelial cell infection

208 are essential to understand the highly tuned tropism of EBV for epithelial cells and B lymphocytes an

209 Analysis of the tissue tropism of GPgV revealed that the spleen and thymus were

210 The restricted host tropism of hepatitis C virus (HCV) remains incompletely

211 ung, in line with the diverse natural tissue tropism of HIV.

212 The strict tropism of HPV requires the use of animal papillomavirus

213 We evaluated the infection and tropism of human and avian H9 influenza virus in the hum

214 terminants for the extended nephropathogenic tropism of IBV-QX.

215 parasite burden, NO production, or host cell tropism of L. major during the acute or persistent phase

216 F-component contributes to the observed host tropism of LukPQ, thereby challenging the current paradi

217 ravasation, and when PAK1 is depleted, brain tropism of metastatic breast cancer cells is significant

218 at LXRalpha expression dictates the cellular tropism of MHV68 in the peritoneal cavity.

219 synthesis and likely involves changes in the tropism of MHV68 in the peritoneal cavity.IMPORTANCE Liv

220 Here, we investigate the cellular tropism of norovirus in specimens from four immunocompro

221 The cellular tropism of noroviruses in immune-competent hosts remains

222 y positionally homologous genes for the cell tropism of other gammaherpesviruses.IMPORTANCE Elucidati

223 However, the selective tropism of P vivax for transferrin receptor (CD71)-posit

224 on but can alter the macaque/human host cell tropism of P. knowlesi.

225 The apparently broad tropism of SARS-CoV-2 at the point of viral entry confir

226 in typical sCJDMM(V)1 suggests that the PNS tropism of sCJD prions is strain dependent.

227 particles (AgNPs) with PL3 peptide increased tropism of systemic nanoparticles towards glioblastoma (

228 across virus RNA genome, indicating a clear tropism of the encapsidated RNA genome.

229 The tropism of the original H9N2:pH1N1 (P0) virus was restri

230 to study due to the relatively strict human tropism of the virus and the paucity of tractable experi

231 ncrease the replicative ability and/or organ tropism of the virus; overall, however, these viruses di

232 f the bat H18N11 influenza A virus, enabling tropism of the viruses in a potentially broad range of v

233 In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 di

234 isease progression, viral spread, and tissue tropism of these viruses.

235 locus, to be major influences on the extreme tropism of this carcinogen.

236 erminant governing the host range and tissue tropism of this zoonotic pathogen.

237 the principles underlying this RAS mutation tropism of urethane, we adapted an error-corrected, high

238 The current study aimed at assessing the tropism of viral integrates in patients' blood during fu

239 Finally, we use host tropisms of these phages to identify alleles of phage st

240 The intrusion induces "preferential tropism" of roots by first generating a humidity gradien

241 As a consequence, conventionally described tropisms omit cell types that undergo transient transduc

242 f this critical role of K8.1A in KSHV B cell tropism opens promising new avenues to unravel the compl

243 ated mortality was not due to expanded viral tropism or increased replication.

244 1A is a critical determinant for KSHV B cell tropism parallels the importance of proteins encoded by

245 , which might influence variability in virus tropism, pathogenesis and transmission route.

246 to characterize determinants of host/tissue tropism, pathogenicity, and antigenicity for the develop

247 at are functionally important in host/tissue tropism, pathogenicity, and antigenicity in other parvov

248 strains of HCMV generally exhibit restricted tropism, produce high levels of cell-free virus, and dev

249 an constrain viral replication, limit tissue tropism, reduce pathogenicity, and inhibit viral transmi

250 desirable properties for gene therapy (e.g., tropism, reduced immunogenicity, and higher potency) req

251 Plant tropism refers to the directed movement of an organ or o

252 ome aspects of virus pathogenesis and tissue tropism remain unclear.

253 nderstanding of the factors that govern host tropism remains incompletely understood for most pathoge

254 echanisms behind this subtype-specific organ-tropism remains largely elusive.

255 the biological basis for such site-specific tropism remains largely unresolved.

256 This study sheds light on EBOV tropism, replication dynamics, and elicited immune respo

257 Analysis of viral tropism revealed that CHIKV RNA was present preferential

258 Because of that, the pathogenesis, cellular tropism, route of transmission, biology, and epidemiolog

259 However, the precise host cell tropism(s) of MCPyV remains unclear: MCPyV is able to re

260 d mortality rates along with extended tissue tropism seen in chickens.

261 duals after loss of control, suggesting that tropism shift might also contribute to disease progressi

262 chea, suggesting that it has a broader organ tropism than the wild-type virus.

263 nd tick cells may reflect host-specific cell tropism that evolved during pathogen life cycle.

264 is highly transmissible with a broad tissue tropism that is likely perpetuating the pandemic.

265 f EV71 infection in mice identified areas of tropism that would have been missed by traditional metho

266 ed a wide range of neuronal and non-neuronal tropism, the infection rate was highest in intermediate

267 e to reduce toxicity and increase hepatocyte tropism; their effects were studied in mouse models of l

268 (TF) or primary HIV-1 isolates, such as CCR5 tropism, tier 2 neutralization resistance, and native tr

269 t to prostate cancer (PCa), where metastatic-tropism to bone predominates over other tissue types.

270 we show that typhoid toxin displays in vivo tropism to cells expressing multiantennal glycoprotein r

271 ted local chemoattractants and increased MSC tropism to CLI muscle.

272 B19 has a strong tropism to erythroid progenitor cells and is able to cau

273 ically, results are mixed partly because MSC tropism to kidneys is minimal following infusion.

274 Plants can acclimate by using tropisms to link the direction of growth to environmenta

275 nvestigated on account of their preferential tropism toward their parental cells.

276 roduce disseminated infections and the viral tropism towards epithelial cells.

277 Additionally, AAVrh10 has tropism towards sensory neurons in skeletal tissue, such

278 t need to comprehensively improve AAV tissue tropism, transduction efficiency, and antibody evasion.

279 try receptor is key to understand SARS-CoV-2 tropism, transmission and pathogenesis.

280 tool; however, it is still limited by viral tropism, uptake and clearance by the liver, and most imp

281 y optimizing the transgene cassette), vector tropism (using capsid engineering) and the ability of th

282 ch, with an emphasis on transmission, tissue tropism, viral pathogenesis, and immune antagonism.

283 Preliminary evidence for regional tropism was also seen, with formation of microtubules an

284 Tropism was further established by in vitro infection of

285 No evidence of tissue tropism was observed, and there was no apparent selectiv

286 ship between coagulopathy and hepatocellular tropism, we compared infection and disease in Fah (-/-),

287 mmunologic mechanism responsible for uterine tropism, we explored the role of regulatory T cells (Tre

288 iral life cycle and in determination of cell tropism, we generated and characterized a mutant KSHV in

289 eceptors are important determinants of viral tropism, we set out to map the CV-A24 receptor repertoir

290 instructive cues responsible for this unique tropism were previously unknown.

291 (HAdV-5) vectors have predominantly hepatic tropism when delivered intravascularly, resulting in imm

292 asive features and alterations in metastatic tropism when xenografted into mice.

293 ome serotypes of AAV are known to have nerve tropism, whether AAV can distribute to sensory nerves th

294 IKV displays broad cell, tissue, and species tropism, which may correlate with the attachment factors

295 lserine might also play active roles in zika tropism, which offers a potential explanation for the va

296 Further understanding of the biological tropism with cells and proteins and the newer generation

297 ective and robust lung endothelial cell (EC) tropism with minimal vector expression throughout many o

298 ) of AAV1 and AAVrh.10 profoundly influences tropism, with altered SIA interactions playing a partial

299 uses SARS-CoV and RaTG13 identified distinct tropisms, with the 2 human viruses being more closely al

300 17beta-estradiol (E2) has broad tropism within the CNS, targeting and inducing beneficia