ライフサイエンスコーパス: tropomyosin

1 spanning seven monomers (i.e. the length of tropomyosin).

2 phil secretory responses to rPen a 1 (shrimp tropomyosin).

3 1 (pollackparvalbumin) and rPen a 1 (shrimp tropomyosin).

4 myocyte sarcomeric proteins, including alpha-tropomyosin.

5 ut uniquely onto one location of actin-bound tropomyosin.

6 ue-to-residue interactions between actin and tropomyosin.

7 e WT linker runs alongside the C terminus of tropomyosin.

8 ow calcium levels to enhance the movement of tropomyosin.

9 n reducing allergic responses towards shrimp tropomyosin.

10 ly site of interaction between leiomodin and tropomyosin.

11 ith the high, 20 nM K(d) binding of TnT onto tropomyosin.

12 ain the uniform, regulatory translocation of tropomyosin.

13 omodin and the N-terminus of striated muscle tropomyosin.

14 d that heterozygous sequence variants in the TROPOMYOSIN 1 (TPM1) and VINCULIN (VCL) genes cose-grega

15 ne encoding the actin cytoskeletal regulator tropomyosin 4 (TPM4) exert an effect on the count and vo

16 2 (GEF-H1, ARHGEF2) and MRTF-A target genes tropomyosin 4.2 (TPM4), vinculin (VCL), and nonmuscle my

17 hosphate isomerase (TPI; 19%-34%) in raw and tropomyosin (6%-32%) in heated extracts.

18 tting low-energy cost regulatory movement of tropomyosin across the filament during muscle activation

19 Here, we show that tropomyosins act as negative regulators of myosin stack

20 r tropomyosin-tropomyosin binding and weaker tropomyosin-actin binding.

21 combined local positive charge, diminishing tropomyosin-actin interaction and facilitating regulator

22 Here, the D292V mutation may predispose tropomyosin-actin positioning to a myosin-blocking state

23 Compelling atomic models of troponin-tropomyosin-actin were published for both apo- and Ca(2+

24 Thus, tropomyosin acts as a check on alpha-actinin to achieve

25 opomyosin, on thin filaments, and conversely tropomyosin affects myosin binding to actin.

26 ed the strongest IgE reactivity to collagen, tropomyosin, aldolase A or beta-enolase but not parvalbu

27 ies detecting 4 fish allergens (parvalbumin, tropomyosin, aldolase and collagen).

28 dimensional grids covering end-to-end bonded tropomyosin alone or tropomyosin on F-actin.

29 ading the actin more substantially than does tropomyosin alone.

30 further identified the target protein as the tropomyosin alpha-4 chain (TPM4) by two-dimensional poly

31 in contractile regulation by diminishing its tropomyosin-anchoring effects, potentially serving as th

32 ate the molecular interaction energy between tropomyosin and actin surface using Brownian dynamics si

33 r this, we found, is the competition between tropomyosin and alpha-actinin for binding actin.

34 olecular interactions now identified between tropomyosin and both actin and myosin.

35 the formation of a selective complex between tropomyosin and immobilized aptamerTROP probe on the sur

36 in but increased strongly the flexibility of tropomyosin and kept its strands near the inner domain o

37 ution has not proven sufficient to determine tropomyosin and myosin contacts at an atomic-level and t

38 Sequence similarities with tropomyosin and myosin from mollusks were detected.

39 een used to define regulatory interaction of tropomyosin and myosin on actin at a structural level.

40 obility and spatial rearrangements of actin, tropomyosin and the myosin heads at different stages of

41 m tropomyosin in under 100 ns, whereas actin-tropomyosin and TnT1 models themselves remain intact.

42 lament is twisted with a larger radius, that tropomyosin and troponin behavior is altered, and that t

43 Ca(2+), or adding excess regulatory proteins tropomyosin and troponin, shifted the relative density o

44 on of dectin-1 as a key player in allergy to tropomyosins and the formyl peptide receptor 3 in allerg

45 IgE-binding to fish tropomyosins and TPIs was demonstrated for the first tim

46 izes molecular interactions of troponin with tropomyosin, and limits binding of PKA to local sarcomer

47 ituted with alpha1-actin, cardiac alphaalpha-tropomyosin, and masseter muscle beta-myosin complexes;

48 Whereas Tmods have alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2

49 no acids in length, and comprise alternating tropomyosin- and actin-binding sites (TMBS1, ABS1, TMBS2

50 -lobe of TnC binds specifically to actin and tropomyosin; and tropomyosin rotates partially away from

51 e mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) a

52 ix of TnT located at the overlap of adjacent tropomyosins are all in positions that would hinder stro

53 Tropomyosins are highly conserved proteins, an attribute

54 Among them, invertebrate tropomyosin, arginine kinase, myosin light chain, sarcop

55 Different variants or isoforms of tropomyosin, arginine or creatine kinase, glyceraldehyde

56 C-terminal TnT region approached Cys-190 of tropomyosin as actin filaments transitioned to the inact

57 blish and maintain interfacial contacts with tropomyosin as well as facilitate its movement over dist

58 and upregulated cardiac troponin (cTn)-T and tropomyosin, as well as cTn-I phosphorylation.

59 de therefore that an initial binding step in tropomyosin assembly onto actin involves interaction of

60 Elongated tropomyosin, associated with actin-subunits along the su

61 rminal region of cardiac troponin T (TnT), a tropomyosin-associated protein, is required for full TnT

62 The displacement of tropomyosin at the relaxed conditions had never been vis

63 oponin T (TnT), TNT1, independently promotes tropomyosin-based, steric inhibition of acto-myosin asso

64 d to identify troponin interactions on actin-tropomyosin because high-resolution experimentally deter

65 Thus, interpretation of mutation-based actin-tropomyosin binding anomalies leading to cardiomyopathie

66 In vitro, tropomyosin binding is masked by explosive tropomyosin p

67 Arguably, little molecular detail on early tropomyosin binding steps has been revealed since Wegner

68 tions that inhibit cofilin binding and allow tropomyosin binding to actin filaments, suggesting that

69 tropomyosin showed weakening of actin-mutant tropomyosin binding.

70 moving conserved, charged residues in TNT1's tropomyosin-binding domain impairs TnT's contribution to

71 l model of the binding interface between the tropomyosin-binding site of cardiac leiomodin and the N-

72 The arrangement of the N-terminal actin- and tropomyosin-binding sites in leiomodin is contradictory

73 lds that at relaxing (low-Ca(2+)) conditions tropomyosin blocks myosin binding sites on F-actin, wher

74 TnT1 docked to either side of isolated tropomyosin but uniquely onto one location of actin-boun

75 hich is regulated through a translocation of tropomyosin by the troponin complex in response to Ca(2+

76 Thus, we also quantified the levels of tropomyosin by using enzyme-linked immunosorbent assay (

77 tural changes moved the linker closer to the tropomyosin C terminus, an effect that was more pronounc

78 olecules must be favorable enough to promote tropomyosin cable formation but not so tenacious that po

79 ta were used to build an atomic model of the tropomyosin cable that fits onto the actin filament betw

80 For example, tropomyosin cable wrapping around actin of thin filament

81 zimuthally distinct regulatory positions for tropomyosin cables along thin filaments on actin dominat

82 to rebuild models of seamless and continuous tropomyosin cables over the F-actin substrate, which wer

83 erevisiae proteins (actin, formin, profilin, tropomyosin, capping protein, cofilin, and AIP1) are suf

84 Deletion of Glu139 in beta-tropomyosin caused by a point mutation in TPM2 gene is a

85 Adf1 enhances their activities, and prevents tropomyosin Cdc8's association with actin patches.

86 By focusing on the stabilizing protein tropomyosin Cdc8, bundling protein fimbrin Fim1, and sev

87 , we provide evidence that the fission yeast tropomyosin, Cdc8, is regulated by phosphorylation of a

88 including well known proteins such as actin, tropomyosin, CDK2, and alpha-synuclein (alphaSyn).

89 filamentous beta-actin with these different tropomyosin cofilaments affects the actin-mediated activ

90 The tropomyosin coil with flexible overlap regions between a

91 The sarcomeric troponin-tropomyosin complex is a critical mediator of excitation

92 structural data indicate that the leiomodin/tropomyosin complex only forms at the pointed end of thi

93 troponin T's N terminus to the actin-mutant tropomyosin complex was also weakened.

94 Here, we report the properties of actomyosin-tropomyosin complexes containing filamentous beta-actin,

95 y the movement of end-to-end-linked troponin-tropomyosin complexes over the thin filament surface, wh

96 Tropomyosins comprise a large family of actin-binding pr

97 es, is capable of tracking the events of the tropomyosin conformational changes as it moves over the

98 The antiparallel interaction with tropomyosin contained abundant salt bridges and intimate

99 Additionally, little is known about tropomyosin contents in crabs consumed in Taiwan.

100 measurements showed that the presence of M8R tropomyosin decreased calcium sensitivity and thin filam

101 has significant implications for perturbing tropomyosin-dependent actin filament function in the con

102 energy measurements strongly favor this TnT1-tropomyosin design over previously proposed models.

103 oelectrochemical (PEC) aptasensor for shrimp tropomyosin determination was fabricated by using graphi

104 Tropomyosins displayed different melting temperatures, w

105 ch is significantly enhanced at high Ca(2+), tropomyosin does not block myosin binding sites on F-act

106 performed here demonstrates that a midpiece tropomyosin domain is essential for normal actin-tropomy

107 Nucleation of a growing tropomyosin domain proceeds with high probability as soo

108 a more detailed molecular connection between tropomyosin dynamics, the trompomyosin-actin interaction

109 ces actin flexibility and distorts the actin-tropomyosin electrostatic energy landscape that, in musc

110 modin mutant that is unable to interact with tropomyosin fails to displace tropomodulin at thin filam

111 The tropomyosin family of proteins form end-to-end polymers

112 d here provides molecular insight into actin-tropomyosin filament formation and the role of tropomyos

113 l for its role in the stabilization of actin-tropomyosin filaments in cells.

114 les and that Tmod-dependent capping of actin-tropomyosin filaments is critical for the regulation of

115 f Tmods shifts the balance from linear actin-tropomyosin filaments to Arp2/3 complex-nucleated branch

116 brils, in non-muscle cells, Tmods bind actin-tropomyosin filaments to protect them from depolymerizin

117 us depletion results in disassembly of actin-tropomyosin filaments, loss of force-generating stress f

118 Acrylodan-tropomyosin fluorescence changes and S1-actin binding ki

119 hereas myosin-dependent motility of troponin/tropomyosin-free D292V F-actin is normal, motility is dr

120 aracteristic of relaxed muscle, troponin and tropomyosin hinder strong myosin-actin binding in severa

121 opomyosin models show the mutation localizes tropomyosin in a blocked-state position on actin defined

122 sor was used for the determination of shrimp tropomyosin in the concentration range of 1-400ngmL(-1)

123 nt in their model partially dissociates from tropomyosin in under 100 ns, whereas actin-tropomyosin a

124 opomyosin filament formation and the role of tropomyosins in regulating actin filament dynamics.

125 Tropomyosins, in addition to parvalbumins, should be con

126 omyosin domain is essential for normal actin-tropomyosin interaction and that this interaction is str

127 e and conquer" protocol to investigate actin-tropomyosin interactions at an atomistic level.

128 e acto-myosin activity by optimizing F-actin-tropomyosin interfacial contacts and by binding to actin

129 Tropomyosin is a coiled-coil actin binding protein key t

130 eriments reveal that Tmod's interaction with tropomyosin is essential for its role in the stabilizati

131 are recognized as crustacean allergens, and tropomyosin is known to be the major one.

132 at either relaxing or activating conditions tropomyosin is not constrained in one structural state,

133 In muscle cells, tropomyosin is subject to calcium regulation, but its re

134 th flexible overlap regions between adjacent tropomyosins is represented in the model as a system of

135 ved the binding of the fluorescently labeled tropomyosin isoform Tpm1.8 to unlabeled actin filaments

136 cle myosin-2B (NM-2B) constructs, and either tropomyosin isoform Tpm1.8cy (b.-.b.d), Tpm1.12br (b.-.b

137 wn how the dynamic association with specific tropomyosin isoforms generates actin filament population

138 Knockdown of any or all tropomyosin isoforms in rat embryonic fibroblasts result

139 rm depression is postsynaptically expressed, tropomyosin kinase B (TrkB) receptor-mediated, and augme

140 ies led us to hypothesize that activation of tropomyosin kinase B (TrkB)-phospholipase-C-gamma-1 (PLC

141 tes, and subsequent activation of tumor cell tropomyosin kinase receptor B (TrkB), is identified.

142 Our results showed tropomyosin levels varied depending on crab species.

143 Accordingly, tropomyosin "ligand" segments were rotated and translate

144 ecule, which alter the azimuthal position of tropomyosin, likely disrupting the mutant thin filament

145 The TnT1-tropomyosin linkage yields well-defined molecular crevic

146 Energy landscapes based on F-actin-tropomyosin models show the mutation localizes tropomyos

147 blish that leiomodin interacts with only one tropomyosin molecule, and this is the only site of inter

148 s extending toward the central region of the tropomyosin molecule, which alter the azimuthal position

149 Likewise, head-to-tail association of tropomyosin molecules must be favorable enough to promot

150 s simulations of single wild-type and mutant tropomyosin molecules on F-actin, is not complicated by

151 Tropomyosin molecules overlap via tropomyosin-tropomyosi

152 propensity to inhibit myosin-driven, F-actin-tropomyosin motility were evaluated.

153 the overlap domain, Ca(2+) causes much less tropomyosin movement, so a more inhibitory orientation p

154 pomyosin-troponin complex and Ca(2+)-induced tropomyosin movements accompanied by structural transiti

155 raction is strictly conserved in a number of tropomyosin mutant species.

156 ance energy transfer to study effects of the tropomyosin mutations on the structure and kinetics of t

157 ed hydrophobic networks joining TnT1 and the tropomyosin N-/C-terminal overlapping domain.

158 the pointed end of thin filaments, where the tropomyosin N-terminus is not blocked by an adjacent tro

159 The contacts between S1 and tropomyosin on actin appear to compete with and displace

160 ruction have defined regulatory positions of tropomyosin on actin but have not, as yet, succeeded at

161 as to be sufficiently strong to localize the tropomyosin on actin, yet not so tight that regulatory m

162 ering end-to-end bonded tropomyosin alone or tropomyosin on F-actin.

163 splace ones normally found between actin and tropomyosin on myosin-free thin filaments in relaxed mus

164 ions to reveal the azimuthal movement of the tropomyosin on the surface of the native cardiac TF upon

165 ates interactions of the regulatory protein, tropomyosin, on thin filaments, and conversely tropomyos

166 The initial binding of tropomyosin onto actin filaments and then its polymeriza

167 zed TnT1 helical domains and either isolated tropomyosin or actin-tropomyosin yet avoided docking TnT

168 The consequent movement of tropomyosin permits myosin binding to actin, generating

169 molecules on F-actin, is not complicated by tropomyosin polymerization at all.

170 , tropomyosin binding is masked by explosive tropomyosin polymerization once cable formation is initi

171 ain impairs TnT's contribution to inhibitory tropomyosin positioning and relaxation.

172 We show that two of these tropomyosin positions restrain actomyosin interactions,

173 ity for regions highly conserved in all four tropomyosins, proliferated weakly to Der p 10, but did n

174 sin N-terminus is not blocked by an adjacent tropomyosin protomer.

175 o identify binding specificity of individual tropomyosin pseudorepeat segments over the actin surface

176 ic residues on successive 39-42 residue-long tropomyosin pseudorepeats.

177 Entrectinib is a potent inhibitor of tropomyosin receptor kinase (TRK) A, B, and C, which has

178 s estimated that around ~20 000 new cases of tropomyosin receptor kinase (TRK) cancers are diagnosed,

179 dy aimed to test the hypothesis that the NGF-tropomyosin receptor kinase A (TrkA) (high-affinity NGF

180 ndogenous expression of Ngf and its receptor tropomyosin receptor kinase A (TrkA) during tibial fract

181 bition of nerve growth factor (NGF)-mediated tropomyosin receptor kinase A (TrkA) signalling, and tre

182 Anti-tropomyosin receptor kinase A (TrkA)-targeted treatment

183 ment H-chain 200, I-B(4) isolectin (IB4), or tropomyosin receptor kinase A expression and assessed fo

184 Tropomyosin receptor kinase A was expressed on MCC tumor

185 Tropomyosin receptor kinase A was found in all 36 evalua

186 ve growth factor-responsive (NGF-responsive) tropomyosin receptor kinase A-expressing (TrKa-expressin

187 IB4(+) and tropomyosin receptor kinase A-positive neurons showed a

188 We have a mouse line with Tropomyosin receptor kinase B (TrkB) receptor deletion f

189 brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) receptor.

190 Furthermore, the BDNF receptor tropomyosin receptor kinase B (TrkB) was enriched on mes

191 Tropomyosin receptor kinase B (TrkB), encoded NTRK2, is

192 actor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB), have important rol

193 rived neurotrophic factor, via activation of tropomyosin receptor kinase B (TrkB), plays a critical r

194 brain-derived neurotrophic factor (BDNF) and Tropomyosin receptor kinase B (TrkB).

195 iated transactivation of beta1-integrins and tropomyosin receptor kinase B (trkB).

196 that was dependent on BDNF and its receptor tropomyosin receptor kinase B (TrkB).

197 At later developmental stages, CaSR enhances tropomyosin receptor kinase B (TrkB)/BDNF-mediated neuri

198 lamine-induced behavioral responses and BDNF-tropomyosin receptor kinase B signaling, suggesting that

199 y impaired brain-derived neurotrophic factor-tropomyosin receptor kinase B-dependent synaptic plastic

200 polamine rapidly stimulates BDNF release and tropomyosin receptor kinase B-extracellular signal-regul

201 aptic density protein 95, NMDA receptor, and tropomyosin receptor kinase B.

202 Tropomyosin receptor kinase C (TrkC) is involved in cell

203 Tropomyosin receptor kinase C (TrkC) targeted ligand-pho

204 show that BDNF signaling through the cognate tropomyosin receptor kinase type B (trkB) receptor occur

205 male rats activates signaling downstream of tropomyosin receptor kinase type B (trkB), namely, phosp

206 We combined catalytic domains of Trk (tropomyosin receptor kinase) family of RTKs, naturally a

207 ) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neurona

208 y investigates the role of neurotrophins and Tropomyosin receptor kinases (Trk) in the development of

209 Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are acti

210 Tropomyosin receptor kinases (TRKs) are promising cancer

211 The proto-oncogenes NTRK1/2/3 encode the tropomyosin receptor kinases TrkA/B/C which play pivotal

212 etic platforms to control three neurotrophic tropomyosin receptor kinases, TrkA, TrkB, and TrkC.

213 l and synaptic plasticity via activating the tropomyosin receptor kinases.

214 Tropomyosin-receptor kinases (TRKs) are essential for th

215 E analysis showed that the band intensity of tropomyosin reduced with the increase of processing temp

216 Tropomyosins regulate the dynamics and functions of the

217 Further, these tropomyosin-regulated mechanisms can be integrated to co

218 facilitate a molecular level elucidation of tropomyosin regulation of myosin interaction with actin

219 -HT treatment increases BDNF receptor, TrkB (tropomyosin related kinase B), levels in mouse primary c

220 though originally identified as an oncogene, Tropomyosin-related kinase A (TrkA) is linked to pain an

221 to bind to the nerve growth factor receptor, tropomyosin-related kinase A (TrkA), and to thereby exer

222 involving the nerve growth factor receptors (tropomyosin-related kinase A [TrkA]/neurotrophin recepto

223 he role of brain-derived neurotrophic factor-tropomyosin-related kinase B (BDNF-TrkB) signaling in th

224 y inflammation using 2 transgenic models: 1) tropomyosin-related kinase B (TrkB) conditional knockin

225 Several antidepressant drugs activate tropomyosin-related kinase B (TRKB) receptor, but it rem

226 v-1, MLRs, and MLR-localization of Cav-1 and tropomyosin-related kinase B receptor independent of age

227 otein 95, to enhance downstream signaling of tropomyosin-related kinase B, a receptor for BDNF, can i

228 K2, which encodes the transmembrane receptor tropomyosin-related kinase B, binds the brain-derived ne

229 matergic receptor expression is regulated by tropomyosin-related kinase receptor subtype B (TrkB) sig

230 the sympathetic nervous system, signals from tropomyosin-related kinase receptors (Trks) and p75 neur

231 TrkB.T1 is the only isoform of tropomyosin-related receptor kinase type B (trkB) recept

232 regulated through changes in the position of tropomyosin relative to the actin surface.

233 s specifically to actin and tropomyosin; and tropomyosin rotates partially away from myosin's binding

234 The mutation did not alter tropomyosin's affinity for actin but increased strongly

235 e R21H mutation causes a twofold decrease in tropomyosin's affinity for F-actin and affects leiomodin

236 standing of the structural basis of troponin-tropomyosin's Ca(2+)-triggered regulation of striated mu

237 ed the hypothesis that coupling of TNT1 with tropomyosin's end-to-end overlap region helps anchor tro

238 acts and by binding to actin, which restrict tropomyosin's movement to activating configurations.

239 associations are critical for propagation of tropomyosin's reconfiguration along the thin filament an

240 In conjunction with troponin, tropomyosin shifts to regulate actomyosin interactions.

241 Heat-shock cognate 70 (HSC-70) and tropomyosin showed IgE reactivity with 60% of the sera,

242 The co-sedimentation of actin and tropomyosin showed weakening of actin-mutant tropomyosin

243 e local dynamical displacement of individual tropomyosin strands in the center of a regulatory unit o

244 s regulated by the translocation of troponin-tropomyosin strands over the thin filament surface.

245 roponin is highly extended and contacts both tropomyosin strands, which lie on opposite sides of the

246 Here, we tested perturbations in tropomyosin structure, biochemistry, and function caused

247 idual interactions displayed by these mutant tropomyosin structures with actin mimic ones that occur

248 etween actin and tropomyosin, which position tropomyosin such that it impedes actomyosin associations

249 molecules, twisting and bending corrupts the tropomyosin superhelices as they "lose their grip" on F-

250 ents within cTFs, we proposed a mechanism of tropomyosin switching from different states that include

251 Tropomyosin T-cell cross-reactivity, unlike IgE cross-re

252 ctural effects of the mutation were found in tropomyosin that ultimately perturb its thin filament re

253 entify the immunodominant T cell epitopes of tropomyosin, the major shrimp allergen of Metapenaeus en

254 We investigated the differences between four tropomyosins-the major shrimp allergen Pen m 1 and the m

255 etween the structural stability of different tropomyosins, their endolysosomal degradation patterns,

256 nstrate that mutation-induced alterations in tropomyosin-thin filament interactions underlie the alte

257 These mutations are clustered in the tropomyosin (Tm) binding region of TnT, TNT1 (residues 8

258 o F-actin by the thin filament troponin (Tn)-tropomyosin (Tm) complex.

259 investigated the functional impact of alpha-tropomyosin (Tm) substituted with one (D137L) or two (D1

260 in a position to activate the TF by shifting tropomyosin (Tm) to the "open" structural state.

261 r the detection of the major shrimp allergen tropomyosin (TM) was developed.

262 treated mice with an HCM-linked mutation in tropomyosin (Tm-E180G) and nontransgenic littermates wit

263 pathy-linked mouse model expressing a mutant tropomyosin (Tm-E54K) for 3 months with either TRV120067

264 possibly due to incorporation of unorthodox tropomyosin-TnT crystal structures and complex FRET meas

265 cular interactions underlying the binding of tropomyosin to actin are still poorly understood.

266 utation lies near residues that help confine tropomyosin to an inhibitory position along thin filamen

267 sin's end-to-end overlap region helps anchor tropomyosin to an inhibitory position on F-actin, where

268 ereospecific but necessarily weak binding of tropomyosin to F-actin is required for effective thin fi

269 with atomic scale protein-protein docking of tropomyosin to the EM models.

270 is dramatically inhibited after addition of tropomyosin to the mutant actin.

271 econstruction of myosin-S1-decorated F-actin-tropomyosin together with atomic scale protein-protein d

272 Tropomyosin, together with the troponin complex, regulat

273 ectively, was increased, and the movement of tropomyosin towards the blocked position at low Ca(2+) w

274 n force in a process negatively regulated by tropomyosin (Tpm) 2.1.

275 tin filaments by five biologically prominent Tropomyosin (TPM) isoforms influences disassembly induce

276 Phosphorylation of the regulatory protein tropomyosin (Tpm) results in altered biochemical propert

277 Muscle contraction is governed by tropomyosin (Tpm) shifting azimuthally between three sta

278 orm critical electrostatic interactions with tropomyosin (Tpm) that promote its binding to filamentou

279 ia the regulatory proteins troponin (Tn) and tropomyosin (Tpm), which are associated with actin filam

280 Tropomyosins (Tpm) determine the functional capacity of

281 ressed this question in S. cerevisiae, where tropomyosins (Tpm1 and Tpm2), profilin (Pfy1), and formi

282 then generalized to account for the observed tropomyosin transitions between its regulatory stable st

283 ereas at activating (high-Ca(2+)) conditions tropomyosin translocation only partially exposes myosin

284 the head-to-tail junction, leading to weaker tropomyosin-tropomyosin binding and weaker tropomyosin-a

285 Tropomyosin molecules overlap via tropomyosin-tropomyosin head-to-tail associations, formi

286 rosophila TnT (TpnT-CD70) retains binding of tropomyosin, troponin I, and troponin C, indicating a pr

287 HS-AFM was used to directly visualize the tropomyosin-troponin complex and Ca(2+)-induced tropomyo

288 y access to atomic structures of actin-bound tropomyosin-troponin.

289 ore domain, the C-terminal third of TnI, and tropomyosin under the influence of a 64-residue helix of

290 Comparison of mutant and WT alpha-tropomyosin was carried out using in vitro motility assa

291 notably, decreased phosphorylation of alpha-tropomyosin was found to be associated with hPSC-cardiom

292 ignificant reduction in the allergenicity of tropomyosin was up to 75% when treated with microwave at

293 stics of sauropsid-specific beta-keratin and tropomyosin were detected in tissues containing remnant

294 a), which together span the entire length of tropomyosin, were weak secretagogues.

295 plementarity between the TnT tail (TnT1) and tropomyosin, which is difficult to reconcile with the hi

296 ent electrostatic contacts between actin and tropomyosin, which position tropomyosin such that it imp

297 may be a key mode of regulation of nonmuscle tropomyosins, which in fission yeast controls actin fila

298 Low-affinity interaction of tropomyosin with actin has to be sufficiently strong to

299 After the incubation of tropomyosin with TROP aptamer probe, the photocurrent si

300 lament, there is a large additional shift in tropomyosin, with molecular interactions now identified

301 ins and either isolated tropomyosin or actin-tropomyosin yet avoided docking TnT domains that lack kn