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1 to the permissivity of MT-4 cells to gp41 CT truncation.
2 essive pediatric DCM due to presumptive JPH2 truncation.
3 tes and risks in settings with censoring and truncation.
4 roportion of variants that predicted protein truncation.
5 optosis is less prominent, resulted in canal truncation.
6 nuates DNA charge transport, inhibits primer truncation.
7 Twitchin and projectin evolved later by truncation.
8 Cox regression analysis accounting for left truncation.
9 T-cell epitopes and contains a PE domain II truncation.
10 ations resulting in frame shift or premature truncation.
11 RAF) and a 13% prevalence of EGFR C-terminal truncation.
12 rst time an explanation for Marks decahedron truncation.
13 types were not observed in clones with LRRK2 truncation.
14 basis relative to cells not permissive to CT truncation.
15 nds of infection of HIV-1 encoding a gp41 CT truncation.
16 ring techniques such as sequence mutation or truncation.
17 ssociated genes are both sensitized to SRCAP truncations.
18 ducts, mixed disulfides, rearrangements, and truncations.
19 l, 81% of STs harbored kinase fusions and/or truncations.
20 60 cell lines with CRISPR/Cas9-mediated CD38 truncations.
21 as well as N-terminal extensions (NTEs) and truncations.
22 as result of mutation-rendered delta-catenin truncations.
23 h swapped ectodomain, 2) stepwise N-terminal truncations, 3) distinct constitutively active mutations
26 ies, it is important to understand how these truncations affect the organization of alphaS into fibri
28 identified an average of 23-24 missense and truncation alleles per gene, with at least one truncatio
32 and animals is associated with small RNA 3' truncation and 3' uridylation and thus relies on exonucl
33 ortance of their association in vivo, serial truncation and alanine scanning was performed on NKAP to
34 parison with other SSB folds and creation of truncation and amino acid substitution mutants, we provi
36 in wild and cultivated accessions show that truncation and deletion of tapetum and pollen developmen
37 sumptive recombination events for which gene truncation and identity have been examined.IMPORTANCE Ak
39 ce isoform of human Raf1 that causes protein truncation and loss of the C-terminal kinase domain (Raf
42 ow that the TDDOs create gene fusions and/or truncations and discuss their potential implications for
43 ind that Rca activity is highly sensitive to truncations and mutations in the conserved N terminus of
44 hat question, sequential cytoplasmic TbetaRI truncations and point mutations identified a targeting m
45 in, but combinatorial analyses for rdxA gene truncations and R16H mutations have utility for determin
46 mutant with constructs encoding RBD1 protein truncations and site-directed mutations demonstrated tha
47 's ability to tolerate many of these massive truncations and substitutions illustrates the overall mu
50 cting on AGO1-bound miRNAs to cause their 3' truncation, and the truncated species are uridylated and
51 non-native constructs involving mutations or truncations, and is challenged by membrane proteins and
52 sociated hypermutations, have limited genome truncations, and over one year show little indication of
53 y toxic properties imparted to alphasyn upon truncation; and 5) discuss pathways through which trunca
54 the increased levels of C-terminal alpha-syn truncations are because of the burden of aggregated alph
57 assumption that pathologies linked to KCNQ3 truncations arise from haplo-insufficiency should be rec
58 to-proline substitution at residue 559 and a truncation at residue 664 (SOSIP.664 trimers)(5,11-18).
59 psin mutants including a proximal C-terminus truncation (at residue 365) and proline mutation of this
61 entation by allowing MVs to be due to either truncation below the LOD or other technical reasons unre
62 genetic impact, we evaluated whether histone truncation by tryptase could have an impact on epigeneti
64 We analyzed a mouse model carrying a poly(A) truncation cassette inserted to prevent RNA transcripts
65 acterization of these mice revealed that the truncation caused a moderate myopathy phenotype reminisc
66 cyclase-activating proteins (GCAP), and RD3 truncation causes severe congenital blindness in humans
69 purified alpha-syn, we identified C-terminal truncations corresponding to amino acids 1-122 and 1-90
70 of our previous work, we propose that these truncations could originate from lysosomal activity attr
71 also found that many strains expressing ede1 truncations could support a normal rate of site initiati
85 on of Soluble Proteins by Random Incremental Truncation (ESPRIT) technique to identify discretely fol
86 on (14.2-21.4%) CRISPR/Cas9-induced specific truncation events, either from GhMYB25-like A DNA site o
88 CTT in eukaryotic translation, we tested how truncations, extensions and substitutions within the CTT
89 In contrast, a partial Ase1 carboxy-terminal truncation fails to form a stable midzone in late anapha
93 isoforms, their phosphorylation profile and truncation in colon biopsy specimens from 16 Crohn's dis
94 al dependence, whereas the exon 4-associated truncation in mE4M-B6 mice facilitated morphine toleranc
95 se assays demonstrated that the 7-amino acid truncation in NUAK2, a serine/threonine kinase, complete
96 several mutations with different degrees of truncation in the C-terminal region of NBD2 reveal the i
98 ion, Hic binds specifically hTSP-1; however, truncation in the N-terminal part of Hic decreases the b
99 increased expression of one gene and modest truncation in the primary protein structure of another.
101 ass of exonucleases responsible for miRNA 3' truncation in vivo and uncovers a mechanism of specifici
103 unequivocally show that C-terminal alpha-syn truncations in LBs are linked to Cts activities, promote
106 , we used CRISPR/Cas9 to generate homozygous truncations in the Z disk (TTN-Z(-/-)) and A-band (TTN-A
109 uR agonist, DHPG, did not result in B56alpha truncation, increased Arc synthesis and reduced levels o
112 ed ALMTs essential for Ma1 function; protein truncations into this conserved domain significantly low
113 ession-based signatures were preserved, with truncations, inversions, and translocations most conserv
115 eficient expression host and thus eliminates truncation issues associated with typical RF1-containing
116 reme genome damage in the form of chromosome truncations, large deletions, partial trisomy, and evide
117 sulted in a premature stop codon and protein truncation leading to complete loss of function and loss
120 vitro Mu transposition to generate a random truncation library and identify the minimal functional r
122 d progressive disease stages, and preventing truncation may be an effective preventative strategy aga
123 m defects in Mybphl mice support that MYBPHL truncations may increase risk for human arrhythmias and
124 the condition described here, MN1 C-terminal truncation (MCTT) syndrome, is not due to MN1 haploinsuf
125 orming activity of BRAF fusions results from truncation-mediated loss of inhibitory domains within th
126 4E, T269E, and S256E/T269E) and a C-terminal truncation mutant (DeltaP242) that lacked all phosphoryl
129 ontribute to the unique ability of a gp41 CT truncation mutant to spread in cultures of MT-4 cells.
130 t its familial adenomatous polyposis-related truncation mutant, prominently enhances HIV-1 production
133 rminal portion in the non-functional Orai1 N-truncation mutants formed new, inhibitory interactions w
135 using on PAK1 and PAK6, we used chimeras and truncation mutants to investigate their differences in l
141 haracterization of Q1412X-CFTR, a C-terminal truncation mutation of cystic fibrosis transmembrane con
142 eads to instability of its substrates and as truncation mutation of MRE11 lacking serines 688/689 lea
143 adult-onset cerebellar ataxia, and a de novo truncation mutation resulting in a dominant-negative eff
147 rdiac disorders indicated that subjects with truncation mutations had an earlier occurrence of cardia
150 ms phase-separated condensates in vitro, and truncation mutations in the intrinsically disordered reg
151 TEMENT We assessed the effects of tmc1/2a/2b truncation mutations on mechanoelectrical transduction (
152 whose members include some of the C-terminal truncation mutations such as Q1412X, is defined as decre
153 C-terminal region, we further characterized truncation mutations with different degrees of deletion
155 ds with ADHCAI and identified 3 novel FAM83H truncation mutations: p.His437*, p.Gln459*, and p.Glu610
156 tens to several hundreds of cells with CSF3R truncation mutations; therapeutic granulocyte colony-sti
158 proach allows numerical precision with large truncation numbers, and thus exploration of the spectral
161 termelon domestication, which results in the truncation of 45 amino acids and shifts the localization
163 l fail to reproduce data and how detrimental truncation of a pathway leads to detectable signatures i
164 calcium channel opening, and resulted in the truncation of a regulatory subunit of PP2A, B56alpha.
165 F-actin across Sertoli cell cytosol, causing truncation of actin microfilament, thereby failing to su
166 fic trait variation by, for example, causing truncation of age and size structure of populations, whe
168 merization barrier through posttranslational truncation of alpha-synuclein reverses the action of the
169 gms should operate under the assumption that truncation of alphasyn is likely occurring in both initi
172 tease generates a high-affinity IRES binding truncation of eIF4G that stimulates eIF4A duplex unwindi
176 e of the patients with homozygous C-terminal truncation of GLI1 demonstrated that the corresponding m
178 100 (encoding glycoprotein M) and a specific truncation of glycoprotein RL13, these did not explain t
182 le in determining fruit acidity and that the truncation of Ma1 to ma1 is genetically responsible for
184 ow fruit acidity is strongly associated with truncation of Ma1, an ortholog of ALUMINUM-ACTIVATED MAL
187 strated that for both H3N8 and H3N2 viruses, truncation of PA-X increased virus yields in MDCK cells
189 n leading to altered splicing and C-terminal truncation of phytoene synthase (PSY), a key enzyme in c
190 tions exhibit greater catalytic activity and truncation of product space towards higher-molecular-wei
192 n pressure, resulting in progressive loss or truncation of tas3 and chp1 genes in S. octosporus and S
195 dels; 2) provide mechanistic insights on how truncation of the amino and carboxyl regions of alphasyn
196 m of the SNARE protein SNAP25 with premature truncation of the C terminus and that were therefore par
198 ins 6 and 7 to N. gonorrhoeae increased with truncation of the heptose I (HepI) chain of LOS and decr
199 20) precluded viral replication, whereas the truncation of the last 10 amino acids from the pUL33 C t
200 duce the LRRK2 G2019S mutation, as well as a truncation of the LRRK2 kinase domain, into marmoset emb
201 facial morphology in Vax1 mutants, including truncation of the midface associated with reduced cell p
202 ption of TACI-mTOR interaction by rapamycin, truncation of the MyD88-binding domain of TACI, or B-cel
205 hosts was enhanced by codon optimization and truncation of the putatively autoregulatory N terminus o
207 nal cord regeneration in geckos represents a truncation of the restorative trajectory observed in som
208 ic activities will soon precipitate a double truncation of the size distribution of the world's verte
209 havior of CYP 19A1 was rather insensitive to truncation of the TM-helix, mutations in the TM-helix of
210 lection who carry a TPM4 variant that causes truncation of the TPM4 protein and segregates with macro
212 apped to the carboxyl acidic domain of TSPX, truncation of which renders TSPX to be stimulatory while
215 t evidence that disease-specific proteolytic truncations of alphasyn occur in Parkinson's disease, Le
216 tional channels on its own, large C-terminal truncations of KCNQ3 (including the KCNQ3-FS534 mutation
219 y catalyzes SUMOylation, we examined various truncations of PIASy for their ability to mediate SUMOyl
222 proteolytic processing resulting in various truncations of the highly charged and flexible carboxyl-
223 variants with up to 45- and 60-residue-long truncations of the N- and C-terminal helices of the gamm
224 t mutations at the phosphorylation sites and truncations of the N-terminal region highlighted reduced
225 In this study, we used structure-guided truncations of the PB2 subunit to show that a PB2 subuni
229 ntial role of RbpA, show the effects of RbpA truncations on transcription and cell physiology, and in
231 uncation alleles per gene, with at least one truncation or deleterious missense mutation in more than
235 atic activity in reconstituted systems after truncation or modification of the N-terminal sequence.
236 rc-binding motif of Kv1.5 through N-terminal truncation or mutagenesis abolished the mechanical stret
237 s to guide patient selection, including that truncation or point mutations in well-defined functional
243 nd more insoluble aggregates with N-terminal truncations predominating in the insoluble material and
246 ximately linear relation between the optimal truncation radius and the average distance of the networ
247 r it is driven largely by a reduction in the truncation radius of the disk(8,9) or by a reduction in
249 Sall4 deletion using TCre caused body/tail truncation, reminiscent of early depletion of NMPs, sugg
250 upported the conformational switch by serial truncation removing 22 (DeltaN22), 32 (DeltaN32), or 42
251 and mutagenesis analyses indicated that the truncation resulted from an internal translation initiat
252 pe mapping revealed enrichment of C-terminal truncations, resulting from CtsB, CtsL, and asparagine e
253 ect is not seen in Apc(1322T) mice whose Apc truncation retains partial function in regulating beta-c
256 ite (1102) surface was studied using crystal truncation rod (CTR) X-ray diffraction coupled with dens
258 ng in the insoluble material and C- terminal truncations segregating into the soluble aggregates.
259 ed xenografts and cell lines with C-terminal truncations showed increased cell surface Frizzled and W
263 We found different levels of C-terminal truncation, soluble protein aggregates, and glycation th
264 cosylation defect that results in N-terminal truncation stabilizes beta1ARs in a conformation that is
265 ification is sometimes assisted by a monomer truncation strategy for the internal functionalization o
267 ty in limbs undergoing PD duplication versus truncation, suggesting differences in patterning and ske
268 mic loop, which is increased upon C-terminus truncation, supporting the idea that these two regions a
269 microtubule-binding repeat domains (3R, 4R), truncation (Tau-C3) or conformation (GT-7, GT-38) and th
271 isoforms, Orai3 tolerates larger N-terminal truncations than Orai1 in retaining store-operated activ
272 runcation of alphasyn, particularly carboxyl truncation that can be augmented by dysfunctional proteo
273 ral and dynamical changes resulting from the truncation that could lead to aggregation and toxicity,
274 tein by removing exon 2 (E2-KO) or an M-band truncation that eliminates proper sarcomeric integration
277 ding, insertions and deletions (indels), and truncations, to unmodified bases in the same contexts.
279 of dilated cardiomyopathy (DCM) due to titin truncation (TTNtv) may help guide patient stratification
280 rly applied proteinase K (PK), an N-terminal truncation up to amino acid residue 209 altered the conf
282 ient was found to have a unique heterozygous truncation variant in suppressor of cytokine signaling 1
283 nalysis of hiPSC-CMs carrying a heterozygous truncation variant in the myosin-binding protein C ( MYB
284 Previously, we identified an N-terminal truncation variant of ASPP2 (t-ASPP2) as a driver of ILC
285 r amyloid assembly of the protein DeltaN6, a truncation variant of human beta(2)-microglobulin (beta(
286 ion, oxidation, chlorination and polypeptide truncation variants and a previously unreported low-abun
287 ture of the IFN-beta-IFNAR1 complex, we used truncation variants and site-directed mutagenesis to inv
291 role in the differential pathology of titin truncation versus deficiency of the full-length protein.
292 elapse, but neither AAP nor the asparaginase truncation was associated with increased risk of relapse
296 Asn391-sites displayed elevated glycan hyper-truncation, which correlated with higher enzyme activiti
300 of MT-4 T-cell line permissivity to gp41 CT truncation would provide key insights into the role of t