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1 metry as N1,N8-bis-(glutathionyl)spermidine (trypanothione).
2 r than the parasite bisglutathione analogue, trypanothione.
3 ermidine and the spermidine-containing thiol trypanothione.
4 uction in catalytic efficiency compared with trypanothione.
5 njugate of glutathione and spermidine termed trypanothione.
6 thesis of N1,N8-bis(glutathionyl)spermidine (trypanothione), a metabolite unique to trypanosomatids t
7 nzyme activity is linked to the reduction of trypanothione, a parasite-specific thiol, by glutathione
8                            Concentrations of trypanothione, a spermidine conjugate, were also reduced
9                                          The trypanothione adduct of arsenite was effectively transpo
10  spermidine to form a unique cofactor termed trypanothione, an essential cofactor for the maintenance
11 t tetracycline induction resulted in loss of trypanothione and accumulation of glutathione, followed
12 red for synthesis of a novel cofactor called trypanothione and for deoxyhypusine modification of euka
13 sociated with an increase in reduced thiols (trypanothione and glutathione) or increased activity of
14 type H(+)-ATPases to pentamidine action, and trypanothione and several putative kinases to melarsopro
15                                  It includes trypanothione and trypanothione reductase (TryR) instead
16 cellularly to Sb(III)/As(III), conjugated to trypanothione, and extruded by the As-thiol pump.
17      While the biosynthesis and reduction of trypanothione are cytosolic, the molecular basis of the
18  the differential binding of glutathione and trypanothione-based substrates, and thus offer a route t
19                                Inhibition of trypanothione biosynthesis by the anti-trypanosomal drug
20 sis of both glutathionylspermidine (Gsp) and trypanothione (bis(glutathionyl)spermidine (T(SH)2)).
21 the reduction of the parasite-specific thiol trypanothione by ascorbate in a process that involves no
22 lso found to exhibit potent control on total trypanothione content but only when they were strongly i
23 ve more efficient inhibitory effect on total trypanothione content in comparison to other enzymes in
24 des in T. cruzi is catalyzed by two distinct trypanothione-dependent enzymes.
25 thylglyoxal detoxification is performed by a trypanothione-dependent glyoxalase I (GLO1) containing a
26  species is reflected in the multiplicity of trypanothione-dependent peroxidases.
27 ) catalyzes the NADPH-dependent reduction of trypanothione disulfide (1).
28 overall yield was exemplified by the case of trypanothione disulfide (TS2), a GSH-spermidine bioconju
29  oxidoreductases, catalyses the reduction of trypanothione disulfide [N1, N8-bis(glutathionyl)spermid
30 lity to regenerate dihydrotrypanothione from trypanothione disulfide following oxidation with diamide
31            Inhibition of Leishmania infantum trypanothione disulfide reductase (LiTryR) by disruption
32 are dependent on the parasite-specific thiol trypanothione for reducing equivalents.
33 zi, probably due to lower levels of TryR and trypanothione in T. brucei.
34                                  The role of trypanothione in the detoxification of reactive oxygen s
35 t curcumin, rapidly depleted glutathione and trypanothione in the wild-type line, although almost all
36 SH-containing disulfides (including oxidized trypanothione) in very fast reactions (k > 5 x 10(5) m(-
37 jugate of glutathione and spermidine, termed trypanothione, in place of glutathione to maintain cellu
38  the biosynthesis of glutathione and thereby trypanothione, is catalyzed by gamma-glutamylcysteine sy
39 the biosynthesis of glutathione, and thereby trypanothione, is catalyzed by the enzyme gamma-glutamyl
40 e considered to be ineffective inhibitors of trypanothione metabolism suggesting that these compounds
41  and amines, some of which are inhibitors of trypanothione metabolism.
42 ytic domains for synthesis and hydrolysis of trypanothione (N(1),N(8)-bis(glutathionyl)spermidine).
43 hione reductase enzyme targets in the unique trypanothione pathway of these parasites.
44 p substrates, so that increased synthesis of trypanothione produces resistance.
45 novel Tpx-roGFP2 is a superior probe for the trypanothione redox couple and that the mitochondrial ma
46                          Trypanosomes have a trypanothione redox metabolism that provides the reducin
47 utational strategy was used to down-regulate trypanothione reductase (TR) activity levels in Leishman
48                                              Trypanothione reductase (TR) catalyzes the NADPH-depende
49                                              Trypanothione reductase (TR) is a suitable target for dr
50                                              Trypanothione reductase (TR), a flavoprotein oxidoreduct
51                                              Trypanothione reductase (TR), a flavoprotein oxidoreduct
52                It includes trypanothione and trypanothione reductase (TryR) instead of the thioredoxi
53 ctase (merA), whereas goR is more related to trypanothione reductase (tryR) than to other members.
54 nhibit glutathionylspermidine synthetase and trypanothione reductase enzyme targets in the unique try
55 propyl]-dime thylammonium chloride inhibited trypanothione reductase from Trypanosoma cruzi with a li
56 gulation nor amplification of the endogenous trypanothione reductase gene (tryA) was observed.
57                      A subset also inhibited trypanothione reductase in vitro and induced oxidase act
58  the functionally homologous glutathione and trypanothione reductase indicates conservation of the ca
59 the inhibition of parasites' survival enzyme trypanothione reductase of replicating amastigotes in ho
60 e reductase, and therefore rely on the novel trypanothione reductase system to detoxify reactive oxyg
61 egulation of the terminal peroxidases of the trypanothione reductase system.
62 s showed that two compounds weakly inhibited trypanothione reductase, but none of them specifically i
63                                              Trypanothione reductase, one of the family of flavin-dep
64 e reductase, dihydrolipoamide dehydrogenase, trypanothione reductase, thioredoxin reductase, and merc
65 ascade composed of trypanothione (T(SH)(2)), trypanothione reductase, tryparedoxin (Tpx), and nonsele
66 w that TcGPXI activity can also be linked to trypanothione reduction by an alternative pathway involv
67                                              Trypanothione replaces glutathione in defence against ce
68                          In trypanosomatids, trypanothione replaces the more common glutathione syste
69                               The enzymes of trypanothione synthesis have recently been identified.
70 ine decarboxylase, which is rate-limiting in trypanothione synthesis.
71                  In pathogenic trypanosomes, trypanothione synthetase (TryS) catalyzes the synthesis
72                             The bifunctional trypanothione synthetase-amidase (TRYS) comprises two st
73 ltogether, EbS and EbS analogues disrupt the trypanothione system, hampering the defense against oxid
74  and that the mitochondrial matrix harbors a trypanothione system.
75 xides relies on a unique cascade composed of trypanothione (T(SH)(2)), trypanothione reductase, trypa
76  redox metabolism based on the small dithiol trypanothione (T(SH)(2)).
77 rypanosoma brucei utilizes a novel cofactor (trypanothione, T(SH)2), which is a conjugate of GSH and
78 r roles in addition to being a precursor for trypanothione, the major low mass thiol present in trypa
79       The system can be readily saturated by trypanothione, the rate-limiting step being the interact
80 dducts of AS-HK014 with both glutathione and trypanothione were identified in AS-HK014-exposed wild-t
81 erent, designed substrate analogues based on trypanothione were prepared by means of a solid-phase ap
82 and TSHSyn (the production catalyst of total trypanothione) were also found to exhibit potent control
83  rate-limiting step being the interaction of trypanothione with the tryparedoxin.