ライフサイエンスコーパス: tryptophan

1 NO to nitrate aromatic substrates such as L-tryptophan.

2 are products of the microbial catabolism of tryptophan.

3 s bypass tryptophan codons in the absence of tryptophan.

4 aromatic residues at the tip of its LBL with tryptophan.

5 d metabolites, including UTP, histidine, and tryptophan.

6 on and has been demonstrated with amino acid tryptophan.

7 flavored beer without hops, fatty acids, and tryptophan.

8 complex that catalyzes the biosynthesis of L-tryptophan.

9 derives substantially from KP metabolism of tryptophan.

10 peroxidases with a solvent-exposed catalytic tryptophan.

11 mediated degradation of methyl linoleate and tryptophan.

12 treatment with an immunostimulant; 1-methyl tryptophan.

13 o acids production e.g., high methionine and tryptophan.

14 tively associated with decreased levels of L-tryptophan.

15 a monooxygenase for oxidative cyclization of tryptophans.

16 e newly developed 1-(2-[(18)F]fluoroethyl)-L-tryptophan (1-L-[(18)F]FETrp) as a PET imaging probe for

17 ysteine residue in place of highly conserved tryptophan 1570 alters the conformation of the region co

18 in their synthesis is normally catalyzed by Tryptophan 2,3 Dioxygenase (TDO [18-20]).

19 This work revealed the first tryptophan 2,3-dioxygenase (Tar13) and kynurenine formam

20 th dioxygen is mediated by two heme enzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dio

21 he enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosu

22 tryptophan 2,3-dioxygenases, and transformed tryptophan 2,3-dioxygenase from Xanthomonas campestris i

23 d the stepwise oxygen-insertion mechanism of tryptophan 2,3-dioxygenases, and transformed tryptophan

24 Tryptophan 213 residue quenching studies indicated moder

25 ) does not activate mouse PXR; 4) depends on tryptophan-299 to activate hPXR; 5) recruits steroid rec

26 sly described TRPM8 antagonist N,N'-dibenzyl tryptophan 4 were prepared and characterized in vitro by

27 her FDHs (tryptophan 7-halogenase [PrnA] and tryptophan 5-halogenase [PyrH]), can react with I(-), Br

28 ed the reaction mechanisms and structures of tryptophan 6-halogenase (Thal) from Streptomyces albogri

29 glucoside, hydroxybenzoic acid diglucoside, tryptophan, 6-C-glucosyl-8-C-arabinosyl-apigenin and dif

30 (C4aOOH-FAD), formed by Thal and other FDHs (tryptophan 7-halogenase [PrnA] and tryptophan 5-halogena

31 changes involving a 100 degrees rotation of tryptophan 9 between exposed (Out) and buried (In) state

32 ory enhancement and demonstrate that dietary tryptophan-a precursor amino acid for serotonin biosynth

33 The metabolism of tryptophan along the kynurenine pathway and its involvem

34 Here, we show that TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS (TAA1), a key

35 n route to access a variety of substituted d-tryptophan analogs in high enantiomeric excess.

36 The tryptophan analogue, 7-aza-Trp (7AW) was incorporated in

37 Cysteine, histidine, phenylalanine, lysine, tryptophan and arginine were the monitored AAs in wort a

38 te and PC 36 : 1/38 : 3, and lower levels of tryptophan and GABA-to-glutamate and GABA-to-glutamine r

39 Finally, among the amino acids, tryptophan and glutamine showed the largest percentage l

40 The results indicated that utilization of tryptophan and kynurenic acid formation were faster in w

41 ssociated with MDD, particularly decreased L-tryptophan and kynurenic acid levels, and alterations in

42 lterations in (1) TCA cycle metabolites, (2) tryptophan and kynurenic acid metabolites, and (3) acylc

43 L-tryptophan and kynurenic acid were consistently downregu

44 Tryptophan and kynurenine are decreased across MDD, BD,

45 Similar results were obtained from both tryptophan and MIR spectra for the prediction of TOTOX (

46 cine, and isoleucine), aromatic amino acids (tryptophan and phenylalanine), and glycerophospholipids

47 roteins, it appears that the distribution of tryptophan and positively charged residues distinguishes

48 for monitoring HP2 movement by incorporating tryptophan and the unnatural amino acid, p-cyanophenylal

49 d that MYC increased intracellular levels of tryptophan and tryptophan metabolites in the kynurenine

50 eties contained higher (P < 0.05) amounts of tryptophan and tyrosine than the imported rice.

51 ions when their supply of the NAD precursors tryptophan and vitamin B3 in the diet was restricted dur

52 relevant for other homologs with a tetrad of tryptophans and tyrosines as electron donors.

53 S) was 7.5, 7.8, and 4.4 nM for paracetamol, tryptophan, and caffeine, respectively.

54 ns of 4 formate precursors (serine, glycine, tryptophan, and methionine) were increased in cord blood

55 tinas and chromatophores, are derivatives of tryptophan, and the first committed step in their synthe

56 s of 11 AAs (some essentials such as lysine, tryptophan, and threonine) displayed a relative-to-prote

57 residues and facilitate the formation of the tryptophan-arginine ladder, thereby influencing the posi

58 bonding and limit the flexibility of the TSR tryptophan-arginine ladder.

59 The importance of tryptophan as a precursor for neuroactive compounds has

60 Protein oxidation, with methionine and tryptophan as the most susceptible moieties, is mainly m

61 t 0 degrees C and are tolerant of spectating tryptophan, asparagine, glutamine, and threonine residue

62 A detailed examination of these tryptophan-associated accumulations of ribosomes-which w

63 was P#2 (LQKW), which contained an aromatic tryptophan at its C-terminus.

64 However, besides 8 tryptophans at the dimer interface to form two critical

65 tially enriched functional modules including tryptophan biosynthesis function.

66 n-dependent mechanism regulating prokaryotic tryptophan biosynthesis that may indicate the existence

67 In tryptophan biosynthesis, the reaction catalyzed by the e

68 tophan synthase and therefore can synthesize tryptophan by indole salvage.

69 repression at P(trpBA) is also dependent on tryptophan by regulating YtgR levels through a rare trip

70 g the side chain of lysine K115 into a tetra-tryptophan cage at the ion channel pore intracellular en

71 Tryptophan catabolism by the enzymes indoleamine 2,3-dio

72 A subset of indole derivatives of tryptophan catabolism produced by E. tarda and other gut

73 disorder of l-lysine, l-hydroxylysine, and l-tryptophan catabolism, associated with clinical presenta

74 10 (IL-10) cytokine, and the down-modulatory tryptophan catabolism.

75 , which is initiated by the flavin-dependent tryptophan chlorinase Tar14 and its flavin reductase par

76 s, along with their expected stalling at the tryptophan codon.

77 This suggested that ribosomes bypass tryptophan codons in the absence of tryptophan.

78 ved accumulations of ribosomes downstream of tryptophan codons, along with their expected stalling at

79 According to the modified logistic model, tryptophan concentration was critical for the maximum pr

80 Leucine, proline, cysteine, and tryptophan concentrations were not influenced by genotyp

81 on profile of nine miRNAs, and increased the tryptophan consumption and cell migration rates in non-t

82 ion of the sequence and the structure of the tryptophan containing hinge loop shows that it has a pro

83 the peroxyl radicals mediated oxidation of a tryptophan-containing peptide.

84 the OH functional group increased while the tryptophan contents decreased with storage time.

85 at confirms the regiochemistry of the lysine-tryptophan cross-link and provides an unambiguous assign

86 Analysis of tryptophan-deficient states as compared to control in bo

87 of the kynurenine-kynurenic acid pathway of tryptophan degradation in both periphery and brain, as w

88 qualitative metabolomics for the analysis of tryptophan degradation metabolites in mouse serum.

89 ere, we use C. elegans genetics to show that tryptophan degradation via the kynurenine pathway is req

90 In the kynurenine pathway for tryptophan degradation, an unstable metabolic intermedia

91 nutritional innate immunity through enhanced tryptophan degradation.

92 es the fundamental importance of maintaining tryptophan-dependent attenuation of the trpRBA operon.

93 TrpR is a tryptophan-dependent repressor that regulates the major

94 Carbon-11 labelled tryptophan derivatives are feasible as PET imaging probe

95 oleamine 2,3-dioxygenase 1 (hIDO1) and human tryptophan dioxygenase (hTDO) are two important heme pro

96 e timescales of all elementary tryptophan-to-tryptophan energy-transfer steps in picoseconds to nanos

97 s with very high affinity as demonstrated by tryptophan-enhanced terbium luminescence.

98 Tryptophan ethyl ester concentration in all wines increa

99 n, N-acetylserotonin, 3-indoleacetic acid, l-tryptophan ethyl ester) in commercial beers is reported

100 d ARD by the means of circular dichroism and tryptophan fluorescence and demonstrate that this region

101 with lipid bilayers is characterized by both tryptophan fluorescence and two-dimensional diffusion or

102 on assays, circular dichroism, and intrinsic tryptophan fluorescence assays allow us to propose a mod

103 bstrate had no or only a minor effect on the tryptophan fluorescence of monomeric CaiT.

104 formulations and that only minor effects in tryptophan fluorescence peak tailing are observed over a

105 Here, using tryptophan fluorescence quenching, we show that the allo

106 Tryptophan fluorescence spectroscopy showed that MatC, t

107 Molecular modeling and tryptophan fluorescence spectroscopy were consistent wit

108 -lipid interactions for MscS by quenching of tryptophan fluorescence with brominated lipids.

109 Here, using surface plasmon resonance, tryptophan fluorescence, and analysis of EAG currents re

110 ounds that target DNA gyrase, the cell wall, tryptophan, folate biosynthesis and RNA polymerase, as w

111 Uniquely, UVR8 uses intrinsic tryptophan for UV-B perception with a homodimer structur

112 and extensive mutations, we find that all 18 tryptophans form light-harvesting networks and funnel th

113 TmTrpB's primary activity of synthesizing L-tryptophan from indole and L-serine.

114 omission of a single essential amino acid - tryptophan - from the diet abrogates CNS autoimmunity in

115 in which amino acids Phenylalanine-Arginine-Tryptophan (FRW) predominate could be visualized by tran

116 cal pyramid perception centers, the other 18 tryptophans' functional role is unknown.

117 The decrease in free amino, thiol and tryptophan groups and increase in molecular weight were

118 Tryptophan hydroxylase (TPH1) and monoamine oxidase (MAO

119 ith mast cells that are highly enriched with tryptophan hydroxylase 1 (Tph1), the rate limiting enzym

120 s (ILC2(INFLAM)) via induction of the enzyme tryptophan hydroxylase 1 (Tph1).

121 Among the SNPs analysed, a tryptophan hydroxylase 2 (TPH2) gene polymorphism-G703T-

122 Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enz

123 sal raphe nucleus (DRN) and colocalized with tryptophan hydroxylase 2 (TPH2), a marker of serotonin (

124 Overexpression of tryptophan hydroxylase-1 (TPH-1), an enzyme involved in

125 esis resulting from deficiency in the enzyme tryptophan hydroxylase-1, restored the thrombocytopenic

126 ssing the biosynthetic enzyme for serotonin, tryptophan-hydroxylase-2 (TPH2), in the ventral subnucle

127 However, higher oxidation susceptibility of tryptophan in heavy chain CDR3 did not linearly correlat

128 le of IDO1 and the consequent degradation of tryptophan in mRNA translation and cancer progression.

129 Further, we find that a contact between a tryptophan in the M(pro)C domain-swapping hinge and an a

130 The proton-selective histidine and gating tryptophan in the open BM2 reorient on the microsecond t

131 When stimulated with tryptophan in the presence of [(15)N]glutamine, HNKO hep

132 We observed strong FRET between engineered tryptophans in the alphaE(C)/J and vesicles containing d

133 ree aromatic probes (phenol, resorcinol, and tryptophan) in water.

134 erial metabolism of the essential amino acid tryptophan, in regulating intestinal barrier function.

135 s, at which locations, are involved with the tryptophan/indole pathway, whose malfunctioning has been

136 Given the role of BCAAs in the regulation of tryptophan influx into the brain, we then explored the a

137 mine 2,3-dioxygenase (IDO) which metabolizes tryptophan into kynurenine.

138 idase (AFMID), involved in the conversion of tryptophan into kynurenine.

139 we report the unprecedented conversion of l-tryptophan into l-4-Cl-Kyn catalyzed by four enzymes in

140 ed enzyme that can monooxygenate unprotected tryptophan into the corresponding 3a-hydroxyhexahydropyr

141 estors that already incorporated the exposed tryptophan into their molecular structure (as well as th

142 The synthesis of quinolinic acid from tryptophan is a critical step in the de novo biosynthesi

143 L-Tryptophan is an essential amino acid required for prote

144 Tryptophan is the most limiting EAA.

145 noparticles were synthesized using tyrosine, tryptophan, isonicotinylhydrazide, epigallocatechin gall

146 Organs were flushed with histidine tryptophan ketoglutarate solution and subjected to stati

147 ly assigned to static storage with histidine-tryptophan-ketoglutarate (HTK) at 4 degrees C (HTK group

148 4, and 8 hours of cold storage in histidine-tryptophan-ketoglutarate preservation solution.

149 (sCD14), soluble CD163 (sCD163), kynurenine/tryptophan (KT) ratio, and intestinal fatty acid binding

150 The milk-to-plasma ratios of tryptophan, kynurenic acid, kynurenine, anthranilic acid

151 L-methionine, hypoxanthine, palmitic acid, L-tryptophan, kynurenic acid, taurine, and 25-hydroxyvitam

152 abolites involved in the kynurenine pathway (tryptophan, kynurenine, kynurenic acid, quinolinic acid,

153 ynurenic acid levels, and alterations in the tryptophan-kynurenine and fatty acid metabolism pathways

154 tochondrial dysfunction, the gut microbiota, tryptophan-kynurenine metabolism, the HPA axis, neurogen

155 hrenia partially through the manipulation of tryptophan-kynurenine metabolism.

156 ism and lipid metabolism, especially for the tryptophan-kynurenine pathway and fatty acid metabolism,

157 normal bladder epithelial cells re-wires the tryptophan-kynurenine pathway resulting in elevated NADP

158 enase (IDO), the rate-limiting enzyme in the tryptophan-kynurenine pathway, is positively associated

159 The tryptophan-kynurenine-nicotinamide adenine dinucleotide

160 which is part of the structurally essential tryptophan ladder.

161 ic episode showed the greatest reductions in tryptophan levels (SMD = -0.51), whereas kynurenic acid

162 Fluorescent natural organic matter at tryptophan-like (TLF) and humic-like fluorescence (HLF)

163 Inhibiting translation during tryptophan limitation at the WWW motif subsequently prom

164 Finally, because all residues in the tryptophan loop are identical in SARS-CoV and SARS-CoV-2

165 While both adipose tissue accumulation and tryptophan metabolism alterations are features of human

166 This review will briefly describe L-tryptophan metabolism and present and discuss the most r

167 e betaine and L-carnitine, and bile acid and tryptophan metabolism are associated with the hypolipide

168 Disruptions in L-tryptophan metabolism are reported in several neurologic

169 results suggest that there is a shift in the tryptophan metabolism from serotonin to the kynurenine p

170 ing 30 d of increased InCO(2); 3) markers of tryptophan metabolism were altered following 24 h, but n

171 1 (IDO) catalyzes 1 rate-limiting step of L-tryptophan metabolism, and emerges as an important regul

172 rences in short-chain fatty acids synthesis, tryptophan metabolism, and synthesis/degradation of neur

173 tissue, alterations in kynurenine pathway of tryptophan metabolism, and systemic inflammation in peop

174 and phospholipase C signaling, serotonin and tryptophan metabolism, autophagy, and B cell receptor si

175 mic state, TXNIP expression, cerebral-spleen tryptophan metabolism, inflammatory cytokine production,

176 deoxycholic acid and the microbiome-derived tryptophan metabolite indoxyl sulfate, both of which inc

177 The tryptophan metabolite L-Kynurenine (Kyn) interacts with

178 We found that only kynurenine and no other tryptophan metabolite promotes the nuclear translocation

179 One such mechanism is the production of tryptophan metabolites along the kynurenine pathway by t

180 ations of microbially derived propionate and tryptophan metabolites in elite-survivors.

181 eased intracellular levels of tryptophan and tryptophan metabolites in the kynurenine pathway.

182 As were associated with changes in levels of tryptophan metabolites, eicosanoids, plasmalogens, and f

183 ith a stable increase in cerebrum and spleen tryptophan metabolites, with a concomitant increase in a

184 and infection up-regulate expression of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygena

185 The tryptophan-metabolizing enzyme indoleamine 2,3 dioxygena

186 The tryptophan metabolome was determined by liquid chromatog

187 nd in nine steps in asymmetric format from d-tryptophan methyl ester.

188 The installation of the substituted tryptophan moieties was accomplished at the very end of

189 These results confirm the tryptophan moiety as a solid pharmacophore template for

190 regulating YtgR levels through a rare triple-tryptophan motif (WWW) in the YtgCR precursor.

191 ns, we generated transgenic flies expressing tryptophan mutant dCRYs in the conserved electron transf

192 Finally, full-length BoNT/B containing two tryptophan mutations in its LBL, together with two addit

193 Oxidation of tryptophan not only generates heterogeneity of a therape

194 Halogenated l- or d-tryptophan obtained by biocatalytic halogenation was inc

195 al transitions between these states, all six tryptophans of Y2R were (13) C-labeled.

196 nalysis and the presence of highly conserved tryptophan or phenylalanine at position 182.

197 tion to direct [(18)F]CF(3) incorporation at tryptophan or tyrosine residues using unmodified peptide

198 The rate of tryptophan oxidation did not decrease in the presence of

199 Tryptophan oxidation in biology has been recently implic

200 For all three mAbs, the structure and tryptophan oxidation relationship was further studied by

201 understanding at the molecular level to the tryptophan oxidation, where high solvent accessibility i

202 ility is a prerequisite for heavy chain CDR3 tryptophan oxidation.

203 The tryptophan pathway was upregulated under UV, with no cha

204 olic parameters (branched-chain amino acids, tryptophan pathway, phenylalanine, and lipoproteins, poi

205 on 5-HT and kynurenine concentrations in the tryptophan pathway.

206 Dark chocolate protein is a good source of tryptophan, phenylalanine + tyrosine, isoleucine, histid

207 we have studied the kinetics of three single tryptophan pHLIP (pH-Low Insertion Peptide) variants, wh

208 Single-tryptophan pHLIP variants allowed us to probe different

209 Upon blue-light excitation, the dominant tryptophan population is reorganized, moves closer to th

210 - proteins and nucleic acids, 1554 cm(-1) - tryptophan, porphyrin, 2885 cm(-1) - lipids, 2940 cm(-1)

211 tio was associated with higher kynurenine-to-tryptophan ratio (P = .009) and quinolinic-to-kynurenic

212 We identify serum kynurenine/tryptophan ratio increases as an adaptive resistance mec

213 creased in MDD and SZ, and the kynurenine to tryptophan ratio is increased in MDD and SZ.

214 PWH had higher kynurenine-to-tryptophan ratio than uninfected individuals (P < .001).

215 including high IL-10:IL-6 and kynurenine to tryptophan ratios show less severe illness.

216 Moreover, 1-methyl tryptophan reduced depressive-like behavior (P <= 0.001)

217 he in vitro and in vivo interactions between tryptophan-related compounds and ABCG2 were investigated

218 sorption process, leading to excitation of a tryptophan residue flanking the retinal chromophore, as

219 A conserved tryptophan residue in the loop was identified as critica

220 neered a GAC protein (GAC(F327W)) in which a tryptophan residue is substituted for phenylalanine in a

221 onous fluorescence spectra revealed that the tryptophan residue microenvironment of betaLG was affect

222 Tryptophan residue number 38 of chNHE1 (W38) in the extr

223 Moreover, the authors identified a tryptophan residue within a specific monoclonal FLC that

224 oscopy on W322F, a mutant of the neighboring tryptophan residue, revealed a decrease of the tyrosyl r

225 exible, acidic sequences containing a single tryptophan residue.

226 in revealed a rather dynamic picture for the tryptophan residue.

227 ng process, C-mannoses orient the underlying tryptophan residues and facilitate the formation of the

228 P (pH-Low Insertion Peptide) variants, where tryptophan residues are located near the N terminus, nea

229 ystallization studies confirm that these two tryptophan residues do not alter the structure of HC/B o

230 members reveals the presence of one or more tryptophan residues in the carbohydrate-recognition doma

231 Excitation of FK1 domain native tryptophan residues in the presence of bound ligand resu

232 DPY19 family that transfer alpha-mannoses to tryptophan residues in the sequence WX (2)WX (2)C, which

233 were confirmed with a major contribution of tryptophan residues to fluorescence quenching.

234 ic amino acids and nucleic acids (AAA + NA), tryptophan residues, nicotinamide adenine dinucleotide (

235 ormed of a pathway of conserved tyrosine and tryptophan residues, which can protect the protein activ

236 competing reaction pathways of (1)O(2) with tryptophan residues.

237 homodimer structure containing 26 structural tryptophan residues.

238 We conclude that dietary tryptophan restriction alters metabolic properties of gu

239 ogical processes, from its dietary precursor tryptophan, resulting in NAD deficiency.

240 the DNMT1 competitive inhibitor N-phthalyl-l-tryptophan (RG108).

241 xpressed, we identified genes that belong to tryptophan-rich antigen and merozoite surface protein 3

242 PL-specific monoclonal antibody (5D2) to the tryptophan-rich lipid-binding loop in the carboxyl termi

243 An extracellular tryptophan ring located at the outer pore created a cons

244 the iron-dependent regulation of the trpRBA tryptophan salvage pathway in C. trachomatis.

245 sites around the surface of gammaM7 using a tryptophan scan with femtosecond spectroscopy and NMR nu

246 omprising a Tat-SF1 binding pocket for a ULM tryptophan (SF3b1 Trp(338)) and electrostatic interactio

247 e 3'-U would result in a steric clash with a tryptophan side chain, suggesting that 2'-O-methylation

248 ith BD have lower peripheral blood levels of tryptophan (SMD = -0.29), kynurenine (SMD = -0.28), kynu

249 In the present work, we took advantage of a tryptophan substitution at position 471, proximal to the

250 Activation by tryptophan substitution is exquisitely specific for posi

251 We previously engineered the beta-subunit of tryptophan synthase (TrpB), which catalyzes the condensa

252 A good example is Tryptophan synthase (TrpS), an allosteric heterodimeric

253 Tryptophan synthase (TS) is a heterotetrameric alphabeta

254 is that only the former express a functional tryptophan synthase and therefore can synthesize tryptop

255 p, we rapidly evolve the Thermotoga maritima tryptophan synthase beta-subunit (TmTrpB) through multi-

256 Our studies demonstrate that tryptophan synthase can catalyze the ammonia-generating

257 to demonstrate that expression of wild-type tryptophan synthase is required for the bactericidal pro

258 indole due to inactivating mutations within tryptophan synthase, indicating a selection against main

259 enases or incorporation of haloindoles using tryptophan synthase.

260 Indole is a degradation product of tryptophan that functions as a signaling molecule in man

261 rations of kynurenine, a major metabolite of tryptophan that plays a role in neuroinflammation.

262 ing of these motifs requires deeply inserted tryptophans that have lower free energy in the LD oil ph

263 ) pathways (upstream of BNA2), which produce tryptophan (the Bna2p substrate).

264 residue 2 lysine with the C7 of a residue 6 tryptophan, thereby forming a 20-membered cyclic peptide

265 ning-guided design recommendations improving tryptophan titer and productivity by up to 74 and 43%, r

266 peroxidase with a solvent-exposed catalytic tryptophan to 194 +/- 70 Mya, coincident with the divers

267 ated with the stereoselective oxidation of L-tryptophan to a tricyclic hydroperoxide via a previously

268 cleic acid complexation and cellular uptake, tryptophan to enhance hydrophobic interaction with cell

269 esis but also promotes the transformation of tryptophan to kynurenine in situ.

270 no acids (BCAAs) and increased catabolism of tryptophan to the active kynurenine metabolite 3-hydroxy

271 t of our knowledge, using natural amino-acid tryptophans to form networks for both light harvesting a

272 the condensation of l-serine and indole to l-tryptophan, to synthesize a range of noncanonical amino

273 6634) locates in an SLC30A8 exon, encoding a tryptophan-to-arginine substitution that decreases SLC30

274 e determine the timescales of all elementary tryptophan-to-tryptophan energy-transfer steps in picose

275 MYC induced the expression of the tryptophan transporters SLC7A5 and SLC1A5 and the enzyme

276 DNA photolyases, which comprises a conserved tryptophan triad.

277 atus affects the kynurenine (Kyn) pathway of tryptophan (Trp) catabolism.

278 d by isothermal titration calorimetry (ITC), tryptophan (Trp) fluorescence, and microscale thermophor

279 sured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 221 cerebrospinal fluid samples from

280 al process for the selective modification of tryptophan (Trp) residues in peptides and small proteins

281 nds contain in their structure three or four tryptophan (Trp) residues linked to a central scaffold.

282 ins that degrade the essential amino acid, l-tryptophan (Trp), along the kynurenine pathway.

283 l-tryptophan (Trp), an essential amino acid for mammals, i

284 id (GLU), glutamine, glycine, proline (PRO), tryptophan (TRP), tyrosine, serine and GABA were quantif

285 ociated with plasma kynurenine (KYN) and KYN/tryptophan (TRP), which was in turn significantly associ

286 N-gamma activates human cells to produce the tryptophan (Trp)-catabolizing enzyme indoleamine 2,3-dio

287 Fluorescence spectroscopy using tryptophans (Trp) inserted at strategic positions is an

288 , lauric acid ('C12'), and the amino acid, L-tryptophan ('Trp'), modulate gastrointestinal functions

289 lation of amino acid derivatives (lysine and tryptophan) under very mild conditions.

290 g branched-chain amino acids, which regulate tryptophan uptake within the brain.

291 ffinity discrepancy has been attributed to a tryptophan (W110(PD-L2)) that is unique to PD-L2 and has

292 acts with CtBP1/2 at a conserved active site tryptophan (W318/324; CtBP1/2) that is unique among euka

293 Displacement of a conserved tryptophan (W571) from its typical pocket in these Env m

294 , L-arginine, L-histidine, L-isoleucine, and tryptophan were accumulated in the leaves of chickpea ex

295 ults suggest that IDO1-mediated depletion of tryptophan, which is induced by IFNgamma, has a role in

296 dine (His), H27, equidistant from the gating tryptophan, which leads to a symmetric H(19)xxxW(23)xxxH

297 predicts that replacement of arginine 498 by tryptophan will de-stabilize VPS33A folding.

298 polymorphism that encodes a substitution of tryptophan with arginine in the protein tyrosine phospha

299 dioxygenative cleavage of the indole ring of tryptophan with dioxygen is mediated by two heme enzymes

300 wed that fulvic acid and UV photoproducts of tryptophan yield excited triplet-state organic matters d