ライフサイエンスコーパス: tryptophan hydroxylase

1 tivity for the serotonin-synthesizing enzyme tryptophan hydroxylase.

2 anine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase.

3 ly using a monoclonal antibody (mAb) against tryptophan hydroxylase.

4 on in a small class of genes such as FAS and tryptophan hydroxylase.

5 n levels of tyrosine hydroxylase, but not of tryptophan hydroxylase.

6 te-limiting enzyme in the synthesis of 5-HT, tryptophan hydroxylase.

7 neurons in mice at any age did not stain for tryptophan hydroxylase.

8 is by the rate-limiting enzymes tyrosine and tryptophan hydroxylases.

9 ropulsion in isolated colons of mice lacking tryptophan hydroxylase 1 (Tph1(-/-) mice), which is the

10 In addition, 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase 1 (Tph1) expression were reduced

11 5-HT biosynthesis depends on tryptophan hydroxylase 1 (TPH1) in EC cells and on TPH2

12 antly in the central nervous system, whereas tryptophan hydroxylase 1 (TPH1) is expressed mostly in p

13 ZBP-89(DeltaInt) mice had reduced levels of tryptophan hydroxylase 1 (Tph1) messenger RNA, encoding

14 ed mice with mammary-specific disruptions of tryptophan hydroxylase 1 (Tph1) or low-density lipoprote

15 receptors (5-HTR), transporter (5-HTT), and tryptophan hydroxylase 1 (TPH1) was assessed in human OC

16 on factor Foxm1, both G1/S and G2/M cyclins, tryptophan hydroxylase 1 (Tph1), and islet serotonin pro

17 ominantly by enterochromaffin (EC) cells via tryptophan hydroxylase 1 (TPH1), is a key modulator of g

18 in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate p

19 ith mast cells that are highly enriched with tryptophan hydroxylase 1 (Tph1), the rate limiting enzym

20 stomach tissues of NeuroD1-cre;ROSA(tdTom), tryptophan hydroxylase 1 (Tph1)-cyan fluorescent protein

21 s (ILC2(INFLAM)) via induction of the enzyme tryptophan hydroxylase 1 (Tph1).

22 Specificity protein 2 (Sp2, rs3708840), tryptophan hydroxylase 1 (Tph1, rs262731280) and seroton

23 ically, there was an increased expression of tryptophan hydroxylase 1 and a suppression of monoamine

24 s211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentrations in blood serum i

25 Mucosal 5-HT, tryptophan hydroxylase 1 messenger RNA, serotonin transp

26 ic production of MafB in beta-cells elevated tryptophan hydroxylase 1 mRNA production during pregnanc

27 mast cells, IL-33 enhanced the expression of tryptophan hydroxylase 1, serotonin synthesis, and stora

28 significantly increased colonic mRNAs Tph1 [(tryptophan hydroxylase) 1, rate limiting for mucosal 5-H

29 Peripheral serotonin, synthesized by tryptophan hydroxylase-1 (TPH(1)), has been shown to pla

30 Overexpression of tryptophan hydroxylase-1 (TPH-1), an enzyme involved in

31 used LP533401, a small molecule inhibitor of tryptophan hydroxylase-1 (Tph-1), the initial enzyme in

32 Expression of serotonin synthetic enzyme tryptophan hydroxylase-1 (Tph1) and serotonin production

33 When BA was combined with a tryptophan hydroxylase-1 (TPH1) inhibitor, which is cruc

34 ulates CD4(+) T-cell differentiation through tryptophan hydroxylase-1 (Tph1), independently of well-e

35 We also analyzed mice that lack tryptophan hydroxylase-1 (TPH1KO mice, which lack mucosa

36 5-MTP was synthesized from L-tryptophan via tryptophan hydroxylase-1 and hydroxyindole O-methyltrans

37 The former pointed to modulation of tryptophan hydroxylase-1 to enhance 5-HT synthesis, whil

38 Here we report the novel finding that Tph-1 (tryptophan hydroxylase-1), a synthase which catalyses th

39 esis resulting from deficiency in the enzyme tryptophan hydroxylase-1, restored the thrombocytopenic

40 We have expressed human tryptophan hydroxylase 2 (hTPH2) and two deletion mutant

41 ain/pons of mice carrying a loxP-conditional tryptophan hydroxylase 2 (Tph2) allele.

42 Tryptophan hydroxylase 2 (TPH2) encodes the rate-limitin

43 y genes, with somata lacking transcripts for tryptophan hydroxylase 2 (Tph2) encoding the rate-limiti

44 was associated with significant decreases in tryptophan hydroxylase 2 (TPH2) expression and activity,

45 y inducing its catabolism and by suppressing tryptophan hydroxylase 2 (Tph2) expression and serotonin

46 genetic activation of microglia also reduced tryptophan hydroxylase 2 (Tph2) expression and was negat

47 Among the SNPs analysed, a tryptophan hydroxylase 2 (TPH2) gene polymorphism-G703T-

48 scription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitami

49 the two variants of tryptophan hydroxylase, tryptophan hydroxylase 2 (TPH2) is expressed predominant

50 Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enz

51 a naturalistic model of 5-HT deficiency, the tryptophan hydroxylase 2 (Tph2) R439H knockin mouse, to

52 nt portions of medullary raphe serotonergic, tryptophan hydroxylase 2 (Tph2)(+) neurons by postnatal

53 rotonin (via a null mutation in the gene for tryptophan hydroxylase 2 (TPH2)) for behaviors that are

54 sal raphe nucleus (DRN) and colocalized with tryptophan hydroxylase 2 (TPH2), a marker of serotonin (

55 cause of a failure to activate expression of tryptophan hydroxylase 2 (Tph2), the key enzyme of serot

56 ant form of the brain 5-HT synthesis enzyme, tryptophan hydroxylase 2 (Tph2).

57 nced MS15 or MS180 demonstrated decreases in tryptophan hydroxylase 2 and serotonin transporter mRNA

58 Genetic deletion of NET almost eliminated tryptophan hydroxylase 2 expression and significantly re

59 tiviral vectors with an upstream sequence of tryptophan hydroxylase 2 gene efficiently transduced ser

60 Expression of tryptophan hydroxylase 2 in the dorsal raphe was normal.

61 pic and scotopic ERGs were recorded in R439H tryptophan hydroxylase 2 knockin (Tph2-KI) mice that hav

62 lity and antidepressant-like responses using tryptophan hydroxylase 2 knockin (Tph2KI) mice, which di

63 s completed in young and old male and female tryptophan hydroxylase 2 knockout (TPH2(-/-)) and wild-t

64 tial for serotonergic development, including tryptophan hydroxylase 2, exhibit typical electrophysiol

65 eptide galanin and its receptors (GalR1-R3), tryptophan hydroxylase 2, tyrosine hydroxylase, and nitr

66 serotonin is synthesized from tryptophan by tryptophan hydroxylase 2, which is transcriptionally act

67 ant form of the brain 5-HT synthesis enzyme, tryptophan hydroxylase 2.

68 nzyme of neuronal serotonin synthesis, human tryptophan hydroxylase-2 (hTPH2).

69 s with regional shRNA interference (RNAi) of tryptophan hydroxylase-2 (Tph-2), the rate-limiting enzy

70 Tryptophan hydroxylase-2 (TPH2) catalyzes the synthesis

71 Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enz

72 Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is pr

73 emical detection of the N-terminal region of tryptophan hydroxylase-2 (TPH2), the brain-specific isof

74 ly mapped gene expression in DRN and MRN for tryptophan hydroxylase-2 (Tph2), the serotonin transport

75 but not neuronal 5-HT) and mice deficient in tryptophan hydroxylase-2 (TPH2KO mice, which lack neuron

76 tic of control mice, including elevations in tryptophan hydroxylase-2 and CRF receptor-1 expression a

77 nduced Cre/loxP-mediated inactivation of the tryptophan hydroxylase-2 gene (Tph2) was used to investi

78 ssing the biosynthetic enzyme for serotonin, tryptophan-hydroxylase-2 (TPH2), in the ventral subnucle

79 phe neurones with an immunocytochemistry for tryptophan hydroxylase (a marker of serotonergic neurone

80 A continuous fluorometric assay for tryptophan hydroxylase activity based on the different s

81 d 3.3 nmol) blocked the increase in cortical tryptophan hydroxylase activity, ex vivo, in response to

82 esidues with N-acetylimidazole did not alter tryptophan hydroxylase activity.

83 ound stress, was used as an index of in vivo tryptophan hydroxylase activity.

84 ditionally, we checked for immunolabeling of tryptophan hydroxylase, an enzyme associated with the sy

85 were immunostained for tyrosine hydroxylase, tryptophan hydroxylase and alpha-synuclein.

86 BH4, which is an essential cofactor for TH, tryptophan hydroxylase and nitric oxide synthase.

87 verlap of expression of the serotonin marker tryptophan hydroxylase and the alpha4 nAChR subunit in t

88 h isoforms of the serotonin synthetic enzyme tryptophan hydroxylase and the archetypal serotonergic t

89 bility, a homologue for aromatic amino acid (tryptophan) hydroxylase and the loss of tryptophan biosy

90 ouse 5-HT1a receptor, serotonin transporter, tryptophan hydroxylase, and aromatic L-amino acid decarb

91 which encodes the serotonin synthetic enzyme tryptophan hydroxylase, and cat-1, which encodes a vesic

92 ase, phenylethanolamine-N-methyltransferase, tryptophan hydroxylase, and histidine decarboxylase immu

93 wed simultaneous expression of the genes for tryptophan hydroxylase, arylalkylamine N-acetyltransfera

94 In contrast, the expression of tryptophan hydroxylase, as well as, the alpha7 nAChR sub

95 ERT -/- bowel, which contained mRNA encoding tryptophan hydroxylase, but no 5-HT was present in the b

96 a relatively minor role in the inhibition of tryptophan hydroxylase catalytic activity.

97 anine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase catalyze the hydroxylation of the

98 Tryptophan hydroxylases catalyze the first and rate-limi

99 Tryptophan hydroxylases catalyze the first and rate-limi

100 interacts with phenylalanine, tyrosine, and tryptophan hydroxylases catalyzing the BH4-activated con

101 anine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase constitute a small family of mono

102 turnover as well as the ex vivo activity of tryptophan hydroxylase (EC 1.14.16.4), the rate-limiting

103 tes tyrosyl residues at pH 8 only, inhibited tryptophan hydroxylase equally at either pH.

104 linesterase-, choline acetyltransferase-, or tryptophan hydroxylase-expressing, small bowel myenteric

105 usly, we showed that daf-7 TGFbeta and tph-1 tryptophan hydroxylase expression in specific neurons en

106 DAF-16 and serotonin-dependent inhibition of tryptophan hydroxylase expression.

107 Sodium bicarbonate protected tryptophan hydroxylase from peroxynitrite-induced inacti

108 enome sequence showed that there is a single tryptophan hydroxylase gene (tph-1)-the key enzyme for s

109 We showed expression of the tryptophan hydroxylase gene and of tryptophan hydroxylas

110 had opposing effects on transcription of the tryptophan hydroxylase gene tph-1, which encodes the rat

111 on analysis confirmed an association between tryptophan hydroxylase genotype and lifetime history of

112 e we show that developmental expression of a tryptophan hydroxylase: :GFP reporter construct is simil

113 ficity and hydroxylation regiospecificity of tryptophan hydroxylase have been investigated using tryp

114 Tyrosine hydroxylase (TH) or tryptophan hydroxylase immunohistochemistry was combined

115 etween CRF-immunoreactive varicose axons and tryptophan hydroxylase-immunoreactive neurons in the are

116 following post hoc immunohistochemistry were tryptophan hydroxylase-immunoreactive, indicating that t

117 coexpression of epsilon-sarcoglycan mRNA and tryptophan hydroxylase immunoreactivity was found in the

118 s, mouse Ucn 2 increased c-Fos expression in tryptophan hydroxylase immunostained neurons in the midd

119 e, in addition to canonical biosynthesis via tryptophan hydroxylase in neurons.

120 rease in the expression of MAO-A, MAO-B, and tryptophan hydroxylase in the dorsal raphe nucleus of hi

121 l immunohistochemical staining for c-Fos and tryptophan hydroxylase in the DR or single immunohistoch

122 rolling serotonin biosynthesis, specifically tryptophan hydroxylase, in a light dark cycle (LD).

123 receptors and transporters and the levels of tryptophan hydroxylase, in rats with obesity induced by

124 HT levels by administration of the selective tryptophan hydroxylase inhibitor p-chlorophenylalanine o

125 tnatal days (PND) 10-20 by treating with the tryptophan hydroxylase inhibitor parachlorophenylalanine

126 natal stress and 5-HT depletion with pCPA, a tryptophan hydroxylase inhibitor, reduced the levels of

127 studies suggested that telotristat ethyl, a tryptophan hydroxylase inhibitor, reduces bowel movement

128 presence of p-chloro-phenylalanine (PCPA), a tryptophan hydroxylase inhibitor, the serotonin levels d

129 toms typical for the carcinoid syndrome, and tryptophan hydroxylase inhibitors are already in clinica

130 Here, we describe a novel class of potent tryptophan hydroxylase inhibitors, characterized by span

131 Tryptophan hydroxylase is a pterin-dependent amino acid

132 s and that the direction of the NIH shift in tryptophan hydroxylase is from carbon 5 to carbon 4.

133 reactions show that the regiospecificity of tryptophan hydroxylase is stringent.

134 enotyped for a biallelic polymorphism at the tryptophan hydroxylase locus.

135 This decreased expression of tryptophan hydroxylase observed in both the daf-2 and un

136 of serotonergic neurons identified by either tryptophan hydroxylase or serotonin immunostaining withi

137 Tryptophan hydroxylase oxidizes L-tryptophan to 5-hydrox

138 rate-limiting enzyme in serotonin synthesis, tryptophan hydroxylase plays an important role in modula

139 e serotonin [5-hydroxytryptamine (5-HT)] and tryptophan hydroxylase-positive clone was isolated, whic

140 Remarkably, Pet-1 RNA colocalizes with tryptophan hydroxylase-positive neurons in raphe nuclei

141 on of the tryptophan hydroxylase gene and of tryptophan hydroxylase protein immunoreactivity in mouse

142 quantitative autoradiography and determined tryptophan hydroxylase protein levels by Western blottin

143 Tryptophan hydroxylase protein levels in the raphe nucle

144 ve null alleles of a 5-HT2-like receptor and tryptophan hydroxylase, respectively, suggesting that se

145 Double immunostaining methods for c-Fos and tryptophan hydroxylase revealed that, consistent with pr

146 hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase--reveals important differences at

147 dy against TPH2, a brain-specific isoform of tryptophan hydroxylase (serotonin synthetic enzyme).

148 posite in phase to the circadian activity of tryptophan hydroxylase, the first enzyme in the melatoni

149 Tryptophan hydroxylase, the initial and rate-limiting en

150 F-beta-dependent developmental regulation of tryptophan hydroxylase, the rate-limiting enzyme in sero

151 sion responses of daf-7 (TGFbeta) and tph-1 (tryptophan hydroxylase) to food availability.

152 ulation of the serotonin-biosynthesis enzyme tryptophan hydroxylase tph-1 in the ADF neurons.

153 ntributes to AAI and whether this depends on tryptophan hydroxylase (TPH) 1, the critical enzyme for

154 ved in anxiety behaviors, the mRNA levels of tryptophan hydroxylase (TPH) 1, TPH2 (both are involved

155 Using tryptophan hydroxylase (TPH) 2 deficient (Tph2-deficient

156 roscopy that the enzymes for 5-HT synthesis, tryptophan hydroxylase (TPH) and aromatic amino acid dec

157 nvestigation of the 5-HT-synthesizing enzyme tryptophan hydroxylase (TPH) and serotonin transporter (

158 rate-limiting serotonin biosynthetic enzyme tryptophan hydroxylase (TPH) are poorly understood.

159 Tryptophan hydroxylase (TPH) as the rate-limiting enzyme

160 Rabbit brain tryptophan hydroxylase (TPH) has been expressed in insec

161 The discovery of a novel class of peripheral tryptophan hydroxylase (TPH) inhibitors is described.

162 e-limiting enzyme in serotonin biosynthesis, tryptophan hydroxylase (TPH) is a potential target for t

163 Tryptophan hydroxylase (TPH) is the initial and rate-lim

164 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme

165 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme

166 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme

167 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme

168 hieved through pharmacological inhibition of tryptophan hydroxylase (Tph) using p-chlorophenylalanine

169 The expression of mRNA for tryptophan hydroxylase (TPH) was examined in ovariectomi

170 We found that the 5-HT biosynthetic enzyme tryptophan hydroxylase (TPH) was expressed in nearly 10%

171 here looked at epidermal Trp metabolism via tryptophan hydroxylase (TPH) with its downstream cascade

172 respectively, tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), and draw an evolutionary s

173 mmunohistochemical analysis of CART and CART+tryptophan hydroxylase (TPH), CART+estrogen receptors (E

174 several loci of interest in neuropsychiatry-tryptophan hydroxylase (TPH), dopamine transporter prote

175 concentrations, and enzymatic activities of tryptophan hydroxylase (TPH), indoleamine 2,3-dioxygenas

176 body to either the 5-HT-synthesizing enzyme, tryptophan hydroxylase (TPH), or to the astrocytic marke

177 Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the me

178 Exposure of tryptophan hydroxylase (TPH), the initial and rate-limit

179 Tryptophan hydroxylase (TPH), the initial and rate-limit

180 whereas other serotonergic markers, such as tryptophan hydroxylase (TPH)- or 5-HT-positive cells and

181 e and no change with ageing in the number of tryptophan hydroxylase (TPH)-positive neurons in the DR

182 alpha and the serotonin-synthesizing enzyme, tryptophan hydroxylase (TPH).

183 rter 3 (VGluT3), or co-expressing VGluT3 and tryptophan hydroxylase (TPH).

184 locally acting, small molecule inhibitor of tryptophan hydroxylase (TPH).

185 Tryptophan hydroxylase (Tph)1-deficient mice, lacking no

186 nsive elements (VDREs) at -7/-10 kb in human tryptophan hydroxylase (TPH)2 were probed.

187 f the gene encoding the 5HT synthesis enzyme tryptophan hydroxylase (tph-1) in the serotonergic chemo

188 genes essential for serotonin biosynthesis (tryptophan hydroxylase [TPH] and aromatic amine decarbox

189 Tryptophan hydroxylase (TPH1) and monoamine oxidase (MAO

190 nthesized through the actions of 2 different tryptophan hydroxylases, TpH1 and TpH2, which are found,

191 female colon from wild-type and mice lacking tryptophan hydroxylase (TPH1KO).

192 exception of serotonin transporter Sert and tryptophan hydroxylase TPH2, whose expression appears to

193 tyrosine hydroxylase (TH), and dorsal raphe tryptophan hydroxylase (TPH2) gene expression in male C5

194 -limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase (TPH2), we showed that quinine co

195 copy to show that neurons immunoreactive for tryptophan hydroxylase (TpOH) are tightly apposed to lar

196 -95, and a marker for 5-HT cells, the enzyme tryptophan hydroxylase (TPOH).

197 n the medullary raphe are immunoreactive for tryptophan hydroxylase (TpOH-ir).

198 le-labelling of NK1R-immunoreactive (ir) and tryptophan-hydroxylase (TPOH)-ir neurones.

199 Wild type rabbit tryptophan hydroxylase (TRH) and two truncated mutant pr

200 m the PFC and immunogold-silver labeling for tryptophan hydroxylase (TrH) or for GABA.

201 fly, Drosophila melanogaster, and identified tryptophan hydroxylase (Trh), serotonin receptor 2a (5HT

202 Using cell-targeted tryptophan hydroxylase (Trhn) RNAi to block serotonin pr

203 vesicular glutamate transporter-2 (VGLUT-2), tryptophan-hydroxylase (TrOH), glial fibrillary acid pro

204 Phenylalanine hydroxylase (PheH) and tryptophan hydroxylase (TrpH) catalyze the aromatic hydr

205 Tryptophan hydroxylase (TrpH) uses a non-heme mononuclea

206 ns by simultaneous histological detection of tryptophan hydroxylase (TrpOH) immunoreactivity with GAD

207 he DR, which were delineated on the basis of tryptophan hydroxylase (TrpOH) immunoreactivity.

208 Of the two variants of tryptophan hydroxylase, tryptophan hydroxylase 2 (TPH2)

209 The less common tryptophan hydroxylase U allele occurred with greater fr

210 data suggest that peroxynitrite inactivates tryptophan hydroxylase via sulfhydryl oxidation.

211 Immunostaining for tryptophan hydroxylase was performed on serial 50 microm

212 Peroxynitrite-modified tryptophan hydroxylase was resistant to reduction by ars

213 K-3 with immunohistochemical localization of tryptophan hydroxylase, we found that a majority of sero

214 7 A) of a truncated functional form of human tryptophan hydroxylase with the bound cofactor analogue

215 caused the nitration of tyrosyl residues in tryptophan hydroxylase, with a maximal modification of 3