ライフサイエンスコーパス: tubulation

1 patients were observed (termed outer retinal tubulation).

2 with increases in cisternal fenestration and tubulation.

3 pin association, GTP hydrolysis and membrane tubulation.

4 rminal BAR domain, which can induce membrane tubulation.

5 ectors modify the vacuole, driving endosomal tubulation.

6 mpartments, reducing the frequency of LE/Lys tubulation.

7 ntiation factor 88, blocked T cell-dependent tubulation.

8 d CD2 are involved in induction of endosomal tubulation.

9 d from ARF1 activity in the control of Golgi tubulation.

10 ans-Golgi network (TGN) and caused extensive tubulation.

11 ant in phagolysosomes, contributing to their tubulation.

12 at the binding of Abeta-40 induces extensive tubulation.

13 a small guanosine triphosphatase, during RE tubulation.

14 small GTPase ARL-8 to the phagolysosome for tubulation.

15 on, budding, neck formation, flattening, and tubulation.

16 ping, and in rare cases spontaneous membrane tubulation.

17 ion membrane and augments inclusion membrane tubulation.

18 kinase VPS34, results in prolonged lysosomal tubulation.

19 l components for the initiation of lysosomal tubulation.

20 Drp1 GTPase activity, as well as of membrane tubulation.

21 coupling as an additional driving force for tubulation.

22 spastin binds, also had increased endosomal tubulation.

23 ry and in occurring by membrane blebbing and tubulation.

24 degradation) proteins to regulate endosomal tubulation.

25 ns promote actin polymerization and membrane tubulation.

26 lations of WHAMM collaborate during membrane tubulation.

27 that contribute to membrane curvature and/or tubulation.

28 d is sufficient to induce extensive membrane tubulations.

29 moving to the OB surface through peroxisome tubulations.

30 ily member, Klp98A, drives the movements and tubulation activities of Rab39, and disruption of this R

31 al homology (ENTH) domain has potent vesicle tubulation activity despite a lack of intrinsic molecula

32 vitro and in vivo assays confirmed membrane-tubulation activity for muniscin EFC/F-BAR domains.

33 and is required for membrane penetration and tubulation activity of FAPP1, whereas the GTP-bound conf

34 The membrane tubulation activity of OPA1 is suppressed by GTPgammaS.

35 uniscins provide a combined adaptor/membrane-tubulation activity that is important for regulating end

36 a critical size is essential for its vesicle tubulation activity.

37 ENTH domain complexes abrogated the vesicle tubulation activity.

38 disrupted, the result of impaired lysosomal tubulation alongside ALR activation is massive cell deat

39 lphaFold, and in vitro reconstitutions of ER tubulation and AGPAT2 activity.

40 show that the function of SNX18 in membrane tubulation and autophagy is negatively regulated by phos

41 ing the regulatory mechanism of KIF13A in RE tubulation and cargo recycling is of fundamental importa

42 pendent mechanisms rescues aberrant retromer tubulation and cholesterol mistrafficking.

43 In vitro, calmodulin enhanced membrane tubulation and constriction by wild-type Rvs167 but not

44 e elucidate the structural basis of membrane tubulation and coupled cargo recognition by metazoan and

45 phology of endosomal compartments, marked by tubulation and enlargement of endosomes containing trans

46 f-war mechanism, leading to MT1-MMP endosome tubulation and exocytosis.

47 thereby independently potentiating membrane tubulation and fission events.

48 mes then move by a dynamic process involving tubulation and fission, followed by rapid retrograde and

49 s lysosomal dynamics including vesiculation, tubulation and fission.

50 evering events, may play a role in endosomal tubulation and fission.

51 ins in a molecular tug-of-war to regulate RE tubulation and homeostasis.

52 ELMOD2 overexpression promotes mitochondrial tubulation and increases the rate of fusion in a mitofus

53 facile template for the analysis of membrane tubulation and inform of mechanisms that coordinate MTCF

54 hat BIN1 plays an important role in membrane tubulation and may promote skeletal muscle weakness in C

55 otein during mitochondrial division, with ER tubulation and mechano-GTPase activities.

56 f Parkin function led to decreased endosomal tubulation and membrane association of vesicle protein s

57 dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer

58 ylglycerol (DAG) directly leads to transient tubulation and rapid fragmentation of the mitochondrial

59 e STIM1-Orai1 coupling because of loss of ER tubulation and redistribution of STIM1 to ER sheets.

60 Extensive tubulation and relatively rapid Golgi resident redistrib

61 at mTOR is required for LPS-induced lysosome tubulation and secretion of major histocompatibility com

62 a dual-functioning protein that promotes ER tubulation and severs mitochondria at ER-mitochondria co

63 brane prevented the formation of a lysosomal tubulation and sorting process we previously named LYTL.

64 ck of assays to monitor dynamics of membrane tubulation and subsequent fission.

65 NTH-domain-induced membrane vesiculation and tubulation and the implications of the epsin's role in c

66 th the ability of RTNLB13 to induce membrane tubulation and to form low-mobility complexes within the

67 early endosomes undergo fusion, fission, and tubulation and transiently interact with one another, la

68 found that purified AMPH-1 is sufficient for tubulation and vesiculation of liposomes in a mechanism

69 Pase dynamin, a protein involved in membrane tubulation and vesiculation, is essential for successful

70 used to characterize the process of liposome tubulation and vesiculation.

71 n preceded by the formation of outer retinal tubulations and choriocapillaris dropout.

72 h the size of the cargo (membrane budding or tubulation), and finally separation of the nascent carri

73 dergo fragmentation through vesicle budding, tubulation, and constriction.

74 ubstantial reduction in binding affinity and tubulation, and simulations of the NAC-null protein sugg

75 at BFA stimulation of Golgi and TGN membrane tubulation, and the resultant retrograde transport of re

76 in biological processes such as endocytosis, tubulation, and vesiculation.

77 ow that the timing and efficiency of vesicle tubulation, as well as the membrane tube widths, are mod

78 er findings also show that cells can control tubulation at their membranes by simply altering the mem

79 owed outer retinal layer loss, outer retinal tubulations at the margin of outer retinal loss, and inn

80 of these residues regulate lipid-binding and tubulation both in vitro and in cells.

81 h experimental observations of the degree of tubulation by amphipathic helices and variation of the f

82 ally dissimilar, the processes necessary for tubulation by epithelial and endothelial cells are very

83 the regulated GTP-GDP cycle of ARL-8 reduces tubulation by kinesin-1, delays corpse clearance, and mi

84 icros provides a dynamic picture of membrane tubulation by lattices of F-BAR domains.

85 uces membrane curvature, supporting membrane tubulation by PspA.

86 ion delayed and altered lung epithelial cell tubulation by selectively inhibiting G protein-mediated

87 Remarkably, lysosome tubulation can be artificially induced via overexpressio

88 It is found that tubulation can be generated by anisotropic N-BAR spontan

89 Endophilin's membrane tubulation capacity is well known.

90 of SNX18 depends on its membrane binding and tubulation capacity.

91 ial polymerization mechanism drives membrane tubulation, constriction and bilayer thinning.

92 BIN1-induced tubulations contained the L-type Ca(2+) channel, were co

93 Membrane tubulation coupled with fission (MTCF) is a widespread p

94 dly, deletion of Oma1 restored mitochondrial tubulation, cristae morphogenesis, and apoptotic resista

95 A tubulation-defective syt mutant was able to promote fusi

96 ions in strumpellin did not rescue endosomal tubulation defects, reduction in CAV1 protein abundance,

97 an N-BAR domain rescued the function of the tubulation-deficient syt mutant.

98 remodeling processes (e.g., vesiculation and tubulation) due to N-BAR domain interactions with the li

99 in nucleation activities to promote membrane tubulation during intracellular transport.

100 and crucial morphogenic factors mediating ER tubulation during mitosis, and define the first cell cyc

101 The tubulation effect is attributable to direct phospholipid

102 tein Syndapin (Synd) is involved in membrane tubulation, endocytosis, and, uniquely, in F-actin stabi

103 s failed to evoke T cell-polarized endosomal tubulation even though both conditions allowed T cell st

104 somal membrane deformation, enabling dynamic tubulation events.

105 n widely implicated in facilitating membrane tubulation, fission, and in select cases, fusion.

106 a vertebrate protein functioning in membrane tubulation for intracellular membrane trafficking and sp

107 Finally, we show that HOPS is required after tubulation for the rapid degradation of cargo in small p

108 the patients and carriers had outer retinal tubulations forming pseudopod-like extensions from islan

109 epithelium, and choroid, with outer retinal tubulations frequently observed.

110 work suggests a model in which SNX9-mediated tubulation generates a membrane environment that promote

111 ssion of RTNLB13 was sufficient to induce ER tubulation in an Arabidopsis mutant (pah1 pah2) whose ER

112 hology, but is dispensable for peripheral ER tubulation in an endogenous context, and that its activi

113 All isoforms were observed to induce tubulation in cardiomyocytes but produced t-tubules with

114 s a function for F-BAR proteins and membrane tubulation in ciliogenesis and explains how the intracel

115 FlnA-PACSIN2 interaction regulates membrane tubulation in MKs and platelets and likely contributes t

116 ells that allow Ag-specific T cells to evoke tubulation in the dendritic cell.

117 no acid segment required for trafficking and tubulation in the endolysosomal pathway.

118 D) is required for trafficking and organelle tubulation in the endolysosome system.

119 cantly increased pRab10 signal and lysosomal tubulation in the perinuclear region.

120 to the tonoplast and is required for vacuole tubulation in the tips of pollen tubes.

121 In exploring the role of tubulation in these events, we unexpectedly found that l

122 its coiled-coil (CC) domain drives membrane tubulation in vitro and endosome association in cells.

123 n and enhanced PACSIN2 F-BAR domain membrane tubulation in vitro.

124 of calmodulin with endophilin A2 potentiated tubulation in vivo.

125 There were outer retinal tubulations in degenerated, nonatrophic retina in the ma

126 le loss of the ER cisternae and extensive ER tubulation, including formation of ER patches comprising

127 aling pathway regulates LPS-induced lysosome tubulation independently of IRAK1/4 and TBK.

128 MTM1 levels were necessary for BIN1-induced tubulation, indicating a central role of phosphoinositid

129 Similarly, we found that Golgi tubulation induced by brefeldin A, a known microtubule-d

130 sed complexity of vacuolar membranes through tubulation, internalization, and/or fission.

131 Membrane tubulation is a hallmark of recycling endosomes (REs), m

132 thick in early stages of disease and retinal tubulation is present in advanced disease.

133 increasing membrane surface area by endosome tubulation is the main mechanism to ensure efficient rec

134 En-face OCTA revealed a curvilinear tubulation-like structure corresponding to SRT without f

135 Our study provides insights into a novel tubulation mechanism of an alpha-PFT protein and a new m

136 However, stimulus-responsive membrane tubulation mediated by DNA reconfiguration remains chall

137 ion reduction initiates membrane budding and tubulation mediated by endocytic proteins, such as endop

138 s in these GUVs, including growth, division, tubulation, membrane budding and fusion.

139 ndosomal/lysosomal trafficking and organelle tubulation observed for the intact molecule, whereas del

140 s was 183.0 mum (n = 33), with outer retinal tubulation observed in 15 (45%).

141 embrane followed by extensive lipid membrane tubulation observed in the late phase.

142 zed cell system, consistent with the lack of tubulation observed upon EHD3 depletion.

143 qualities, such as helical self-assembly and tubulation of a lipid bilayer.

144 he MT-severing protein spastin had increased tubulation of and defective receptor sorting through end

145 in the intermediate compartment (IC) and the tubulation of cis-Golgi and IC membranes.

146 utes to the membrane curvature induction and tubulation of cristae.

147 ber that participates in the trafficking and tubulation of early endosomes along microtubules.

148 Surprisingly, the addition of EHD3 causes tubulation of endocytic membranes in our semipermeabiliz

149 oplasmic huntingtin also exhibited increased tubulation of endosomal membranes.

150 Tubulation of ERCs within human DCs requires antigen-spe

151 We conclude from these observations that tubulation of Golgi complex and TGN membranes requires a

152 ine acyltransferase (LPAT) induces the rapid tubulation of Golgi membranes, leading in their retrogra

153 opsis CURT1A proteins oligomerize and induce tubulation of liposomes, implying that CURT1 proteins su

154 udies have shown that IMDs can induce inward tubulation of liposomes.

155 e that is activated by RhoA, SifA can induce tubulation of mammalian endosomes.

156 ther show that the protein is able to induce tubulation of membranes in vitro, an observation that ma

157 uorescence and a significant aggregation and tubulation of mitochondria by immunofluorescence microsc

158 tion in transiently transfected cells caused tubulation of organelle membranes as well as mitochondri

159 , and loss of Rab11 prevents TBC1D14-induced tubulation of REs.

160 omain, the RCB domain/IMD did not cause long tubulation of the artificial liposomes; however, the Rac

161 Fenestration and tubulation of the ER correlates with a reduced number of

162 ature of Golgi membranes, producing dramatic tubulation of the Golgi, but does not support forward tr

163 med by a dynamic process of congregation and tubulation of the newly inherited Golgi fragments.

164 s authentic dynamins) function in fission or tubulation of the plasma membrane, trans-Golgi network,

165 ctor protein SifA regulates the assembly and tubulation of the Salmonella phagosome.

166 utrient deprivation stimulated the excessive tubulation of these autolysosomal compartments.

167 TLR triggering was insufficient for induced tubulation of transferrin-positive endosomal recycling c

168 To document outer retinal tubulation (ORT) formation in advanced retinal disorders

169 iants that potentially lead to outer retinal tubulation (ORT), estimate the prevalence of ORT in thes

170 a: atrophic lesion borders and outer retinal tubulations (ORTs).

171 oscopy, we show that SNX9 generates membrane tubulation out of CD28 clusters.

172 is also maintained by proteins acting in the tubulation pathway.

173 Rather, tubulation promotes MHC-II presentation by enabling maxi

174 g and hydrolysis to the membrane binding and tubulation required for transport carrier formation.

175 This tubulation requires mTOR activity, and we identified two

176 their differential roles in vesiculation and tubulation, respectively.

177 We propose that such tubulation serves to facilitate the ensuing T-cell respo

178 spastin or IST1 also had abnormal endosomal tubulation, so we propose this phenotype is important fo

179 iously uncovered a process we term LYsosomal Tubulation/sorting driven by LRRK2 (LYTL), wherein damag

180 uggest that proteins able to induce membrane tubulation, such as those containing N-BAR domains, can

181 iochemical properties lysosomes acquire upon tubulation that could drive their functionality.

182 e ring formation and perturbed Bin1-mediated tubulation that may explain defective T-tubule organizat

183 iated Arl8b, a lysosomal GTPase required for tubulation that promotes kinesin-dependent lysosome move

184 We also found that Drp1 induced membrane tubulation that was stimulated by cardiolipin.

185 required to support Sar1p-dependent membrane tubulation, the subsequent Sar1p-dependent recruitment o

186 induction is different for vesiculation and tubulation, these data also explain why previous studies

187 ologies at intermediate coverages below this tubulation threshold, in contrast, strongly depend on th

188 ge the membrane shape at coverages below the tubulation threshold, whereas scaffolds with arc angles

189 in lysosome identity by initiating lysosomal tubulation through a process termed autophagosome-lysoso

190 We find that AGPAT2-generated PA drives ER tubulation through gene knockout, 3D structural analysis

191 ture morphology of mitotic ER and promote ER tubulation through their reticulon homology domains (RHD

192 t links phospholipid remodeling and membrane tubulation to dynein-dependent transport.

193 HLH-30 cooperate to trigger robust lysosomal tubulation under various contexts, which contributes to

194 Finally, we establish that mitochondrial tubulation upon nutrient deprivation protects mitochondr

195 Significantly, without WASH, retromer tubulation was exaggerated, supporting a model wherein W

196 Tubulation was suppressed in the context of the full-len

197 bution of the same markers, without apparent tubulation, was observed under hyperosmotic conditions.

198 To look into the mechanism of membrane tubulation, we chose a set of membrane conditions varyin

199 Outer retinal tubulations were associated with absence of underlying r

200 pigment epithelium detachment, outer retinal tubulation) were identified in the retinae of the GA pat

201 roliferation involving membrane blebbing and tubulation, which is dependent on an altered rate of mem

202 t with microtubules plays a role in membrane tubulation, while its capacity to induce actin assembly