ライフサイエンスコーパス: tularensis

1 vaccine-induced immune responses against F. tularensis.

2 role in the oxidative stress response of F. tularensis.

3 role of OxyR has not been established in F. tularensis.

4 anthracis, Yersinia pestis, and Francisella tularensis.

5 he intramacrophage growth and survival of F. tularensis.

6 acrophage growth and survival of Francisella tularensis.

7 to macrophage inflammation in response to F. tularensis.

8 etic pathway in macrophages infected with F. tularensis.

9 the live vaccine strain (LVS) of Francisella tularensis.

10 and the antioxidant defence mechanisms of F. tularensis.

11 ired for macrophage cytokine responses to F. tularensis.

12 l for misidentification of F. novicida as F. tularensis.

13 66c as a new virulence factor in Francisella tularensis.

14 -negative coccoid rod bacterium, Francisella tularensis.

15 establishment of a fulminate infection by F. tularensis.

16 lls with the live vaccine strain (LVS) of F. tularensis.

17 d with Dichelobacter nodosus and Francisella tularensis.

18 highly divergent sequences from Francisella tularensis.

19 the live vaccine strain (LVS) of Francisella tularensis.

20 lling survival of infection with virulent F. tularensis.

21 rucial role in innate immune responses to F. tularensis.

22 al during pulmonary infection by virulent F. tularensis.

23 e lethal intracellular bacterium Francisella tularensis.

24 r zoonotic infections, including that for F. tularensis.

25 lar bears to C. burnetii, N. caninum, and F. tularensis.

26 ring intracellular infections with type A F. tularensis.

27 The assay LOD was 8.5 CFU/ml for F. tularensis, 10 CFU/ml for B. anthracis, and 4.5 CFU/ml f

28 molecular weight (VHMW)] by expressing in F. tularensis a heterologous chain-length regulator gene (w

29 Francisella tularensis, a Gram-negative bacterium, is the causative

30 Our objective was to identify F. tularensis-activated host signaling pathways that regula

31 Francisella tularensis and Anaplasma phagocytophilum alter host auto

32 the observed profiles of each of the two F. tularensis and B. anthracis strains exhibited some simil

33 F. tularensis and B. anthracis were grown in liquid broth f

34 ally misassembled contigs in assemblies of F.tularensis and between 31% and 100% of extensively misas

35 ) and priority pathogens such as Francisella tularensis and Burkholderia pseudomallei.

36 izoferrin is also synthesized by Francisella tularensis and Francisella novicida, but unlike R. picke

37 on of host cell death during infection by F. tularensis and highlight how shifts in the magnitude and

38 otential correlates of protection against F. tularensis and to expand and refine a comprehensive set

39 optical mapping data for loblolly pine and F.tularensis and used real optical mapping data for rice a

40 lasma gondii, Coxiella burnetii, Francisella tularensis, and Neospora caninum, estimate concentration

41 rrorism, but the pathogenic mechanisms of F. tularensis are largely unknown.

42 or this suppression of innate immunity by F. tularensis are not defined.

43 ns such as Coxiella burnetii and Francisella tularensis, as well as Coxiella-like and Francisella-lik

44 We found that viable Francisella tularensis, as well as Salmonella enterica bacteria tran

45 Here, we demonstrate a highly sensitive F. tularensis assay that incorporates sample processing and

46 ltiplex nested PCR assay for detection of F. tularensis, B. anthracis, and Y. pestis directly from pa

47 der spectrum of growth inhibition against F. tularensis , Bacillus anthracis , and Staphylococcus aur

48 Francisella tularensis, Bacillus anthracis, and Yersinia pestis are

49 Francisella tularensis bacteria acquired from infected cells were fo

50 haride antigen and 31 bacteria/mL for the F. tularensis bacteria were achieved.

51 sensor formats for the detection of whole F. tularensis bacteria were developed and their performance

52 the lipopolysaccharide (LPS) of Francisella tularensis bacteria, a Tier 1 Select Agent of bioterrori

53 In Mycobacteria tuberculosis and Francisella tularensis, biotin biosynthesis is a key fitness determi

54 llus anthracis, Yersinia pestis, Francisella tularensis, Brucella spp., Burkholderia spp., and Ricket

55 llus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, Burkholderia pseudomall

56 genic bacteria: Yersinia pestis, Francisella tularensis, Burkholderia pseudomallei and Acinetobacter

57 indicate that recognition of C3-opsonized F. tularensis, but not extensive cytosolic replication, pla

58 gainst infection with attenuated Francisella tularensis, but their role in infection mediated by full

59 ed and required for virulence of Francisella tularensis by subverting the host innate immune response

60 cultative intracellular pathogen Francisella tularensis can persist in water, amoebae, and arthropods

61 e methods currently available to genotype F. tularensis cannot conclusively identify the associated s

62 findings provide compelling evidence that F. tularensis catalase restricts reactive oxygen species to

63 Francisella tularensis causes a lethal human disease known as tulare

64 Francisella tularensis causes lethal pneumonia following infection o

65 Inhalation of Francisella tularensis causes pneumonic tularemia in humans, a sever

66 intracellular bacterial pathogen Francisella tularensis causes tularemia, a zoonosis that can be fata

67 C 25015 and on Francisella tularensis subsp. tularensis CCUG 2112, the most virulent Francisella subs

68 c immune responses and protection against F. tularensis challenge.

69 rotective effects against virulent type A F. tularensis challenge.

70 t, we evaluated Escherichia coli-Francisella tularensis chimeric variants of tmRNA and SmpB.

71 RNA-Seq we identify those regions of the F. tularensis chromosome occupied by PmrA and those genes t

72 sociates with 252 distinct regions of the F. tularensis chromosome, but exerts regulatory effects at

73 nvolved in bacterial immune evasion, like F. tularensis clpB, can serve as a model for the rational d

74 in neutrophils is necessary for limiting F. tularensis colonisation and proliferation.

75 cacy against Bacillus anthracis; Francisella tularensis; Coxiella burnetii; and Ebola, Marburg, and L

76 hepatocytic cell line compared to that of F. tularensis cultured in broth.

77 ive vaccine strain) or catalase-deficient F. tularensis (DeltakatG) show distinct profiles in their H

78 The pathogenicity of F. tularensis depends on its ability to persist inside host

79 F. tularensis DNA in buffer or CFU of F. tularensis was spi

80 owever, the molecular mechanisms by which F. tularensis DsbA contributes to virulence are unknown.

81 Here, we demonstrate that F. tularensis DsbA is a bifunctional protein that oxidizes

82 ments in F. tularensis identified over 50 F. tularensis DsbA substrates, including outer membrane pro

83 , implicate the enzyme as a potential key F. tularensis effector protein, and may help elucidate a me

84 Infection with Francisella tularensis elicits innate and adaptive immune responses.

85 epresses inflammasome activation and that F. tularensis-encoded FTL_0325 mediates this effect.

86 The intracellular pathogen Francisella tularensis encodes a disulfide bond formation protein or

87 ted in culture by bacterial taxa Francisella tularensis (F. tularensis) subspecies novicida and Bacil

88 am-negative facultative anaerobe Francisella tularensis: F. tularensis subsp. tularensis (type A) and

89 Multiple independent acquisitions of F. tularensis from the environment over a short time period

90 Escape of F. tularensis from the phagosome into the cytosol of the ma

91 Francisella tularensis (Ft) is a highly infectious intracellular pat

92 The bacterium Francisella tularensis (Ft) is one of the most infectious agents kno

93 such as virulent Francisella tularensis spp. tularensis (Ftt).

94 nd was applicable to multiple isolates of F. tularensis Further improvements in the accuracy and prec

95 Es) with significant homology to Francisella tularensis (gamma-proteobacteria) have been characterize

96 Several in vivo screens have identified F. tularensis genes necessary for virulence.

97 identified 95 lung infectivity-associated F. tularensis genes, including those encoding the Lon and C

98 ofile of the live vaccine strain (LVS) of F. tularensis grown in the FL83B murine hepatocytic cell li

99 A REP34 knock-out strain of F. tularensis has a reduced ability to both induce encystme

100 popolysaccharide (LPS) O antigen (OAg) of F. tularensis has been considered for use in a glycoconjuga

101 n both cases, forward primer for Francisella tularensis holarctica genomic DNA was surface immobilise

102 cribed as virulence-associated factors in F. tularensis Identification of these Lon substrates has th

103 Trapping experiments in F. tularensis identified over 50 F. tularensis DsbA substra

104 at targeting fixed (inactivated) Francisella tularensis (iFT) organisms to FcR in mice i.n., with MAb

105 crophages (BMDMs) to inactivated Francisella tularensis (iFt)-containing immune complexes, we observe

106 ted Listeria monocytogenes expressing the F. tularensis immunoprotective antigen IglC) as the booster

107 results also demonstrate that FTL_0325 of F. tularensis impacts proIL-1beta expression as early as 2

108 this study, we demonstrate that virulent F. tularensis impairs production of inflammatory cytokines

109 st aerosol challenge with virulent type A F. tularensis in a species other than a rodent since the or

110 Francisella tularensis in an intracellular bacterial pathogen that c

111 er biofilm formation enhances survival of F. tularensis in aquatic or other environmental niches has

112 cartridge-based assay can rapidly detect F. tularensis in bloodstream infections directly in whole b

113 uivalents (GE) per reaction and 10 CFU/ml F. tularensis in both human and macaque blood.

114 joint infections (PJI) caused by Francisella tularensis in Europe (one in Switzerland and one in the

115 reover, p38 MAPK activity is required for F. tularensis-induced COX-2 protein synthesis, but not for

116 nase 3 (JAK3) signaling are necessary for F. tularensis-induced PGE2 production.

117 Francisella tularensis induces the synthesis of prostaglandin E(2) (

118 he mechanisms that recruit neutrophils to F. tularensis-infected lungs, opsonization and phagocytosis

119 sly demonstrated that PGE(2) synthesis by F. tularensis-infected macrophages requires cytosolic phosp

120 However, in F. tularensis-infected macrophages we observed a temporal d

121 tion of AA to be converted into PGE(2) by F. tularensis-infected macrophages.

122 or memory (EM) CD4(+) T cells elicited by F. tularensis infection (postimmunization) is increased in

123 Gram-negative bacterial pathogen Francisella tularensis Infection of macrophages and their subsequent

124 elucidate a mechanistic understanding of F. tularensis infection of phagocytic cells.

125 rophil niche in CD200R(-/-) mice restores F. tularensis infection to levels seen in wild-type mice.

126 We study the pathogenesis of Francisella tularensis infection with an experimental mouse model, a

127 type mice highly sensitive to respiratory F. tularensis infection, and depletion beginning at 3 days

128 literature exists on the host response to F. tularensis infection, the vast majority of work has been

129 with the extent of necrotic damage during F. tularensis infection.

130 s interleukin 12 (IL-12) protects against F. tularensis infection; this protection was lost in MIIG m

131 n of antibodies from patients with type B F. tularensis infections and that these can be used for the

132 We also report that F. tularensis inhibits ROS-dependent autophagy to promote i

133 Francisella tularensis is a category A biodefence agent that causes

134 Francisella tularensis is a facultative bacterial pathogen that repl

135 Francisella tularensis is a facultative intracellular bacterial path

136 Francisella tularensis is a facultative intracellular bacterium that

137 Francisella tularensis is a facultative intracellular bacterium that

138 Francisella tularensis is a facultative intracellular, Gram-negative

139 Francisella tularensis is a Gram-negative bacterium and the causativ

140 Francisella tularensis is a Gram-negative, facultative intracellular

141 Francisella tularensis is a highly infectious bacterium that causes

142 Francisella tularensis is a highly infectious intracellular bacteriu

143 Francisella tularensis is a highly virulent Gram-negative intracellu

144 metabolic reprogramming of host cells by F. tularensis is a key component of both inhibition of host

145 Francisella tularensis is a potential bioterrorism agent that is hig

146 Although F. tularensis is a recognized biothreat agent with broad an

147 Tularemia caused by Francisella tularensis is a zoonotic infection of the Northern Hemis

148 Because of its extreme pathogenicity, F. tularensis is classified as a category A bioweapon by th

149 The adaptive immune response to Francisella tularensis is dependent on the route of inoculation.

150 Extreme infectivity and virulence of F. tularensis is due to its ability to evade immune detecti

151 f intraocular inflammation in areas where F. tularensis is endemic.

152 e in infection mediated by fully virulent F. tularensis is not known.

153 We propose that the extreme virulence of F. tularensis is partially due to the bifunctional nature o

154 The bacterium Francisella tularensis is recognized for its virulence, infectivity,

155 Such outbreaks are exceedingly rare, and F. tularensis is seldom recovered from clinical specimens.

156 Francisella tularensis is the causative agent of tularemia and a cat

157 Francisella tularensis is the causative agent of tularemia, a catego

158 Francisella tularensis is the causative agent of tularemia.

159 infectious and zoonotic pathogen Francisella tularensis is the etiologic agent of tularemia, a potent

160 Francisella tularensis is the etiological agent of tularemia, or rab

161 an essential virulence factor of Francisella tularensis, is a lipoprotein with two conserved domains

162 zoonose caused by the bacterium Francisella tularensis, largely refer to Parinaud's oculoglandular s

163 Here we establish that F. tularensis limits Ca(2+) entry in macrophages, thereby l

164 ated rabbits were seropositive for IgG to F. tularensis lipopolysaccharide (LPS).

165 larensis vs Pseudomonas aeruginosa and by F. tularensis live bacteria vs the closely related bacteriu

166 ntified TolC as a virulence factor of the F. tularensis live vaccine strain (LVS) and demonstrated th

167 Using PBLs from mice vaccinated with F. tularensis Live Vaccine Strain (LVS) and related attenua

168 of OAg size in protection, we created an F. tularensis live vaccine strain (LVS) mutant with a signi

169 Intradermal inoculation with the F. tularensis live vaccine strain (LVS) results in a robust

170 We employed Francisella tularensis live vaccine strain (LVS) to study mechanisms

171 se gene (FTL_0724) as being important for F. tularensis live vaccine strain (LVS) virulence.

172 by using unmarked deletion mutants of the F. tularensis live vaccine strain (LVS).

173 immunity against pulmonary infection with F. tularensis live vaccine strain, its production is tightl

174 mortality after pulmonary infection with F. tularensis live vaccine strain.

175 riments identified five substrates of the F. tularensis Lon protease (FTL578, FTL663, FTL1217, FTL122

176 We were particularly interested in the F. tularensis LVS (live vaccine strain) clpB (FTL_0094) mut

177 s of MAb-iFT-immunized mice subsequent to F. tularensis LVS challenge.

178 monocytes and neutrophils, infected with F. tularensis LVS ex vivo, display enhanced restriction of

179 Infection of mice in vivo with a F. tularensis LVS FTL_0724 mutant resulted in diminished mo

180 infected lungs, and control of pulmonary F. tularensis LVS growth.

181 reening a transposon insertion library of F. tularensis LVS in the presence of hydrogen peroxide, we

182 Importantly, pulmonary F. tularensis LVS infection of MR1-deficient (MR1(-/-)) mic

183 We found that the lethality of pulmonary F. tularensis LVS infection was exacerbated under condition

184 7Ralpha(-/-) mice are more susceptible to F. tularensis LVS infection, our studies, using a virulent

185 4(+) T cells to the lungs after pulmonary F. tularensis LVS infection.

186 a critical protective role in respiratory F. tularensis LVS infection.

187 growth that can be restored to wild-type F. tularensis LVS levels by either transcomplementation, in

188 These findings further illustrate that F. tularensis LVS possesses numerous genes that influence i

189 e-derived DCs (Mo-DCs) in the lungs after F. tularensis LVS pulmonary infection.

190 tively, this study provides evidence that F. tularensis LVS represses inflammasome activation and tha

191 r of the oxidative stress response of the F. tularensis LVS.

192 thesized that the antioxidant defenses of F. tularensis maintain redox homeostasis in infected macrop

193 factors and the mechanisms through which F. tularensis mediates these suppressive effects remain rel

194 , we sought an alternative means by which F. tularensis might obtain iron.

195 The means by which F. tularensis modulates macrophage activation are not fully

196 revealed that the immune response to the F. tularensis mutant strains was significantly different fr

197 sis Types A and B form poor biofilms, but F. tularensis mutants lacking lipopolysaccharide O-antigen,

198 oli cells yielded glycOMVs that displayed F. tularensis O-PS.

199 When F. tularensis OAg was purified under standard conditions, t

200 In infected macaques, the assay detected F. tularensis on days 1 to 4 postinfection in 21%, 17%, 60%

201 The data also indicate that F. tularensis pathogenesis is controlled by a highly interc

202 The Francisella tularensis pathogenicity island (FPI) encodes many prote

203 e demonstrate that antioxidant enzymes of F. tularensis prevent the activation of redox-sensitive MAP

204 Francisella tularensis produces a lipopolysaccharide (LPS) that is e

205 Previously, we identified seven F. tularensis proteins that induce a rapid encystment pheno

206 wherein the immunomodulatory capacity of F. tularensis relies, at least in part, on TolC-secreted ef

207 F. tularensis represses inflammasome; a cytosolic multi-pro

208 ction by the live vaccine strain (LVS) of F. tularensis Resistance is characterized by reduced lethal

209 Analysis of the MglA and SspA mutants in F. tularensis reveals that interaction between PigR and the

210 assemblies of the loblolly pine, Francisella tularensis, rice and budgerigar genomes.

211 d survival upon subsequent challenge with F. tularensis Schu S4 and provided complete protection agai

212 n blood drawn from macaques infected with F. tularensis Schu S4 at daily intervals.

213 ses (LD50) of aerosolized highly virulent F. tularensis Schu S4 had a significantly higher survival r

214 Using an F. tularensis Schu S4 mutant library, we identified strains

215 nosis of BALB/c mice infected with either F. tularensis SCHU S4 or Y. pestis CO92.

216 C and SilC, present in the fully virulent F. tularensis Schu S4 strain for their contributions to mul

217 hallenged via aerosol with human-virulent F. tularensis SCHU S4 that had been cultivated in either Mu

218 ity island genes tested are essential for F. tularensis Schu S4 virulence and further suggest that pd

219 llowing inhalational exposure to Francisella tularensis SCHU S4, a small initial number of bacteria e

220 terminants from the select agent Francisella tularensis SCHU S4.

221 inoculated with F. novicida U112, LVS, or F. tularensis Schu S4.

222 orm of the enzyme and inhibited growth of F. tularensis SchuS4 at concentrations near that of their m

223 escribe novel inhibitors against Francisella tularensis SchuS4 FabI identified from structure-based i

224 osed to virulent (Francisella tularensis ssp tularensis SchuS4).

225 tudies, using a virulent type A strain of F. tularensis (SchuS4), indicate that IL-17Ralpha(-/-) mice

226 , with MAb-iFT immune complexes, enhances F. tularensis-specific immune responses and protection agai

227 ice with the live vaccine strain (LVS) of F. tularensis, splenic IL-10 levels increased rapidly and r

228 rial pathogens, such as virulent Francisella tularensis spp. tularensis (Ftt).

229 e from mice exposed to virulent (Francisella tularensis ssp tularensis SchuS4).

230 ed whether complement-dependent uptake of F. tularensis strain SCHU S4 affects the survival of primar

231 ulent counterparts, F. tularensis subspecies tularensis strain SCHU S4 and B. anthracis Ames.

232 strate that lipids enriched from virulent F. tularensis strain SchuS4, but not attenuated live vaccin

233 erosolized Francisella tularensis subspecies tularensis, strain SCHU S4.

234 nt clues for further understanding of the F. tularensis stress response and pathogenesis.

235 ate identification and differentiation of F. tularensis subpopulations during epidemiological investi

236 ularensis subsp. tularensis subtype A.II, F. tularensis subsp. holarctica (also referred to as type B

237 tion against challenge with two different F. tularensis subsp. holarctica (type B) live vaccine strai

238 tularensis subsp. tularensis (type A) and F. tularensis subsp. holarctica (type B).

239 de putative TPR-like proteins in Francisella tularensis subsp. holarctica FSC200.

240 ereby contributing to the survival of the F. tularensis subsp. holarctica live vaccine strain (LVS) i

241 DI-TOF) mass spectrometry on the Francisella tularensis subsp. holarctica LVS defined three protein b

242 arctica (also referred to as type B), and F. tularensis subsp. mediasiatica, as well as opportunistic

243 p. mediasiatica, as well as opportunistic F. tularensis subsp. novicida from each other and near neig

244 luding the opportunistic microbe Francisella tularensis subsp. novicida, there are considerable diffe

245 ultative anaerobe Francisella tularensis: F. tularensis subsp. tularensis (type A) and F. tularensis

246 cluster from the highly virulent Francisella tularensis subsp. tularensis (type A) strain Schu S4 in

247 a philomiragia ATCC 25015 and on Francisella tularensis subsp. tularensis CCUG 2112, the most virulen

248 ely detect and identify the hypervirulent F. tularensis subsp. tularensis subtype A.I, the virulent F

249 bsp. tularensis subtype A.I, the virulent F. tularensis subsp. tularensis subtype A.II, F. tularensis

250 s probe, providing sensitive and specific F. tularensis subspecies and subtype identification in a ra

251 in virulence observed between the various F. tularensis subspecies and subtypes.

252 F. tularensis subspecies holarctica was isolated from the b

253 masome during infection with the Francisella tularensis subspecies novicida (F. novicida), whereas en

254 s from their fully virulent counterparts, F. tularensis subspecies tularensis strain SCHU S4 and B. a

255 e to lethal doses of aerosolized Francisella tularensis subspecies tularensis, strain SCHU S4.

256 level with the identification of Francisella tularensis subspecies.

257 by bacterial taxa Francisella tularensis (F. tularensis) subspecies novicida and Bacillus anthracis (

258 ntify the hypervirulent F. tularensis subsp. tularensis subtype A.I, the virulent F. tularensis subsp

259 btype A.I, the virulent F. tularensis subsp. tularensis subtype A.II, F. tularensis subsp. holarctica

260 Furthermore, sequencing of the amplified F. tularensis targets provides clade confirmation and infor

261 outbreak was caused by diverse clones of F. tularensis that occurred concomitantly, were widespread,

262 SCHU S4 strain of the bacterium Francisella tularensis, that infects alveolar macrophages.

263 ts close genetic relationship to Francisella tularensis, the agent of tularemia.

264 Francisella tularensis, the causative agent of a fatal human disease

265 tudy, we developed a model using Francisella tularensis, the causative agent of tularemia, in which p

266 Francisella tularensis, the causative agent of tularemia, is most de

267 Francisella tularensis, the causative agent of tularemia, modulates

268 Francisella tularensis, the etiological agent of tularemia, is one o

269 In Francisella tularensis, the putative DNA-binding protein PigR works

270 anism of immune evasion is the ability of F. tularensis to induce the synthesis of the small lipid me

271 ls novel pathogenic mechanisms adopted by F. tularensis to modulate macrophage innate immune function

272 delay in host cell death is required for F. tularensis to preserve its intracellular replicative nic

273 nse mechanisms, as well as the ability of F. tularensis to prolong neutrophil lifespan.

274 Based on the ability of F. tularensis to resist high ROS/RNS levels, we have hypoth

275 er, the factors that govern adaptation of F. tularensis to the intrahepatocytic niche have not been i

276 as the highly virulent bacterium Francisella tularensis, to ensure their replication and transmission

277 d that lon and clpP are also required for F. tularensis tolerance to stressful conditions.

278 on the highly virulent bacterium Francisella tularensis tularensis.

279 e against attenuated F. tularensis versus F. tularensis type A differs.

280 FTT_0166c in the highly virulent Francisella tularensis type A strain SchuS4 are required for proper

281 of mice infected with the LVS rather than F. tularensis type A, while IL-23p19 mRNA expression was fo

282 As with phagosomal escape, the F. tularensis Type VI Secretion System (T6SS) was required

283 Francisella tularensis: F. tularensis subsp. tularensis (type A) and F. tularensis subsp. holarctica

284 ighly virulent Francisella tularensis subsp. tularensis (type A) strain Schu S4 in hypervesiculating

285 F. tularensis Types A and B form poor biofilms, but F. tula

286 charides may promote biofilm formation by F. tularensis Types A and B.

287 ccine-induced protection against Francisella tularensis using murine splenocytes and further demonstr

288 The Gram-negative bacterium Francisella tularensis utilizes its antioxidant armature to limit th

289 ective immune response against attenuated F. tularensis versus F. tularensis type A differs.

290 A hallmark of F. tularensis virulence is its ability to quickly grow to h

291 F. tularensis virulence stems from genes encoded on the Fra

292 1548 and FTL_1709, which are required for F. tularensis virulence.

293 n to modulate both isomerase activity and F. tularensis virulence.

294 Thus, IglE is essential for Francisella tularensis virulence.

295 nal transducer and model drug by LPS from F. tularensis vs Pseudomonas aeruginosa and by F. tularensi

296 F. tularensis DNA in buffer or CFU of F. tularensis was spiked into human or macaque blood.

297 te (NZW) rabbits with aerosols containing F. tularensis We evaluated the relative humidity, aerosol e

298 Distinct VOC profiles where observed for F. tularensis when compared with B. anthracis while the obs

299 Only the OxyR homolog is present in F. tularensis, while the SoxR homologs are absent.

300 n (CDC) and include the bacteria Francisella tularensis, Yersinia pestis, Burkholderia mallei, and Br