ライフサイエンスコーパス: tumble

1 domain changes orientation rapidly (rocks or tumbles).

2 at increases the tendency of the bacteria to tumble.

3 erial motility, especially reorientation and tumble.

4 motors, even under conditions in which cells tumbled.

5 lue that compares with that measured in bulk tumbles.

6 and robust against Brownian motion and cell tumbling.

7 polar interaction due to the rapid molecular tumbling.

8 mics in the absence of the overall molecular tumbling.

9 h a correlation time consistent with vesicle tumbling.

10 to large bicelles, resulting in slow protein tumbling.

11 ule, combined with fully anisotropic overall tumbling.

12 local backbone dynamics and overall protein tumbling.

13 tion of the polysaccharide and not molecular tumbling.

14 nse of rotation, increasing the frequency of tumbling.

15 iM, inducing clockwise filament rotation and tumbling.

16 ly active complexes via directional Brownian tumbling.

17 erol and a longer DNA duplex to slow overall tumbling.

18 nge of direction defining the beginning of a tumble and increased swimming speed defining the end.

19 olar couplings indicate that the two domains tumble and move independently of each other.

20 e bacterial chemotactic strategies using run-tumble and run-reverse-flick motility patterns.

21 We will focus on two motility patterns, run-tumble and run-reverse-flick, that are observed and char

22 generate sufficient clockwise (CW) signal to tumble and thus swim exclusively smoothly (run).

23 eloped which identifies individual bacterial tumbles and so allows rapid, quantitative measurements o

24 plex coacervate phase, tau is locally freely tumbling and capable of diffusing through the droplet in

25 Besides the conventional tumbling and directional swimming, T. carassii can chang

26 These spectra are consistent with a rapidly tumbling and highly dynamic peptide.

27 ces a loss of separability between molecular tumbling and internal dynamics, while motions between di

28 it does not require separability of overall tumbling and internal motions, which makes it applicable

29 erdomain motions, in addition to the overall tumbling and local intradomain dynamics.

30 Under simple shear flow, only two motions, "tumbling" and "tank-treading," have been described exper

31 nd flagellation; however, swarm cells rarely tumbled, and cells of Enterococcus tended to swim in loo

32 A stochastic process generates the runs and tumbles, and in a chemoeffector gradient, runs that carr

33 us muscle was brine enhanced by injection or tumbling, and HP treated at 600 MPa following storage at

34 NafY domain structure, molecular tumbling, and interdomain motion, as well as NafY intera

35 ivity to the in vivo environment or particle tumbling, and surfaces favourable for functionalization.

36 reversal of the rotation of a flagellum in a tumble; and 3), the associated polymorphic transformatio

37 The two zinc fingers tumble anisotropically as folded domains, with the tumbl

38 Tumbles are defined by a combination of the parameters r

39 In the central region of the cluster, tumbles are strongly suppressed whereas near the edge of

40 of the proximal region and both zinc fingers tumble as a single domain and exhibit significantly redu

41 solved in a low-viscosity fluid allows it to tumble as fast as a much smaller protein.

42 temporal resolution (500 Hz), we identified tumbles as events starting (or finishing, respectively)

43 times, indicating that the knuckles are not tumbling as a single globular domain.

44 ffective correlation time representing helix tumbling as well as internal motion.

45 ent dynamics that alters between sliding and tumbling, as a result of the off-shear plane rotational

46 bore little or no relation to the rough-and-tumble aspects of patient care.

47 stituted aromatics are either static or only tumble at elevated temperatures via flexing motions of t

48 Whereas F508del tumbles at a rate nearly consistent with the monomeric s

49 Comparison of global macromolecular tumbling at 0.1mM and 1.0mM prolactin revealed reversibl

50 These mutants regained tumbling at a frequency similar to that of the wild type

51 mpromised; straight-swimming cells unable to tumble become trapped within the agar matrix.

52 op a hybrid model that includes both run and tumble behavior and heterogeneous noise during the runs,

53 ucing bacteria are motile with their run-and-tumble behavior exhibiting series of flights and waiting

54 of inter-flagellar correlations is that run/tumble behavior is only weakly dependent on number of fl

55 The normal run-tumble behavior seen in swimming chemotaxis is largely s

56 such statistics in other cell types: run and tumble behavior with Levy-distributed run times, and ens

57 icroscope they exhibited random movement and tumbling behavior.

58 liquid crystals exhibit 'shear aligning' or 'tumbling' behaviour under shear, and are described quant

59 of CheR and CheB affect the population mean tumble bias and its variance independently.

60 thematical expression relates the cell's run/tumble bias to the number and average rotational state o

61 , we quantitatively mapped motile phenotype (tumble bias) to protein numbers using thousands of singl

62 Cells treated with saxitoxin swam with a tumbling bias.

63 with our earlier report using small and fast tumbling bicelles, the present work of well aligned bice

64 However, cells induced to run and tumble by the unphosphorylated mutant protein CheY13DK10

65 change directions at different times, and a tumble can result from the change in direction of only o

66 iform correlation time for overall molecular tumbling can be problematic for biomolecules containing

67 et transform multiscale analysis shows these tumbles cause in-plane diffusive reorientations with 1.5

68 markably similar to the widely known run-and-tumble chemotactic behavior of Escherichia coli bacteria

69 ontinuous version based on classical run-and-tumble chemotaxis.

70 decay was associated with slower, whole-body tumbling, confirming that PKI alpha is highly disordered

71 0, reveal the presence of an N-terminal slow-tumbling core and a highly disordered flexible C-terminu

72 ollowing parameters were determined: overall tumbling correlation time for the protein molecule (tau

73 ination of two movements: one of the overall tumbling (correlation time, 8.65 ns) and the other of fa

74 transient phase desynchronization, or "phase tumbling", could arise from intrinsic, stochastic noise

75 The variation of tumble duration over growth was consistent with a hydrod

76 The tumbling dynamics of a 20-mer HIV-1 RNA stem loop 3 spin

77 logarithm of the minimum angle of resolution tumbling E chart and then with trial frame based on auto

78 ions and high (100%)- and low (20%)-contrast tumbling E visual acuity (VA) were measured in four mode

79 ngle of resolution) VA for briefly presented tumbling E's was measured in 10 visually normal individu

80 logarithm of the minimal angle of resolution tumbling-E chart, underwent autorefraction, and thereby

81 sfully measured with retroilluminated logMAR tumbling-E charts in 3997 to 5949 children; cycloplegic

82 Resolution was also measured for tumbling-E discrimination at these locations.

83 ty using retro-illuminated logMAR chart with tumbling-E optotypes, and cycloplegic refractive error u

84 This defect lowered the frequency of tumbling episodes during swimming and impaired chemotact

85 ncy of switching between smooth-swimming and tumbling episodes in response to changes in concentratio

86 es exhibits persistence over the course of a tumbling event, which is a novel result with important i

87 behavior occurs within a small number of run/tumble events) and overshoot (the degree of excessive re

88 in general but not used to identify discrete tumble events.

89 Tumbles (events that enable swimming cells to alter cour

90 lymorphic transformation of a flagellum in a tumble facilitates the reorientation of the cell, and th

91 These tumbles follow a common long (about 300 +/- 100 ms, N =

92 The model also predicted that phase tumbling following brief VIP treatment would accelerate

93 nit of cAPK decreased the rate of whole-body tumbling for all three mutants.

94 sufficient to account for overall molecular tumbling for both apo and EACA-bound K1(Pg).

95 insoluble proteins, and proteins that cannot tumble freely due to associations within the cell cannot

96 scale, but the bound Cob+ ions rotate and/or tumble freely inside the molecular capsules.

97 w-abundance receptors exhibit abnormally low tumble frequencies and do not migrate effectively in spa

98 P, defined as the ratio between steady-state tumbling frequencies in the presence and absence of attr

99 These features could account for the low tumble frequency and inefficient taxis exhibited by Trg-

100 e receptors, cells exhibit an abnormally low tumble frequency and the ability of the remaining recept

101 o allows rapid, quantitative measurements of tumble frequency in free-swimming bacteria.

102 Tumble frequency is modulated by cells to enable chemota

103 ed whereas near the edge of the cluster, the tumble frequency is restored for exiting cells, thereby

104 The tumble frequency of an individual cell strongly depends

105 The tumble frequency of wild-type Escherichia coli exposed t

106 ay is to quantitatively measure steady-state tumble frequency to enable comparisons of mutant strain

107 pathway typically have phenotypes of altered tumble frequency.

108 he motility apparatus resulting in a nonzero tumbling frequency allows for unjamming of otherwise str

109 Steady-state average tumbling frequency and adaptation time increased nearly

110 increasing diffusive spread with increasing tumbling frequency in the small pore limit, consistent w

111 nce of obstacles is a consequence of reduced tumbling frequency that is adjusted by the E. coli cells

112 Tumbling frequency was found to vary with P-CheY concent

113 P1 domains in the CheADeltaP2 mutant raised tumbling frequency, presumably by buffering the irrevers

114 The tumbling half-response times were subsecond for onset bu

115 most simply by forcing the macromolecules to tumble in an asymmetric environment that restricts some

116 opper nanorods were also found to rotate and tumble in aqueous Br(2) solution because of the ion grad

117 The two domains of the protein tumble in solution overall as a whole with an overall mo

118 domains in tSH2(pm) are partly uncoupled and tumble in solution with a faster correlation time.

119 The reversals of motor direction that cause tumbles in Eschericia coli taxis are replaced by brief m

120 previously been shown to be correlated with tumbles in general but not used to identify discrete tum

121 ich has an unusually flat, triangular shape, tumbles in solution at 28 degrees C with an effective ro

122 Even at -110 degrees C, methane rapidly tumbles in the coordination sphere of rhodium, exchangin

123 Although superficially similar to tumbling in a bulk nematic phase, the kinematic details

124 mplying specific motor damage, but prolonged tumbling in buffer alone.

125 he wild type, a cheB mutant was incapable of tumbling in response to decreasing concentrations of asp

126 . coli but similar to the probability of not tumbling in swimming E. coli.

127 main exhibits some degree of independence in tumbling, in addition to other fast internal motions.

128 Models for rigid molecule tumbling, including two based on helical conformations p

129 e consistent with the modules in the F2 pair tumbling independent of one another.

130 d retained a significant degree of molecular tumbling independent of Sos(Cat), while Sos(Cat) also tu

131 comparisons confirmed that RPA70A and RPA70B tumble independently in solution in the absence of ssDNA

132 The two domains tumble independently in solution, having no fixed relati

133 cillus stearothermophilus synthetases do not tumble independently in solution, suggesting restricted

134 e motifs do not interact with each other and tumble independently in solution.

135 The results show that the CTD and NC domains tumble independently.

136 es retain their structural individuality and tumble independently.

137 troponin C bound cardiac troponin I-(1-80)DD tumble independently.

138 ain protrudes outside of the cavity where it tumbles independently from the rest of the complex.

139 Flexible guests such as hexane tumble inside the cavity with an activation barrier of D

140 performed experiments in which a string was tumbled inside a box and found that complex knots often

141 n of filaments were involved in tumbles, the tumble intervals were shorter and the angles between run

142 R) spectrum is highly sensitive to molecular tumbling is reported.

143 components by spin diffusion when molecular tumbling is slow due to solvent viscosity, thus strongly

144 osphorothioates at the end of the lower stem tumbled isotropically in mini c TAR DNA, mini TAR RNA, a

145 5N relaxation parameters indicates that PGAM tumbles isotropically with a rotational correlation time

146 gh most marginated platelets are observed to tumble just outside the RBC-rich zone, platelets further

147 independent of Sos(Cat), while Sos(Cat) also tumbled largely independently of H-Ras.

148 otions on a time-scale faster than molecular tumbling may be determined by analysis of (15)N NMR rela

149 d, when target landscape is patchy, adequate tumbling may help to explore better local scale heteroge

150 o show that micelles or other small, rapidly tumbling membrane fragments are not formed in the presen

151 avorable relaxation properties of the slowly tumbling membrane protein-nanodisc complex.

152 re the intracellular signal for inducing the tumbling mode of swimming.

153 es a bacterium to switch between running and tumbling modes; however, the mechanism governing the fil

154 The strategy easily distinguishes lone-tumbling molecules versus nanoentities of various sizes.

155 cosecond) motions revealed that F508del NBD1 tumbles more rapidly in solution than WT NBD1.

156 Here we reveal that the paradigm of run-and-tumble motility is dramatically altered in a porous medi

157 ethod for Escherichia coli (E. coli) run-and-tumble motility was combined with the phage CTRW model t

158 erge from Escherichia coli's classic run-and-tumble motility, yet how they relate to the strong and r

159 responsible for the enhancement in bacterial tumble motility.

160 , including defects in FAD binding, constant tumbling motility, and an inverse response in which E. c

161 imensional random-walk trajectory in run-and-tumble motion and steady clockwise swimming near a wall.

162 ple flagellar motors to generate the run-and-tumble motion of the cell.

163 tory swimming, helical swimming, and run-and-tumble motion.

164 of chemoattractants by biasing their run-and-tumble motion.

165 Residual overall tumbling motion involving the N-terminal beta-sheet and

166 The correlation times of tumbling motion of the (13)C-(1)H internuclear vectors i

167 r, whereas the measured correlation times of tumbling motion of water across the samples were similar

168 platelet effective reactive area due to its tumbling motion, and the platelet surface receptor densi

169 relaxation time (tau(R)) of the end-over-end tumbling motion, from which P(tot) = 500 A is estimated.

170 experience time-varying forces due to their tumbling motion.

171 direction actively, we simulate the "run-and-tumble" motion by using a bead-spring model to account f

172 h yield a eukaryotic version of the "run-and-tumble" motion of peritrichously flagellated bacteria.

173 order to capture phenomena such as "hindered tumbling" motion of the RBC and the sudden transition fr

174 s suggest that the increasing rotational and tumbling motions of larger-size non-spherical NPs in the

175 al component to probing nanosecond molecular tumbling motions that are modulated by macromolecular pr

176 l bond formation and either translational or tumbling motions within a solvent cage reach an asymptot

177 utants are shifted toward oligomeric states; tumble mutants are shifted toward monomeric states.

178 show that the classical drawback of run-and-tumble navigation-wasteful runs in the wrong direction-c

179 Whether they can tumble near a solid surface is a basic issue for the inc

180 Studies of nitrogen inversion and tumbling of [2.2.2]-diazabicyclooctane within the introv

181 bulk xenon relaxation rate induced by slowed tumbling of a cryptophane-based sensor upon target bindi

182 ation; this timescale is consistent with the tumbling of a lipid-sized cylinder in a medium with the

183 shift analysis suggests that the more rapid tumbling of F508del is the result of an impaired ability

184 he constituent protein subunits, akin to the tumbling of gears in a lock.

185 Slow tumbling of guest on the NMR time scale inside the capsu

186 onance (EPR) at 236.6 and 9.5 GHz probed the tumbling of nitroxide spin probes in the lower stem, in

187 Tumbling of platelets in the red-blood-cell depleted zon

188 of guests, the shape of the capsule prevents tumbling of rigid molecules, and the chemical surface of

189 e relaxes at a rate that correlates with the tumbling of the bicelle, suggesting that it is relativel

190 ockwise rotation of the flagellar motors and tumbling of the cell.

191 Anisotropic tumbling of the elongated TC14 dimer can account for the

192 , and the slower motion is attributed to the tumbling of the enzyme.

193 this picture and further reveals independent tumbling of the finger domains in solution.

194 .5 ns, consistent with that expected for the tumbling of the four helix bundle itself, indicating the

195 MRI contrast agents is to slow the molecular tumbling of the gadolinium(III) ion, which increases the

196 anisotropically as folded domains, with the tumbling of the individual fingers being only partly cor

197 ing that polarization decay is determined by tumbling of the molecular rotor about the long acene axi

198 were observed, consistent with end-over-end tumbling of the molecule.

199 eak broadening caused by the slow rotational tumbling of the nanometer-sized nanoparticles.

200 100 ns correlation time representing overall tumbling of the protein conjugate.

201 r correlation time in the range of molecular tumbling of the protein-DNA complex.

202 (N)) are dominated by the overall rotational tumbling of the protein.

203 -terminal domain, in addition to the overall tumbling of the protein.

204 correlation time characterizing the overall tumbling of the protein.

205 by solution NMR can be difficult due to slow tumbling of the system and the difficulty in identifying

206 otion and the influence of global rotational tumbling on the observed magnetic relaxation.

207 ilayer phases with a higher rate of Brownian tumbling or lateral diffusion.

208 of components necessary for this new pathway tumbled out.

209 Applying this method to a run-and-tumble particle in a 2D Lorentz gas environment provides

210 that is distinctively different from the run-tumble pattern adopted by Escherichia coli.

211 stinctively different from the two-step (run-tumble) pattern of Escherichia coli.

212 Bacteria tumble periodically, following environmental cues.

213 n time scales faster than overall rotational tumbling (picoseconds to nanoseconds).

214 produces higher levels of juvenile rough-and-tumble play by males.

215 ctive states is by human-simulated rough and tumble play or 'tickling' [3,4].

216 USVs, approximately 55 kHz) during rough-and-tumble play.

217 upling between movement and sensation, since tumbling probability is controlled by the internal state

218 an arise when motion up the gradient reduces tumbling probability, further boosting drift up the grad

219 lts suggest that the details of the cellular tumbling process may be adapted to enable bacteria to pr

220 Flexible species such as n-alkanes tumble rapidly on the NMR time scale inside the cavity,

221 the experimental data and indicates that the tumble rate and consequently the morphology of the clust

222 nder particular conditions of viscosity, the tumbling rate of small and medium-sized molecules slows

223 taining the TolB box compared to the overall tumbling rate of the protein was identified from the rel

224 experiment, which is sensitive to molecular tumbling rates and can expose larger aggregate species t

225 e, soluble agents due to decreased molecular tumbling rates following surface immobilization, leading

226 ility, capsule symmetry and structure, guest tumbling rates, susceptibility to disruption by polar so

227 esonances are unobservable due to their slow tumbling rates.

228 Mainly because of the unfavorable tumbling regime, the elucidation of the solution conform

229 In the slow tumbling regime, the R1R2 product results in a constant

230 tively determine whether the cell 'runs' or 'tumbles' remains poorly characterized.

231 verse relaxation times (associated with slow tumbling) render application of the usual techniques tha

232 eatedly (while normal-sized bacteria run and tumble repeatedly).

233 nt (1.37 +/- 0.15 ns), independent of global tumbling, represents a characteristic timescale for shor

234 ysis of inert derivatives) triggered swim or tumble responses in Escherichia coli mutants lacking Tsr

235 The relatively fast overall tumbling results in sharp NMR resonances.

236 ted in a slight increase in the frequency of tumbling/reversal with no obvious defects in chemotactic

237 sm circulate, we show that RBCs successively tumble, roll, deform into rolling stomatocytes, and, fin

238 heir individually isolated counterparts, and tumble semi-independently of one another in the absence

239 These first observations of surface tumbles set a foundation for statistical models of run-a

240 of the response regulator CheY promotes the tumble signal in Escherichia coli chemotaxis.

241 The decay of the tumble signal is caused by dephosphorylation of CheY.

242 lanine change (Y106F) resulting in decreased tumble signaling and chemotaxis; and (iii) no activity,

243 ryptophan mutation (Y106W) causing increased tumble signaling but impairing chemotaxis; (ii) low-leve

244 ent with the monomeric state, the WT protein tumbles significantly more slowly.

245 Tumble speeds were approximately 2/3 as large as run spe

246 The run-and-tumble statistics were nearly the same regardless of cel

247 non-normal dynamics implicit in the run-and-tumble strategy.

248 above a characteristic length, as found for tumbled strings.

249 romotes cell reorientation and mitigates the tumble suppression and re-orientation confinement found

250 foundation for statistical models of run-and-tumble surface motion different from that in bulk and le

251 Enteric bacteria tumble, swim slowly, and are then paralyzed upon exposur

252 itions, Aer alone established the cell's run/tumble swimming pattern and modulated that behavior in r

253 They exhibit a run-tumble swimming pattern, driven by switching of the rota

254 , which are known to undergo motions such as tumbling, swinging, tanktreading, and deformation.

255 ut twice as long as that for the most slowly tumbling system, for which N-H RDCs could be measured, s

256 he time scale on which the overall molecular tumbling takes place.

257 consistent with a hydrodynamic mechanism for tumble termination.

258 acteristics consistent with an isotropically tumbling tetramer experiencing slow (nanosecond) motions

259 ces, the correlation times for their overall tumbling that best account for the NMR data correspond t

260 ns of the UTR complex and display an overall tumbling that is uncorrelated from the core of the compl

261 aller fraction of filaments were involved in tumbles, the tumble intervals were shorter and the angle

262 in arrangement and parameters of the overall tumbling: the HIV-1 protease homodimer and Maltose Bindi

263 cterized the long-term statistics of the run-tumble time series in individual Escherichia coli cells.

264 The overall molecular tumbling time (6.5 ns) determined from the 15N relaxatio

265 rigid proteins, the prediction of rotational tumbling time (tau(c)) using atomic coordinates is reaso

266 3 in a 1:1 ratio increased the spin-labeled tumbling time by about 40%.

267 hold ratio for chaperone effects), the probe tumbling time markedly increased to several nanoseconds,

268 he molecular volume and hence the rotational tumbling time of the agent, are highlighted.

269 The global tumbling time of TM2e in micelles was 14.4 +/- 0.2 ns; t

270 surface and effectively doubles the overall tumbling time.

271 )N relaxation results show comparable global tumbling times (tau(m)) and model-free order parameters

272 NCp7 to mini c TAR DNA, all labels reported tumbling times of >5 ns, indicating a condensation of NC

273 A salt dependence of NMR rotational tumbling times substantiates the electrostatic nature of

274 ame smaller, forcing a change from a run-and-tumble to a run-and-stop/reverse pattern.

275 tained at a relatively low concentration and tumbling to blue light at an intensity effective for hem

276 ewhat better than 100-fold more sensitive in tumbling to blue light compared to its wild-type parent.

277 more sensitive than its wild-type parent in tumbling to blue light.

278 The function of tumbling to light is most likely to allow escape from th

279 While some R. sphaeroides proteins restore tumbling to smooth-swimming E. coli mutants, their activ

280 ntributions of residence time and rotational tumbling to the total effective correlation time of the

281 iously believed, but rather it is due to the tumbling-to-tanktreading transition.

282 solution NMR methods, primarily because they tumble too slowly in solution.

283 t motions (runs) with random reorientations (tumbles), transiently suppressing tumbles whenever attra

284 As a consequence, they spin and tumble uncontrollably, occasionally moving backward.

285 topping (unlike normal-sized bacteria, which tumble), until adaptation restored unstimulated behavior

286 ar emphasis on how the beam shape rotates or tumbles versus z.

287 antagonists swam with a running bias, i.e., tumbling was inhibited.

288 change was slow on the NMR time scale, while tumbling was slow or close to the NMR time scale dependi

289 hange of swimming direction while running or tumbling were smaller when cells swam more rapidly.

290 relation times, tau(e), distinct from global tumbling, were detected in the calcium-binding loops.

291 ilament sized, and those mutants that always tumbled when they were normal sized always stopped when

292 entations (tumbles), transiently suppressing tumbles whenever attractant signal increases.

293 , whereas CW rotation might be optimized for tumbles, where the object is to change cell trajectories

294 ed clockwise they fly apart, resulting in a "tumble" which reorients the cell with little translocati

295 asure of the correlation function of protein tumbling, which cannot be approximated by a single expon

296 COOH-terminal domains of cardiac troponin C tumble with similar correlation times when bound to card

297 The 5'-labeled RNA tumbled with a subnanosecond isotropic correlation time

298 m acetate, pH 4.5, 20 degreesC), and that it tumbles with an axially symmetric diffusion tensor (D pa

299 N-labeled Trp RNA-binding attenuator protein tumbling with a correlation time tauc of 120 ns.

300 rient upstream while downstream-facing cells tumble within the same streamline.