ライフサイエンスコーパス: tumor specificity

1 or imaging with nanoprobes suffers from poor tumor specificity.

2 en challenging due to the lack of sufficient tumor specificity.

3 mal rearrangements have demonstrated greater tumor specificity.

4 data partially explain the observed in vivo tumor specificity.

5 ing agents and TRAIL molecules with improved tumor specificity.

6 sting that another mechanism underlies NDV's tumor specificity.

7 ental, but not control, tumors, establishing tumor specificity.

8 read distribution of delivered cells without tumor specificity.

9 seems to be important for the maintenance of tumor specificity.

10 of controllable CAR therapies with improved tumor specificity.

11 estricted by severe side effects and lack of tumor specificity.

12 ues to determine the tissue distribution and tumor specificity.

13 ls with high signal-to-noise ratios and good tumor specificity.

14 onditionally active antibodies with enhanced tumor specificity.

15 ression to enhance nuclear drug delivery and tumor specificity.

16 M targeting moiety by characterizing its (1) tumor specificity, (2) expression level, (3) cellular in

17 rated in several in vivo cancer models, with tumor specificity achieved through display of an alpha(v

18 Their tumor specificity and broad expression bolster their pot

19 Because of its strong promoter activity, tumor specificity and capacity for clinical translation,

20 To both increase tumor specificity and decrease nonspecific side effects,

21 erapeutic target for melanoma because of its tumor specificity and expression in the majority of thes

22 naerobic growth conditions were required for tumor specificity and intratumoral replication.

23 s DNA-intercalating agent has relatively low tumor specificity and limited efficacy.

24 trial, was specifically designed to improve tumor specificity and minimize off-target toxicity, addr

25 Overall, HJ-4 exhibits promising tumor specificity and multiple antitumor mechanisms, sup

26 0 (NSC 748747), which displayed much broader tumor specificity and notably increased potency over the

27 r blood-brain barrier (BBB) penetration, low tumor specificity and rapid washout from tumors.

28 t display significantly enhanced potency and tumor specificity and suggests a divergent mechanistic r

29 erapy (PDT), undesired side effects like low tumor specificity and the "always-on" phenomenon should

30 we investigate the mechanistic basis for the tumor specificity and vast overexpression of FR-alpha.

31 post-surgery serum specimens indicated their tumor-specificity and their potential source of origin i

32 ariants with lower in vivo toxicity and high tumor specificity, and therefore greater potential for c

33 NanoPDLIM2 showed low toxicity, high tumor specificity, antitumor activity, and greatly impro

34 cell receptors does not encode for different tumor specificities but for different intrinsic reactivi

35 tumors in BALB/c recipients and demonstrated tumor specificity, but had no therapeutic efficacy in th

36 verall, this well-tolerated therapy achieves tumor specificity by redirecting inflammation to a funct

37 Here, we demonstrate that Salmonella tumor specificity can be significantly improved via a su

38 ssing whether oncolytic viruses with reduced tumor-specificity can more effectively eliminate tumors

39 iltrating lymphocytes with potent autologous tumor specificity, despite low mutational burden and res

40 rum levels of 3-Ga NPs in mice revealed high tumor specificity, favorable pharmacokinetics, fast abso

41 PET imaging confirmed excellent tumor specificity for [(89)Zr]Zr-DFO-scFv-Fc-CD44 when c

42 ent strategy should provide a high degree of tumor specificity for increasing the effectiveness of hy

43 press chimeric antigen receptors (CARs) with tumor specificity have shown remarkable success in treat

44 As a mAb conjugate, this agent shows high tumor specificity in a longitudinal imaging study in a m

45 rica (hereafter named AD95+) showed superior tumor specificity in breast and ovarian cancer murine mo

46 vector (RRV), Toca 511, which has displayed tumor specificity in resected brain tumor material and b

47 uinone payload and utilize several layers of tumor specificity in the hope of effectively treating pa

48 a promising delivery vehicle because of its tumor specificity, increasing its intra-tumoral motility

49 rine MOSEC tumor cells indicate that Sindbis tumor specificity is not attributable to a species diffe

50 ique localization in tumors and its relative tumor specificity may make p32 a useful target in tumor

51 The tumor specificity of (89)Zr-DFO-azepin-onartuzumab was a

52 We document the anti-tumor specificity of a vector that systemically targets

53 ceptors have been developed that combine the tumor specificity of antibodies with T-cell effector fun

54 lapse method for evaluating the efficacy and tumor specificity of CAR-NK cells using a two-photon mic

55 PD-1(-) cells was the limiting factor in the tumor specificity of cells derived from bulk CD8 TILs.

56 We showed that the tumor specificity of CYGB methylation in discriminating

57 ether, these results highlight the intrinsic tumor specificity of MILs and describe a novel approach

58 orophores, the optimized probe increases the tumor specificity of monoclonal antibody (mAb) and nanob

59 conjunction with new algorithms to rank the tumor specificity of neoantigens (BayesTS) and to predic

60 To improve the tumor specificity of our mesoporous silica nanoparticle

61 ined or separately, explain the differential tumor specificity of some MUC-1 antibodies and T cells.

62 Tumor specificity of the catalysts together with their a

63 Overall, tumor specificity of the CRAds was limited compared with

64 Furthermore, the tumor specificity of the immunity induced by the two cel

65 ntribution of multiple mechanisms to enhance tumor specificity of the microregions.

66 The tumor specificity of the most promising conjugate was al

67 The tumor specificity of the MSN particle was improved with

68 1In/90Y-2IT-BAD-Lym-1 to the extent that the tumor specificity of the radioactive metabolites was los

69 brid biologics that enhance the affinity and tumor specificity of the small-molecule drug-pharmacopho

70 e tumor-infiltrating lymphocytes (TILs), the tumor specificity of these TILs, and the correlation bet

71 We further showed the tumor specificity of this assay with multiple other epit

72 Together with the good tumor specificity of this compound's class, this work su

73 The tumor specificity of this response is thought to reflect

74 The tumor specificity of this strategy spares healthy and no

75 To enhance the tumor specificity of this vector, we have developed a co

76 Determining tumor-specificity of MHC-bound peptides is crucial for c

77 ncer nanomedicines commonly suffer from poor tumor specificity, "off-target" toxicity, and limited cl

78 iple cancer types combined with an exquisite tumor specificity opens a new door to widespread applica

79 Lack of tumor specificity remains a major problem with chemother

80 atorial effect is strongly context specific, tumor specificity should be achievable.

81 ted patients is warranted, and viral- versus tumor-specificity should be carefully analyzed.

82 ess cancer cell heterogeneity while endowing tumor specificity, the approach of charge shielding/desh

83 Tissue staining also showed distinct tumor specificity to pancreatic tumor tissue in relation

84 The hepatocyte targeting ligands introduce tumor specificity to the RNA nanoparticles as they selec

85 cers of many MuLVs are major determinants of tumor specificity, we tested the role of the SRS 19-6 Mu

86 ement in BiTE technology given its exquisite tumor specificity, which enables precise elimination of

87 imal release rates, low solubility, and poor tumor specificity, which have hindered their advancement