ライフサイエンスコーパス: tumor suppressor protein

1 in the phosphatase and tensin homolog (PTEN) tumor suppressor protein.

2 lysis to demonstrate the role of MOAP-1 as a tumor suppressor protein.

3 (Cip1) cyclin-dependent kinase inhibitor and tumor suppressor protein.

4 fork recovery is mediated through the PALB2 tumor suppressor protein.

5 Tazarotene-induced gene 3 (TIG3) is a tumor suppressor protein.

6 of the human homologue of Mod5, TRIT1, as a tumor suppressor protein.

7 h SIRT2 may function, at least in part, as a tumor suppressor protein.

8 nt loss of function of the von Hippel-Lindau tumor suppressor protein.

9 and in cancer via interaction with the DAL-1 tumor suppressor protein.

10 gene doc-1 (deleted in oral cancer 1), is a tumor suppressor protein.

11 ubsequently stabilizes and activates the p53 tumor suppressor protein.

12 The transcription factor p53 is a key tumor suppressor protein.

13 of mutations in the von Hippel Lindau (VHL) tumor suppressor protein.

14 ied, including the c-JUN oncoprotein and p53 tumor suppressor protein.

15 ability of E7 to inhibit the retinoblastoma tumor suppressor protein.

16 a significant role in the regulation of the tumor suppressor protein.

17 s, and binding of inhibitors such as the p27 tumor suppressor protein.

18 the functionally critical UCH domain in this tumor suppressor protein.

19 roteins inactivated the function of cellular tumor suppressor proteins.

20 program controlled by the p53 and p16(INK4a) tumor suppressor proteins.

21 increase in biosynthesis of miR-21-regulated tumor suppressor proteins.

22 the cytoplasmic mislocalization of multiple tumor suppressor proteins.

23 ol systems in the degradative fate of mutant tumor suppressor proteins.

24 is by altering the activity of oncogenic and tumor suppressor proteins.

25 development of small molecule activators of tumor suppressor proteins.

26 bor a high prevalence of pDGVs that truncate tumor suppressor proteins.

27 The expression of tumor suppressor protein 53 (p53) and its target genes:

28 Unlike in most adult tumors, tumor suppressor protein 53 (p53) mutations occur with a

29 The tumor suppressor protein 53BP1 plays key roles in respon

30 The tumor suppressor protein 53BP1, a pivotal regulator of D

31 In contrast, CYLD (cylindromatosis tumor-suppressor protein), a K63-specific deubiquitinase

32 Many tumor suppressor proteins act to blunt the effects of mi

33 The ARF tumor suppressor protein activates p53 in response to on

34 In this study, the tumor suppressor protein adenomatous polyposis coli (APC

35 The tumor suppressor protein adenomatous polyposis coli (APC

36 Here, we show that the tumor suppressor protein adenomatous polyposis coli (APC

37 The tumor suppressor protein adenomatous polyposis coli (APC

38 sly shown that striatin colocalizes with the tumor suppressor protein adenomatous polyposis coli in t

39 In one such pathway the tumor-suppressor protein adenomatous polyposis coli (APC

40 are expected for oncoproteins, we found that tumor suppressor proteins also exhibit strong biases tow

41 ased HIF-1alpha binding to von Hippel-Lindau tumor suppressor protein, an E3 ligase component and an

42 sis for understanding the role of menin as a tumor suppressor protein and as an oncogenic co-factor o

43 g TS and RR was enriched with retinoblastoma tumor suppressor protein and histone H3 tri-methylated a

44 cer include suppressing induction of the p53 tumor suppressor protein and maintaining metabolic funct

45 sequence-specific DNA-binding domain of the tumor suppressor protein and preventing it from transcri

46 resents evidence that de-ph-S302-CUGBP1 is a tumor suppressor protein and that the Gank-UPS-mediated

47 15-PGDH is a tumor suppressor protein and the primary enzyme responsi

48 n homolog of the Drosophila polycomb L(3)MBT tumor suppressor protein and thus a candidate tumor supp

49 s the key mediator of nuclear export of many tumor suppressor proteins and is overexpressed in human

50 A-encoded products form complexes with other tumor suppressor proteins and with the recombinase enzym

51 s responsible for the nuclear export of many tumor-suppressor proteins and viral ribonucleoproteins.

52 E-cadherin is a tumor suppressor protein, and the loss of its expression

53 ) function, leads to nuclear accumulation of tumor suppressor proteins, and induces cancer cell death

54 gulated by the retinoblastoma (RB) family of tumor suppressor proteins, and virus-encoded oncogenes d

55 de exchange factor, and are regulated by the tumor-suppressor protein APC.

56 asmic dynein, the adenomatous polyposis coli tumor suppressor protein (APC), and glycogen synthase ki

57 ctasia mutated (ATM) kinase and H2AX histone tumor suppressor proteins are each critical for maintena

58 Tumor-suppressor proteins are inactivated by many differ

59 BACKGROUND & AIMS: Tumor-suppressor proteins are inactivated by many differ

60 We show that the tumor suppressor protein ARF mediates this switch by inh

61 ell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to

62 study, we have examined the roles of the p53 tumor suppressor protein, as well as its downstream targ

63 The tumor suppressor protein ASPP (Apoptosis-Stimulating Pro

64 Mutation of the von Hippel-Lindau (VHL) tumor suppressor protein at codon 200 (R200W) is associa

65 entify a new role for these well-established tumor suppressor proteins at an early stage of the cellu

66 The tumor suppressor protein BRCA1 is a constituent of sever

67 The tumor suppressor protein BRCA1 promotes homologous recom

68 air-mediated helicase unloading involves the tumor suppressor protein BRCA1, which acts upstream of M

69 The tumor suppressor proteins BRCA1, PALB2 and BRCA2 constit

70 The human tumor suppressor protein BRCA2 plays a key role in recom

71 otif is reminiscent of the FVPP motif in the tumor suppressor protein BRCA2 that mediates DMC1 intera

72 s as a crucial negative regulator of the p53 tumor suppressor protein by antagonizing p53 transactiva

73 rmore, we find that TRIB2 relieves the liver tumor suppressor protein C/EBPalpha-mediated inhibition

74 by mutations in the NF2 gene that encodes a tumor-suppressor protein called merlin.

75 rticles containing the gene encoding the p53 tumor suppressor protein (chi-p53) and/or doxorubicin (D

76 rous transcription factors including the p53 tumor suppressor protein constitutes a vital early step

77 The ING3 tumor suppressor protein contains a plant homeodomain (P

78 g extracts and human cells, we show that the tumor suppressor protein CtIP plays a critical role in t

79 p53 is an important tumor-suppressor protein deactivation of which by mdm2 r

80 s revealed increased nuclear accumulation of tumor suppressor proteins, decreased cell proliferation,

81 e in the transcription and expression of the tumor suppressor protein E-cadherin (CDH1).

82 y TGFbeta is dependent on the retinoblastoma tumor suppressor protein/E2 promoter binding factor (pRb

83 ike protein, also known as schwannomin) is a tumor suppressor protein encoded by the neurofibromatosi

84 The mouse p19(Arf) (human p14(ARF)) tumor suppressor protein, encoded in part from an altern

85 Loss of the E-cadherin tumor suppressor protein enhanced cell invasion, but inh

86 Members of the Myb oncoprotein and E2F-Rb tumor suppressor protein families are present within the

87 Fanconi anemia (FA) DNA repair pathway, the tumor suppressor proteins FANCI and FANCD2 (the ID compl

88 Argast et al. has shown that plexin B1 is a tumor-suppressor protein for melanoma metastasis in a mo

89 1, the Semaphorin 4D (Sema4D) receptor, is a tumor-suppressor protein for melanoma, which functions,

90 mplexes, leading to subsequent protection of tumor suppressor proteins from degradation.

91 analysis also demonstrated that recovery of tumor suppressor protein function is possible, indicatin

92 suppressor protein, the role of MOAP-1 as a tumor suppressor protein has yet to be determined.

93 The BRCA1 tumor suppressor protein heterodimerizes with its partne

94 This process results in the reduction of a tumor suppressor protein (HOXD10), RhoA/RhoC up-regulati

95 roduction, leading to the down-regulation of tumor suppressor protein (HOXD10), RhoGTPase-ROK activat

96 Here, we report that loss of p53, a tumor suppressor protein, impaired repression of NF-kapp

97 pVHL is a tumor-suppressor protein implicated in a variety of cell

98 ssion, and decreased nuclear levels of BRCA1 tumor suppressor protein in invasive breast carcinomas.

99 earliest detectable epigenetically silenced tumor suppressor proteins in cancer, and we speculate th

100 xin B1 is predicted to function as a classic tumor-suppressor protein in melanoma, in part through su

101 Menin (MEN1) is a tumor-suppressor protein in neuroendocrine tissue.

102 it CRM-1 and promote nuclear accumulation of tumor-suppressor proteins in pancreatic cancer cells.

103 e propose that WASp functions as a putative "tumor-suppressor" protein in normal T and B cells, and "

104 clude ARF and P16INK4A, both of which encode tumor suppressor proteins, in both human and mouse retin

105 ncogenic transformation by inhibition of key tumor suppressor proteins, including p53 and members of

106 oncogenic proteins, decreased expression of tumor suppressor protein, increased proliferation, decre

107 Herein, we identify a tumor suppressor protein, inhibitor of growth 4 (ING4),

108 orces nuclear accumulation and activation of tumor suppressor proteins, inhibits nuclear factor kappa

109 The RASSF1A tumor suppressor protein interacts with the pro-apoptoti

110 p16(INK4a) is a tumor suppressor protein involved in several stress-rela

111 nterferon-regulated transcription factor and tumor suppressor protein IRF-1 is predicted to be largel

112 The BRCA1 tumor suppressor protein is a central constituent of sev

113 The p53 tumor suppressor protein is a major sensor of cellular s

114 The Rb1 tumor suppressor protein is a molecular adaptor that phy

115 lar senescence through activation of the p53 tumor suppressor protein is a new option for treating pr

116 The p53 tumor suppressor protein is a potent activator of prolif

117 The p53 tumor suppressor protein is a transcription factor and m

118 The p53 tumor suppressor protein is a transcription factor that

119 The adenomatous polyposis coli (APC) tumor suppressor protein is associated with the regulati

120 special note is the observation that the p53 tumor suppressor protein is confined to the open chromat

121 The p53 tumor suppressor protein is regulated by multiple post-t

122 The von Hippel-Lindau tumor suppressor protein is the substrate binding subuni

123 Our studies found that the p27(Kip1) tumor suppressor protein is upregulated and relocalized

124 ow that Beclin 1, an essential autophagy and tumor suppressor protein, is a target of the protein kin

125 In colorectal cancer cells, APC, a tumor suppressor protein, is commonly expressed in trunc

126 ic response element, in conjunction with the tumor suppressor protein Kruppel-like factor 6 functioni

127 One example is the conserved Drosophila tumor-suppressor protein Lethal giant larvae (Lgl).

128 r cells, and this is associated with reduced tumor suppressor protein level and enhanced cell surviva

129 tal Cell, Jossin et al. (2017) show that the tumor suppressor protein Lgl1 interacts with N-cadherin

130 ical differences in mTORC1 regulation by the tumor suppressor proteins Lkb1 and Tsc1/Tsc2 may underli

131 The tumor suppressor protein Merlin inhibits cell proliferat

132 The tumor suppressor protein Merlin is proteasomally degrade

133 2 tumor suppressor gene that encodes for the tumor suppressor protein merlin.

134 The neurofibromatosis type 2 (NF2) tumor-suppressor protein Merlin is a member of the ERM f

135 antagonized by the neurofibromatosis type 2 tumor-suppressor protein merlin.

136 The neurofibromatosis type 2 tumor suppressor protein, merlin, is related to the ERM

137 Folliculin (FLCN) is a tumor-suppressor protein mutated in the Birt-Hogg-Dube (

138 E2F1 and retinoblastoma (RB) tumor-suppressor protein not only regulate the periodic

139 Cavin-3 is a tumor suppressor protein of unknown function.

140 The tumor suppressor proteins p15(INK4B), p16(INK4A), and p1

141 INK4b-ARF-INK4a encodes 3 tumor-suppressor proteins, p15(INK4b), p14(ARF), and p16

142 arcinomas (CxCaRNA(+)), and the HPV-targeted tumor suppressor protein p16(INK4a) as markers for HPV i

143 sive breast cancer cells, down-regulates the tumor suppressor proteins p16(INK4A), p21(WAF1), and p53

144 Indeed, the binding of a human tumor suppressor protein, p21, to PCNA contributes to it

145 of cells incubated with KPT-185 accumulated tumor-suppressor proteins (p27, FOXO, p73, and prostate

146 ferentiation defect that is dependent on the tumor suppressor protein p53 (encoded by Trp53 in mice)

147 but not the oncoprotein Myc, or loss of the tumor suppressor protein p53 (encoded by Trp53 in mice)

148 Under influence of Myc, AMPK-stabilized tumor suppressor protein p53 accumulates in the mitochon

149 The tumor suppressor protein p53 acts as a transcription fac

150 phosphorylation and increased levels of the tumor suppressor protein p53 and a cell cycle inhibitor

151 es cell survival by decreasing levels of the tumor suppressor protein p53 and downstream target genes

152 Inhibition of the interaction between the tumor suppressor protein p53 and its negative regulators

153 ules selectively delivered recombinant human tumor suppressor protein p53 and its tumor-selective sup

154 showed that EBNA3C can directly bind to the tumor suppressor protein p53 and repress its functions,

155 We also identified the tumor suppressor protein p53 as a mediator of podocyte a

156 verexpressed in many cancers, stabilizes the tumor suppressor protein p53 by abrogating its MDM2-depe

157 Inactivation of the tumor suppressor protein p53 by mutagenesis, chemical mo

158 Here we report that the tumor suppressor protein p53 can associate with PXR and

159 Additionally, we show that Na and the tumor suppressor protein p53 cooperate to induce lytic g

160 Here we show that the tumor suppressor protein p53 cooperates with DNA methyla

161 The tumor suppressor protein p53 coordinates the cellular re

162 reasing intrinsic disorder-cytochrome c, the tumor suppressor protein p53 DNA binding domain (p53 DBD

163 The tumor suppressor protein p53 down-regulates a number of

164 The tumor suppressor protein p53 exhibits high affinity to t

165 The roles and actions of the tumor suppressor protein p53 have been extensively studi

166 ay format was used to detect unlabeled human tumor suppressor protein p53 in crude lysates, without a

167 the dynamics of the tetramers formed by the tumor suppressor protein p53 in single living cells.

168 The major tumor suppressor protein p53 is a key cell regulator inv

169 Because tumor suppressor protein p53 is also a redox active tran

170 Antagonizing MDM2 and MDMX to activate the tumor suppressor protein p53 is an attractive therapeuti

171 The tumor suppressor protein p53 is critical for cell fate d

172 Under normal cellular conditions, the tumor suppressor protein p53 is kept at low levels in pa

173 lium leads to marked hyperacetylation of the tumor suppressor protein p53 on lysine 370, 379 and 383;

174 3-3 with the recognition motif of either the tumor suppressor protein p53 or the oncogenic transcript

175 The tumor suppressor protein p53 plays a central role in tum

176 The tumor suppressor protein p53 plays a crucial role in coo

177 The tumor suppressor protein p53 regulates numerous signalin

178 nges in small and large regions of the human tumor suppressor protein p53 to identify single amino-ac

179 o induce the accumulation and acetylation of tumor suppressor protein p53 upon the cell cycle entry o

180 nk between mitochondrial dysfunction and the tumor suppressor protein p53 using a set of respiration-

181 eous shrinking: the intrinsically disordered tumor suppressor protein p53 was analyzed by using a com

182 MDMX have been reported as activators of the tumor suppressor protein p53 with therapeutic potential.

183 y regulate the activity and stability of the tumor suppressor protein p53, conferring tumor developme

184 te mechanism to ubiquitinate and degrade the tumor suppressor protein p53, involving interactions wit

185 Tumor suppressor protein p53, our most critical defense

186 The tumor suppressor protein p53, the "guardian of the genom

187 and MDM4 are key negative regulators of the tumor suppressor protein p53, which are frequently upreg

188 fection by human cytomegalovirus (HCMV), the tumor suppressor protein p53, which promotes efficient v

189 tion of the intrinsic apoptotic pathway in a tumor suppressor protein p53-dependent manner.

190 Mdm2 is a critical negative regulator of the tumor suppressor protein p53.

191 is through its interaction with the cellular tumor suppressor protein p53.

192 n regulating numerous proteins including the tumor suppressor protein p53.

193 factors such as PPARgamma, NFkappaB, and the tumor suppressor protein p53.

194 aration of reduced and oxidized forms of the tumor suppressor protein p53.

195 mor-associated HPV induce the degradation of tumor suppressor protein p53.

196 on of the tetramerization domain (TD) of the tumor suppressor protein p53.

197 into the intrinsically disordered tetrameric tumor suppressor protein p53.

198 apoptosis and autophagy; not reliant on the tumor suppressor protein p53; and effective against mous

199 wth, was remarkably downregulated, while the tumor suppressor proteins p53 and p21 were substantially

200 ssential in this process by inactivating the tumor suppressor proteins p53 and Rb, respectively, in a

201 hat represses the functional activity of the tumor suppressor proteins p53 and RB.

202 eltaIEC)) and mice that also had deletion of tumor-suppressor protein p53 (H2b/p53(DeltaIEC)); we com

203 The tumor-suppressor protein p53 is mutated in approximately

204 The tumor-suppressor protein p53 is tightly controlled in no

205 zmB also induces a rapid accumulation of the tumor-suppressor protein p53 within target cells, which

206 lation of lysine residue(s) of histones, the tumor-suppressor protein p53, and splicing regulatory pr

207 ine mutations in TP53, the gene encoding the tumor-suppressor protein p53.

208 ealed common signatures of activation of the tumor-suppressor protein p53.

209 n Chk1, increased phosphorylation of the p53 tumor suppressor protein (p53) at serine 18, and increas

210 ed the expression of their downstream target tumor suppressor proteins (p53, Rb and PTPN 13).

211 We found induction of tumor suppressor protein, p53, and apoptosis with suppre

212 The tumor suppressor protein, p53, is either mutated or abse

213 to cancer progression by down-regulating the tumor suppressor protein, p53.

214 In summary, our phosphorylation analysis of tumor suppressor protein PALB2 uncovers new layers of re

215 XAF1, a tumor suppressor protein, paradoxically emerged as a med

216 e for the cyclin D1/Cdk4/pRb (retinoblastoma tumor suppressor protein) pathway in delayed neuronal de

217 The tumor suppressor protein Pdcd4 has been shown to inhibit

218 This process results in a decrease of a tumor suppressor protein (PDCD4), and an upregulation of

219 ukemic HSCs in BM requires inhibition of the tumor suppressor protein phosphatase 2A (PP2A) and expre

220 The tumor suppressor protein phosphatase 2A (PP2A) is a seri

221 we have demonstrated that activation of the tumor suppressor protein phosphatase 2A (PP2A), a negati

222 multiple cellular processes, inhibiting the tumor suppressor protein phosphatase 2A (PP2A), and inhi

223 In this study, we show that the tumor suppressor protein phosphatase 2A (PP2A), one of t

224 trocytes deficient in the major glioblastoma tumor suppressor protein phosphatase and tensin homolog

225 High glucose-induced reduction of the tumor suppressor protein phosphatase and tensin homolog

226 The p53 tumor suppressor protein plays a critical role in cellul

227 The p53 tumor suppressor protein plays a critical role in orches

228 ast cancer by showing how it upregulates the tumor suppressor protein PML.

229 The retinoblastoma tumor suppressor protein pRb is a key regulator of cell

230 The retinoblastoma tumor suppressor protein pRB is conventionally regarded

231 The retinoblastoma tumor suppressor protein pRb restricts cell growth throu

232 tion, UL97 phosphorylates the retinoblastoma tumor suppressor protein (pRb) on sites ordinarily phosp

233 of Cdc25A led to reduction in retinoblastoma tumor suppressor protein (pRb) phosphorylation.

234 key downstream target of the retinoblastoma tumor suppressor protein (pRB), which is frequently inac

235 previously showed that inactivating the p53 tumor suppressor protein prevents neural tube and cardia

236 MO, which in turn promotes expression of the tumor suppressor protein promyelocytic leukemia (PML).

237 The tumor-suppressor protein promyelocytic leukemia (PML) is

238 effect of C-terminal phosphorylation on the tumor suppressor protein PTEN.

239 d predictive markers, such as alterations of tumor suppressor proteins PTEN or p53, to augment curren

240 The von Hippel-Lindau (VHL) tumor suppressor protein pVHL is commonly mutated in cle

241 sing pathway including the von Hippel-Lindau tumor suppressor protein (pVHL) and the hypoxia inducibl

242 endent and -independent functions of the VHL tumor suppressor protein (pVHL) can contribute to tumor

243 tered metabolism in cancer cells related to: tumor suppressor protein (pVHL) function, the histone ac

244 ) have inactivation of the von Hippel-Lindau tumor suppressor protein (pVHL), resulting in the accumu

245 Inactivation of von Hippel-Lindau tumor-suppressor protein (pVHL) is associated with von H

246 oded proteins with cell cycle regulators and tumor suppressor proteins, raising the possibility that

247 It is an integral partner to the tumor suppressor protein, Ras association domain family

248 iferation via proteasomal degradation of the tumor suppressor protein Rb.

249 pment of liver cancer is a neutralization of tumor suppressor proteins Rb, p53, hepatocyte nuclear fa

250 romote phosphorylation of the retinoblastoma tumor suppressor protein (Rb) and other substrates.

251 Disruption of murine retinoblastoma tumor suppressor protein (Rb) in mature pancreatic beta-

252 The retinoblastoma tumor suppressor protein (RB) plays a critical role in c

253 The retinoblastoma tumor suppressor protein (RB) plays an important role in

254 control, Cdks inactivate the retinoblastoma tumor suppressor protein (Rb) through phosphorylation, w

255 lid tumor cells, requires the retinoblastoma tumor suppressor protein (Rb).

256 N-terminal domain of the retinoblastoma (Rb) tumor suppressor protein (RbN) harbors in-frame exon del

257 biopsies showed nuclear accumulation of key tumor-suppressor proteins, reduction of cell proliferati

258 The tumor suppressor protein retinoblastoma (RB) is mechanis

259 The latter inactivates the tumor suppressor protein retinoblastoma (Rb), which lead

260 ell division and cell differentiation is the tumor suppressor protein RETINOBLASTOMA.

261 C-terminal domain (RbC) is necessary for the tumor suppressor protein's activities in growth suppress

262 The tumor suppressor protein Scribble (SCRIB) plays an evolu

263 motes a variety of human tumors by degrading tumor suppressor proteins such as p53.

264 The tumor suppressor protein Suppressor of fused (Sufu) play

265 IRF-1 is a tumor suppressor protein that activates gene expression

266 p53 is a tumor suppressor protein that acts as a transcription fa

267 st cancer susceptibility gene 1 (BRCA1) is a tumor suppressor protein that functions to maintain geno

268 Tazarotene-induced gene 3 (TIG3) is a tumor suppressor protein that has a key role in controll

269 p53 is a key tumor suppressor protein that has numerous functions.

270 AM and SH3 domain-containing protein 1) is a tumor suppressor protein that has roles in key cellular

271 on-associated miRNA-mediated regulation of a tumor suppressor protein that has the ability to influen

272 Menin is a tumor suppressor protein that is encoded by the MEN1 (mu

273 WTX is a tumor suppressor protein that is lost or mutated in up t

274 lysine 63 deubiquitinase gene (CYLD) encodes tumor suppressor protein that is mutated in familial cyl

275 p53 is a tumor suppressor protein that maintains genome stability

276 bunit of an SCF ubiquitin ligase and a major tumor-suppressor protein that is altered in several huma

277 homolog deleted on chromosome 10 (PTEN) is a tumor-suppressor protein that regulates phosphatidylinos

278 though RASSF1A is now considered a bona fide tumor suppressor protein, the role of MOAP-1 as a tumor

279 proteins and host cell cycle regulators and tumor suppressor proteins, the relevance of these observ

280 Small molecule mediated stabilization of p53 tumor suppressor protein through sumoylation is a promis

281 method showed that translocation of the p53 tumor-suppressor protein to the perinucleus in immortali

282 By providing a means to restore a functional tumor-suppressor protein to tumor cells, PTEN-Long may h

283 Telomeres and tumor suppressor protein TP53 (p53) function in genome p

284 The tumor suppressor protein TP53 (p53) plays a multifaceted

285 Here we identify the tumor suppressor Protein tyrosine phosphatase receptor-t

286 The Ras-assocation domain family (RASSF) of tumor suppressor proteins until recently contained six p

287 Here, we use the von Hippel-Lindau tumor suppressor protein VHL as a model substrate for st

288 specific disruption of the von Hippel-Lindau tumor suppressor protein (VHL) resulted in constitutive

289 tion of genes encoding the von Hippel-Lindau tumor suppressor protein (Vhl), hypoxia-inducible factor

290 ter for degradation by the von Hippel-Lindau tumor-suppressor protein (VHL).

291 The levels of p53 (TRP53) tumor suppressor protein were also increased in the same

292 SMARCB1 has also been recognized to be a tumor suppressor protein which controls many tumorigenic

293 residues creates binding sites for the COP1 tumor suppressor protein, which is an ubiquitin ligase c

294 f cancers with defects in the BRCA1 or BRCA2 tumor suppressor proteins, which are involved in the rep

295 DLC1 is a tumor suppressor protein whose full activity depends on

296 p53 is a tumor suppressor protein whose function is frequently lo

297 LKB1 is a tumor suppressor protein whose loss leads to HIF1alpha-m

298 MCPH1 is also a tumor suppressor protein, with roles in DNA damage repai

299 ortance of FAK following deletion of the Apc tumor suppressor protein within the intestinal epitheliu

300 9 locus harbors an imprinted gene encoding a tumor suppressor protein within the long-sought WT2 locu