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1 express influenza hemagglutinin as a unique, tumor-associated antigen.
2 that specifically targets the HER2/neu human tumor-associated antigen.
3 first report of BCG engineered to express a tumor-associated antigen.
4 in cells that overexpress the corresponding tumor-associated antigen.
5 o previously described CTL epitopes for this tumor-associated antigen.
6 on and function of CD8 T cells recognizing a tumor-associated antigen.
7 ptible to cellular immunotherapy targeted to tumor associated antigens.
8 ive imaging of cancer based on expression of tumor associated antigens.
9 cells that recognize MHC class II restricted tumor associated antigens.
10 pecific memory T cells that cross-react with tumor-associated antigens.
11 vely stimulate allogeneic T cells or present tumor-associated antigens.
12 DNA vaccine that may be applicable to other tumor-associated antigens.
13 ic T lymphocyte (CTL) responses against self-tumor-associated antigens.
14 screen the sera of MGUS patients to identify tumor-associated antigens.
15 mmune responses that may be directed against tumor-associated antigens.
16 ed from mucin MUC1 are an important class of tumor-associated antigens.
17 ulate the induction of an immune response to tumor-associated antigens.
18 ion of cytokine effects and/or expression of tumor-associated antigens.
19 d array of naturally processed and presented tumor-associated antigens.
20 gens rather than minor histocompatibility or tumor-associated antigens.
21 sequences from various sources, including 84 tumor-associated antigens.
22 ctive immunization in the absence of defined tumor-associated antigens.
23 ion in order to break tolerance against self tumor-associated antigens.
24 ed eight of nine selected genes as candidate tumor-associated antigens.
25 sed to identify and characterize novel colon tumor-associated antigens.
26 ing cells (APCs) able to take up and present tumor-associated antigens.
27 n obstacle to generating T cell responses to tumor-associated antigens.
28 of monoclonal antibodies (mAbs) recognizing tumor-associated antigens.
29 ptide epitopes that are derived from defined tumor-associated antigens.
30 vaccine strategies to enhance reactivity to tumor-associated antigens.
31 munoglobulin M (IgM), which is reactive with tumor-associated antigens.
32 both CD4(+) and CD8(+) T cells specific for tumor-associated antigens.
33 nes is of importance to immunization against tumor-associated antigens.
34 ab' fragments from antibodies that recognize tumor-associated antigens.
35 nses to cancer by stimulating the release of tumor-associated antigens.
36 sing patient T cells redirected to recognize tumor-associated antigens.
37 rgeted therapies, such as mAbs, that bind to tumor-associated antigens.
38 itoring of T-cell responses to microbial and tumor-associated antigens.
39 is also being evaluated to target non-viral tumor-associated antigens.
40 ic antigen receptors (CARs) directed against tumor-associated antigens.
41 nd IgE classes directed specifically against tumor-associated antigens.
42 fy antitumor immunity through the release of tumor-associated antigens.
43 variants endowed with enhanced affinity for tumor-associated antigens.
44 nking strategy applicable to many additional tumor-associated antigens.
45 nity directed toward tumors bearing distinct tumor-associated antigens.
49 mph nodes, where the processed and presented tumor-associated antigens activate tumor-specific naive
50 viral gene products are capable of acting as tumor-associated antigens activating both T-cell and B-c
51 lopment of CD8(+) T-cell responses targeting tumor-associated antigens after autologous stem cell tra
53 expressed Y-encoded minor H antigen or to a tumor-associated antigen, although poorly effective if i
55 ssed individual seroreactivity to meningioma tumor-associated antigens among participants enrolled in
56 ands, cationic W-TBP mediates PDT to release tumor associated antigens and delivers immunostimulatory
57 esis and progression, MUCL1 is an attractive tumor-associated antigen and a potential therapeutic tar
60 carcinoma cells reverse unresponsiveness to tumor-associated antigens and induce the rejection of es
61 ortant in this context as they may recognize tumor-associated antigens and induce tumor regression.
62 to naturally occurring tumor peptides (both tumor-associated antigens and neoantigens), as well as t
64 u tumor vaccine, induce CD8+ T cells against tumor-associated antigens and provide a viable oncologic
65 dritic cells (DCs) are capable of presenting tumor-associated antigens and subsequently play an essen
66 lack of enough high-affinity T cells against tumor-associated antigens and the unpredictability of tu
67 e modulation of CD40 to reverse tolerance to tumor-associated antigens and the use of OX40 to enhance
68 potent antigen-presenting cells, to present tumor-associated antigens and thereby generate tumor-spe
69 y increase the immune response to autologous tumor-associated antigens and, thus, may elicit immune-m
71 s compared with normal tissues; these "self" tumor-associated antigens are also expressed during feta
72 proven challenging, as the vast majority of tumor-associated antigens are also expressed in normal t
73 poxviruses (vaccinia and fowlpox) expressing tumor-associated antigens are currently being evaluated
75 show that CD8 T-cell responses to viral and tumor-associated antigens are greatly underestimated in
77 derlying poor immune responses to autologous tumor-associated antigens are overwhelming tumor kinetic
78 s, like EBV-immortalized B cells, expressing tumor-associated antigens are potentially useful immunog
80 for a unique class of shared immunodominant tumor associated antigens as targets for antitumor immun
81 offers insight into the possible use of this tumor-associated antigen as a target for immunotherapy.
82 tain endogenous immunity against non-mutated tumor-associated antigens as well as uniquely mutant ant
83 The p53 molecule might serve as a common tumor-associated antigen, as the tumor suppressor gene p
84 vely, these findings provide a rationale for tumor-associated antigen-based immunization as a means o
85 specific for and associated with unknown 4T1 tumor-associated antigens, because rejection of mKSA did
87 (sc) Fv phage library was used to search for tumor-associated antigens by panning with a lung adenoca
88 of HSV can be retargeted to cells expressing tumor-associated antigens by single-chain antibodies fus
90 gies which enhance immune activation against tumor-associated antigens can also be used to enhance th
91 Recombinant viruses and plasmid DNA encoding tumor-associated antigens can elicit powerful and specif
92 dies have demonstrated that vaccination with tumor-associated antigens can expand Tregs, posing a cha
94 tumor microenvironment, primed to recognize tumor-associated antigens, can occur in response to immu
95 hat expresses the targetable, membrane-bound tumor-associated antigen carbonic anhydrase type 9 (CA I
102 gen spreading and a reduction in circulating tumor-associated antigen DNA levels in patients with rel
103 ic T lymphocytes (CTLs) directed to nonviral tumor-associated antigens do not survive long term and h
104 bulin-like proteins, which include the mouse tumor-associated antigen E4 (Tage4) and three proteins t
105 ifferentially recognizes various epitopes of tumor-associated antigens either as self or as foreign,
107 T cells specific for LMP as well as nonviral tumor-associated antigens (epitope spreading) could be d
109 d to the diasialoganglioside GD2, a nonviral tumor-associated antigen expressed by human neuroblastom
110 opes derived from the MAGE-6 gene product; a tumor-associated antigen expressed by most melanomas and
112 Telomerase reverse transcriptase (TRT) is a tumor-associated antigen expressed in the vast majority
115 procedure for generating mAbs reacting with tumor-associated antigens expressed on human prostate ca
116 .5) mAbs have been developed that react with tumor-associated antigens expressed on human prostate ca
117 several mechanisms: (a) increase in MHC and tumor-associated antigen expression by tumor cells; (b)
119 r cytotoxin/immunotoxin, or alternatively, a tumor-associated antigen for active, specific immunother
120 s, hedgehog-interacting protein (Hip1), as a tumor-associated antigen for immunoprevention of BCCs in
122 onstraints have led to a relative paucity of tumor-associated antigens for antibody targeting in onco
124 sferred epidermal cells were able to present tumor-associated antigens for in vivo anti-tumor immunit
125 nt a soluble extract of tumor as a source of tumor-associated antigens for the induction of in vivo a
126 f dermal antigen-presenting cells to present tumor-associated antigens for the induction of in vivo a
127 For example, Langerhans cells can present tumor-associated antigens for the induction of substanti
129 resent a wide variety of antigens, including tumor-associated antigens, for various immune responses.
130 fusion protein composed of an amino-terminal tumor-associated antigen fragment fused to the CD40 liga
131 thelial cell adhesion molecule (HEPCAM) is a tumor-associated antigen frequently expressed in carcino
133 also of T cells that are specific for known tumor-associated antigens from the endogenous immune rep
134 ha1-->2FucT, which are known to be important tumor-associated antigens (fucosyl-GM1 and fucosyl-Gb5),
135 oexpressing high levels of human TfR and the tumor-associated antigen gp40 by binding to both target
137 for spontaneous CD8+ T cell priming against tumor-associated antigens has generated renewed interest
139 encies of T lymphocytes specific for certain tumor-associated antigens have been detected in some can
144 c antigen receptor (CAR), which recognizes a tumor-associated antigen, have shown activity against he
145 vivo while down-regulating the expression of tumor-associated antigens important in eliciting CTL res
146 ed to be a useful method to detect tumor and tumor-associated antigens in a variety of malignancies.
149 92, a human NK cell line, may be targeted to tumor-associated antigens in solid malignancies where it
152 eted expansion of autologous T cells against tumor-associated antigens, including prostate-specific m
153 s were directed against a broad set of renal tumor-associated antigens, including telomerase reverse
154 iation therapy can enhance the expression of tumor-associated antigens, induce immune-mediated target
155 these experiments, dermal cells pulsed with tumor-associated antigens induced protective immunity to
156 eptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2
158 emonstrate that unresponsiveness to the MUC1 tumor-associated antigen is reversible by immunization w
159 sfer of T-cell receptors (TCRs) specific for tumor-associated antigens is a promising approach for ca
160 ed intracerebral immunity against endogenous tumor-associated antigens is dependent on both CD4(+) an
161 sgenic plants that recognizes the nonprotein tumor-associated antigen Lewis Y oligosaccharide overexp
163 alyses showed that T cells reactive with the tumor-associated antigen LMP2 were present in the infuse
164 The vector-mediated in vivo activation, and tumor-associated antigen loading of dendritic cells does
165 pecific T-cell clones against one or more of tumor-associated antigens MAGE-1, gp100, and HER-2 after
168 transferred CD8+ T cell clones targeting the tumor-associated antigens, MART1MelanA and gp100 for the
170 ified by recombinant adenoviruses expressing tumor-associated antigens may provide an effective antit
171 neoplastic agents to antibodies specific for tumor-associated antigens may represent a novel platform
175 aturally occurring antibody responses to the tumor-associated antigen mucin 1 (MUC1), but the host ge
177 re simultaneously the immune reactivity to a tumor-associated antigen, neu, and an unrelated self-ant
184 erived from tumor-bearing patients recognize tumor-associated antigens presented by major histocompat
185 ich can eradicate tumor cells by recognizing tumor-associated antigens presented by MHC class I molec
186 in situ so that the cancer cells can act as tumor-associated antigen-presenting cells (tAPCs) by ind
187 ts establish that cps preferentially invades tumor-associated antigen-presenting cells and restores t
191 may be caused by exaggerated suppression of tumor-associated antigen-reactive lymphocytes mediated b
192 g cancer patients, CAR-T cells targeting the tumor-associated antigen receptor tyrosine kinase-like o
196 ting either MHC class I or II neoantigens or tumor-associated antigens rendered up to 60% of the tota
198 isteria DeltaactA/DeltainlB expressing human tumor-associated antigens represents an attractive thera
199 proliferation of CD8(+) T cells specific to tumor-associated antigens, resulting in cancer-specific
200 g lymphodepletion, CAR-T cells targeting the tumor-associated antigen ROR1 lysed tumors in mice but i
201 he use of whole tumor lysates as a source of tumor-associated antigen(s) for pulsing of DC circumvent
202 inhibitor, that can, without using exogenous tumor-associated antigen(s), eliminate various large tum
203 s macrophage-derived dendritic cells induced tumor-associated antigen-specific CD8+ T cells with effe
204 sed and characterized functional recombinant tumor-associated antigen-specific chimeric IgE/kappa and
205 pressing cells and reversal of inhibition to tumor-associated antigen-specific CTL generation in vitr
206 tly suppress myeloid dendritic cell-mediated tumor-associated antigen-specific T cell effector functi
211 e target for CAR therapy or be combined with tumor-associated antigens such as melanoma cell adhesion
212 malignant glioma cells express certain known tumor-associated antigens, such as HER-2, gp100, and MAG
213 antibodies recognizing MCPyV large and small tumor-associated antigens (T-Ag) would be more specifica
216 receptor (CAR) to redirect specificity to a tumor associated antigen (TAA) thereby conferring antitu
217 fixed antigen specificity such that only one tumor-associated antigen (TAA) can be targeted, limiting
218 s potent immune modulatory effects, inducing tumor-associated antigen (TAA) cross-priming with antitu
219 tients with advanced melanoma that is of low tumor-associated antigen (TAA) expression often respond
224 (MART-1) antigen system as a prototype human tumor-associated antigen (TAA)- and dendritic cell (DC)-
226 ession of PD-1, TIM3, and LAG3 was higher on tumor-associated antigen (TAA)-specific CD8(+) TIL, comp
234 yanin and MHC-I alone or MHC-I/II-restricted tumor-associated antigens (TAA) of tyrosinase and gp100,
236 e vectors may not be effective at presenting tumor-associated antigens (TAA) to the immune system in
241 a panel of 10 proteins, including well-known tumor-associated antigens (TAAs) and potential new bioma
242 ful method for serological identification of tumor-associated antigens (TAAs) and/or tumor rejection
244 influenza virus vectors expressing selected tumor-associated antigens (TAAs) as therapeutic agents i
245 ) and chimeric antigen receptors recognizing tumor-associated antigens (TAAs) can now be engineered t
246 cer relies in the identification of relevant tumor-associated antigens (TAAs) capable of eliciting st
247 apeutic monoclonal antibodies (mAbs) against tumor-associated antigens (TAAs) is that their mechanism
248 ing CD8+ T-cell populations specific for the tumor-associated antigens (TAAs) MART-1 (27-35) or tyros
249 uggest that immunotherapy targeting specific tumor-associated antigens (TAAs) may be beneficial in ca
251 cyte responses against multiple epitopes and tumor-associated antigens (TAAs) may provide effective i
253 se expression of tumor-specific antigens and tumor-associated antigens (TAAs) that can activate antit
254 lls serve as the superior source of multiple tumor-associated antigens (TAAs) to pulse dendritic cell
256 gies to enhance immune responses to specific tumor-associated antigens (TAAs), including the increasi
257 late proliferation of T cells that recognize tumor-associated antigens (TAAs), this expansion does no
263 e normal tissues by specifically targeting a tumor-associated antigen that is also expressed on those
264 ancer is overcoming immunologic tolerance to tumor-associated antigens that are expressed on both mal
267 reatment-induced suppression nor tolerant to tumor-associated antigens that have been encountered in
268 tumor cells can enable T-cell recognition of tumor-associated antigens that were previously silent wh
269 CD8+ and CD4+ T-cell responses against a new tumor-associated antigen, the receptor tyrosine kinase E
272 g to additional T cell responses to nonviral tumor-associated antigens through epitope spreading.
274 monoclonal antibody (MAb) that recognizes a tumor-associated antigen to image the fluorescence emitt
275 aboratory has established that the fusion of tumor-associated antigens to a truncated form of the Lis
278 ich simultaneously target CD3 on T cells and tumor-associated antigens to recruit cytotoxic T cells t
279 s resulted in enhanced cross-presentation of tumor-associated antigens to specific T cells in vitro.
280 les of neutrophils and B cells in presenting tumor-associated antigens to T cells in this combination
282 ide evidence that immunological targeting of tumor-associated antigen TRP-2 significantly increases s
283 gen spreading and a reduction in circulating tumor-associated antigens using digital droplet polymera
284 on augments the host immune response against tumor-associated antigens via delivery of immune stimula
285 noclonal antibody raised against the 250 kDa tumor associated antigen was reached by using only seven
286 Similarly, the promoter for the DF3/MUC1 tumor-associated antigen was cloned into a third HSV-1 m
287 uman model for eliciting T-cell responses to tumor-associated antigens, we develop a novel strategy t
288 b to activate cytolytic T cells specific for tumor-associated antigens, we found that the specificity
290 carcinoembryonic antigen (CEA) and MUC1/DF3 tumor-associated antigens were characterized and cloned
292 ) cells express idiotypic proteins and other tumor-associated antigens which make them ideal targets
293 mbryonic antigen (CEA) is an important self, tumor-associated antigen, which is expressed by differen
294 ntation of a broad repertoire of (undefined) tumor-associated antigens, which reduces emergence of tr
295 variable fragment (Fv) from an antibody to a tumor-associated antigen with a 38-kDa fragment of PE (P
296 ognizing a naturally processed and presented tumor-associated antigen with a chimeric PD-1:28 recepto
297 ion of human epitope-specific CTLs against a tumor-associated antigen with a live attenuated recombin
299 e T cells with ability to directly recognize tumor-associated antigens without the need for presentat
300 utated oncogenic growth factor receptors, as tumor-associated antigens yields rational targets for sp