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1 umor growth in an EZH2-dependent manner, and tumors bearing a non-GNA-interacting C668S-EZH2 mutation
2 (MAPK) kinase (MEK) can induce regression of tumors bearing activating mutations in the Ras pathway b
3 d with (64)Cu, and administered to normal or tumor-bearing aged, female, retired breeder Sprague-Dawl
4 altered novel object investigation for both tumor-bearing and -resected mice relative to surgical co
6 Bone marrow and splenic cells extracted from tumor-bearing and control mice (n= 3/group) were coincub
7 sing (18)F-FDG was successfully performed on tumor-bearing and non-tumor-bearing mice, as well as on
9 cryosectioning and fluorescence imaging of 1 tumor-bearing animal as well as PSMA immunohistochemistr
10 line uptake of (18)F-AH113804, determined in tumor-bearing animals after 10 d, was approximately 2-fo
11 early as 6 d after surgery in the recurrent tumor-bearing animals and exhibited significantly higher
13 odistribution and in vivo PET imaging in non-tumor-bearing animals as well as in KB-3-1 and COLO-205
14 en leukemia models and prolonged survival of tumor-bearing animals by accelerating apoptosis of leuke
19 although the nonloading group increased the tumor bearing as well as expression of IL-8 and matrix m
24 es were performed using CD-1 nu/nu and LNCaP tumor-bearing CB-17 severe combined immunodeficiency mic
31 uced by experimenter-induced movement of the tumor-bearing hindlimb with a context produces condition
38 oup of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produ
39 We hypothesized that NO producing MDSC in tumor-bearing hosts would inhibit DC antigen presentatio
40 these effects reduced mMDSC accumulation in tumor-bearing hosts, limiting the outgrowth of KRas-driv
44 ells, in various tissue compartments of oral tumor-bearing hu-BLT mice in response to immunotherapy b
45 treatment with CEA-TCB/CEA-4-1BBL in MKN-45 tumor-bearing humanized mice correlated with intratumora
46 wed different therapeutic responses in E.G-7 tumor-bearing immune-competent mice, in which they were
49 s (MDSC) contribute to immune suppression in tumor-bearing individuals and are a major obstacle to ef
51 rmacologic inhibition of the PI3K pathway in tumor-bearing Kit(V558Delta/+) mice with the dual PI3K/m
53 an be used to ablate target tissues in a non-tumor-bearing large-animal model while selectively spari
54 breast adenocarcinoma tumors had normal non-tumor-bearing liver treated with RFA (70 degrees C x 5 m
55 ystemically delivering TTK siRNAs to already tumor-bearing liver, limits intrahepatic spread of liver
56 ore, fractionated radiation delivered to one tumor-bearing lung synergizes with inhaled NP-cGAMP, eli
60 i-CTLA-4 siRNA-loaded NPs into CT26 and 4 T1 tumor -bearing mice led to the downregulation of CTLA-4
62 so detected in tumor-draining lymph nodes of tumor bearing mice and in biopsies of patients with glio
63 r models develop overt metastasis while EMT6-tumor bearing mice clear DTCs shed from primary tumors a
67 r intravenous treatment of RDLPNPs into Hela tumor bearing mice, fluorescent (from DiR) and enhanced
71 py was determined by longitudinal imaging of tumor-bearing mice (MC38 and A9F1) undergoing 2 types of
72 f dasatinib and extended the survival of PPK tumor-bearing mice (mutant TP53, mutant PDGFRA, H3K27M).
73 umumab- versus IgG1-treated COLO205 and HT29 tumor-bearing mice (P = 0.104 and 0.779, respectively) a
74 ssing VEGF-B or control vector to normal and tumor-bearing mice 1 wk before DOX treatment, using dose
76 or-infiltrating PD-L1(+) cells isolated from tumor-bearing mice also exerted morphology of tumor-asso
78 ite elevated plasma levels of VEGFA in fs120 tumor-bearing mice and a dependence on VEGF receptor 1 a
82 IL6 was abundantly expressed in MDSCs in tumor-bearing mice and patients with human colorectal ca
83 a signaling was increased in tumor-MDSC from tumor-bearing mice and patients with ovarian cancer.
84 h 3P10 reverses excessive lipid oxidation in tumor-bearing mice and prevents cancer cachexia, even un
85 both significantly increased the survival of tumor-bearing mice and showed promising antitumor effica
86 in tumor cells induced complete responses in tumor-bearing mice and supported memory development in t
87 R5 ligand interactions increased survival of tumor-bearing mice and was associated with reduced migra
88 did not affect circulating levels of MDSC in tumor-bearing mice because the decreased apoptotic rate
89 NETs were detected in the omentum of ovarian tumor-bearing mice before metastasis and of women with e
90 -PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in
91 tudy, we demonstrate that IL-2c treatment in tumor-bearing mice can enhance NK cell and tumor-specifi
92 sion was significantly reduced in MDSCs from tumor-bearing mice compared to non-tumor-bearing hosts.
93 greater antitumor efficacy in EG.7 and TC-1 tumor-bearing mice compared to the control (p < 0.01).
98 Dendritic cells (DCs) from NK cell-depleted tumor-bearing mice exhibited a more mature phenotype.
100 that the pan-BET inhibitor (+)-JQ1 protects tumor-bearing mice from body weight loss and muscle and
103 recipient cells, and circulating EC-EVs from tumor-bearing mice harbor elevated levels of specific mi
104 n occupancy and gene expression in young and tumor-bearing mice identified a set of shared targets fo
106 siRNA-mediated LPP silencing in ovarian tumor-bearing mice improved paclitaxel delivery to cance
108 c model and improved the overall survival of tumor-bearing mice in the GL26 syngeneic glioma model.
112 ransfer of monocytes into anti-PD-L1-treated tumor-bearing mice led to macrophage differentiation int
113 at doxorubicin (DOX) treatment of 4T1 breast tumor-bearing mice led to the induction of IL-13R(+)miR-
114 generated by treating HER2(+)/PIK3CA(H1047R) tumor-bearing mice long term with the drug combination.
117 tinib at a low dose (0.5 mg/kg/day, i.p.) in tumor-bearing mice not only alleviated muscle wasting, b
118 h increased monoclonal (M) protein (g/dL) in tumor-bearing mice over time (3.29 +/- 0.58 at week 0 an
120 sed in multiple brain regions of LPS-treated tumor-bearing mice relative to LPS-treated controls; tum
123 positive PC-3 PIP and PSMA-negative PC-3 flu tumor-bearing mice revealed that (86)Y- 4-6: had high si
124 ing lymph nodes of IL-12 plus GM-CSF-treated tumor-bearing mice revealed that whereas IFN-gamma induc
127 stration of PNC-gel extended the survival of tumor-bearing mice significantly better than Taxol, but
128 esultant FA-3DNA-siHuR conjugates to ovarian tumor-bearing mice suppressed tumor growth and ascites d
129 We demonstrate that glutamine blockade in tumor-bearing mice suppresses oxidative and glycolytic m
132 logy model of VEGF transport and kinetics in tumor-bearing mice to include a tumor compartment whose
133 l for a productive CD8(+) T cell response in tumor-bearing mice treated with anti-PD-1 but were not r
135 urvival/proliferation, and survival in brain tumor-bearing mice treated with PT2385 alone and in comb
138 CuSarTATE in AR42J (rat pancreatic exocrine) tumor-bearing mice was compared with (177)Lu-LuTATE.
139 hematopoiesis and myeloid differentiation in tumor-bearing mice was induced by TNFalpha, which was ma
141 claudin-low tumors, and Tregs isolated from tumor-bearing mice were able to suppress effector T cell
146 hment of this preclinical model, a cohort of tumor-bearing mice were injected with the chemotherapeut
148 HCC cells in vitro.Materials and MethodsHCC tumor-bearing mice were randomized to neoadjuvant PI3K/m
151 triple-negative breast cancer model, whereby tumor-bearing mice were treated with pan-TAM kinase inhi
152 y, in the murine model, approximately 40% of tumor-bearing mice were tumor-free after a single treatm
158 eting platelet function pharmacologically in tumor-bearing mice with aspirin and clopidogrel in combi
159 1 immunity in CNS tissues, we infected GL261 tumor-bearing mice with attenuated rabies virus (RABV).
160 istribution studies were performed in LS174T tumor-bearing mice with AVP04-07-TCO(n) (where n indicat
165 ncing in MCL cells and prolonged survival of tumor-bearing mice with no observed adverse effects.
166 s mechanism of action is preserved, to treat tumor-bearing mice with otherwise lethal levels of chemo
170 mor model system, a single s.c. injection of tumor-bearing mice with R-DOTAP plus human papillomaviru
171 y decreased tumor weight and splenomegaly in tumor-bearing mice with reduced accumulation of polymorp
172 ine liver metastasis (LM) model, by treating tumor-bearing mice with STAT3 inhibitors (STATTIC or BBI
173 P78-regulated metabolite changes by treating tumor-bearing mice with tamoxifen and/or linoleic acid.
176 omparison with controls after injection into tumor-bearing mice, and promoted DC maturation, leading
177 cessfully performed on tumor-bearing and non-tumor-bearing mice, as well as on controls bearing sites
179 foundly block naive CD8(+) T cell priming in tumor-bearing mice, but actually increased the number of
180 show that upon systemic administration into tumor-bearing mice, CRV selectively homes to tumors, ext
181 s, or therapeutic inhibition of Ampkalpha in tumor-bearing mice, delayed tumor growth, inhibited the
183 sfer of granulocytic-MDSCs isolated from 4T1 tumor-bearing mice, induce metastasis by suppressing CD8
186 e prolonged survival but did not cure HDLM-2 tumor-bearing mice, whereas BV combined with ruxolitinib
187 D-1-expressing cells extends the survival of tumor-bearing mice, whereas free drugs have no effect at
188 o(LA)8-PTX induced tumor regression in A549 tumor-bearing mice, whereas PTX delayed tumor growth.
189 high-dimensional analysis of immune cells in tumor-bearing mice, which eliminates gating biases and i
253 and image the endogenous NQO1 in three live tumor-bearing mouse models (A549 lung cancer, Lewis lung
258 aterials and Methods A total of 21 VX2 liver tumor-bearing New Zealand white rabbits were used betwee
262 r systemic administration into orthotopic MB tumor bearing NSG mice compared to non-targeted JQ1 load
263 dose of 20 mg/kg into orthotopic pancreatic tumor-bearing NSG mice every alternate day resulted in s
265 all-animal PET experiments were performed on tumor-bearing nude mice after subcutaneous injection of
269 average elastic moduli of non-neoplastic and tumor-bearing optic nerves were approximately 3 and appr
272 nistration of into hepatic arteries of a VX2 tumor-bearing rabbit under fluoroscopy, followed by subs
274 injections of rat hepatoma cells (H4IIE); 24 tumor-bearing rats (mean tumor diameter, approximately 1
276 13)C]glycine SNR was significantly higher in tumor-bearing rats compared to controls, and in tumor re
282 ium-2G11 mAb was performed in 143B and OS-17 tumor-bearing SCID mice and followed by radioimmunothera
283 = 7) and control groups (n = 6-7) using C4-2 tumor-bearing SCID mice by evaluating tumor growth and s
284 functional capacity of PD-1(hi) CD8 TILs in tumor-bearing sepsis survivors, checkpoint blockade ther
285 and (177)Lu-PSMA I&T was determined in LNCaP tumor-bearing severe combined immunodeficiency (SCID) mi
286 in PD-L1-positive, PD-L1-negative, and mixed tumor-bearing severe combined immunodeficiency mice.
289 ify transcriptional programs associated with tumors bearing specific genetic driver alterations.
290 epletion of CD4(+) but not CD8(+) T cells in tumor-bearing subjects reversed the inhibitory effects o
297 a, PMNs were recruited less intensely to the tumor-bearing uterus, but the recruited cells much more