ライフサイエンスコーパス: tumor-initiating cell

1 dictated by the proliferative status of the tumor-initiating cell.

2 es are separable based on the lineage of the tumor-initiating cell.

3 odulating the lineage potential of MMTV-Wnt1 tumor initiating cells.

4 t in primary CRC, which potentially includes tumor initiating cells.

5 he elimination of undifferentiated stem-like tumor initiating cells.

6 from noisy expression data of CD44+CD24-/low tumor initiating cells.

7 gene target expression segregate to CD133(+) tumor initiating cells.

8 Tetraspanins mark stem cells and tumor initiating cells.

9 operties of 3T3 fibroblasts and glioblastoma tumor initiating cells.

10 nomic profile of residual, therapy resistant tumor initiating cells.

11 nses to NOTCH3 and expands therapy-resistant tumor-initiating cells.

12 ected strategy of immunotherapy to eradicate tumor-initiating cells.

13 ttributed to the presence of CD44-expressing tumor-initiating cells.

14 t attenuation of tumorigenicity by targeting tumor-initiating cells.

15 ewal is thought to be a critical property of tumor-initiating cells.

16 and also has been linked to the capacity of tumor-initiating cells.

17 and lung metastases are highly enriched for tumor-initiating cells.

18 dentify MELK as a potential target in breast tumor-initiating cells.

19 r eradication of primary tumors derived from tumor-initiating cells.

20 hology, suggesting a mixed-lineage origin of tumor-initiating cells.

21 say, a Lin(-)CD29(H)CD24(H) subpopulation of tumor-initiating cells.

22 gating the normal differentiation program of tumor-initiating cells.

23 sis, providing signals that maintain mammary tumor-initiating cells.

24 d in a decline in kynurenine production from tumor-initiating cells.

25 nt of effective therapeutic agents targeting tumor-initiating cells.

26 ed to be resistant to chemotherapy caused by tumor-initiating cells.

27 t Rspo1 and the Sca1-population, enriched in tumor-initiating cells.

28 emalignant cells and activates quiescence in tumor-initiating cells.

29 oRNA-203 promotes selection and expansion of tumor-initiating cells.

30 ions suggest an active selection process for tumor-initiating cells.

31 ignature similar to that observed for human 'tumor-initiating' cells.

32 flammatory cytokine production, and increase tumor-initiating cell abundance and metastatic progressi

33 the effects of Smoothened antagonists on BCC tumor initiating cell and also suggest that currently av

34 evels results in reduced tumor growth, fewer tumor initiating cells and reduced metastasis within the

35 in turn, regulate the relative proportion of tumor initiating cells and the latency of her-2-driven t

36 the mTORC1 kinase induces differentiation of tumor-initiating cells and allows their subsequent deple

37 at the oncofetal protein 5T4 is expressed on tumor-initiating cells and associated with worse clinica

38 cancer models, we found that TcdBFBD reduces tumor-initiating cells and attenuates growth of basal-li

39 mal transition-driving genes, reminiscent of tumor-initiating cells and claudin-low breast cancer.

40 ed endothelial cells (TDECs) originated from tumor-initiating cells and did not result from cell fusi

41 horylated by a Jak2-mediated pathway only in tumor-initiating cells and in human SHH-type medulloblas

42 to maintain proper exon recognition in brain tumor-initiating cells and may provide new inroads for n

43 at the intersections of stem cell function, tumor-initiating cells and multilineage tumor developmen

44 ms by which RA targets GBM-derived stem-like tumor-initiating cells and novel targets applicable to d

45 how that Fzd7 marks a population of putative tumor-initiating cells and that targeting Fzd7 offers a

46 However, tumor-initiating cells and the biological processes that

47 glioblastoma identifies regulators of brain tumor-initiating cells and tumor growth that could serve

48 In this study, the subpopulation of tumor-initiating cells and Wnt signaling pathway activat

49 ined a mixture of red cells (PDGF-expressing/tumor-initiating cells) and green cells (recruited proge

50 iforme (GBM) research is the identity of the tumor-initiating cell, and its contribution to the malig

51 mor cell growth, decreased the proportion of tumor-initiating cells, and decreased tumor formation in

52 resistance, identification of stem cells and tumor-initiating cells, and development of mouse models

53 ) in ovarian cancer cells and ovarian cancer tumor-initiating cells, and that knockdown of SFXN4 inhi

54 This osteosarcoma tumor-initiating cell appears highly prolific and consti

55 and cell deformability, and demonstrate that tumor-initiating cells are less differentiated in terms

56 While tumor-initiating cells are Lgr5(+), most disseminated ca

57 Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progressio

58 an prospectively identify glioblastoma brain tumor initiating cells as well as human muscle stem cell

59 ng possibility that these cells could be the tumor-initiating cells, as has been suggested for adult

60 pithelial progenitor cell reprogramming into tumor initiating cells at single cell resolution.

61 rowth through the generation or expansion of tumor initiating cells bearing stem-like characteristics

62 onchio-alveolar stem cells (BASCs), putative tumor-initiating cells, both in vitro and in vivo.

63 Breast tumors may derive from self-renewing tumor-initiating cells (BT-ICs), which contribute to tum

64 nd has an important role in regulating brain tumor-initiating cells (BTIC) in GBM.

65 enic signaling by NOTCH is elevated in brain tumor-initiating cells (BTIC) in malignant glioma, but t

66 bolic dysregulation in patient-derived brain tumor-initiating cells (BTIC) to a nexus between MYC and

67 ere elevated in areas infiltrated with brain tumor-initiating cells (BTIC).

68 Brain tumor initiating cells (BTICs) co-opt the neuronal high

69 of the endosomal GTPase Rab35 in human brain tumor initiating cells (BTICs) increases glioblastoma gr

70 to tumor progression by enriching for brain tumor initiating cells (BTICs) owing to preferential BTI

71 Brain tumor initiating cells (BTICs), also known as cancer ste

72 eractions modulate the galvanotaxis of brain tumor initiating cells (BTICs).

73 Brain tumor-initiating cells (BTICs) and orthotopic xenografts

74 Here we used brain tumor-initiating cells (BTICs) and show that BTICs expre

75 Brain tumor-initiating cells (BTICs) drive glioblastoma growth

76 e et al. determined that GSI-resistant brain tumor-initiating cells (BTICs) from GBM express a higher

77 Brain tumor-initiating cells (BTICs) have been identified as k

78 both glioma stemlike cells (GSCs) and brain tumor-initiating cells (BTICs) have been implicated in G

79 In addition, GBM brain tumor-initiating cells (BTICs) increase expression of ca

80 m cell regulatory pathways to maintain brain tumor-initiating cells (BTICs), also known as cancer ste

81 sub-fraction of cancer cells, termed breast tumor-initiating cells (BTICs), that undergo epithelial

82 r cell lines and patient tumor-derived brain tumor-initiating cells (BTICs).

83 rtance of TrkB and TrkC in survival of brain tumor-initiating cells (BTICs).

84 duced tumors contained a large percentage of tumor-initiating cells, but these were reduced significa

85 e tumor growth, angiogenesis, metastasis and tumor-initiating cells by in vivo imaging and provide a

86 An accumulation of tumor-initiating cells can be found in 2% to 50% of all

87 The concept that tumor-initiating cells can co-opt the self-renewal progr

88 CD133+ tumor-initiating cells can originate from proliferating

89 to the unique properties of iron handling in tumor-initiating cells (cancer stem cells), novel contri

90 Cancer stem cells are proposed to be tumor-initiating cells capable of tumorigenesis, recurre

91 Tumor-initiating cells (CD44(+)) have been described for

92 Fbeta drives Notch1-mediated EMT to generate tumor initiating cells characterized by high CD44 expres

93 proposed to be composed of two compartments: tumor-initiating cells characterized by a slow and asymm

94 )CXCR4(+) (CXC receptor 4) colorectal cancer tumor-initiating cells (Co-TICs) and the LN stromal micr

95 Cancer stem cells (CSC; also called tumor-initiating cells) comprise tumor cell subpopulatio

96 Cancer stem cells (CSCs), or tumor-initiating cells, comprise a subset of tumor cells

97 equired for maintenance of cancer stem cells/tumor-initiating cells (CSCs/TICs), which drive tumorige

98 e showed recently that cancer stem cells, or tumor-initiating cells, derived from human glioblastoma

99 Cancer stem/tumor-initiating cells display stress tolerance and meta

100 Tumor initiating cells displayed a distinct stem-like st

101 p19(ARF) profoundly influences the nature of tumor-initiating cells during BCR/ABL-mediated leukemoge

102 ell tracking method to follow up the fate of tumor-initiating cells during chemotherapy.

103 lineage-associated OLIG2(+) progenitors are tumor-initiating cells during medulloblastoma tumorigene

104 ations, as well as the CD61(high)CD49f(high) tumor-initiating cell-enriched population.

105 e: Coupling single-cell transcriptomics with tumor-initiating cell enrichment identified IFN response

106 These tumor-initiating cells express stem cell markers.

107 tiation in prostate progenitors, presumptive tumor initiating cells for prostate cancer.

108 of cancer.(1-4) The nature and existence of tumor-initiating cells for leukemia and other malignanci

109 xenograft growth assays, we determined that tumor initiating cell frequencies approximate one per 1.

110 SFX-01 significantly reduced tumor-initiating cell frequency in secondary transplants

111 he growth of a range of tumor types, reduces tumor-initiating cell frequency, and exhibits synergisti

112 bition of SCD1 abrogates chemoresistance and tumor-initiating cell frequency.

113 ink colitis and cancer identifying potential tumor-initiating cells from colitic patients, suggesting

114 d basal-like TNBC tumors in mice and blocked tumor-initiating cell function and macrometastasis.

115 n expression of antigens thought to identify tumor initiating cells, generation of 3D aggregates when

116 novel HSP90 inhibitor, NVP-HSP990, in glioma tumor-initiating cell (GIC) populations, which are stron

117 t brain tumor, harbors a small population of tumor initiating cells (glioblastoma stem cells) that ha

118 rmation and viability of primary human colon tumor-initiating cells harboring mutant KRAS.

119 ther tumor cell holoclones genuinely contain tumor-initiating cells has not been directly addressed.

120 Tumor-initiating cells have been suggested to be rare in

121 , the mechanisms that regulate quiescence in tumor-initiating cells have not been analyzed in detail

122 ulations called cancer stem cells (CSCs), or tumor-initiating cells, have been defined in functional

123 astic modulus induced in 3T3 fibroblasts and tumor initiating cells in response to agents that soften

124 ed in airway epithelial repair that may be a tumor-initiating cell in lung cancer and which may be as

125 We explored the nature of the tumor-initiating cell in osteosarcoma, a bone malignancy

126 terogeneity between tumor-initiating and non-tumor-initiating cells in glioblastoma.

127 tify the entire population of epithelial and tumor-initiating cells in human metastatic colon cancer.

128 em cells or intermediate progenitors are the tumor-initiating cells in lola mutants.

129 However, the precise contribution of CD133+ tumor-initiating cells in mediating colon cancer metasta

130 commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.

131 in signaling can further demarcate high-ALDH tumor-initiating cells in the nondysplastic epithelium o

132 that reparative K14+ progenitor cells may be tumor-initiating cells in this subgroup of smokers with

133 this LEFTY1-BMPR2 interaction is specific to tumor-initiating cells in triple-negative breast cancer

134 erapeutic agents is effective in killing the tumor-initiating cells in vitro and inhibits tumor forma

135 nation in inducing differentiation of breast tumor-initiating cells in vivo Furthermore, gene express

136 astasis, and recurrence, and targeting these tumor-initiating cells is necessary to eradicate tumors.

137 Although the role of CD271 as a marker of tumor-initiating cells is still a matter of debate, its

138 that human malignant glioma tissues and also tumor-initiating cells isolated from fresh human maligna

139 eficiencies) that were derived from CD44(hi) tumor-initiating cells isolated from PCa-20a cells.

140 The tumor-initiating cells isolated from these tumors that f

141 CNOT3 expression, as might be expected for a tumor-initiating cell marker.

142 ve and tumorigenic capacities of the mammary tumor-initiating cells (MaTICs) of claudin-low breast ca

143 val in brain tumors and other cancers; thus, tumor initiating cells may extract nutrients with high a

144 in pre-malignant DCIS lesions and that these tumor-initiating cells may determine the phenotype of DC

145 e viability and maintenance of self-renewing tumor-initiating cells may ultimately lead to improved t

146 However, despite the diversity of tumor-initiating cells, most prostate cancer cells expre

147 livary gland imaginal ring, we find that the tumor-initiating cells normally undergo endoreplication

148 nd by increased reliance of cancer cells and tumor-initiating cells on mitochondria, resulting in pot

149 od that enriches cancer stem cells (CSCs) or tumor-initiating cells on the basis of cell adhesion pro

150 renewing, and highly metastatic cells called tumor initiating cells or cancer stem cells (CSCs).

151 for tumor initiation and propagation, termed tumor initiating cells or cancer stem cells (CSCs).

152 y a reservoir of self-renewing cells, termed tumor-initiating cells or cancer stem cells.

153 In SC precursors, which model tumor-initiating cells, pharmacological and genetic inhi

154 n epithelial-to-mesenchymal transition and a tumor initiating cell phenotype, and that it is required

155 PKCiota-ELF3-NOTCH3 signaling controls the tumor-initiating cell phenotype by regulating asymmetric

156 the Lin(-)CD29(H)CD24(H) mouse mammary gland tumor-initiating cell population include those involved

157 Focusing on one example of a tumor-initiating cell population, we demonstrate that th

158 arker for distinct subsets of chemoresistant tumor-initiating cell populations in diverse human malig

159 to target both established tumor masses and tumor-initiating cell populations.

160 pigenomic profiling revealed that IFE and HF tumor-initiating cells possess distinct chromatin landsc

161 ), consistent with the selective survival of tumor-initiating cells posttreatment.

162 elf-renewal, acting in a small population of tumor-initiating cells present in tumors.

163 YAP-mediated tumor initiating cell programs included activation of on

164 r subpopulation, termed cancer stem cells or tumor-initiating cells, promotes therapeutic resistance

165 The identification of tumor-initiating cells represents a significant challeng

166 uding glioma stem cells (GSC), which are the tumor-initiating cells responsible for treatment failure

167 tumors, which are driven by a component of 'tumor-initiating cells' retaining stem cell properties.

168 enuate cancer stem cell markers, inhibit the tumor-initiating cell's neurosphere-forming capacity, an

169 ddition to angiogenic effects, VEGF promotes tumor-initiating cell self-renewal through VEGFR-2/STAT3

170 rt differential drug sensitivity, indicating tumor-initiating cell states and genetic drivers dictate

171 Here we showed that the basal cell carcinoma tumor-initiating cell surface protein CD200, through ect

172 140/SOX2 pathway critically regulates breast tumor-initiating cell survival, providing a new link bet

173 ribe the isolation and characterization of a tumor-initiating cell (T-IC) subpopulation in primary hu

174 t evidence has demonstrated the existence of tumor-initiating cells (T-ICs) as the culprit for treatm

175 r can arise from a cancer stem cell (CSC), a tumor-initiating cell that has properties similar to tho

176 Human melanomas contain a population of tumor-initiating cells that are able to maintain the gro

177 existence of a small population of CD133(+) tumor-initiating cells that are capable of regenerating

178 own about chromatin mechanisms that regulate tumor-initiating cells that are proposed to be responsib

179 fectively eliminate the subpopulation of GBM tumor-initiating cells that are responsible for relapse.

180 mor growth in vivo, decreasing the number of tumor-initiating cells, thus supporting its pro-oncogeni

181 The effectiveness of CD133NPs in reducing tumor initiating cell (TIC) fraction was investigated us

182 s leads to an induction of a CD24(-)/CD44(+) tumor initiating cell (TIC) population (4) sGRP78(+) bre

183 in pancreatic cancer along with a decreased tumor initiating cell (TIC) population in pancreatic tum

184 tumor sphere formation, a characteristics of tumor initiating cell (TIC).

185 Tumor initiating cells (TIC) have been suggested as a me

186 al-mesenchymal transition (EMT), promoting a tumor-initiating cell (TIC) phenotype characterized by i

187 sition reversibly between slow-proliferating tumor-initiating cells (TIC) and their differentiated, f

188 Tumor-initiating cells (TIC) are critical yet evasive ta

189 Tumor-initiating cells (TIC) are dynamic cancer cell sub

190 y of continuous culture models and human GBM tumor-initiating cells (TIC) in both Boyden chamber and

191 ALDH1(+)CD44(+) cells are putative tumor-initiating cells (TIC) in head and neck squamous c

192 f) receptor 2 (CCR2) decreases the number of tumor-initiating cells (TIC) in pancreatic tumors.

193 Understanding the mechanisms supporting tumor-initiating cells (TIC) is vital to combat advanced

194 Breast tumor-initiating cells (TIC) may contribute to tumor pro

195 A tumor cell subpopulation of tumor-initiating cells (TIC) or "cancer stem cells" is a

196 Emerging evidence indicates the presence of tumor-initiating cells (TIC) or cancer stem cells in ost

197 Tumor-initiating cells (TIC) perpetuate tumor growth, en

198 ypothesis that HER2/HER3 signaling in breast tumor-initiating cells (TIC) promotes self-renewal and s

199 Tumor-initiating cells (TIC) represent cancer stem-like

200 play cellular hierarchies with self-renewing tumor-initiating cells (TIC), also known as cancer stem

201 y organized and driven by a subpopulation of tumor-initiating cells (TIC), or cancer stem cells.

202 P) cells showed up to a 3-fold enrichment of tumor-initiating cells (TIC), suggestive of a sanctuary

203 In examining the role of EGFR in tumor-initiating cells (TIC), we found that EGFR express

204 cancer recurrence is thought to be driven by tumor-initiating cells (TIC).

205 inflammatory markers and spheroid-generating tumor-initiating cells (TIC).

206 ibitors, in particular those that can target tumor-initiating cells (TIC).

207 microenvironment to promote proliferation of tumor initiating cells (TICs) and carcinogenesis.

208 Isolating tumor initiating cells (TICs) often requires screening o

209 rogression and relapse is conceivably due to tumor initiating cells (TICs)/cancer stem cells.

210 (RTK)/RAS signaling can lead to outgrowth of tumor-initiating cells (TICs) and drive therapeutic resi

211 ene expression signatures derived from human tumor-initiating cells (TICs) and human mammary stem cel

212 s by activating JAK/STAT signaling in breast tumor-initiating cells (TICs) and promoted TIC self rene

213 east cancer cells bearing characteristics of tumor-initiating cells (TICs) and that strongly associat

214 Targeting the cross-talk between tumor-initiating cells (TICs) and the niche microenviron

215 Tumor-initiating cells (TICs) are a sub-population of ce

216 Tumor-initiating cells (TICs) are particularly efficient

217 To determine if tumor-initiating cells (TICs) are present in SCCas, we u

218 Tumor-initiating cells (TICs) are thought to be critical

219 These distinct tumor-initiating cells (TICs) clonally recapitulated the

220 rogression in cancer requires populations of tumor-initiating cells (TICs) endowed with unlimited sel

221 Tumor-initiating cells (TICs) have been shown both exper

222 (MECs) to mammary stem cells (MaSCs) and to tumor-initiating cells (TICs) have not been entirely elu

223 The proportion of tumor-initiating cells (TICs) in the mammary tumors from

224 dentification of therapeutic targets against tumor-initiating cells (TICs) is a priority in the devel

225 Tumor-initiating cells (TICs) share features and regulat

226 ucing kinase (NIK), support the expansion of tumor-initiating cells (TICs) that copurify with a CD24(

227 , and treatment resistance is potentiated by tumor-initiating cells (TICs) that thrive under hypoxia.

228 Moreover, GDF15 induces the expansion of MM tumor-initiating cells (TICs), and changes in the serum

229 of cancer in which only a fraction of cells, tumor-initiating cells (TICs), can sustain tumor growth.

230 lentiviral particles, and transduction into tumor-initiating cells (TICs), followed by in vivo trans

231 o has therapeutic implications for targeting tumor-initiating cells (TICs), the tumor stroma, and che

232 oncogene-induced expansion and activities of tumor-initiating cells (TICs), whereas it is largely dis

233 njury and establishes selective pressure for tumor-initiating cells (TICs), which proliferate to form

234 ncer of Zeste Homolog 2 (EZH2) and increased tumor-initiating cells (TICs).

235 ane transport in bulk tumor cells (BTCs) and tumor-initiating cells (TICs).

236 tributed to cancer stem-like cells (CSCs) or tumor-initiating cells (TICs).

237 ssed in and regulates self renewal of breast tumor-initiating cells (TICs).

238 n by a population of stem-like cells, called tumor-initiating cells (TICs).

239 ry significantly stimulates the expansion of tumor-initiating cells (TICs).

240 bserved in a genetic model of ovarian cancer tumor-initiating cells (TICs).

241 ancy-associated traits and the properties of tumor-initiating cells (TICs).

242 as been attributed to expansion of stem-like tumor-initiating cells (TICs).

243 drugs that specifically target glioblastoma tumor-initiating cells (TICs).

244 gulation of CD44, a ubiquitous marker of PCa tumor-initiating cells (TICs)/stem cells.

245 ds on a small subset of tumor cells, called "tumor-initiating cells" (TICs), with SC-like properties.

246 inhibition of SOS1 reduced the frequency of tumor-initiating cells to curb spheroid growth in situ a

247 Tumor initiating cell transcriptional programs are conse

248 C receptors by ligands BDNF and NT3 enhances tumor-initiating cell viability through activation of ER

249 that breast cancer is derived from a single tumor-initiating cell with stem-like properties, but the

250 Tumor-initiating cells with reprogramming plasticity or

251 Within established GBM, a subpopulation of tumor-initiating cells with stem-like properties (GBM st

252 ver, interaction of accessory cells with the tumor-initiating cell within the microenvironment is oft