ライフサイエンスコーパス: tumorigenic

1 ncer, strongly suggesting that this virus is tumorigenic.

2 onstitutive TGF-beta signaling and were less tumorigenic.

3 as multiple nonapoptotic activities that are tumorigenic.

4 at differ from one another in their relative tumorigenic abilities.

5 In cancer research, the tumorigenic ability of pathogens is being recognized, fo

6 recently found to bind KRAS and inhibit its tumorigenic action by unknown mechanisms.

7 factor C/EBPdelta can exhibit pro- and anti-tumorigenic activities, but the mechanisms underlying th

8 te the cellular proliferation, invasion, and tumorigenic activity in a TWIST1-dependent manner in vit

9 -beta signaling has been associated with the tumorigenic activity of GIC.

10 e expression of Vps34 is correlated with the tumorigenic activity of human breast cancer cells.

11 increased ceramide levels, and inhibited the tumorigenic activity of human melanoma A2058 cells, wher

12 g PTN expression in MLCs mitigated their pro-tumorigenic activity.

13 evels in chemoresistant LSCs and reduced LSC tumorigenic activity.

14 and/or a general survival mechanism to anti-tumorigenic agents.

15 ing to the TME and examine their diverse pro-tumorigenic and antitumorigenic functions.

16 ing cells that can self-renew and are highly tumorigenic and chemoresistant.

17 ffects of the vaccine revealed a highly anti-tumorigenic and homogenous microenvironment after vaccin

18 Here, we discuss the tumorigenic and immunoregulatory effects of ER stress in

19 invasive capacity of B16-F10 cells and their tumorigenic and metastatic activity when grafted in syng

20 FPR2 deletion also reduced the tumorigenic and metastatic capabilities of GC cells in v

21 a hallmark of cancer and contributes to the tumorigenic and metastatic phenotypes of cancer cells.

22 Ormeloxifene efficiently attenuated tumorigenic and metastatic properties of cervical cancer

23 Identifying and sorting highly tumorigenic and metastatic tumor cells from a heterogene

24 rinsic softness is a unique marker of highly tumorigenic and metastatic tumor cells.

25 (pIL6; (IL6) beta2SP(+/-) LSCs) were highly tumorigenic and metastatic, whereas those derived from W

26 ing treatment with P-AscH(-) was examined in tumorigenic and nontumorigenic cells.

27 mesenchymal stromal cells, which induce pro-tumorigenic and pro-metastatic neutrophils.

28 r and metastatic clinical features were also tumorigenic and prometastatic in experimental models of

29 onize tumorigenesis, MMe macrophages are pro-tumorigenic and represent the dominant macrophage phenot

30 ancer stem cell (CSC)-like cells with highly tumorigenic and self-renewing abilities, which were sele

31 Highly tumorigenic and stem-like lung adenocarcinoma cells were

32 Down-regulation of MBNL1 led to increased tumorigenic and stem/progenitor-like properties in vitro

33 CM protein constituents have distinguishable tumorigenic and tumor-repressive functions.

34 on that shape host responses to physiologic, tumorigenic, and pathogenic conditions.

35 e pro-angiogenic, immune suppressive and pro-tumorigenic behavior of these cells by upregulating the

36 K3 is a HSF1 effector that modulates the pro-tumorigenic behaviour of CAFs in vitro and in vivo.

37 tigen marker combination, we isolated highly tumorigenic breast cancer cells residing stably-both in

38 t CSCs over bulk breast cancer cells and non-tumorigenic breast cells.

39 nd hypoxic culture conditions on healthy and tumorigenic breast epithelial cells, MCF-10A cells and B

40 to why a subtle dysfunction of BCCIP can be tumorigenic but a complete depletion of BCCIP is lethal.

41 Deregulated MYC alone was not tumorigenic, but coexpression with NeuNT resulted in inc

42 Here, we identify a highly tumorigenic cancer stem cell population in a mouse model

43 PDAC cells vary in their tumorigenic capabilities with the presence of a subset o

44 rupting F-actin binding are defective in its tumorigenic capabilities.

45 cer agent, whereas our work demonstrates its tumorigenic capability via myeloid-mediated immune suppr

46 ishing cellular miR-16-5p leading to reduced tumorigenic capacity and miR-16-5p target oncoproteins C

47 acity in normal mammary epithelial cells and tumorigenic capacity in TNBC is independent of expressio

48 Furthermore, we find that tumorigenic capacity is dependent on the dosage of phf7

49 ed p53 protein turnover, which blocked their tumorigenic capacity through cellular senescence and apo

50 and elucidate the mechanisms underlying its tumorigenic capacity.

51 ds were validated for efficacy using two non-tumorigenic cell lines in soft agar.

52 SCs displayed normal genotypes compared with tumorigenic cell lines.

53 y contributes to transformation (stage a non-tumorigenic cell undergoes to become malignant) is unkno

54 human body to eliminate pathogen-infected or tumorigenic cells (also known as target cells).

55 human body to eliminate pathogen-infected or tumorigenic cells (i.e., target cells).

56 ell-cell adhesion molecule E-cadherin on non-tumorigenic cells and promote tumor invasion.

57 cMASCs was tested by co-implanting them with tumorigenic cells in mice.

58 We saw active 5' LTR use in tumorigenic cells only, suggesting that the cellular env

59 ts of MCF7/SKBR3 breast cancer and MCF10 non-tumorigenic cells were used as a surrogate to support th

60 Despite being defined as non-tumorigenic cells with high translational potential, hum

61 ng allows monitoring of the clonal output of tumorigenic cells without prospective isolation.

62 However, ERK3 is stabilized and activated in tumorigenic cells, but deteriorates over time in primary

63 , LTR-driven transcription was restricted to tumorigenic cells, suggesting that LTR promoter activity

64 tself, but more selectively toxic toward the tumorigenic cells.

65 specifically stimulated in tumors and highly tumorigenic cells.

66 ng interleukin-8 (IL-8), in both, normal and tumorigenic cells.

67 in TNBC cells with negligible effects in non-tumorigenic cells.

68 egulin, which is exclusively secreted by non-tumorigenic clones.

69 t prostate cancer cell lines singled out pro-tumorigenic CXC motif chemokine ligand 5 (CXCL5) as a ta

70 receptor on LPA-stimulated expression of pro-tumorigenic cytokines and chemokines overexpressed in ov

71 res, elevated expression of pro-inflammatory tumorigenic cytokines, such as IL-17A and IL-6, and incr

72 To investigate the tumorigenic determinants, we analyzed gastric tissues fr

73 tion of rapidly proliferating infectious and tumorigenic diseases has resulted in an urgent need to d

74 e of established and emerging infectious and tumorigenic diseases.

75 strate that overexpressed IGF-2 is the major tumorigenic driver in a subset of CRCs and encourage tes

76 Our results implicate activated AKT as a tumorigenic driver in ganglioneuroma.

77 Although tumorigenic drivers are numerous and varied, the drivers

78 ired during cancer progression or can act as tumorigenic drivers is a topic of ongoing investigation.

79 putational method, RegNetDriver, to identify tumorigenic drivers using the combined effects of coding

80 Furthermore, transition from the highly tumorigenic E/M state to a fully mesenchymal phenotype,

81 We provide evidence that the tumorigenic effect of AVIL is partly mediated by FOXM1,

82 Importantly, the in vivo pro-tumorigenic effect of CA-MSC is abrogated by dual blocka

83 Here, we show that the anti-tumorigenic effect of KLF4 extends to PC3 human prostate

84 The tumorigenic effect of tRXRalpha is primarily dependent o

85 These classical tumour-suppressor genes have tumorigenic effects associated with somatic biallelic in

86 ioid but not vice versa; and ZEB1 exerts its tumorigenic effects by promoting cell dedifferentiation,

87 Myc oncoproteins exert tumorigenic effects by regulating expression of target o

88 DeltaNp63alpha elicits its tumorigenic effects in part by promoting cellular prolif

89 We therefore sought to evaluate the tumorigenic effects of CA-MSC paracrine LIF signaling an

90 dentified mediator(s) to suppress off-target tumorigenic effects of hepatic RFA.

91 downstream targets by which they exert their tumorigenic effects remain elusive.

92 This can elicit both pro- and anti-tumorigenic effects that engender significant challenges

93 Such tumorigenic effects were mediated primarily by IL-21 and

94 is for its dramatically higher mutagenic and tumorigenic effects.

95 vitamin D prevented these calcium-triggered tumorigenic effects.

96 ndidate live biotherapeutic with proven anti-tumorigenic efficacy.

97 l proteins contribute to the generation of a tumorigenic environment and are targets for drug and vac

98 resident innate immune cells creating a pro-tumorigenic environment.

99 (UPR), a significant attenuation of the pro-tumorigenic Epidermal Growth Factor Receptor (EGFR)-Akt

100 me-wide distribution of 8-oxodG in human non-tumorigenic epithelial breast cells (MCF10A), and mouse

101 LINCS cellular signatures such as their non-tumorigenic epithelial cell type, three-dimensional grow

102 spheroids (1:1 mixture of metastatic and non-tumorigenic epithelial cells), we show that IFs downregu

103 donors stimulated growth in soft agar of non-tumorigenic epithelial cells.

104 ion of the tumour suppressor NF2, a frequent tumorigenic event in mesothelioma(10,11), rendered cance

105 tumor suppressor protein which controls many tumorigenic events associated with the hedgehog (hh) sig

106 In the center of tumorigenic events caused by GERD is repeated damage of

107 gain-of-function (GOF) activities to promote tumorigenic events.

108 n and its loss enhances the secretion of pro-tumorigenic exosomes for breast cancer invasion.

109 y, our data show that HIF-1 is a pivotal pro-tumorigenic factor for intestinal tumor formation, contr

110 and kidney cancers suggest that it is a pro-tumorigenic factor in genitourinary malignancy.

111 tumor tissue, secrete pro-angiogenic and pro-tumorigenic factors and thereby increase tumor growth, t

112 Tumorigenic factors may act specifically on one of these

113 Some tumorigenic factors, such as activation of ErbB2 or loss

114 ssion of antitumor T cells and production of tumorigenic factors.

115 ontrol conditions and in response to various tumorigenic factors.

116 pigenetic programs are selected for enhanced tumorigenic fitness during the evolution of distant meta

117 K1 is known as a cytoskeleton regulator, its tumorigenic function in MPNSTs remains largely unknown.

118 Importantly, we linked the profound tumorigenic function of HuR to its ability to simultaneo

119 These observations connect WDR5 to a core tumorigenic function of MYC and establish that, if a the

120 eporter mice we confirm the presence and pro-tumorigenic function of TdT(OSX)+ cells in extra-skeleta

121 e cells that can perform both pro- and anti- tumorigenic functions (Figure 1).

122 en consumption and ATP generation, promoting tumorigenic functions and tumor growth in NSCLC.

123 immune components that possess pro- and anti-tumorigenic functions in individual cancers remain large

124 primary osteosarcoma patient tissues and its tumorigenic functions in these malignancies.

125 heme uptake, intracellular heme levels, and tumorigenic functions of NSCLC cells.

126 more, we show that the pro-apoptotic and pro-tumorigenic functions of PKCdelta also segregate based o

127 rom Rab11a compartments of exosomes with pro-tumorigenic functions, which we propose promote stress-i

128 cT on oxygen consumption, proliferation, and tumorigenic functions.

129 ant cells can shift the immune system to pro-tumorigenic functions.

130 heme largely reversed the effect of HSPs on tumorigenic functions.

131 Many tumorigenic fusion genes have retained or lost functiona

132 tic transcriptional machinery to drive a pro-tumorigenic gene expression program in TNBC.

133 netic events, resulting in activation of pro-tumorigenic genes but can go as far as reactivation of t

134 gulated by STAT3 at the promoters of several tumorigenic genes, including c-Myc, known to be critical

135 in mouse and human expresses pro-angiogenic/tumorigenic genes.

136 ntains a population of self-renewing, highly tumorigenic glioma stem cells (GSCs), which contributes

137 Self-renewing, highly tumorigenic glioma-initiating cells (GIC) have been link

138 The depletion of KDM3 inhibits tumorigenic growth and chemoresistance of human colorect

139 that genetic inhibition of SHOC2 suppresses tumorigenic growth in a subset of KRAS-mutant NSCLC cell

140 unlike the loss of merlin, failed to promote tumorigenic growth in an orthotopic model.

141 ession promoted proliferation, migration and tumorigenic growth of human CRC cells in vitro and in vi

142 aracterized by KRAS- and autophagy-dependent tumorigenic growth, but the role of KRAS in supporting a

143 cancers, and the PYCR1 knock-out suppresses tumorigenic growth, suggesting that PYCR1 is a potential

144 or a key autocrine signaler known to promote tumorigenic growth.

145 owed that cells of NSC-like origin were more tumorigenic, had a higher rate of self-renewal and proli

146 Comparisons with non-tumorigenic human breast epithelial MCF-10A and MCF7 cel

147 asmic localization of PELP1 up-regulates pro-tumorigenic IKK and secreted inflammatory signals, which

148 ute to tumor growth and to maintaining a pro-tumorigenic, immunosuppressed microenvironment.

149 out the epigenomic changes that underlie the tumorigenic impact of extracellular matrix mechanics.

150 cells support tumor growth because IL-17 is tumorigenic in many cancer types and regulatory T cells

151 sistant cell line, ELT3-245, which is highly tumorigenic in mice, and refractory to rapamycin treatme

152 lling can be both tumour suppressive and pro-tumorigenic in small-cell lung cancer.

153 nclear if these common cutaneous viruses are tumorigenic in the general population.

154 sorted CK5+ compared to CK5- cells were more tumorigenic in vivo.

155 t express ER-alpha- and Her-2 and are highly tumorigenic in xenograft models.

156 well as mathematical modeling, we derived a tumorigenic index (TI) to quantify tumorigenic signal st

157 stinctions between tissue-protective and pro-tumorigenic inflammation, including spatiotemporal consi

158 d primary human HNSCC samples contain highly tumorigenic, invasive, and cisplatin-resistant BMI1(+) C

159 ecific and cell-autonomous activation of the tumorigenic JNK stress-activated pathway drives the expr

160 The siRNA internalization into non-tumorigenic kidney cells was negligible with all fatty a

161 drivers of LEC fate in the regulation of the tumorigenic KSHV life cycle.

162 ilities may occur downstream of the same pro-tumorigenic lesions, depending on environmental factors

163 This was accompanied by a shift toward pro-tumorigenic M2 macrophage activation in Slc7a2-deficient

164 Pro-tumorigenic M2 macrophage activation was diminished in m

165 l memory, and a significant reduction of pro-tumorigenic M2 macrophages.

166 rophages from an antitumor M1 phenotype to a tumorigenic M2 phenotype.

167 ize tumor-associated macrophages (TAMs) to a tumorigenic M2 phenotype.

168 rable prognosis, and the infiltration of pro-tumorigenic macrophages.

169 e of the stem cell-like populations from non-tumorigenic mammary epithelial cells and non-aggressive

170 ment has a substantially lower effect on non-tumorigenic mammary epithelial MCF10A cells (67% viabili

171 Compounds 8b, 11a, and 11b were tested on tumorigenic MCF-7 and A2058 cells expressing high levels

172 Hence, non-tumorigenic MCF10-2A cells with reduced SENP7S exhibit g

173 fusivity significantly increased for the non-tumorigenic MCF10A (99%) and the non-invasive MCF7 (56%)

174 fts-in MCF7 and SKBR3 breast cancer, and non-tumorigenic MCF10A cells.

175 sults were not observed in OMA1-depleted non-tumorigenic MCF10A mammary epithelial cells.

176 ional oncoprotein interactions could improve tumorigenic mechanism characterization and therapeutic r

177 ng that loss of enzyme function is a primary tumorigenic mechanism.

178 provide a window on the interaction between tumorigenic mechanisms and host environment.

179 e role of mRNA expression changes in driving tumorigenic mechanisms that are either universal or spec

180 sensors endows malignant cells with greater tumorigenic, metastatic, and drug-resistant capacity.

181 One highly tumorigenic MI line harbored membrane-bound, constitutiv

182 Livers of Nod2(-/-) tumorigenic mice had increased expression of genes invol

183 sal progenitor cells expressing pre-existing tumorigenic mutation(s) and genetic alteration(s).

184 ogenitors as transit-amplifying cells at the tumorigenic onset.

185 cell lines (PDCs) of stromal and one PDC of tumorigenic origin were generated from breast or lung CM

186 nduction of EGFR-regulated genes and related tumorigenic outcomes.

187 We analyze the 20 most common tumorigenic p53 mutations and find that 80% impair zinc

188 tional studies show a strikingly constrained tumorigenic pathway underlying heterogeneous genetic var

189 s a distinct premalignant state and multiple tumorigenic pathways caused by loss of function of Id2 a

190 ic PTEN null mouse embryonic fibroblasts and tumorigenic PCa cell lines reduced Akt phosphorylation a

191 a pro-tumorigenic phenotype (M2) to an anti-tumorigenic phenotype (M1) have facilitated a paradigm s

192 mor associated macrophages (TAMs) from a pro-tumorigenic phenotype (M2) to an anti-tumorigenic phenot

193 TGFBR3-PLAG1 promotes a tumorigenic phenotype in vitro, and is absent in 723 oth

194 t or activate PP2A and failed to reverse the tumorigenic phenotype induced by PTPA suppression, indic

195 (shR-SOCS1) led to partial reversion of the tumorigenic phenotype of B16F10-Nex2 melanoma cells.

196 The HCC transformation to a non-tumorigenic phenotype post mechanochemical disruption wa

197 er that stiff extracellular matrix induces a tumorigenic phenotype through changes in chromatin state

198 s, this stress signaling was shown to induce tumorigenic phenotypes in immortalized cells.

199 ovarian cancer cells manifest a spectrum of tumorigenic phenotypes upon knockdown of PIK3R1.

200 T-independent PDK1/SGK3 signaling to promote tumorigenic phenotypes, which are all abolished upon inh

201 mbryos and investigate the developmental and tumorigenic phenotypes.

202 pha positive and epithelial type with little tumorigenic potency, while SP cells are very similar to

203 ells resulted in inhibition of neuroblastoma tumorigenic potential and prevented the TGFbeta1-depende

204 tone demethylases plays an important role in tumorigenic potential and survival of human colorectal C

205 experimental framework to determine in vivo tumorigenic potential in mice, we found that NetSig cand

206 TPCs resist DNA damage and exhibit increased tumorigenic potential in response to chemotherapy, where

207 totic cell death in vitro, and hindered ALCL tumorigenic potential in vivo.

208 roperty of TICs in vitro and decreased their tumorigenic potential in vivo.

209 Notably, we found the tumorigenic potential of BVE(Cyp24a1-null)-derived tumor

210 an inflammatory signaling that increases the tumorigenic potential of cancer cells promoting their im

211 ion of the aforementioned genes and with the tumorigenic potential of cell lines.

212 Loss of myristoylation abolished the tumorigenic potential of Src and its synergy with androg

213 Also, enhanced tumorigenic potential was observed when P152Lp53-express

214 e dependent on PP2A disruption for sustained tumorigenic potential, and restoration of wild-type Aalp

215 ffected their metabolism and abolished their tumorigenic potential, suggesting that the effects of MA

216 bor chromosomal aberrations, affecting their tumorigenic potential.

217 terized by self-renewal, differentiation and tumorigenic potential.

218 rupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential.

219 wild-type hosts, reaffirming their inherent tumorigenic potential.

220 genomic instability, immune reactivity, and tumorigenic potential.

221 rm tumours despite retaining their intrinsic tumorigenic potential.

222 led that it is required for collagen-induced tumorigenic potential.

223 ressed cell proliferation, cell survival and tumorigenic potential.

224 ells that are characterized by uniquely high tumorigenic potential.

225 as a critical step in the control of CAF pro-tumorigenic potential.

226 eneoplastic cells evolve to reach their full tumorigenic potential.

227 as abrogated exhibiting enhancement of their tumorigenic potential.

228 ver, KDM3A knockdown also potently inhibited tumorigenic potentials of breast cancer stem-like cells

229 ve zebrafish, and characterize the different tumorigenic probabilities when kRASG12V is expressed tra

230 gnificantly expands our understanding of the tumorigenic process of human colorectal cancer.

231 hether it is a cause or a consequence of the tumorigenic process.

232 n humans, implying their crucial role in the tumorigenic process.

233 ll selectively proliferate to facilitate the tumorigenic process.

234 of etiology, and remained modified along the tumorigenic process.

235 -Src as a key mediator of thyroid cancer pro-tumorigenic processes and a promising therapeutic target

236 mation to a functional target fundamental to tumorigenic processes but expressed at significantly low

237 TERT) genes contribute to distinct aging and tumorigenic processes in humans and mice.

238 s have been implicated in multiple stages of tumorigenic processes.

239 oth endogenous and exogenous antioxidants in tumorigenic processes.

240 ties might not be sufficient per se to block tumorigenic processes.

241 p strands function together to regulate core tumorigenic processes/pathways and reveal a previously u

242 er stem cells (CSCs) differentiates into non-tumorigenic progeny, providing a rationale for therapeut

243 g enzyme, Usp9x, and has major impact on the tumorigenic program of metastatic melanoma.

244 These express a strong regenerative/tumorigenic program, driven by the Hippo pathway effecto

245 molecular profile that facilitates the full tumorigenic program; furthermore, our outcomes uncover n

246 ng tumorigenesis in mice and upregulates pro-tumorigenic programs, including glycolysis.

247 human pancreatic cancer cells reduced their tumorigenic propensity, as indicated by a significant de

248 here PDHK4 regulates KRAS signalling and its tumorigenic properties and suggest that inhibition of PD

249 These increased tumorigenic properties could represent the other side of

250 o identify compounds that increased the anti-tumorigenic properties of CX-4945.

251 Deletion of either Egfr or Axl decreased the tumorigenic properties of HBEGF-transformed cells; howev

252 t of MUC5AC in bolstering the CSC-associated tumorigenic properties of Kras-induced metaplastic cells

253 SENP7S depletion directly potentiates tumorigenic properties of MCF10-2A cells with induction

254 re essential effectors of Ras signaling, the tumorigenic properties of specific Ras-Raf complexes are

255 e intrinsic self-renewal characteristics and tumorigenic properties of these cells provide them with

256 miR-29b/RARbeta/ING4 pathway that regulates tumorigenic properties of Tsc2-deficient cells, and that

257 MIF-2 shares pro-inflammatory and tumorigenic properties with the clinical target MIF (MIF

258 Remarkably, RNF4 tumorigenic properties, including therapy resistance, re

259 s EAhy926 cells exhibit both endothelial and tumorigenic properties, the anti-angiogenic effect of PS

260 lt in enhanced nuclear EGFR localization and tumorigenic properties.

261 had significantly less proliferation and no tumorigenic properties.

262 c have additional anti-inflammatory and anti-tumorigenic properties.

263 ecule with potent anti-inflammatory and anti-tumorigenic properties; yet the molecular targets of HNK

264 features of migratory cancer stem cells with tumorigenic property is important to predict patient pro

265 Cancer cells require both migratory and tumorigenic property to establish metastatic tumors outs

266 nine kinases downstream of multiple critical tumorigenic receptor tyrosine kinase receptors and oncog

267 guards against illegitimate and potentially tumorigenic recombination.

268 ontext of MTG16 loss reversed injury and pro-tumorigenic responses in the intestinal epithelium follo

269 regulatory B (B(reg)) cells that exert a pro-tumorigenic role by promoting tumor cell proliferation.

270 y oncogenic Ras, suggesting an important pro-tumorigenic role for CIB1.

271 tatic breast cancers, our data support a pro-tumorigenic role of C/EBPdelta when expressed in subsets

272 nature of necrosis in GBMs and reveals a pro-tumorigenic role of ferroptosis.

273 Together, our data suggests an anti-tumorigenic role of these miRNAs in CRC and warrant futu

274 ndocrine tumour cells, consistent with a pro-tumorigenic role.

275 Overall, we have identified two novel pro-tumorigenic roles (promoting cell survival and altering

276 The pro-tumorigenic roles of IL-1 were counteracted by its effec

277 mediated oncogenic mechanisms and tested the tumorigenic roles of TBC1D15 in vivo.

278 ally, GLI2 upregulates expression of the pro-tumorigenic secreted protein, Osteopontin (OPN), which i

279 el insight into the regulation of p53beta in tumorigenic settings.

280 derived a tumorigenic index (TI) to quantify tumorigenic signal strengths.

281 of STAT3/NFkappaB-mediated inflammatory and tumorigenic signaling pathways can explain the absence o

282 many of the observed anti-inflammatory/anti-tumorigenic signaling pathways.

283 Treating non-tumorigenic, skin epithelial JB6 P(+) cells with FGF2 st

284 sult of activation of macrophages to an anti-tumorigenic state is considered as a hallmark of M1 and

285 llular state to a self-renewing and strongly tumorigenic state, expressing NANOG and OCT4.

286 on via multiple mechanisms drives cells to a tumorigenic state.

287 cancer progression and robustly predict the tumorigenic state.

288 vities of decorin as the molecular basis for tumorigenic suppression.

289 e immune synapse, to kill virus-infected and tumorigenic target cells.

290 part, by loss of PRC2-mediated repression of tumorigenic target genes and by acquisition of stem cell

291 ication to activate transcription of the pro-tumorigenic TNF-NF-kappaB gene network.

292 Furthermore, FOSL1 re-enforced pro-tumorigenic transcription factors MYC, E2F3 and AP-1.

293 del of ischemic injury and were resistant to tumorigenic transformation both in vitro and in vivo.

294 enting DNA damage and decreasing the risk of tumorigenic transformation caused by GERD.

295 ons for chronic wound healing pathologies or tumorigenic transformation.

296 Epstein-Barr virus (EBV) is a tumorigenic virus that can cause various human malignanc

297 ating human cancers associated with this new tumorigenic virus.

298 so represent a viable strategy against other tumorigenic viruses and may have potential benefits in d

299 aintained normal function, but became highly tumorigenic when challenged with tumor-promoting stimuli

300 ncerous tissues is immunosuppressive and pro-tumorigenic, whereas the microenvironment of tissues aff