ライフサイエンスコーパス: tumorigenic potential

1 terized by self-renewal, differentiation and tumorigenic potential.

2 ells that are characterized by uniquely high tumorigenic potential.

3 t cancer cell senescence, thereby increasing tumorigenic potential.

4 ion of p53-dependent senescence and enhanced tumorigenic potential.

5 ormation as well as increased clonogenic and tumorigenic potential.

6 NA knockdown of FoxO3a led to an increase in tumorigenic potential.

7 nes in GC B cells and counterbalance its own tumorigenic potential.

8 ve increased in vitro clonogenic and in vivo tumorigenic potential.

9 nitor cell differentiation, self-renewal and tumorigenic potential.

10 Card9 in VHL(-/-) cancer cells reduced their tumorigenic potential.

11 he kaposin A sequence has been shown to have tumorigenic potential.

12 of the HMGA2 transcript is required for its tumorigenic potential.

13 45 cells does not significantly affect their tumorigenic potential.

14 whereby altered expression of Bcl-3 leads to tumorigenic potential.

15 MCF-7 human breast cancer cells of differing tumorigenic potential.

16 y pro-HB-EGF did not exhibit any significant tumorigenic potential.

17 human and mouse cells in transformation and tumorigenic potential.

18 rupting PTPRZ1 abrogated GSC maintenance and tumorigenic potential.

19 wild-type hosts, reaffirming their inherent tumorigenic potential.

20 ve, and aneuploid, and had various levels of tumorigenic potential.

21 genomic instability, immune reactivity, and tumorigenic potential.

22 as a critical step in the control of CAF pro-tumorigenic potential.

23 c T lymphocytes (CTL), contributing to their tumorigenic potential.

24 ntation into nude mice diminished the cells' tumorigenic potential.

25 microcolonies in soft agar without acquiring tumorigenic potential.

26 rm tumours despite retaining their intrinsic tumorigenic potential.

27 pesvirus 8, is a newly identified virus with tumorigenic potential.

28 expressed in NIH 3T3 cells, enhancing their tumorigenic potential.

29 ogenes or creation of chimeric proteins with tumorigenic potential.

30 nt growth abilities and demonstrated similar tumorigenic potential.

31 grammed cell death, which could affect their tumorigenic potential.

32 l of metastasis is molecularly distinct from tumorigenic potential.

33 ccumulation and enhances their stem cell and tumorigenic potential.

34 eduction in stem cell properties and in vivo tumorigenic potential.

35 ike cells, thus significantly reducing their tumorigenic potential.

36 dent growth of bladder organoids, indicating tumorigenic potential.

37 led that it is required for collagen-induced tumorigenic potential.

38 genes such as KRAS and MYC, highlighting its tumorigenic potential.

39 ressed cell proliferation, cell survival and tumorigenic potential.

40 as a critical step in the control of CAF pro-tumorigenic potential.

41 e regions of patient tumors retain selective tumorigenic potential.

42 is often used as a surrogate to evaluate the tumorigenic potential.

43 ogression, and lack of miR-21(a) reduces the tumorigenic potential.

44 on cancer-initiating cells (CCIC), have high tumorigenic potential.

45 eneoplastic cells evolve to reach their full tumorigenic potential.

46 fferentiation properties along with a higher tumorigenic potential.

47 hich facilitate oncogenic transformation and tumorigenic potential.

48 tablished and primary breast cancer cells on tumorigenic potential.

49 as abrogated exhibiting enhancement of their tumorigenic potential.

50 he sub-pool of cancer cells that retain high tumorigenic potential.

51 d osteoblastic differentiation and repressed tumorigenic potential.

52 tiated stem cell-like cancer cells with high tumorigenic potential.

53 , resulting in increased cancer stemness and tumorigenic potential.

54 e cells reduced invasion, although not their tumorigenic potential.

55 resulting in cellular senescence and reduced tumorigenic potential.

56 91Y) were assessed for cancer metabolism and tumorigenic potential.

57 -renew, resulting in the abrogation of their tumorigenic potential.

58 ing CSC self-renewal, invasive capacity, and tumorigenic potential.

59 terruption of the MIF pathway also decreased tumorigenic potential.

60 and targeting Glut3 inhibits BTIC growth and tumorigenic potential.

61 cell stemness and increasing metastatic and tumorigenic potential.

62 levels, as well as to an attenuation of the tumorigenic potential.

63 bor chromosomal aberrations, affecting their tumorigenic potential.

64 transplantation, drastically reducing their tumorigenic potential.

65 ation of eIF4E at Ser209 is critical for its tumorigenic potential.

66 f DLK1 inhibits differentiation and enhances tumorigenic potentials.

67 radigm in oncology establishes a spectrum of tumorigenic potential across the heterogeneous phenotype

68 a4 were negatively selected and did not show tumorigenic potential after transplantation in adult fem

69 and METT-1) with differing developmental and tumorigenic potentials all were able to direct early emb

70 nti-tumorigenicity without promoting its pro-tumorigenic potential, an RARgamma agonist (IRX4647) was

71 feron signalling, leading to compromised GSC tumorigenic potential and elevated CD8(+) T cell infiltr

72 -metastatic genes, thereby controlling their tumorigenic potential and metastasis.

73 Decreased GABRP reduces in vitro tumorigenic potential and migration concurrent with alte

74 opulation of slow-cycling cells endowed with tumorigenic potential and multidrug resistance has been

75 ells resulted in inhibition of neuroblastoma tumorigenic potential and prevented the TGFbeta1-depende

76 erimental protocol also results in a loss of tumorigenic potential and profound changes in gene expre

77 tone demethylases plays an important role in tumorigenic potential and survival of human colorectal C

78 anoma cells growth arrest irreversibly, lose tumorigenic potential and terminally differentiate after

79 ers could lead to significant alterations in tumorigenic potential and/or progression.

80 le-targeting drugs, as well as the invasion, tumorigenic potential, and angiogenic potential.

81 al dynamics with respect to genetic changes, tumorigenic potential, and response to drug treatment.

82 e dependent on PP2A disruption for sustained tumorigenic potential, and restoration of wild-type Aalp

83 NS4B has in vitro and in vivo tumorigenic potential, and the NS4B transforming activit

84 tion in cancer biology is whether cells with tumorigenic potential are common or rare within human ca

85 e highly proliferative and they retain their tumorigenic potential, as judged by their ability to for

86 expression changes reflective of attenuated tumorigenic potential, as marked by a nearly 10-fold ind

87 creased osteoblast maturation, and increased tumorigenic potential, as mice specifically deleted for

88 -transformed cells contributes to their high tumorigenic potential by enabling them to escape immune

89 of residual undifferentiated PSC, negligible tumorigenic potential by ISC-hpNSC and provide additiona

90 riple-negative breast cancer cells and their tumorigenic potential by secreting amphiregulin.

91 self-renewable and multipotent iNSCs without tumorigenic potential can be generated directly from fib

92 growth control mechanisms and an absence of tumorigenic potential can be readily screened and ensure

93 or there are multiple "stem-like" cells with tumorigenic potential casting some doubt on the hypothes

94 trend was observed for oxidative endurance, tumorigenic potential, cellular proliferation, and tumor

95 eatic cancer cells) had a 100-fold increased tumorigenic potential compared with nontumorigenic cance

96 gic flux, invasion, migration potential, and tumorigenic potential compared with PC-9/OSI cells in vi

97 or cells display increased proliferation and tumorigenic potential compared with progenitor cells fro

98 Akata cells restores tumorigenicity and that tumorigenic potential correlates with an increased resis

99 CSCs reduced their self-renewal and in vivo tumorigenic potential, defining DNMT1 as a candidate CSC

100 n kinase and then Lyn kinase, exhibit ranked tumorigenic potential during both paracrine-induced and

101 rative phase during which cells with limited tumorigenic potential expand is followed by a crisis per

102 neural crest stem cells, based on their high tumorigenic potential, expression of stem cell markers,

103 er cells can exhibit striking differences in tumorigenic potential following experimental transplanta

104 with our previous study showing an elevated tumorigenic potential for C-terminally truncated mutants

105 The tumorigenic potential has been linked to repair efficien

106 PCGEM1's tumorigenic potential has been recently shown to be in p

107 that the MPeM tumors contain stem cells with tumorigenic potential has important implications for und

108 hese data demonstrate that ACF with distinct tumorigenic potential have distinguishing molecular feat

109 F or wild-type HB-EGF significantly enhanced tumorigenic potential in athymic nude mice and exerted a

110 ith reduced anchorage-independent growth and tumorigenic potential in athymic nude mice.

111 ion in both anchorage-independent growth and tumorigenic potential in athymic nude mice.

112 ed on mammary tumor cells that show enhanced tumorigenic potential in both orthotopic transplantation

113 of stem-like cancer cells and reduces their tumorigenic potential in both subcutaneous and orthotopi

114 owever, phosphorylated N3ICD still maintains tumorigenic potential in breast cancer cells under estro

115 These cultures had low tumorigenic potential in classical in vitro assays yet s

116 ght to determine whether CDX2 contributes to tumorigenic potential in established gastric cancer.

117 f HIP1 leads to such phenotypes, we analyzed tumorigenic potential in mice homozygous for a Hip1 muta

118 experimental framework to determine in vivo tumorigenic potential in mice, we found that NetSig cand

119 c-Met(high) cells had increased tumorigenic potential in mice; those that expressed c-Me

120 nescence in tumor cells and diminished their tumorigenic potential in mouse xenograft models.

121 atic organoid cultures in vitro and enhanced tumorigenic potential in Myc-activated organoids when tr

122 ling properties, as well as reduction of the tumorigenic potential in nude mice.

123 unction to these cells greatly reduced their tumorigenic potential in nude mice.

124 nchorage-independent growth on soft agar and tumorigenic potential in nude mice.

125 tingly, ICAM-2 suppressed metastatic but not tumorigenic potential in preclinical models, supporting

126 provides a genetic platform for identifying tumorigenic potential in putative oncogenes and tumor su

127 omic instability preceded the acquisition of tumorigenic potential in rat liver epithelial cells subj

128 TPCs resist DNA damage and exhibit increased tumorigenic potential in response to chemotherapy, where

129 To examine tumorigenic potential in the eye and brain, we injected

130 Thus, CDX2 has tumorigenic potential in the human colon cancer cell lin

131 The results revealed a hierarchy in tumorigenic potential in the order of CD44(+)alpha2beta1

132 ls were highly tumorigenic in nude mice, the tumorigenic potential in vivo of shL5 cells was found to

133 ls showed a markedly higher repopulation and tumorigenic potential in vivo, which correlated with an

134 al components of mir-17-92 by assaying their tumorigenic potential in vivo.

135 totic cell death in vitro, and hindered ALCL tumorigenic potential in vivo.

136 roperty of TICs in vitro and decreased their tumorigenic potential in vivo.

137 tumor cells reduces to the same degree their tumorigenic potential in vivo.

138 dothelial cells in vitro and inhibited their tumorigenic potential in vivo.

139 suppression of colony formation and reduced tumorigenic potential in vivo.

140 cells and a concurrent suppression of their tumorigenic potential in vivo.

141 ced granulocytic differentiation and reduced tumorigenic potential in vivo.

142 ll-like properties in vitro as well as their tumorigenic potential in vivo.

143 nd migration in vitro and a dramatic loss of tumorigenic potential in vivo.

144 lar adaptation to hypoxia in vitro or confer tumorigenic potential in xenograft assays.

145 ity to HCC cells and increases their in vivo tumorigenic potential in xenografts in mice.

146 s: an EBER-dependent mechanism that enhances tumorigenic potential independent of a direct effect on

147 owed with unique self-renewal properties and tumorigenic potential is present in some, and perhaps al

148 miR-200b decreased the tumorigenic potential of a cancer cell line resistant to

149 RNA (hTR) antagonist, GRN163L, inhibited the tumorigenic potential of A549-luciferase (A549-luc) lung

150 levels of class I antigens contribute to the tumorigenic potential of Ad12 transformed cells by favor

151 limits de novo protein biosynthesis and the tumorigenic potential of advanced colorectal cancer cell

152 ementation rescues stemness and promotes the tumorigenic potential of aged alveolar cells.

153 capability for self-renewal and the highest tumorigenic potential of all cell populations studied.

154 the mechanism by which beta(1C) inhibits the tumorigenic potential of beta(1A), we analyzed changes i

155 Knockdown of SET or CIP2A reduces the tumorigenic potential of breast cancer cell lines both i

156 , a novel SET antagonist, also decreases the tumorigenic potential of breast cancer cells and induces

157 Here, we report that the tumorigenic potential of breast cancer cells is determin

158 ow a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells and ther

159 direct evidence that EBV contributes to the tumorigenic potential of Burkitt lymphoma and suggest a

160 Notably, we found the tumorigenic potential of BVE(Cyp24a1-null)-derived tumor

161 tissue against oxidative stress and suppress tumorigenic potential of c-myc oncogene.

162 an inflammatory signaling that increases the tumorigenic potential of cancer cells promoting their im

163 gain of function and consequently reduce the tumorigenic potential of cancer cells.

164 egulated in TNBC and involved in driving the tumorigenic potential of cancer cells.

165 ion of the aforementioned genes and with the tumorigenic potential of cell lines.

166 ced expression of this gene led to increased tumorigenic potential of cells implanted into nude mice

167 components Raptor and Rictor, abolished the tumorigenic potential of cells overexpressing SF2/ASF.

168 portantly, loss of DBC1 inhibited growth and tumorigenic potential of colon cancer cells, and DBC1 ex

169 docrine gastrins have been implicated in the tumorigenic potential of colon cancer cells.

170 ase signaling system in AR expression and in tumorigenic potential of colon cancer cells.

171 ely inhibits the proliferation, survival and tumorigenic potential of colorectal cancer cells with he

172 de slow and inefficient differentiation, and tumorigenic potential of contaminating undifferentiated

173 ocked activation of NF-kappaB caused loss of tumorigenic potential of CSMLO cells.

174 d an immunodeficient mouse model to test the tumorigenic potential of different populations of cancer

175 The tumorigenic potential of E4-ORF1, as well as its ability

176 V-positive cells, significantly enhanced the tumorigenic potential of EBV-negative BL cells in SCID m

177 electively inhibits growth, survival and the tumorigenic potential of ENO1-deleted GBM cells, and tha

178 pecially significant given the known greater tumorigenic potential of fjord region compared to bay re

179 These findings unravel a general and rapid tumorigenic potential of genomic instability, as opposed

180 We conclude that the increased tumorigenic potential of glioblastoma cells expressing t

181 ANXA7 haploinsufficiency doubles tumorigenic potential of glioblastoma cells, and combine

182 identified significantly contributes to the tumorigenic potential of glioblastoma stem cells.

183 mors, where it supports the self-renewal and tumorigenic potential of GSCs.

184 In vivo tumorigenic potential of heat-treated versus untreated H

185 ER-2/neu promoter activity, and suppress the tumorigenic potential of HER-2/neu-overexpressing ovaria

186 asiveness, anchorage-independent growth, and tumorigenic potential of highly invasive breast cancer c

187 e, we used xenotransplantation to assess the tumorigenic potential of human breast cancer cells follo

188 The gold standard for determining the tumorigenic potential of human cancer cells is a xenotra

189 odels may not properly reflect the long-term tumorigenic potential of human cells.

190 However, the tumorigenic potential of human pancreatic acinar cells r

191 The tumorigenic potential of IGF-IR is mediated through its

192 attenuates the proliferation, migration, and tumorigenic potential of Ink4a/Arf(-/-) Pten(-/-) Egfr(v

193 cell death caused by PGE2 would enhance the tumorigenic potential of intestinal epithelial cells.

194 ceptibility involving a global change in the tumorigenic potential of keratinized epithelium in Atp2a

195 To determine how the tumorigenic potential of lineally related stem cells cha

196 xpression of repressed miRNAs diminishes the tumorigenic potential of lymphoma cells.

197 If amplified, the mdm2 gene can enhance the tumorigenic potential of murine cells.

198 To investigate the tumorigenic potential of mutant p53 when selectively exp

199 that silencing or loss of CDK4 augmented the tumorigenic potential of Myc-driven mouse and human B ce

200 Importantly, DPPIV suppressed the tumorigenic potential of NB cells in a xenotransplantati

201 antation-site microenvironment influence the tumorigenic potential of neoplastically transformed live

202 n, countering REST/NRSF function blocked the tumorigenic potential of NSC-M-R cells.

203 confirm and extend previous findings on the tumorigenic potential of ORF74.

204 rotein kinase B (AKT) signaling, and reduced tumorigenic potential of ovarian cancer cells in a nude

205 Myc also serves to maintain robust tumorigenic potential of p53(-/-) Pten(-/-) TNSs.

206 h kinases is required to maximally block the tumorigenic potential of pancreatic cancer cells.

207 Deletion of the Pak1 gene reduced the tumorigenic potential of PDAC cells.

208 nisms that provide evidence for the emerging tumorigenic potential of PLD, the role of the microenvir

209 3/EHF inhibited the stem-like properties and tumorigenic potential of prostate cancer cells.

210 ithin EC nuclei define the developmental and tumorigenic potential of resulting NT ES cells.

211 The tumorigenic potential of s-HB-EGF has been studied exten

212 ic acids (LNAs) blunts the proliferation and tumorigenic potential of SCC cells and promotes differen

213 gr1 expression is to decrease the growth and tumorigenic potential of several tumor cell types.

214 The tumorigenic potential of spontaneously transformed cells

215 Loss of myristoylation abolished the tumorigenic potential of Src and its synergy with androg

216 We propose that the tumorigenic potential of SV40 Tag in some human mesothel

217 these findings uncover the regenerative and tumorigenic potential of tanycytes.

218 The proliferative and tumorigenic potential of the AS clones from the gastrin-

219 The tumorigenic potential of the Burkitt lymphoma (BL) cell

220 -2) expression and consequently suppress the tumorigenic potential of the HER2/neu-overexpressing ova

221 CD45 suppresses the tumorigenic potential of the kinase by dephosphorylation

222 which the resulting cell death increases the tumorigenic potential of the neighboring cells.

223 , the role of TGF-beta RII in regulating the tumorigenic potential of the SNU-638 human gastric cance

224 This combination affected the tumorigenic potential of these cancer cells to a signifi

225 However, the tumorigenic potential of these cells remains a great con

226 FLCN) knockdown was required to increase the tumorigenic potential of these cells, as evidenced by th

227 resulted in tumor development verifying the tumorigenic potential of these cells.

228 n D1, concomitantly with the loss or reduced tumorigenic potential of these cells.

229 cells without toxic effects and limited the tumorigenic potential of these cells.

230 ignalling is instrumental in suppressing the tumorigenic potential of these foetal-like progenitor ce

231 treatment with 4-hydroxytamoxifen decreased tumorigenic potential of these MCF10A cells.

232 a cell cycle arrest, effectively abating the tumorigenic potential of these stimuli.

233 We have investigated the in vitro tumorigenic potential of these viruses using cultured no

234 RLTS1 reexpression significantly reduced the tumorigenic potential of TOV-112 in nude mice.

235 cell carcinoma formation, demonstrating the tumorigenic potential of transduced cells.

236 The tumorigenic potential of USP6 was attenuated significant

237 utation clusters examined contributed to the tumorigenic potential of v-Rel with the relative strengt

238 ver, KDM3A knockdown also potently inhibited tumorigenic potentials of breast cancer stem-like cells

239 de in understanding the self-renewal and pro-tumorigenic potentials of CSCs, a key challenge remains

240 he cellular factor DLG may contribute to the tumorigenic potentials of several different human virus

241 esults, we propose that the transforming and tumorigenic potentials of the adenovirus E4-ORF1 oncopro

242 proteins and, in addition, suggest that the tumorigenic potentials of these viral oncoproteins depen

243 Comparing the tumorigenic potentials of these viruses has allowed us t

244 cient to confer malignant transformation and tumorigenic potential on nontransformed (MCF-10A) mammar

245 ived HSCs express normal HBB in mice without tumorigenic potential, suggesting a safe strategy for pe

246 segregated with decreased transformation and tumorigenic potential, suggesting that an unrecognized t

247 l lineage relationship and display different tumorigenic potential, suggesting that effective therape

248 ffected their metabolism and abolished their tumorigenic potential, suggesting that the effects of MA

249 A cells depleted for AQP1 displayed a higher tumorigenic potential than control cells.

250 Wnt activity exhibited higher clonogenic and tumorigenic potential than pCCSCs with the lowest Wnt ac

251 with the FLI1 C-terminus confering a greater tumorigenic potential than the corresponding ETV1 domain

252 compound mezerein (MEZ) results in a loss of tumorigenic potential that correlates with an irreversib

253 cells within a variety of tumor types with a tumorigenic potential that is lacking in the rest of the

254 CtBP is a transcriptional corepressor with tumorigenic potential that targets the promoter of the t

255 enewing NSCLC stem-like cells with increased tumorigenic potential, that NSCLCs harboring tumor cells

256 ently isolated MSC populations exhibited low tumorigenic potential under syngeneic conditions, which

257 EBERs have been shown to impart significant tumorigenic potential upon EBV-negative Burkitt lymphoma

258 logous region on mouse chromosome 11 for its tumorigenic potential using segmental haploidy in combin

259 Tumorigenic potential was evaluated in vitro or in xenog

260 Also, enhanced tumorigenic potential was observed when P152Lp53-express

261 anced angiogenesis, but the most significant tumorigenic potential was realized by coexpression of bo

262 ssing some forms of mutant p53 show enhanced tumorigenic potential with increased resistance to chemo

263 C-high, CD44-negative cells exhibited higher tumorigenic potential within the lung microenvironment.

264 tration of adult liver stem cells possessing tumorigenic potential without the use of a carcinogen or