ライフサイエンスコーパス: turnover

1 exp(H)], and community change (plant species turnover).

2 osteoblast-mediated bone formation and bone-turnover.

3 ssure, markers of inflammation, or cartilage turnover.

4 oth taxonomic and phylogenetic diversity and turnover.

5 rotonolysis reactions required for catalytic turnover.

6 chondrial fusion and decreased mitochondrial turnover.

7 ndrial populations are maintained by regular turnover.

8 nase) as required for LIN-45 degron-mediated turnover.

9 featured exceptionally high rates of Pol II turnover.

10 h regulate channel conductance, assembly and turnover.

11 ate, thereby promoting their own proteasomal turnover.

12 eloped to automate the estimation of protein turnover.

13 e continuously undergoing rapid assembly and turnover.

14 king key cell cycle proteins for proteasomal turnover.

15 neuron-specific alteration in autophagosome turnover.

16 racellular loop 1 that helps determine Orai1 turnover.

17 homologous enzymes are shown to exhibit MHET turnover.

18 ols appears to determine changes in c-di-GMP turnover.

19 ated lipid exchange is also important for FA turnover.

20 solution, migration and extracellular matrix turnover.

21 nd RNA modifications, thereby regulating RNA turnover.

22 emory differentiation, suggesting heightened turnover.

23 cross both species through CTCF binding site turnover.

24 in E3 ligase homologue, leading to its rapid turnover.

25 g needed to be improved to accommodate staff turnover.

26 rich amine substrates that enable catalytic turnover.

27 AX2) but is also subject to MAX2-independent turnover.

28 undergoes minimal structural changes during turnover.

29 which contains stem cells supporting tissue turnover.

30 aracterize the dynamics of their homeostatic turnover.

31 aying effect of many phosphosites on protein turnover.

32 roenvironment, imposed by the stages of bone turnover.

33 resulting in translation inhibition and RNA turnover.

34 d retrograde transport to control autophagic turnover.

35 cts, particularly on measures of soil carbon turnover.

36 to industrial processes and suffer from low turnovers.

37 change were found to be the major drivers of turnover acceleration.

38 large compositional differences and seasonal turnover across ecotones.

39 Brachiopods experienced a wholesale turnover across the early warming phase and were replace

40 tabilize RNA-Ag-complexes that upon cellular turnover activate dendritic cells, which amplify psorias

41 Rab27b KD also decreased LC3 turnover after treatment with an autophagosome-lysosome

42 ated with antigen processing (TAP) by single-turnover analyses at single-liposome resolution.

43 ed for CAP1 functions in both actin filament turnover and adhesion, and the novel mechanistic insight

44 rtition changes into those due to individual turnover and association rewiring.

45 ct BET protein domains that regulate protein turnover and biological activities.

46 cesses, such as focal adhesion formation and turnover and cell division.

47 ith sunitinib inhibition reduces microvessel turnover and decreases heterogeneity of the tumor microe

48 lation is recognized for its influence on Ig turnover and effector functions.

49 ynereis CRZ1/GnRHL1 coordinates glycoprotein turnover and energy homeostasis with growth and sexual m

50 ions predispose to elevated subchondral bone turnover and hypertrophy in calcified cartilage, yet add

51 on on Rab7-S72 phosphorylation limited STING turnover and increased downstream production of IRF3 tar

52 nd that PSR accelerated microbial growth and turnover and increased microbial biomass and necromass.

53 clining seroprevalence due to bat-population turnover and individual loss of humoral immunity.

54 hannels that are important for autophagosome turnover and lysosomal pH regulation and are associated

55 itions promote tumour cell proliferation and turnover and modulate blood vessel networks in xenograft

56 was positively associated with woody biomass turnover and negatively associated with aboveground biom

57 At steady state, neutrophil turnover and replenishment are continually maintained vi

58 in environmental variability affects species turnover and thus the change in BEF slope with scale; (5

59 a preferential role in promoting glyceollin turnover and/or competing biosynthetic pathways.

60 to p120-catenin in epithelial integrity and turnover, and additional phenotypes that suggest mesench

61 1) treatment reduced GA levels, increased GA turnover, and decreased RAN toxicity and co-aggregation

62 ess to rewarding food increases SCN dopamine turnover, and elevated Drd1-signaling decreases SCN neur

63 t kinetochores is high to promote attachment turnover, and in later mitosis, activity decreases to en

64 se (Akt) activation, membrane focal adhesion turnover, and increased epithelial cell migration.

65 ightly coordinated with cell wall growth and turnover, and many of these control activities depend up

66 involves phosphorylation, increased protein turnover, and nucleo-cytoplasmic trafficking.

67 zo-Engine is driven by rhizodeposition, root turnover, and plant uptake of nutrients and water, there

68 net negative feedback among exp(H), species turnover, and soil water potential.

69 l on, protein absorption, whole-body protein turnover, and splanchnic amino acid metabolism.

70 the production of microbial necromass N, its turnover, and stabilization in soil remain poorly unders

71 bacterial and fungal necromass N production, turnover, and stabilization, we incubated (15) N-labeled

72 tion of storage carbohydrates, increased ATP turnover, and the export of osmolytes.

73 responsible for regulating D-serine synaptic turnover, and the glutamine-glutamate cycle.

74 ing sites promote rapid Cdk8-dependent Notch turnover, and thereby reduce Notch-dependent transcripti

75 2 act as receptors for autophagy-mediated ER turnover, and thus are critical for ER homeostasis and s

76 e model with a prescribed live woody biomass turnover, applied at a forest research site where multid

77 The causes of Neanderthal-modern human (MH) turnover are ambiguous.

78 of isozymes implicated in starch and malate turnover are discussed in line with the contrasting role

79 Most studies of homeostatic turnover assume an initial steady-state balance of produ

80 lex FACT (SPT16 and SSRP1) in governing Cas9 turnover at the DNA target site during genome and epigen

81 catalytic site for degradation to facilitate turnover but can also equilibrate between the sites to m

82 harges to the reaction centres and catalytic turnover, but also understanding degradation processes o

83 as been implicated in Abeta42 production and turnover, but whether it plays a direct role in modulati

84 ildren exhibited signs of increased collagen turnover by being taller (14.4 cm) and having more perma

85 e chain crafted to act as a latch to inhibit turnover by fastening down the SULT1A3 active-site cap.

86 n real-time for adenosine triphosphate (ATP) turnover by myosin, the actomyosin system and for insolu

87 e is a pre-requisite for its recognition and turnover by Pgp3.

88 gether, our work indicates that glycerolipid turnover by Sl-LIP8 is an important early step in the sy

89 use islet beta-cells facilitates microtubule turnover, causing increased basal insulin secretion, dep

90 functions in diverse processes, including PG turnover, cell elongation/division, and antibiotic resis

91 Characterization of the turnover chemistry of Pgp3 reveals cell wall D,D-endopep

92 ormational space of these nanomachines under turnover conditions and thereby gain detailed mechanisti

93 ine that the NI decays rapidly under optimal turnover conditions, and the mechanism thereby becomes r

94 ate in the conformational ensemble under ATP turnover conditions.

95 es modified with branched chains under multi-turnover conditions.

96 diseases, suggesting defective mitochondrial turnover contributes to neurodegeneration.

97 tic manipulation-free procedures and a quick turnover cycle, FucoID should have the potential of acce

98 The extent to which AGB increases and carbon turnover decreases will thus depend on the mechanisms of

99 of FA dynamics during microtubule-induced FA turnover demonstrated that Ift20 loss specifically impai

100 sis reveals the reductive elimination as the turnover determining step for the preferred S linear ald

101 Computational studies suggest that the turnover determining step is likely the oxidative additi

102 ASN depleted cells leads to reduced adhesion turnover downstream of paxillin serine phosphorylation,

103 he composition of the population (individual turnover) drive network dynamics.

104 DNA through transcription-coupled histone H3 turnover, driving the replacement of resident H3 nucleos

105 of increased immune activation and cellular turnover due to long-standing HIV infection with delayed

106 e approach to mathematically model basal ECM turnover during embryogenesis by exploiting our ability

107 ble for translation and subject to lysosomal turnover during nutrient stress(3-5).

108 rotospacer-adjacent motifs (PAM); is a multi-turnover enzyme; cleaves ssDNA, dsDNA and RNA targets in

109 Using H(2)O(2) as oxidant, up to ~300 turnovers for the oxidation of benzylic C-H bonds were o

110 data, we propose that, in each cycle of ATP turnover, forward kinesin steps can only occur before Pi

111 oxidation catalyst achieving record maximum turnover frequencies (TOF(max)) on the order of 16 000 s

112 high turnover numbers (TON, up to 6700) and turnover frequencies (TOF).

113 se that oxidize organic substrates with high turnover frequencies (TOFs) up to 560 s(-1) and those th

114 atalysts, PtAl and PtGa chiral crystals show turnover frequencies as high as 5.6 and 17.1 s(-1) and a

115 This catalyst offers turnover frequencies of up to 60 h(-1), affording full c

116 that exhibits significantly better activity (turnover frequency > 12,000 h(-1)) and high selectivity

117 This catalyst exhibits an extremely large turnover frequency (TOF) up to 12500 h(-1) at -0.95 V ve

118 els, with greatly improved mass transfer and turnover frequency as a result of 100 % utilization of t

119 rnover number up to 320 000, and a long-term turnover frequency of 11 412 hour(-1) , which is a 32-fo

120 ficiency of up to 51%, leading to a distinct turnover frequency of 2,176 h(-1) under air mass 1.5 glo

121 33 % vacancies exhibited unprecedented high turnover frequency of 29.5 h(-1) in visible-light-driven

122 most active, a Co(III)/K(I) complex, shows a turnover frequency of 800 h(-1) at low catalyst loading

123 ility of the active site and higher catalyst turnover frequency.

124 that systematic loss exhibited by an abrupt turnover from the Daptocephalus to the Lystrosaurus Asse

125 e mechanisms by which cis-regulatory element turnover generate emergent phenotypes is crucial to our

126 ike 2-4, tissue transglutaminase-2), and ECM turnover genes/enzymes (matrix metalloproteinases-MMP2,1

127 ion in glutamate concentration and glutamate turnover (glutamate-to-glutamine ratio) in the putamen i

128 Guanosine triphosphate (GTP) turnover, guanosine diphosphate release, GTP binding, an

129 This reveals rapid turnover (half-life ~7-10 h), which we confirmed by in v

130 that tau(eco) has been reduced (i.e., carbon turnover has accelerated) by 13.5% from the 1860s (74 ye

131 proteins for membrane abscission and protein turnover.IMPORTANCE We extended the known annotation spa

132 Despite the high turnover in active ensemble membership across learning,

133 h active downcutting associated with greater turnover in canopy traits along hillslopes.

134 oxidation reactions exceeds the rate of ATP turnover in cells, NAD(+) regeneration by mitochondrial

135 individual species, indicating considerable turnover in community composition.

136 lass 2, Class 1 consistently showed a higher turnover in each period.

137 future elucidation of the kinetics of their turnover in humans.

138 Diel rescheduling of guard cell starch turnover in K. fedtschenkoi compared with that observed

139 tein and show a role of microlipophagy in LD turnover in N. oceanica CCMP1779.

140 of latest Permian age and that the purported turnover in the basin preceded the end-Permian marine ev

141 ts for approximately 90% of homeostatic cell turnover in the body(1), and regulates inflammation, cel

142 Notably, it is important to consider cell turnover in the tumor, and we discuss its role in modula

143 alytic production of hydrogen with 170 +/- 5 turnovers in 24 hours and an initial rate of 28 turnover

144 '-diphosphate (pGpp) (collectively (pp)pGpp) turnover, including those shown to produce pGpp and its

145 , we present evidence for the predicted cost-turnover interplay in data from 67 patients with prostat

146 H(2) turnover involves different catalytic intermediates incl

147 How long-lived memories withstand molecular turnover is a fundamental question.

148 RNA turnover is a general process that maintains appropriate

149 entally difficult to determine whether basal turnover is also important.

150 Here, we report that Ndc80 turnover is also tightly regulated in meiosis: Ndc80 deg

151 tion factor binding sites, while methylation turnover is elevated in transcribed gene bodies.

152 re available for comparison, we show that if turnover is fast the accumulation of respiring biomass i

153 NK cell homeostatic turnover is further accelerated without the transcriptio

154 mation capture experiments show that cohesin turnover is important for maintaining promoter-enhancer

155 that the ClpXP protease involved in protein turnover is important for pathogenesis in a murine model

156 sal neuronal activity and found that protein turnover is influenced by subcellular localization, prot

157 Here we report that CHIP-mediated protein turnover is markedly post-translationally enhanced by di

158 emerging evidence suggests that soil carbon turnover is not dominantly controlled by the chemistry o

159 ammett kinetic analysis shows that catalytic turnover is promoted by electron rich amine substrates t

160 epends primarily on photosynthesis; while if turnover is slow the accumulation of respiring biomass i

161 , but whether FAT10 affects PDE6 function or turnover is unknown.

162 n perspective, the global profile of protein turnover is usefully in understanding the protein-basis

163 ctional molecule, including the hook-effect, turnover, isoform specificity, dose and temporal control

164 ircuit potentiometry (OCP) to measure enzyme turnover kinetics, k(turn).

165 ent small RNAs, resulting in their continued turnover likely to free the NAD(+) molecules.

166 favors faster rates of microbial growth and turnover, likely due to greater plant productivity, resu

167 ional analysis shows that Fro-DO accelerates turnover limiting reductive elimination via LUMO lowerin

168 Mechanistic studies suggest a change in the turnover-limiting and selectivity-determining step induc

169 for the reaction using Ir(ppy)(3) supports a turnover-limiting reductive elimination.

170 iate, and loss of SO(2) from this complex is turnover-limiting.

171 g state intermediate, and transmetalation is turnover-limiting.

172 plant and bee communities have high species turnover, making the study of disease dynamics challengi

173 Bone turnover markers (BTMs) demonstrated presence of bone re

174 Plasma bone turnover markers and bone mineral density (BMD) were qua

175 therapy may be beneficial and suggests that turnover may play an unexpectedly important role in the

176 performed bisulfite sequencing-based single-turnover methylation analysis on both complexes.

177 phenomenon and propose that DNA methylation turnover might facilitate key lineage decisions.

178 ne as the enigmatic large-capacity and rapid-turnover N reserve of microalgae.

179 tion is fivefold faster, permitting multiple turnover NP bond formation to yield NP-DNA strands from

180 SHE) for 20 hours with a turnover number (TON) of 266 300, and photolytic HER for

181 electively oxidized to glyceraldehyde with a turnover number (TON) of ~1000 and Faradaic efficiency (

182 o the wildtype (WT) Km value but had a lower turnover number and transfructosylation/hydrolysis ratio

183 conversion to hydrogen gas of ~4.0% (with a turnover number of >7,000 over 5 h, a frequency of >1,40

184 e active in vitro, with the fastest having a turnover number of 22 +/- 1 s(-1) -sixfold faster than t

185 from Pseudomonas aeruginosa has the highest turnover number of all characterized IGPS enzymes, provi

186 faradaic efficiency of 96 %, an exceptional turnover number up to 320 000, and a long-term turnover

187 Enzyme turnover numbers (k (cat)s) are essential for a quantita

188 degrees C, 1 bar N(2)O), together with high turnover numbers (TON, up to 6700) and turnover frequenc

189 240 h with a Faradaic efficiency of 90% and turnover numbers exceeding 100,000.

190 the bottleneck for determining the specific turnover numbers of individual whole-cell biocatalysts.

191 d 3-alkylindoles and bisindolylmethanes with turnover numbers of up to 500 and 460, respectively, ill

192 hloroperbenzoic acid (mCPBA) occur with high turnover numbers under mild conditions, but the mechanis

193 Biocatalyst turnover numbers were analyzed using rationally designed

194 oduction of PPC polyols, outstanding yields (turnover numbers), quantitative carbon dioxide uptake (>

195 lles that participate in the degradation and turnover of a large subset of the proteome.

196 The turnover of abscisic acid (ABA) signaling core component

197 ort of this organelle has been implicated in turnover of aged organelles through lysosomal degradatio

198 n filaments and is required to slow down the turnover of apical actin.

199 Gradient Forest analysis showed that allele turnover of candidate SNPs was significantly associated

200 gy is a cellular homeostatic program for the turnover of cellular organelles and proteins, in which d

201 sduction cascade; an increase in the rate of turnover of cGMP in darkness; and an increase in the rat

202 These emissions are driven by turnover of contemporary terrestrial carbon and addition

203 But what is the purpose of this intriguing turnover of DNA methylation?

204 sx as a mimicry locus, and that evolutionary turnover of dsx alleles may underlie the wing pattern di

205 chlamydial elementary bodies and diminished turnover of EGFR.

206 asing inputs of root-derived C, and reducing turnover of existing mineral-associated C due to suppres

207 s were controlled by higher cofilin-mediated turnover of F-actin in the front.

208 tible response of molluscs versus the marked turnover of foraminifera and reef faunas.

209 B cell clones at steady state, despite rapid turnover of germinal-centre B cells.

210 Complementation with NCgl2764 normalized turnover of hTMCM to h2TDCM.

211 lum of MCD cell line models and promotes the turnover of immature glycoforms of BCR subunits, reducin

212 We devised a proteomics assay to measure the turnover of individual proteins in mouse kidney.

213 It is also involved in the normal turnover of intestinal epithelium.

214 In vitro expression and turnover of large T (LT) proteins from BK, JC, Merkel ce

215 y conserved with loss of CL triggering rapid turnover of MCU homologs and impaired calcium transport.

216 r N-rich compounds corresponded with greater turnover of microcystins in cells grown on urea compared

217 nucleotide polymorphisms (SNPs) and constant turnover of minor population variants, each rising and f

218 Due to rapid turnover of most epithelial cell types, the cytoplasmic

219 and dendritic spine formation, and increases turnover of neurotransmitters, such as dopamine.

220 lays a pivotal role in maintaining effective turnover of proteins and damaged organelles in cells.

221 We apply our system to analyze the turnover of rRNA during ribophagy induced by oxidative s

222 ata identify hemolysis as a key event in the turnover of senescent erythrocytes, which alters our cur

223 eflects larger-scale spatial patterns in the turnover of species' ranges.

224 ernative for HydG, both supporting enzymatic turnover of substrate tyrosine and forming the organomet

225 folded state that are required for catalytic turnover of substrate.

226 throughout infection, nutrient exchange, and turnover of symbiosis.

227 compare these mechanisms to those regulating turnover of the endoplasmic reticulum and the clearance

228 our understanding about the maintenance and turnover of the GBM improves, therapies to replace GBM c

229 The turnover of the glycocalyx is dynamic to fine-tune these

230 This implies that evolutionary turnover of the mammalian stem lineage during the Early-

231 formation in both embryonic development and turnover of the olfactory epithelium in adult mice, and

232 the G-protein cascade; (2) a faster rate of turnover of the second messenger cGMP in darkness; and (

233 fect on the outcome of TBI, but inducing the turnover of these cells through either pharmacologic or

234 In proteomics, the protein turnover of thousands of proteins can be estimated from

235 directed at the FcRn can rapidly enhance the turnover of total IgG, including pathogenic IgG.

236 The secretion of Wnt ligands, the turnover of Wnt receptors, and the signaling transductio

237 m less saturated communities, higher species turnover or greater environmental change, may ultimately

238 s, which may be protective against uncoupled turnover or provide an ET pathway to the active site wit

239 lthough both enzymes contribute to substrate turnover, our results suggest a prominent role for Hrd1

240 hifted, and how the transition zone impacted turnover patterns.

241 novers in 24 hours and an initial rate of 28 turnovers per hour.

242 gulator of crucial processes such as protein turnover, protein-protein interaction, and protein targe

243 t modulate gene expression, second-messenger turnover, quorum sensing, biofilm formation, motility, h

244 nyl azides with over 10 000-14 000 catalytic turnovers, ranking among the most efficient nitrene tran

245 ion is affected in two ways: by limiting the turnover rate and by a large overpotential requirement t

246 (2+) transport by improving both the SERCA2a turnover rate and catalytic efficacy.

247 bility and found that the protein has a high turnover rate and is degraded by the proteasome 26S in a

248 nergy reserve) and the digestive gland (fast turnover rate organ, reflecting recent consumption).

249 he ovary to those of the mantle muscle (slow turnover rate tissue, representing an energy reserve) an

250 iggers an increase in the specific activity (turnover rate) of the membrane-bound kinase molecule.

251 A submodule attenuates supercomplex I+III(2) turnover rate, indicating an unexpected molecular adapta

252 Depending on the myosin turnover rate, junctions either preserve stable length o

253 fatty acid hydroxylation at a >3,000 min(-1) turnover rate.

254 ed from cell growth and showed high specific turnover rates (~1 fmol/(cell h)), high conversion yield

255 Previously, we analyzed protein turnover rates in cultured brain cells under basal neuro

256 main largely undefined, as do differences in turnover rates of individual proteins in the collagen an

257 pectrometry and bioinformatics, we calculate turnover rates of individual proteins within rat Achille

258 n hydrophilic Sn-Beta, giving rise to higher turnover rates on hydrophobic Sn-Beta.

259 The channel/PDE5 tandem encodes cGMP turnover rates rather than concentrations.

260 The plot was characterized by high AMF turnover rates with a positive spatiotemporal relationsh

261 ndon, with ~1000 fold differences in protein turnover rates, and overall faster protein turnover with

262 Serotonin turnover (ratio 5-HIAA/5-HT) was reduced in exposed fema

263 was altered, with significant compositional turnover, reduced richness, and evidence of negative MP

264 ths, which all exhibit improved PET and MHET turnover relative to the free enzymes.

265 Synapse formation, maturation, and turnover require a finely regulated transport system tha

266 r undergoes significant rearrangement during turnover; resolution of these issues will require the co

267 nt availability corresponded to greater leaf turnover, resulting in decreased greenness.

268 roteinase-7 (related to extracellular matrix turnover), ST-2, and N-terminal pro-B-type natriuretic p

269 EDC4 not only serves as an enhancer of mRNA turnover that binds DCP2, but also as a repressor that b

270 y a selective mechanism of lysosome membrane turnover that is induced by stress and uncover a functio

271 r cells with an extraordinarily high rate of turnover that maintained JE integrity for 1.4 y in mice.

272 ne, a well-studied model of homeostatic cell turnover, the linchpin of cell equilibrium is feedback c

273 utrients and water, thereby accelerating SOC turnover through both stabilization and destabilization

274 ntial importance in facilitating erythrocyte turnover through induction of hemolysis.

275 vegetation productivity and ecosystem carbon turnover time (tau(eco) ).

276 a constant background mortality rate, carbon turnover time decreased by 2.1% and AGB increased by 24.

277 es to changes in biomass is dependent on the turnover time of the carbon, and thus tree mortality rat

278 s our capacity to accurately estimate carbon turnover times and carbon sinks.

279 SIMS datasets and revise estimated microbial turnover times in the marine subsurface and nitrogen fix

280 turbulent flow, and find that balancing the turnover times of biological particles and coherent stru

281 ch, we found that simply introducing protein turnover to a standard modification cycle has profound e

282 ate that NPC6 promotes membrane glycerolipid turnover to accumulate TAG production in oil seeds and t

283 ver, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains

284 llows us to follow the steps that couple ATP turnover to mechanical work.

285 association with FACT that precludes histone turnover to promote gene silencing and preserve epigenet

286 rinciples linking redox reactions to quinone turnover to proton translocation in complex I.

287 n a chemical oxidant was used (Ce(IV) , 7400 turnovers, TOF 0.88 s(-1) ).

288 enin and p120-catenin, which undergo kinetic turnover, transmit intercellular calcium transients and

289 a 50-year co-evolution of landscape and SOC turnover, we find that the dominant mechanisms that dete

290 ulates mitochondrial function, dynamics, and turnover, we hypothesized that alterations in endogenous

291 nucleosomes genome-wide would obligate H2A.Z turnover, we propose that global transcription at yeast

292 , however, absolute values of AGB and carbon turnover were higher than in either size- or age-depende

293 associated with lipid catabolism and chitin turnover were significantly upregulated in heat stressed

294 lorophyll catabolism and chloroplast protein turnover were subdued in bzip60-2, and these genes were

295 richness, and temporal species replacement (turnover) were intensified by as much as 48% after fores

296 lls exist in other tissues with low rates of turnover where they may have been mistaken for different

297 free cohesin, in a process known as cohesin turnover, which reloads it to cell-type-specific binding

298 nous LAPTM4B-24 protein was subject to rapid turnover with a t(1/2) of approximately 1 hour.

299 of coupled microbial dynamics and pesticide turnover with measurements of the abundance and expressi

300 n turnover rates, and overall faster protein turnover within the glycoprotein-rich interfascicular ma