ライフサイエンスコーパス: twitching

1 lar DNA, kin recognition, and cell motility (twitching).

2 specific cortical activity during periods of twitching.

3 swarming motility, and type IV pilus-driven twitching.

4 ly during periods of sleep-related myoclonic twitching.

5 in vitro would be associated with AS-related twitching.

6 sulting in myotube formation and spontaneous twitching.

7 ally decreased sleep durations and inhibited twitching.

8 ly during transitions from awake behavior to twitching.

9 dent form of multicellular motility known as twitching.

10 ements, and continued throughout the whisker twitching.

11 in transections had no significant effect on twitching.

12 temperature and decreased rates of myoclonic twitching.

13 ons of corollary discharge are absent during twitching.

14 IV pili (TFP), a motility mechanism known as twitching(1,2).

15 ts that spinal reflexes are inhibited during twitching [9-11], this finding suggests that twitches tr

16 and maintained baseline levels of myoclonic twitching, a behavior commonly associated with active sl

17 ese findings, we propose that during whisker twitching, a descending signal from SI triggers thalamic

18 By chelating iron, lactoferrin stimulates twitching, a specialized form of surface motility, causi

19 py) of more-complex, multi-joint patterns of twitching; again, wild-types/heterozygotes exhibited dev

20 accompanied by sharp decreases in myoclonic twitching and equally sharp increases in spontaneous SBs

21 vity in muscle bundles was linked with early twitching and eventual coordinated movement.

22 esults show that the forces generated during twitching and gliding have complementary characters, and

23 es the basic mechanochemistry of single cell twitching and gliding movements, so cell-to-cell signall

24 ing swimming in aqueous media, and swarming, twitching and gliding on solid and semi-solid surfaces.

25 ty mechanisms of Myxococcus xanthus, namely, twitching and gliding.

26 Twitching and social gliding motility allow many gram ne

27 Type IV pili (Tfp) are required for twitching and social gliding, but the mechanism by which

28 e IV pili, cellular appendages implicated in twitching and social motility in a range of bacteria.

29 and btaR3 genes altered colony morphology on twitching and swarming motility plates and induced pigme

30 crocolonies despite being proficient in both twitching and swimming motility.

31 Neurons in the RN fired phasically before twitching and wake movements of the contralateral foreli

32 llowed by a marked and prolonged decrease in twitching and wake movements.

33 enerating muscle fibers of the type II (fast-twitching) and were in part associated with overexpressi

34 ing brain and spinal mechanisms that produce twitching, and the role that sensory feedback from twitc

35 cells utilize endogenous factors to organize twitching, and we purified from wild-type cells a lipid

36 echanisms, including swimming, swarming, and twitching, are known to have important roles in biofilm

37 results also highlight the potential use of twitching as a uniquely informative diagnostic tool for

38 dentified the neural mechanisms that produce twitching as well as those that convey sensory feedback

39 ng to assess the spatiotemporal structure of twitching at forelimb joints in 2- and 8-day-old rats.

40 ticellular movements, a conserved feature in twitching bacteria.

41 Twitching bacterial groups also produce traction hotspot

42 arming bacteria and the pilGHIJ genes of the twitching bacterium Pseudomonas aeruginosa, the M. xanth

43 The effects of fingolimod on twitching behavior and life span were also demonstrated.

44 enhanced signal detection during the whisker twitching behavior.

45 many phenotypes tested, mucoidy and reduced twitching best predicted subsequent PE.

46 ion eliminated PFCN stimulation-induced anal twitching but did not change the stimulation-induced bla

47 76%, rostral pontine decerebrations reduced twitching by 40%, and midbrain transections had no signi

48 dal pontine decerebrations reduced myoclonic twitching by 76%, rostral pontine decerebrations reduced

49 In this article we track individual twitching cells and observe that their trajectories cons

50 hanism established by PilG, allowing forward-twitching cells to reverse.

51 lly structured, or whether the patterning of twitching changes with age; such information is critical

52 xpectedly revealed a category of reflex-like twitching-comprising an agonist twitch followed immediat

53 arvae exhibited abnormal swimming, increased twitching, defective eye movement and pectoral fin contr

54 development of local and global features of twitching, demonstrating that twitching is shaped by sen

55 is helps to maintain high rates of myoclonic twitching during cold exposure in infant rats.

56 0-min deprivation period, leading to rebound twitching during recovery sleep.

57 altered the temporal patterning of myoclonic twitching, extreme cooling substantially decreased sleep

58 of motility, from paralysis with flaccid or twitching flagella as other spoke mutants to wildtype-li

59 ed different types of motility, with reduced twitching for DeltafimX and reduced swimming for Deltadi

60 strain PAO1 to assess the roles of motility, twitching, growth rate, and overproduction of a capsular

61 line or amphetamine treatment, produced mild twitching in 61% of rats but did not affect amphetamine

62 N is also a major source of motor output for twitching in early infancy, a period when twitching is a

63 tagonist ketanserin reduces DOI-induced head twitching in MIA offspring.

64 gated the contributions of proprioception to twitching in newborn ErbB2 conditional knockout mice tha

65 as social gliding in Myxococcus xanthus and twitching in organisms such as Pseudomonas aeruginosa an

66 adient in comparison to transcription during twitching in the absence of any externally applied phosp

67 with 2 months of diffuse, involuntary muscle twitching in the absence of myasthenic symptoms, electro

68 As QS-related twitching increases with age, sleep spindle rate also in

69 er, analysis of the temporal organization of twitching indicated that pontine decerebrations predomin

70 atonia (with or without concurrent myoclonic twitching), indicative of REM sleep.

71 Myoclonic twitching is a ubiquitous feature of infant behavior tha

72 or twitching in early infancy, a period when twitching is an especially abundant motor behavior.

73 Bacterial twitching is important for initial bacterial colonizatio

74 The existing research about bacteria twitching is largely experimental orientated.

75 all shear stress in which bacterial upstream twitching is most efficient.

76 esults support the hypothesis that myoclonic twitching is sensitive to the prevailing air temperature

77 al features of twitching, demonstrating that twitching is shaped by sensory experience.

78 ted by the observation that reafference from twitching limbs reliably and substantially triggers brai

79 l as those that convey sensory feedback from twitching limbs to the spinal cord and brain.

80 The sensorimotor circuits activated by twitching limbs, and the developmental context in which

81 asic motor activity in the form of myoclonic twitching, may provide conditions that are conducive to

82 t was discovered that P. aeruginosa exhibits twitching-mediated chemotaxis toward unsaturated LCFAs (

83 r twitching motility per se, is required for twitching-mediated migration up a gradient of PE or phos

84 re new ideas about the functional roles that twitching might play in the self-organization of spinal

85 omain, pilF, involved in pilus formation and twitching mobility.

86 In particular, twitching-mode motility employs hair-like pili to transv

87 dynamics and rule-based simulations to study twitching-mode motility of model bacilliforms and show t

88 confidence interval, 1.19-2.57) and reduced twitching motility (odds ratio, 1.43; 95% confidence int

89 their resistance to phage PO4 and/or loss of twitching motility (twt-).

90 ycosylation, reduced its capacity to inhibit twitching motility (~57%), without reducing pili binding

91 Strains that display gliding or twitching motility across semisolid surfaces are powered

92 stic pathogen Pseudomonas aeruginosa mediate twitching motility and act as receptors for bacteriophag

93 showed that the PilC1 site is necessary for twitching motility and adherence to Chang epithelial cel

94 n that utilizes polar type IV pili (T4P) for twitching motility and adhesion in the environment and d

95 anscription factor that positively regulates twitching motility and alginate synthesis, two phenotype

96 norrhoeae pilT mutants, pilU mutants express twitching motility and are competent for DNA transformat

97 N. gonorrhoeae type IV pilus (Tfp) mediates twitching motility and attachment.

98 lting transgenic strains showed differential twitching motility and biofilm formation while maintaini

99 promote different characteristics, favoring twitching motility and biofilm formation, respectively.

100 a, the Pil-Chp system regulates T4P-mediated twitching motility and cAMP levels, both of which play r

101 e for organelle biogenesis but essential for twitching motility and competence for genetic transforma

102 associated properties of auto-agglutination, twitching motility and human epithelial cell adherence.

103 mutant is deficient in type IV pili-mediated twitching motility and in a "swarming motility" previous

104 rs were significantly or greatly impaired in twitching motility and in susceptibility to D3112cts.

105 Both twitching motility and infection by pilus-specific phage

106 are also required for type 4 pilus-dependent twitching motility and infection by the pilus-specific p

107 Bacteria lacking FimX are deficient in twitching motility and microcolony formation.

108 the PilC2 site has only a minor influence on twitching motility and no influence on adherence.

109 t appears that PAI-2 plays a crucial role in twitching motility and phage infection by affecting the

110 Twitching motility and phage susceptibility in the autoi

111 CDE, a gene cluster known to be required for twitching motility and potentially encoding a signal tra

112 fective in two defined multigenic processes (twitching motility and prototrophic growth) identified m

113 eat-denatured DMBT1 lost capacity to inhibit twitching motility and showed reduced pili binding (~40%

114 olishing c-di-GMP binding to GSPII-B reduces twitching motility and surface attachment but not natura

115 y of AlgZ is essential for the regulation of twitching motility and that this is independent of the r

116 cs, we simultaneously monitored the speed of twitching motility and the concentration of oxygen.

117 f spontaneous mutants that failed to express twitching motility and transformability carried mutation

118 d for Tfp biogenesis) and PilT (required for twitching motility and transformation) share significant

119 ly system, which promotes surface-associated twitching motility and virulence, is composed of inner a

120 Swimming and twitching motility are important for attachment and biof

121 of fluid flow rate and surface topography on twitching motility are studied.

122 stidiosa migrates via type IV-pilus-mediated twitching motility at speeds up to 5 mum min(-1) against

123 54), which is required for surface-dependent twitching motility but not alginate production, was foun

124 AlgR activates alginate production and twitching motility but represses the Rhl quorum-sensing

125 tial attachment, early biofilm formation, or twitching motility but were observed to arrest biofilm d

126 that domain in the wild-type protein reduced twitching motility by approximately 50% compared with th

127 ion of a single residue disrupts Pseudomonas twitching motility by eliminating surface pili.

128 we reveal for the first time the dynamics of twitching motility by N. gonorrhoeae in its natural envi

129 ic monoclonal antibody, which also inhibited twitching motility by P. aeruginosa bearing glycosylated

130 We reported previously that twitching motility ceases in maturing AW1 colonies and t

131 y, jerky slingshot motions characteristic of twitching motility comprise the transition region betwee

132 Thus, twitching motility contributed to the role of pili in co

133 Further, the twitching motility defect of an algR mutant was compleme

134 At present, it is not clear how twitching motility emerges from these initial minimal co

135 Outstandingly, twitching motility enables a poorly understood process b

136 These results show that twitching motility enables P. aeruginosa to translocate

137 ressed by a loss-of-function mutation in the twitching motility gene pilT.

138 Two sets of candidate twitching motility genes are present within the genome,

139 Pseudomonas aeruginosa pilus biogenesis and twitching motility has revealed the requirement for seve

140 In this study the role of twitching motility in P. aeruginosa epithelial cell inva

141 ween these in vitro findings and the role of twitching motility in P. aeruginosa virulence in vivo re

142 mily of proteins, required for Tfp-dependent twitching motility in Pseudomonas aeruginosa and social

143 hown to be required for pilus biogenesis and twitching motility in Pseudomonas aeruginosa.

144 ing motility (S-motility) in Myxococcus, and twitching motility in Pseudomonas and Neisseria [6,7].

145 ovel two-point tracking algorithm to dissect twitching motility in this context.

146 To study the role of twitching motility in virulence, Pseudomonas traversal o

147 at AlgZ DNA-binding activity is required for twitching motility independently of its role in alginate

148 Microscopic analysis of twitching motility indicated that mutants which were una

149 mined molecular characteristics required for twitching motility inhibition.

150 Therefore, DMBT1 inhibition of P. aeruginosa twitching motility involves its N-glycosylation, its pil

151 Twitching motility is a form of surface-associated bacte

152 ation of cAMP while control of TFP-dependent twitching motility is cAMP-independent.

153 owever, the mechanism by which AlgR controls twitching motility is not completely understood.

154 al bacteria Myxococcus xanthus, we know that twitching motility is under the dependence of the small

155 eir compact colony morphology indicated that twitching motility itself was not required for full viru

156 We speculate that PE-directed twitching motility may be involved in biofilm formation

157 Each twitching motility mutant (pilU, pilT with pili, pilA la

158 ed with the invasive strain PAK and isogenic twitching motility mutants.

159 There is a lack of models of twitching motility of bacteria in shear flows, which cou

160 ns of propulsion has much in common with the twitching motility of heterotrophs such as Pseudomonas a

161 ility and upregulate type IV pilus-dependent twitching motility of P. aeruginosa.

162 The model can successfully predict upstream twitching motility of rod-shaped bacteria in shear flows

163 osa PilE-mCherry fusion failed to complement twitching motility or piliation of a pilE mutant.

164 uginosa (i.e., PlcB), while not required for twitching motility per se, is required for twitching-med

165 We also identified a twitching motility phenotype active at low-nutrient conc

166 nd altered colony morphology on swarming and twitching motility plates.

167 Twitching motility plays a critical role in redistributi

168 swarming motilities powered by flagella, and twitching motility powered by Type IV pili, little is kn

169 phosphorylated AlgR (AlgR-P) is required for twitching motility through the fimU promoter but is not

170 t not PlcH or PlcN, is required for directed twitching motility up a gradient of certain kinds of pho

171 onstrates type IV pilus-mediated directional twitching motility up a gradient of phosphatidylethanola

172 function as an oscillatory motor that powers twitching motility via cycles of pilus extension and ret

173 position 54) that does not activate fimU or twitching motility was compared to PAO1, PAO1 algRD54E,

174 that H. influenzae possesses a mechanism for twitching motility will likely profoundly influence our

175 echocystis gliding are similar to bacterial "twitching motility" and rely on type IV pilus extension

176 eudomonas aeruginosa type IV pilus-dependent twitching motility, a flagellum-independent mode of soli

177 The authors have shown that twitching motility, a pilus-mediated form of bacterial s

178 d Pseudomonas aeruginosa pili, and inhibited twitching motility, a pilus-mediated movement important

179 tion of this domain had a dramatic effect on twitching motility, adhesion, and piliation but did not

180 ed type III secretion system (TTSS), reduced twitching motility, and a decrease in association with,

181 Genetic competence, wild-type twitching motility, and attachment to human urogenital e

182 or microcolony formation, biofilm formation, twitching motility, and attachment.

183 re involved in adherence to host epithelium, twitching motility, and DNA transformation.

184 thiothreitol, reduced type IV pilin-mediated twitching motility, and reduced accumulation of extracel

185 ession of Tfp-associated properties, such as twitching motility, autoagglutination and the ability to

186 s, including lipase production, swarming and twitching motility, beta-hemolysis of sheep erythrocytes

187 tures of Pseudomonas aeruginosa required for twitching motility, biofilm formation and adherence.

188 of diverse functions, including attachment, twitching motility, biofilm formation, and horizontal ge

189 ce structures, involved in processes such as twitching motility, biofilm formation, bacteriophage inf

190 ence factors, including alginate production, twitching motility, biofilm formation, quorum sensing, a

191 only uses type IV pili for surface-specific twitching motility, but also as a sensor regulating surf

192 nd are important for processes as diverse as twitching motility, cellular adhesion, and colonization.

193 s with adherence to human epithelial tissue, twitching motility, competence for natural transformatio

194 in pilT, a gene required for pilus-mediated twitching motility, confer a partial defect in cortical

195 ent to explain why pilA expression, and thus twitching motility, decreases at high cell densities.

196 mutants, which are piliated but defective in twitching motility, display reduced cytotoxic capacity t

197 enally diverse array of functions, including twitching motility, DNA uptake and microcolony formation

198 They are required for twitching motility, e.g., in Pseudomonas aeruginosa and

199 These families have functions including twitching motility, effector export, rotary propulsion,

200 Tfp are required for twitching motility, efficient biofilm formation, and for

201 host cell attachment, biofilm formation, and twitching motility, making this system a promising targe

202 cterial species, for processes as diverse as twitching motility, natural competence, biofilm or micro

203 y due to defects in cell adhesion or loss of twitching motility, or both.

204 is required for the coordinate activation of twitching motility, rhamnolipid production, and swarming

205 utant inactivated for pilB was deficient for twitching motility, suggesting a role for PilB in this p

206 sembly but had a reduced capacity to support twitching motility, suggesting impairment of putative Pi

207 in covalent homo- or heterodimers eliminated twitching motility, suggesting that specific PilNO confi

208 onents of intersecting pathways that control twitching motility, TTSS and autolysis in P. aeruginosa.

209 ly activates fimU transcription and exhibits twitching motility, was created.

210 n addition, this strain had somewhat reduced twitching motility, was sensitive to pilus-specific bact

211 Given this new role in twitching motility, we propose that algZ (PA3385) be des

212 , competence for natural transformation, and twitching motility, whereas L-phase cells lacked these f

213 were significantly impaired in T4P-mediated twitching motility, whereas the motility of the N3 mutan

214 gellum-independent form of locomotion called twitching motility, which is dependent upon the extensio

215 K60 mutants lacking Hrp pili still exhibited twitching motility, which requires type 4 pili (Tfp), an

216 anced localized adherence, and abolished the twitching motility-dispersal phase of the autoaggregatio

217 Twitching motility-mediated biofilm expansion is a compl

218 al, calcium-dependent regulator of bacterial twitching motility.

219 red for colonization of host tissues and for twitching motility.

220 the surface translocation is not swarming or twitching motility.

221 in and fibronectin but not collagen, and (v) twitching motility.

222 nnot undergo phosphorylation (AlgRD54N) lack twitching motility.

223 anide production, and type IV pilus-mediated twitching motility.

224 tion and can move on surfaces via gliding or twitching motility.

225 xanB are necessary for biofilm formation and twitching motility.

226 Importantly, these organisms exhibit twitching motility.

227 he biogenesis or function of type IV pili in twitching motility.

228 lginate biosynthetic operon, is required for twitching motility.

229 wth or early biofilm formation, swimming, or twitching motility.

230 aeruginosa upon infection of HeLa cells, and twitching motility.

231 results in colonies that continue to exhibit twitching motility.

232 the 17 kDa PilA protein and did not exhibit twitching motility.

233 result in a nonmucoid phenotype and loss of twitching motility.

234 ants are defective in type IV pilus-mediated twitching motility.

235 rs is the type IV pili that are required for twitching motility.

236 ct on adhesion, transformation, piliation or twitching motility.

237 cing and associations required for effective twitching motility.

238 T and pilU retain surface pili but have lost twitching motility.

239 of the P. aeruginosa pilus, which results in twitching motility.

240 tants constructed in vitro no longer display twitching motility.

241 are required for type IV pili biogenesis and twitching motility.

242 relate mechanistically to the phenomenon of twitching motility.

243 ontrols P. aeruginosa pilus biosynthesis and twitching motility.

244 e sensing, virulence, protein secretion, and twitching motility.

245 nerate surface motions collectively known as twitching motility.

246 transformation, while PilA5 is important for twitching motility.

247 use type IVa pili (T4aP) for attachment and twitching motility.

248 The bacteria move on a surface by means of twitching motility.

249 yperpiliated but defective in pilus-mediated twitching motility.

250 lagella-mediated swimming and pilus-mediated twitching motility.

251 of processes, including surface adhesion and twitching motility.

252 member and biogenesis component PilQ and the twitching motility/pilus retraction protein PilT.

253 strongly impaired in fly killing also lacked twitching motility; most such strains had a mutation in

254 ve toward chemoattractants using pili-based "twitching" motility and the Chp chemosensory system.

255 The "twitching" motility mode employed by many bacterial spec

256 Several bacterial pathogens require the "twitching" motility produced by filamentous type IV pili

257 acteria that move by type IV pilus-mediated (twitching) motility.

258 dition, the rpoS mutant displayed an altered twitching-motility phenotype, suggesting that the coloni

259 g, the outer membrane secretin PilQ, and the twitching-motility-regulating protein PilT.

260 y use of a microfluidic device, the speed of twitching movement by wild-type cells on a glass surface

261 During small-amplitude, 7-12 Hz whisker-twitching movements, a significant reduction in SI respo

262 scillatory activity occurring before whisker twitching movements, and continued throughout the whiske

263 , as measured by the occurrence of myoclonic twitching (MT), is the most prevalent behavioral state i

264 of the myotome, where they develop into slow-twitching muscle fibers.

265 l-angle X-ray diffraction measurements of WT twitching muscles during diastole revealed stretch-induc

266 All twitching mutants were competent for cell invasion but d

267 had a rapid onset of progressive confusion, twitching of the face and hand, and abnormal basal gangl

268 rally or bilaterally produced mild transient twitching of the forelimbs but did not affect behaviors

269 ory cortex, which reflected the synchronized twitching of the limbs and tail.

270 eir firing rates during periods of myoclonic twitching of the limbs, and a subset of these neurons ex

271 ent Method (DEM) proposed to study bacterial twitching on flat and groove surfaces under shear flow c

272 companied by a calcium transient that drives twitching or full contraction of the egg-laying muscles.

273 There is no evidence for twitching or swarming motility in A. tumefaciens.

274 life span and a male-specific wing extension/twitching phenotype that occurs in response to other mal

275 th expression of the pilus structure and the twitching phenotype, whereas a mutant lacking ComE, a Ps

276 mical results together with in vivo cAMP and twitching phenotypes of key ChpA phosphorylation site po

277 ing, and the role that sensory feedback from twitching plays in sensorimotor system development.

278 Twitching-positive cells had an extracellular 17 kDa pro

279 For twitching, powered by type-IV pilus retraction, we find

280 s analysis revealed developmental changes in twitching quantity and patterning.

281 Although PilH is not strictly required for twitching reversals, it becomes activated upon phosphory

282 ge-amplitude whisker movements), and whisker twitching (small-amplitude, 7- to 12-Hz whisker movement

283 r, thalamic bursting occurred during whisker twitching substantially more often than during the other

284 They are involved in bacterial motility (twitching), surface adhesion, biofilm formation and DNA

285 Pseudomonas aeruginosa is capable of twitching, swimming, and swarming motility.

286 uginosa is a ubiquitous bacterium capable of twitching, swimming, and swarming motility.

287 onal coherence from SI to VPM during whisker twitching than during the other behaviors.

288 g while leaving unaffected the low-frequency twitching that is thought to be contributed by local spi

289 To test this hypothesis, the sensitivity of twitching to various levels of cold exposure was assesse

290 pitulate movement signatures associated with twitching: Two TFP can already produce movements reminis

291 assessed by analysis of transcription during twitching up a PE gradient in comparison to transcriptio

292 In muscles, we found that the initiation of twitching was associated with a spreading calcium wave i

293 as inactivated by muscimol infusion, whisker twitching was never observed.

294 y of half of the threshold for inducing anal twitching was required.

295 In addition, myoclonic twitching was suppressed during the 30-min deprivation p

296 response to sensory feedback from myoclonic twitching, we hypothesized that the state-dependent acti

297 Furthermore, they indicate that twitching, which is characterized by discrete motor outp

298 ations predominantly affected high-frequency twitching while leaving unaffected the low-frequency twi

299 The discovery of whisker twitching will allow us to attain a better understanding

300 undamental understanding about how bacterial twitching would be affected by bacteria associated prope