ライフサイエンスコーパス: two-state

1 nduced S-->D transitions are cooperative and two-state.

2 ons that shift the equilibrium between those two states.

3 be were found to differ the most between the two states.

4 rences in effective connectivity between the two states.

5 unclear how the same network supports these two states.

6 eatures as well as differences between these two states.

7 thin the exhibition swine populations of the two states.

8 e dynamic sequence of events that span these two states.

9 we can switch conductance digitally between two states.

10 was known about the difference between these two states.

11 istent with a low-energy barrier between the two states.

12 lly distributed time interval in each of the two states.

13 nted that indicates the relatedness of these two states.

14 ism underlying operation of the CCM in these two states.

15 in motions involving interconversion between two states.

16 anges in free-energy differences between the two states.

17 hlighting differences in interactions in the two states.

18 mechanism controlling the switch between the two states.

19 chronized and slowed Ca(2+) release in these two states.

20 ne- and reward-dependent transitions between two states: a "spontaneous" state involving beta (~15-30

21 merase exhibit a dynamic equilibrium between two states: a docked conformation and an alternative con

22 e of the T6SS gene clusters (Aux3) exists in two states: a mobile, prophage-like element in a small s

23 ism in which the transporter adopts at least two states, accessible from two different sides of the m

24 We show that these two states acquire highly divergent genomic distribution

25 ve natural variation in the frequency of the two states across wild yeast strains.

26 ctivation curves that correspond to a simple two-state activation.

27 GMP inhibits PfPKG not simply by reverting a two-state active versus inactive equilibrium, but by sam

28 The switching between the two states (all-trans and cis-enriched capsules) proceed

29 ach other is far more complex than a simple, two-state allosteric model and instead is probably kinet

30 simplest extension of the classic quaternary two-state allosteric model of Monod, Wyman, and Changeux

31 In spite of its simplicity, a two-state allosteric model was able to satisfactorily re

32 ined crystallographic snapshots of DrDXPS in two states along the reaction coordinate: a structure of

33 e rates of unwinding and rewinding for these two states and show that the rewinding rates from each s

34 nformational changes occurring between these two states and the resulting changes in classical electr

35 sed to derive its secondary structure in the two states and to pinpoint some subtle conformational ch

36 ctivation reduced the transition between the two states and, thus, promoted the accumulation of the A

37 Additionally, two-state and downhill folding scenarios were identified

38 omolecular structure-function relationships: two-state and multistate conformational ensembles, confo

39 In this study, kinetic models accounting for two-state and three-state mechanisms were fitted to our

40 was used to treat transitions between these two states, and obtain the average angular velocity of t

41 This enabled functional studies of the two states, and we show that while the Ub-CR conformatio

42 The two states are cycled using an electrically controllable

43 These two states are interpreted as a bifurcation of magnetic

44 These two states are related: the larger the t1/2, the longer

45 The two states are the 'locked' ground state where the FliJ

46 naling pathways capable of switching between two states are ubiquitous within living organisms.

47 mice on a high-fat diet and during fasting, two states associated with enhanced hepatic TG content.

48 the structures of the bacterial HeR-48C12 in two states at the resolution of 1.5 angstrom, which high

49 these in mind, following characterization of two states (before and after induction of a single TF of

50 en unfolded conformations result in apparent two-state behavior and make different pathways indisting

51 a solvent-excluded core, explaining the non-two-state behavior observed during refolding in molecula

52 ectly two-state, while small deviations from two-state behavior were observed for CTL9.

53 nfolding revealed significant deviation from two-state behavior, with a core region that was selectiv

54 rce (f), and temperature exhibit an apparent two-state behavior, without revealing the presence of th

55 eal varying degrees of deviation from simple two-state behavior.

56 the slowest folding processes that adhere to two-state behavior.

57 plasmon resonance with a recently developed two-state binding model with loss.

58 reversible covalent binding affinity using a two-state binding model.

59 cence imaging, we discover that SA1 displays two-state binding on DNA: searching by one-dimensional (

60 An area motor model, based on two-state Boltzmann statistics, was developed about two

61 t physical model of F1 motor as a simplified two-state Brownian ratchet using the asymmetry of torsio

62 s been characterized by a transition between two states, but the conformational path that leads to th

63 Comparison between the two states by electron microscopy identified regions of

64 These two states can be assessed by fractionating tissue or ce

65 Theses two states can each be reversibly oxidized by the redox

66 The two states can encode the two binary bits, and, using th

67 of Schizosaccharomyces pombe Ub E1 in these two states, captured using semisynthetic Ub probes.

68 were able to correctly discriminate between two states carrying OAM [Formula: see text] and differen

69 ding studies support a previously unreported two-state "catch-clamp" mechanism of Fn binding by CshA,

70 l elements computed to contribute to the non-two-state character coincide with regions where Von Will

71 vely assigned to histidine Hdelta1 display a two-state chemical exchange with exchange rates in the o

72 The two-state coagonist model has been successfully used to

73 for Healthcare Research and Quality funded a two-state collaborative to reduce ventilator-associated

74 the N- and C-terminal domains, also induced two-state conformational exchange throughout the kinase

75 cGMP activation is adequately explained by a two-state conformational selection model, the partial ag

76 assicality and the mutual incompatibility of two states connected by time evolution.

77 lective, as no conversion is observed if the two states consist of opposite enantiomers.

78 PVL cells clustered into two states consistent with a differentiated and immature

79 croorganisms switch photochromically between two states, controlling numerous important biological pr

80 in inhibitor 2 (CI-2) is a classic model for two-state cooperative protein folding and is one of the

81 other folding landscape with nearly an ideal two-state (cooperative) unfolding transition.

82 rge state distribution are consistent with a two-state, cooperative unfolding transition having a mel

83 e latch constriction, and by the loss of the two-state current signature in low pH buffers (<6.3), wh

84 rt-finned pilot whales is often described by two states; deep foraging and shallow, non-foraging dive

85 izes an active-like state, we show how these two state-dependent nanobodies can provide real-time rep

86 oligomeric state, with the population of the two states depending on the local Ca(2+) concentration.

87 walk, caged diffusion, obstructed diffusion, two-state diffusion, and diffusing diffusivity) in varia

88 value of sporadic cases on outbreaks using a two-state discrete Markov model.

89 The two states display resistivity contrast, which is exploi

90 e often assumed to involve an all-or-nothing two-state dissociation pathway, but deviations from this

91 plore optimization principles using a simple two-state dynamical model.

92 cally described in the framework of coherent two-state electron tunneling or multistep hopping.

93 Together, these two states enable the organism to respond to two types o

94 We fit the simulation data to a two-state equation of state to provide an estimate of th

95 from various detergent micelles by urea in a two-state equilibrium and where the unfolded state is in

96 enzyme and we analyse the data in terms of a two-state equilibrium between compact and extended confo

97 ) ionic strength, and is well described by a two-state equilibrium model.

98 low and high activities, we concluded that a two-state equilibrium that was present only in phosphory

99 ta indicate that the CBD exists in a dynamic two-state equilibrium, whose position as gauged by NMR c

100 Our HMMs separate elephant movements into two states: exploratory movements that are fast and dire

101 omputational grid where every cell can be in two states: fluid or solid.

102 Unlike the case of the two-state folder [three-alpha-helix bundle (alpha(3)D)],

103 ng of cold shock protein B (Csp), a showcase two-state folder, using single-molecule force-spectrosco

104 2, and find strong evidence for diffuse, yet two-state folding and binding of the N-terminal region t

105 mechanisms that purportedly underlie simple two-state folding behaviour.

106 The hairpins followed two-state folding dynamics with a closing rate increasin

107 e states and confirm earlier findings of non-two-state folding for insulin through a folding intermed

108 The resulting two-state folding model is a powerful template for measu

109 We found cooperative two-state folding on a sub-millisecond time scale throug

110 of multiple unfolding pathways in a simple, two-state folding protein.

111 the binding of brinzolamide to BCA II, a non-two-state folding protein.

112 ol yielded accurate DeltaG(f) values for the two-state folding proteins, lysozyme and cytochrome c.

113 stablished the free energy landscape of this two-state folding system.

114 addition, we demonstrate that nonequilibrium two-state folding, a hallmark of FimA with the Nte inser

115 impse at the nanoscale complexity underlying two-state folding, and postulate these combined methods

116 monomeric protein CI2, a paradigm of simple two-state folding, and the toroidal arrangement with 6-f

117 lthough the isolated C-terminal domain shows two-state folding, we find that the isolated N-terminal

118 equation to fit complex cases within a full two-state framework with the possibility of incorporatin

119 ness of restraint revealed switching between two states: frictional coupling to retrograde flow and A

120 ecovering the free energy difference between two states from exponentially averaged work performed to

121 nditions tested, the reaction appeared to be two-state from dimer to 120-dimer capsid with some dimer

122 These two states generalize our previous understanding of meta

123 r absence of PSB then determines whether the two states have fused or not, leading to the creation of

124 We find that these two states have specific effects on the decisions to sto

125 aries of transcription units de novo using a two state hidden-Markov model (HMM).

126 The impulsive two-state (I2S) model was used to describe the Br atom r

127 ning membranes, we found that there are only two states identifiable by CD, one before and another af

128 ot point during the transition between these two states.IMPORTANCE Glycoprotein spikes on the surface

129 tors are known to reversibly convert between two states in a photoinitiated process that involves a b

130 rained model of phenotypic switching between two states in the presence of cytotoxic stress from chem

131 The switching process consists of two states, in which the trans isomer has a stretched an

132 We identified two-state interconversion dynamics on the millisecond ti

133 losteric ligand, the equilibrium between the two states is shifted towards domain-domain interaction,

134 imental data from both protocols with simple two-state kinetic polymer theory allows to unambiguously

135 Both genes follow similar two-state kinetics.

136 es global motions involving exchange between two states, L and R.

137 th switches that are locked in either of the two states lead to biofilms with altered architecture an

138 ation/dissociation kinetics switch from slow two-state-like exchange at low protein concentrations to

139 to denaturant is the surprising result of a two-state-like transition from a compact to an expanded

140 vestigate the folding of gpW, a protein with two-state-like, fast folding dynamics and cooperative eq

141 , the HIV virus makes a key decision between two states: lytic and lysogenic fate.

142 However, the protein folds in a kinetically two-state manner and is moderately stable at room temper

143 Folding of small proteins often occurs in a two-state manner and is well understood both experimenta

144 transfer is not well modeled by the standard two-state Marcus model, since no inverted region is obse

145 ntical open probabilities: the commonly used two-state Markov gating model, one that utilizes multipl

146 The tool uses a two-state Markov model to simulate the evolution of meth

147 t activity evolves according to a stochastic two-state Markov switching-diffusion process that depend

148 A two-state mathematical model for long-chain hydrocarbons

149 e mechanism, while A3 unfolds by a classical two-state mechanism.

150 for a protein-protein interaction; namely, a two-state mechanism.

151 Taken together, our results illustrate how two-state micropatterns provide a dynamic migration assa

152 occupancy probability of cells in asymmetric two-state microstructures that consist of two fibronecti

153 to 190 K, consistent with the predictions of two-state "mixture" models for supercooled water in the

154 y concept, from a conformational change in a two-state model (1965, 1966) to dynamic allostery in the

155 We use a simple two-state model adapted from studies of linear molecular

156 centration, thus arguing against a classical two-state model as found for many globular soluble prote

157 FD-AFM data are inconsistent with a two-state model but instead require models that incorpor

158 We show that only the tertiary two-state model can provide a near quantitative explanat

159 rotein unfolding, in contrast to the typical two-state model described for most domain-swapping prote

160 theory makes it easy to derive the extended two-state model equations for complex regulatory archite

161 We propose a two-state model for Cas9 binding and cleavage, in which

162 fusion can be quantitatively modeled using a two-state model for polymers in the gel, where diffusivi

163 Our data support a two-state model for selectins in which Glu-88 must engag

164 scribed by an extension of the Peccoud-Ycart two-state model in which both (repressor-free and repres

165 al structures of P- and E-selectin suggest a two-state model in which ligand binding to the lectin do

166 Line shape and relaxation data suggested a two-state model in which the domain's free state undergo

167 state of the serpin were inconsistent with a two-state model of allosteric activation and suggested m

168 be explained using the Monod-Wyman-Changeux two-state model of allostery.

169 A generalized two-state model of bursty transcription that neglects Ry

170 of Monod, Wyman, and Changeux; the tertiary two-state model of Henry et al., which is the simplest e

171 These results support the tertiary two-state model of ligand binding.

172 steric models for hemoglobin: the quaternary two-state model of Monod, Wyman, and Changeux; the terti

173 We conclude that the two-state model of motor learning is a close approximati

174 types, can be quantitatively reproduced by a two-state model of the [Formula: see text], and thus the

175 Using our data, a stochastic two-state model of the central dogma was constructed and

176 In comparison, the two-state model produces frequent, large, and long Ca(2+

177 The solution of this extended two-state model reveals that the steady-state mRNA distr

178 easingly precise and the deviations from the two-state model start to be observable, we ask about the

179 This difference stems from the two-state model's single-RyR OT and CT distributions bei

180 show that a remarkably simple extension of a two-state model, initially developed to reproduce thermo

181 Using a two-state model, we explore the effect of RLC phosphoryl

182 ry to think of gene regulation in terms of a two-state model, where the promoter of a gene can stocha

183 mpare them with the baseline provided by the two-state model.

184 aviors that are not compatible with discrete two-state models of core complex signaling states.

185 otection can be rationalized on the basis of two-state models that equate structural dynamics with gl

186 vity of GPCRs has been described in terms of two-state models where the receptor can achieve only a s

187 ch bonds have respectively been explained by two-state models.

188 es were calculated and analyzed using global two-state Monod-Wyman-Changeux models to derive log(d) p

189 erifiable fold that constrains the system to two states - monomer or dimer.

190 proteins, whereas the A39P mutant follows a two-state N <--> U folding mechanism consistent with the

191 ly concentrated geographically, with the top two states (New York and New Jersey) each experiencing o

192 han 34000 directed interactions, we compared two states: normal/uninfected and infected.

193 pends only on the relative affinities of the two states, not on their relative intrinsic stabilities,

194 belief, proteins are multistate rather than two-state objects.

195 avibactam orientation similar to one of the two states observed in the BlaR1-avibactam structure.

196 ompact than the heat-denatured states, these two states occupy similar volumes in IscU.

197 Two states of folding, fully extended fibers containing

198 esent the full-length structure of PfMyoA in two states of its motor cycle.

199 njection of solutions containing selenium in two states of oxidation (either Se((IV)) or Se((VI))), p

200 he compression tests suggests that there are two states of shear-branching structures: the fractal st

201 ify a pressure-dependent equilibrium between two states of the enzyme, where an increase in pressure

202 ity of the S-peptide to the S-protein in the two states of the photoswitch.

203 The experiment that compares TEP-Finder with two state-of-art algorithms shows that the emerging phen

204 We run a selection of algorithms on two state-of-the-art 5-qubit quantum computers that are

205 ased and standalone servers, SURPI leverages two state-of-the-art aligners for accelerated analyses,

206 e 10th CASP experiment; and (iii) outperform two state-of-the-art approaches and a baseline counterpa

207 ow and remotely sensed vegetation cover) and two state-of-the-art biospheric models, we show that cli

208 ossy compression for nanopore raw data using two state-of-the-art lossy time-series compressors, and

209 tify the validation rate and compare against two state-of-the-art methods, DEEP-ENCODE and RFECS.

210 Compared with two state-of-the-art methods, MT-SCCALR yields better or

211 precision by 80% and 36% in comparison with two state-of-the-art methods, PSICOV and GREMLIN.

212 les and the superiority of our approach over two state-of-the-art methods.

213 (-22) are measured for ITIC-2Cl and ITIC-2F, two state-of-the-art non-fullerene acceptors.

214 l-NGS, Illumina TruSeq and QIAGEN QIAseq) on two state-of-the-art sequencing platforms (Illumina Nova

215 ple experimental datasets, MBBC outperformed two state-of-the-art taxonomy-independent methods, in te

216 ein undergoes a microsecond exchange between two states, one of which is predisposed to interact with

217 small GTPase K-Ras4A have a single state or two states, one resembling K-Ras4B and the other N-Ras?

218 ucture reveals the auxiliary Fe-S cluster in two states: one monomer contains a [4Fe-5S] cluster, and

219 Muscle myosin 2 monomers exist in two states: one with a folded tail that interacts with t

220 ires the protein to convert between at least two states open to opposite sides of the membrane, it is

221 This suggests that AncMsPFK mainly populates two states (open and closed) during the catalytic cycle,

222 Our findings challenge the conventional two-state paradigm and may aid future identification of

223 istance and relative orientation but also by two state parameters concerning the rotameric state of t

224 Ion conduction involves two states per cycle, the late M- (M2) with a deprotonat

225 The dynamics are well described by a two-state persistent random walk model, which allows cel

226 rus dsRNA-dependent RNA polymerase (RdRp) in two states pertaining to transcription.

227 of the unbinding process, replacing a simple two-state picture with one that involves many routes to

228 We modeled the dynamics as a two-state Poisson process and calculated the kinetic rat

229 We used a two-state Poisson process to describe the dynamics and c

230 epresentation of the protein and construct a two-state potential by combining two elastic network mod

231 The two-state potential has a cusp hypersurface in the confi

232 protein folding is often more complex than a two-state process, which leads to the spontaneous foldin

233 e focused on the construction and control of two-state quantum systems, or qubits, in which each quan

234 ometry, and kinetic modeling, we showed that two states--quiescence and cell cycling--can coexist wit

235 Two-state ratiometric biosensors change conformation and

236 orOverlord, that predicts the input range of two-state ratiometric biosensors given the experimental

237 s, NCS-1 unfolds and refolds reversibly in a two-state reaction involving only the C-domain, whereas

238 state, which determines the kinetics of the two-state reaction, remains poorly characterized.

239 /FRAP data, we have generalized the standard two-state reaction-diffusion equations by 1), accounting

240 results corroborate the initially predicted two-state reactivity (TSR) scenario for these reactions.

241 In principle, dynamical ideas and two-state reactivity are each individually able to expla

242 hich has been postulated to be involved in a two-state reactivity model, and 2) the Mn(III/IV) reduct

243 A two-state reactivity scenario is mandatory for the oxida

244 reduce the kinetic barrier, a unique case of two-state reactivity without a change in the net spin mu

245 sigma-pathways and quenches any chances for two-state reactivity, thus proceeding via the (3)Hpi pat

246 ce on the quintet surface and hence quenches two-state reactivity.

247 in contrast to complex A reported to feature two-state-reactivity with contributions from both triple

248 on is resolved, showing a unique behavior of two-state reversible reaction with fast structural defor

249 important quantum attribute-the spin-between two states separated by a potential barrier is to trigge

250 genetic data, we redefine the disorder into two states: severe (triglyceride concentration >10 mmol/

251 the near-identical SRP architecture of these two states, show many of the SRP-ribosome interactions a

252 rather than a simple funnel, that folding is two-state (single-exponential) when secondary structures

253 This all-or-nothing two-state solution is a hallmark of positive cooperativi

254 tion that entails the partition of land (the Two-State Solution) whereas associating peace with struc

255 ionally equivalent to one of two fundamental two-state spin systems.

256 none reduction site, providing support for a two-state stabilization-change mechanism of proton pumpi

257 A two-state stable isotope labeling by amino acids in cell

258 Indeed, two-state stochastic models that seek to describe microt

259 eters were found to be unchanged between the two states, such as most aspects of spatial processing,

260 havior characterizing the GNSs dynamics to a two-state switching between Brownian diffusion in the cy

261 ctivity of the entire cell into a stochastic two-state switching regime.

262 By picturing replication initiation as a two-state system and considering all possible transition

263 other mammalian P450s is more complex than a two-state system and has been proposed to involve mechan

264 the model can be simplified to a reversible two-state system and solved analytically using a rapid e

265 t it is bounded by the Shannon entropy for a two-state system.

266 to P450 17A1 was more complex than a simple two-state system.

267 al form inspired by a thermodynamic model of two-state TF-DNA binding.

268 as attributable to the retention of cells in two states that exhibited different condition-specific g

269 resented, resulting in the identification of two states that might be targeted with molecular scaffol

270 The entanglement of these two states, the topological superconducting state, will

271 CAFs clustered into two states: the first with features of myofibroblasts an

272 tes concerted conformational changes between two states: the intrinsically more stable T state with r

273 ndly graphical user interface (GUI) to model two-state, three-state, and four-state binding processes

274 nd uses the surface displacement between the two states to calculate the stress development during th

275 ing density functional theory, we assign the two states to two different permanent electrical dipole

276 VHS domain switches from a three-state to a two-state transition behavior.

277 onsistent with TRAP SBPs undergoing a simple two-state transition from an open-unliganded to closed-l

278 ransition profiles suggest a highly specific two-state transition in which the folding and unfolding

279 ration, normally thought of as a cooperative two-state transition involving the native state and unst

280 is of ion mobility distributions reveals the two-state transition is a composite of transitions invol

281 g the folding reaction both in cases where a two-state transition is valid and in some cases consisti

282 The two-state transition of the TMD, from an inward- to an o

283 e generated 268 epigenomic datasets spanning two state transitions-from normal prostate epithelium to

284 eveals that short segments of chromatin make two-state transitions between closed conformations and o

285 g data within the theoretical framework of a two state two path model, where two slip bonds are coupl

286 nction dynamics revealed transitions between two states under high salt conditions, but smFRET could

287 ticomponent complexes reveal an almost ideal two-state unfolding behavior.

288 he unfolding transition suggests a classical two-state unfolding behavior.

289 The observation of two-state unfolding for many small single-domain protein

290 globulin domain can be explained by a simple two-state unfolding process, with different unfolding ra

291 Significant deviation from two-state unfolding under pressure reveals an intermedia

292 this structure to reversibly switch between two states upon pH changes.

293 Two state variables are responsible for generating rapid

294 levels throughout the transition in terms of two state variables.

295 A novel prediction is derived by the Two-State-Vector-Formalism (TSVF) for a particle superpo

296 The proline rings occupied one of two states, while the helix was found to have a well-def

297 vealed that NTL9 folding is almost perfectly two-state, while small deviations from two-state behavio

298 via a pressure-induced rejuvenation between two states with distinct structural order characteristic

299 RfaH exists in two states, with its C-terminal domain (CTD) folded eith

300 Oscillation between the two states would result in rapid Na(+)/H(+) antiport.