ライフサイエンスコーパス: two-step

1 es captured in these simulations proceeds in two steps.

2 ide variety of indenoisoquinolinones in just two steps.

3 ha-aminoamides bearing a congested carbon in two steps.

4 es from diisopropyl phthalate in just one or two steps.

5 The hydrogenation typically proceeds in two steps.

6 A systematic review was performed in two steps.

7 g in stretching and cleaving the gate-DNA in two steps.

8 e of Gaussian mixture models (GMMs) in these two steps.

9 we demonstrate that this selection occurs in two steps.

10 in patients who do not respond to the first two steps.

11 lysis, demonstrating that it uncouples these two steps.

12 The LMF process comprises two steps: (1) applying ultrathin-film metal deposition,

13 called spike sorting, typically consists of two steps: (1) extracting relevant waveform features (e.

14 The synthesis consisted of two-steps: (1) enzymatic hydrolysis of lactose and (2) c

15 e measured in the fasting state and during a two-step (10 and 20 mU/m(2)/min) hyperinsulinemic-euglyc

16 The initial recovery occurred in two steps: a rapid return of activity to an average 24%

17 closed and intermediate states that suggest two-step activation of TRPV3 by heat.

18 crRNA for target recognition and undergoes a two-step activation through crRNA-DNA hybridization.

19 citabine-nab-paclitaxel chemotherapy using a two-step adaptive continual re-assessment method trial d

20 location for planning foot placement nearly two steps ahead of reaching the obstacle.

21 ed conditional regression models fit using a two-step algorithm.

22 ylating oxygenase (ADO), which function in a two-step alkane biosynthesis pathway.

23 the following noteworthy developments: (1) a two-step all-catalytic sequence for conversion of a term

24 The utility of this two-step aminoethylation strategy was demonstrated in th

25 multiplex, one-pot detection method based on two-step amplification of the signal measured by Reflect

26 he CrPV IGR and the 40S subunit consisted of two-steps: an initial fast binding step of the IRES to t

27 two samples were subjected to the developed two-step analysis method.

28 onal simplicity of the method involving just two steps and use of an efficient C-C bond-forming react

29 hibited an early maturation in Ec and Ecl, a two-step and early maturation in Ei, and a late maturati

30 The synthesis involves a two-step annulation process that rapidly assembles the t

31 Taken together, we propose a two-step APE1/APE2-mediated mechanism for SSB end resect

32 The authors used a two-step approach in identifying and then empirically te

33 A selective and scalable two-step approach to the dimerization of norbornadiene (

34 It performs imputation using a two-step approach.

35 ISC components of the first two steps are also required for biogenesis of numerous e

36 The first two steps are typical hydroxylations, mediated by an ele

37 To develop a sequential, two-step assay with high specificity, we used PBMCs from

38 A two-step assembly-welding mechanism is proposed for this

39 probabilities increase during this proposed two-step association process.

40 ein ligase (LplJ) that catalyzes a classical two-step ATP-dependent reaction.

41 f nested experimental design, we developed a two-step bioinformatics approach based on the Bayesian I

42 A two-step bulk synthesis was adopted to produce CoP on a

43 We applied a two-step bulked segregant RNA sequencing (BSR-Seq) appro

44 To address these problems, we developed a two-step calibration strategy under the consideration of

45 MR mice using a chemotherapy followed by the two-step carcinogenesis protocol potentiated the convers

46 and tetrahydroquinolines were obtained via a two-step catalytic asymmetric reduction and cyclization

47 osis produces gametes through a specialized, two-step cell division, which is highly error prone in h

48 Combined with a two-step cell picking protocol to retrieve ultrapure sin

49 grin subunit fail to form skin tumors during two-step chemical tumorigenesis, indicating a protumorig

50 In this study, we develop a two-step computational pipeline for the rapid parameteri

51 This two-step concurrent cross-coupling approach, resembling

52 The difference in signals in these two steps constitute the response of the assay, which of

53 orous host, which transforms to K(2) Se by a two-step conversion reaction via an "all-solid-state" el

54 appended metal-organic frameworks exhibiting two-step cooperative CO(2) adsorption, we report a famil

55 ts show that CrSiTe(3) evades this law via a two-step crossover from two- to three-dimensional magnet

56 etical computations identified a barrierless two-step cyclization mechanism for the formation of 2 up

57 et (dd)RT-PCR than with two-step RT-QPCR and two-step ddRT-PCR, likely owing to reduced inhibition wi

58 A two-step degradation-reconstruction approach to the carb

59 We implemented a two-step DEP sorting scheme, consisting of analysis to d

60 l, 3-4 h for a simple coupling and 8 h for a two-step deprotection/coupling process.

61 based on streptavidin-PEG-neridronate and a two-step detection scheme involving a biotinylated antib

62 neity in the DerSimonian and Laird (DSL) and two-step DSL (DSLR2) RE models and the Bayesian random-e

63 exhibited early maturation in Ec and Ecl, a two-step/early maturation in Ei and a late maturation in

64 Two-step enrichment of these glycosylated nascent chains

65 Combined with a protecting group free two-step enzymatic glycosylation of vancomycin aglycon,

66 amed GlyCLICK was suggested, consisting of a two-step enzymatic procedure to transform Fc-glycans pre

67 Here, we report the discovery of a two-step enzymatic synthesis of (2S,6S)-6-methyl pipecol

68 xide carbonylation reactions, we developed a two-step epoxidation/deoxygenation process that results

69 Dynamic immune activation and a two-step escalation/activation pattern were observed.

70 Thus, we propose DiscreeTest, a two-step evaluation metric for ranking discretization me

71 evolutionary scenario counterproposal for a "two-step" evolution of Merge does not work.

72 s via single component photocatalysts or via two-step excitation processes mimicking the Z-scheme of

73 sh the synthesis of alkenes using a one-pot, two-step experimental setup.

74 Our findings present an alternative two-step explanation for the formation of actin bundles

75 graphic column lifespan, samples underwent a two-step extraction, using solvent protein precipitation

76 pproach to more predictable and reproducible two-step fabrication of ultrasmall (<=10 nm radius) poli

77 We employed a two-step fabrication process to ensure an even mixture a

78 sequence and structural features and uses a two-step feature selection procedure to further remove r

79 MCR was carried out in two steps, first with the fraction and then the extract

80 We presented a two-step framework to model miRNA-mRNA relationships and

81 d dimethoxyfulvene was similarly prepared in two steps from 2,4-dimethoxybenzaldehyde.

82 cis-diol moiety has been readily achieved in two steps from a known bis-Weinreb amide derived from l-

83 rtant heterocycles under mild conditions, in two steps from cheap, commercially available starting ma

84 mides are simultaneously synthesized through two steps from commercially available materials in a rap

85 The new CSAs are prepared in two steps from Lambda-(S,S)-1(3+) 3Cl(-) by standard ani

86 ocess giving access to [(18) F]arylSCF(3) in two steps from the corresponding aryl boronic pinacol es

87 utational cost of large-scale simulations, a two-step Gaussian process interpolation based gradient m

88 entioned obstacle is circumvented by using a two-step germline substitution procedure, maintaining po

89 muRN-eChem was shown to enable a two-step gram-scale electrosynthesis of a nematic liquid

90 kinetic and thermodynamic properties of the two-step, halogen-atom abstraction mechanism, validated

91 In general, two steps have to be involved in treatment of the diseas

92 etrathiotungstate ((NH(4))(2)WS(4)) films by two-step high temperature annealing without additional s

93 Here, we report a two-step, high-yielding synthesis toward a new class of

94 orphological structures in CsPb(2) Br(5) , a two-step highly sensitive and noninvasive optical techni

95 We show the two-step hydrogenation of dimethyl acetylenedicarboxylat

96 received an oral glucose tolerance test and two-step hyperglycemic clamp (100 and 300 mg/dL) followe

97 ial-derived exosomes (EDEs) were enriched by two-step immunoabsorption from four groups of participan

98 couple PksH/PksI, responsible for the final two steps in beta-methyl branch installation in this tra

99 ally important (indol-2-yl)methanamines over two steps in good yields (up to 88%) with an excellent l

100 IPS-beta-tyrosine-was prepared in 78% yield (two steps in one pot).

101 ighly desired to simplify or eliminate these two steps in order to improve the assay throughput and r

102 riments indicate that MYC activates at least two steps in the transcription-cycle to explain the non-

103 Using a two-step, in vitro/in vivo epigenomic shRNA inhibition s

104 iral factors that affect numerous viruses at two steps: in target cells by sequestering incoming viru

105 In this study, we used a two-step incubation approach to reveal the relative cont

106 morphology generated in the second step of a two-step inorganic phototropic growth process depends on

107 A simple and effective one-pot, two-step intramolecular aryl C-N and C-O bond forming pr

108 In contrast, two-step ionization approaches produce detailed PAH mass

109 is subdivided into direct (or one-step) and two-step labeling approaches and will start with DNA bef

110 However, a two-step labeling sequence is required, which suffers fr

111 2-D graphene sheets were synthesized using a two-step laser liquid solid interaction approach.

112 The sensor showed a two-step linear response from 0.05 to 5 muM and 5-30 muM

113 of an iminium ion intermediate, supporting a two-step mechanism based on THIQ oxidation and R(3)In nu

114 covered unique and important insights into a two-step mechanism by which alphaBc interacts with misfo

115 NMR spectroscopy studies lend support for a two-step mechanism involving generation of a lambda(3)-b

116 tics of all the probes are consistent with a two-step mechanism involving ligand binding and isomeriz

117 n all results, including the preference of a two-step mechanism involving the zwitterionic pair Cys10

118 te that the palindrome cleavage occurs via a two-step mechanism leading to a blunt-ended DNA product,

119 bunit exchange provide strong evidence for a two-step mechanism whereby the tetramer dissociates to d

120 y can be explained based on an unprecedented two-step mechanism wherein the protonated triradical fir

121 letion of early synaptogenesis may require a two-step mechanism.

122 ate and may allow import of substrates via a two-step mechanism.

123 Together, PBS3 and EPS1 form a two-step metabolic pathway to produce SA from isochorism

124 similar results as compared to the classical two-step method (i.e. lipid extraction and FA methylatio

125 The two-step method accurately infers phylogenetic networks

126 In this article, we introduce a novel two-step method for scalable inference of phylogenetic n

127 In this proof-of-concept study, a new two-step method for the detection and identification of

128 Co/C nanocomposites were synthesized using a two-step method including mechanochemical treatment of p

129 hus we have demonstrated, that the developed two-step methodology has the potential as a new platform

130 defined paCOS available, we have developed a two-step, microtiter plate-based high-throughput screeni

131 Together, our data points to a two-step mode of J-domain action, a recognition stage fo

132 The two-site, two-step model describes these interactions.

133 On the basis of our results, we propose a two-step model for inhibition of Wee1 by Cdr1 and Cdr2 a

134 Our data establish a previously unrecognized two-step model for MCC development: GMNC functions in th

135 We propose a two-step model for the progression of focal seizures, wh

136 This suggests a two-step model of ciliary entry; PC2 first traffics to t

137 Further, we propose a two-step model of electron or/and ion transfer and demon

138 Taken together, our study presents a two-step model of folding that pertains to primate neoco

139 We build a two-step model to perform information recovery and artif

140 Taken together, these data suggest a two-step model whereby the strength of self-peptide-indu

141 , we propose an elaboration of the two-site, two-step model-the "three-step" model-in which initial i

142 Finally, we update the originally proposed "two-step" model of thymic T(reg) differentiation by inco

143 By combining survey and case data using this two-step modelling approach, we were able to take advant

144 ullerenes GF1 and GF2 were synthesized using two-step modified Bingel-Hirsch methodology.

145 Second, we used two-step MR to investigate whether DNA methylation media

146 raction procedures are optimized by use of a two-step multivariate optimization strategy.

147 corresponding 1,4-dihydroquinazolines via a two-step N1 dealkylation and regioselective N3 functiona

148 thyltransferase activity catalyzes the final two steps, NAD(+)-dependent dehydrogenation and iron che

149 precise redox-state control, and includes a two-step nickel-binding process.

150 cell transformation, we utilized the classic two-step NIH/3T3 cell transformation assay and observed

151 crystal nucleus formation occurred through a two-step nucleation mechanism.

152 ) pathway is followed by features exhibiting two-step nucleation.

153 We suggest a two-step nucleosome destabilization-depletion model, in

154 The two-step O-trifluoromethylation of phenols via aryl xant

155 ual-site cascade mechanism wherein the first two steps occur on SnO (x) sites and the remaining steps

156 For two steps of DASC, data-adaptive shrinkage and semi-non-

157 In bacteria, the first two steps of gene expression-transcription and translati

158 D) as the most common liver disease occur by two steps of liver injury ranges from steatosis to nonal

159 d with successful patient navigation through two steps of the continuum using multivariable logistic

160 tes then can chelate two Mg(2+) ions for the two steps of the reaction.

161 lopropane amino acids were synthesized via a two-step olefination and cyclopropanation procedure.

162 on Li(+)-catalyzed DA reactions changes to a two-step one for the reaction with dimethyl propynamine.

163 hosphinate building block was prepared via a two-step, one-pot condensation of a chiral auxiliary wit

164 ing of the C-borylated indoles in an overall two-step, one-pot process providing an efficient method

165 onia surrogate to afford primary amines in a two-step/one-pot process.

166 he calibrated POMs in a bang-bang (on-off or two-step) optimal control setting.

167 rther degrade EDDA into ethylenediamine in a two-step oxidation.

168 ajor role in steroidogenesis, catalyzing the two-step oxidations of progesterone and pregnenolone to

169 Here we report a two-step oxygen reduction approach by pre-depositing a p

170 Our findings indicate that training on the two-step paradigm in its current form does not support a

171 through a novel genetic algorithm (GA) based two-step parameter optimization strategy.

172 our experiments and show that both one- and two-step pathways are driven by thermodynamics alone.

173 classical one-step pathways and nonclassical two-step pathways that proceed via a solid-solid transfo

174 A two-step photon-assisted tunneling charge pumping mechan

175 Here, we evaluate a two-step pipeline for the imputation of common variants

176 d from total plasma RNA were analyzed with a two-step pipeline: (i) de novo genome assembly, followed

177 Here, we introduce a simple dual-wavelength, two-step polymerize and click approach for making combin

178 that converts sorbitol into fructose in the two-step polyol pathway previously implicated in diabeti

179 We performed a two-step positive end-expiratory pressure trial with cha

180 ariable macroring size were synthesized in a two-step postfunctionalization protocol by double N-benz

181 In this work, we explored a two-step "pretargeting" approach through engineering a b

182 re efficiently prepared using an alternative two-step procedure and controlled hydrogenation conditio

183 strained bridged polycyclic structures by a two-step procedure consisting of an initial reductive al

184 formed either as a direct one-pot or one-pot two-step procedure depending on the reactivity of the el

185 re, BV is used as a test case to establish a two-step procedure for developing high throughput serolo

186 In the present study, we propose a two-step procedure in bridging the genome to phenome gap

187 The one-pot, two-step procedure includes reductive synthesis of the i

188 ryl oxindoles are accessed from isatin via a two-step procedure involving a phospha-Brook rearrangeme

189 Here we report a new two-step procedure, consisting of Pd-catalyzed hydrothio

190 drazines, and TMSN(3) afforded, in a one-pot two-step procedure, valuable scaffolds such as ketene am

191 ith a histidine tag and purified by a simple two-step procedure.

192 sembles through an unusual and unprecedented two-step process as elucidated by solid-state NMR and mo

193 Here, we provide evidence for a two-step process for the development of neurologic adver

194 Atomization is performed as a two-step process in order to meet ideal conditions for b

195 ogy to show that electrophiles act through a two-step process in which modification of a highly react

196 owth self-assembly pathway, but rather via a two-step process involving first liquid-liquid phase sep

197 Described herein is the two-step process involving the initial formation of aldi

198 This two-step process might increase developmental flexibilit

199 lysis, and mathematical modeling to show the two-step process of intra-aortic hematopoietic cluster (

200 channels (VGCCs) and purinoceptors induced a two-step process of neuronal differentiation.

201 A two-step process of protein detection at a single molecu

202 dibromobenzene, which can be performed as a two-step process or as a one-pot three-component couplin

203 tions showed that EHB1 membrane binding is a two-step process that precedes the interaction between E

204 NAs is intact in the mammalian cytosol via a two-step process that requires the removal of a 2',3'-cy

205 obleaching, (*)OH exposure degrades CDs in a two-step process that will span several decades in natur

206 -onartuzumab was prepared via a conventional two-step process using prepurified onartuzumab and DFO-B

207 This one-pot two-step process was found to be general for a variety o

208 xta, we discovered that clot nucleation is a two-step process whereby cell aggregation is the time-li

209 t the rate dependence of epsilon is due to a two-step process, where diffusive transport of U(VI) fro

210 ctivity, and longevity than that made from a two-step process.

211 t with the binding to the beta-clamp being a two-step process.

212 on-carbon bond between these substances in a two-step process.

213 y the collinear activation of Hox genes in a two-step process.

214 ics of adamantane dications takes place in a two-step process: barrierless cage opening followed by C

215 hin the extended model TACE is included as a two-step process: First, the purely mechanical influence

216 SOUP involves a two-step process: Identify the set of pure cells and the

217 tection, simplicity, enzyme-free nature, and two-steps process without any immobilization and washing

218 scent cells in vivo, to the well-established two-step protocol of squamous cell skin carcinoma, in wh

219 rylacetic acid products have further enabled two-step protocols for the delivery of valuable building

220 onalized Matryoshka structure is formed in a two-step PSM procedure using trifluoroacetyl isocyanate

221 A sequential two-step purification by size exclusion chromatography w

222 s with para-substituted azides, suggesting a two-step radical pathway.

223 Here, to address this problem, we develop a two-step rational design method for the discovery of oli

224 m its trinitro-TANG precursor via a one-pot, two-step reaction involving Pd-catalyzed hydrogenation a

225 Biosynthesis of hypusine is a two-step reaction involving the enzymes deoxyhypusine sy

226 This two-step reaction is associated to NAD(+) regeneration,

227 Tpt1 catalyzes a unique two-step reaction whereby the 2'-PO(4) attacks NAD(+) to

228 )) from major and minor isomer products of a two-step reaction without any purification.

229 as an activator, and that Sw-5b NLR adopts a two-step recognition mechanism to enhance viral effector

230 We used a two-step reference standard approach to estimate disease

231 We describe a two-step refinement procedure that involves identifying

232 A general, scalable two-step regio- and diastereoselective method has been d

233 (d ~ 5.7 nm) were synthesized via a one-pot two-step reverse microemulsion method.

234 trahydrocarbazole derivative and its one-pot two-step ring opening and aromatization mediated by para

235 noindolizinoindolizinoquinazolines through a two-step route involving direct arylation followed by ac

236 lfonyl dibenzo-oxabicyclo[3.3.1]nonanes by a two-step route is described, including (i) NaBH(4)/LiCl-

237 ne-step digital droplet (dd)RT-PCR than with two-step RT-QPCR and two-step ddRT-PCR, likely owing to

238 concerted (cS(N) Ar) rather than classical, two-step, S(N) Ar mechanisms.

239 This two-step sample preparation led to excellent extraction

240 y mechanisms for signaling, we implemented a two-step screen that uses coexpression analysis of human

241 alkenyl-beta-diketones are synthesized via a two-step sequence consisting of (i) potassium tert-butox

242 The rate-limiting step in the two-step sequence depends on the steric demands of the c

243 We described herein a two-step sequence for synthesizing cyclopenta[ b]indoles

244 ith primary amines and cesium carbonate in a two-step sequence gives rise to 3-amino-2,3-dihydroisoqu

245 and 33 healthy participants (CP) completed a two-step sequential choice task for which model-based an

246 CO(2) ions scatter from solid surfaces in a two-step sequential collision process at hyperthermal in

247 an artificial light-harvesting system with a two-step sequential Forster resonance energy transfer pr

248 y predict that MHETase follows the canonical two-step serine hydrolase mechanism.

249 A new and simple two-step SFODME using 4-nitro-o-phenylenediamine (4-NOPD

250 ynthesized by either a one-step (SNZVI-1) or two-step (SNZVI-2) process were characterized, and the r

251 Specifically, the two-step solid-solid transition is governed by a competi

252 clear VT complexes confers an advantage over two-step spin crossover complexes for future application

253 uclear spliceosomal introns and use the same two-step splicing pathway.

254 y studied in vitro, in vivo kinetics for the two-step splicing reaction remain poorly understood.

255 rbornadienones 41 have been prepared in just two steps starting from anthracene 38.

256 (AFM) shows that micelle assembly occurs in two steps, starting with "precursor" particles that tran

257 We did a pragmatic, two-step, stepped-wedge, randomised controlled trial at

258 A cascade one-pot variant of this two-step strategy offers a comparable overall yield of t

259 equential and structural features and used a two-step strategy to select the relevant features.

260 A two-step strategy was used while reviewing publications:

261 urface of cardiolipin-containing vesicles, a two-step structural rearrangement is observed with a sma

262 Chain synthesis requires two steps: substrate modification with ubiquitin (primin

263 A two-step synthesis of a Cu-click compatible alkynyl oxoa

264 A straightforward two-step synthesis of benzoxepinones was developed via b

265 stry community, we have developed a one-pot, two-step synthesis of high-molar-activity [(18)F]FDOPA b

266 A facile and efficient two-step synthesis of p-substituted tris(2-pyridylmethyl

267 coupled to an acrylate monomer via a facile two-step synthesis to yield bulk-modified membranes upon

268 ng of favipiravir was achieved in a one-pot, two-step synthesis using a commercially available precur

269 dsorbents PAF-1-NMDG and P2-NMDG in a simple two-step synthesis.

270 l molecule which is readily accessible via a two-step synthesis.

271 olybdenum carbide (beta-Mo(2)C:Co) through a two-step synthesis: first an intercalation of gallium yi

272 in is easily accessible by a straightforward two-step synthetic approach that involves an octuple Suz

273 Herein, we report a practical two-step synthetic route to alpha-arylpyrrolidines throu

274 hy participants performed a well-established two-step task that differentiates MB from MF control, ac

275 By a novel two-step templated growth, a highly ordered Au-BaTiO(3)

276 Two-step testing with a toxin enzyme immunoassay is reco

277 Here, we introduce a two-step "tether and mask" strategy wherein large porphy

278 f single nucleotide variants (SNVs) involves two steps, the first step is to convert DNA to protein a

279 zodioxoles can be prepared from catechols in two steps through conversion into thionobenzodioxoles, f

280 competent state of the FoxA transporter in a two-step TonB-binding mechanism.

281 A two-step topotactic pathway for the preparation of phosp

282 It is a two-step touch-trigger system that consists of a pretarg

283 formed single-cell RNA-seq, which revealed a two-step transcriptional reprogramming process character

284 sion stages before meiosis was followed by a two-step transcriptome reorganization in leptotene, duri

285 Spacer integration proceeds through a two-step transesterification reaction where the 3' hydro

286 as9-Traget AID) using either a one-step or a two-step transfection platform to obtain triply mutated

287 tagenesis of partially edited regenerants (a two-step transfection protocol) allowed us to derive ETR

288 A two-step treatment regimen, beginning with neoadjuvant m

289 protein-coupled receptors (GPCRs) through a two-step, two-site mechanism and, through this interacti

290 m (Path2Surv) that conjointly performs these two steps using multiple kernel learning.

291 tetraazacyclotetradecane), which undergoes a two-step valence tautomerism (VT).

292 ring on-body measurements are supported by a two-step validation protocol: with the biosensor operati

293 ted preferred hydrolysis pathway proceeds in two steps via a pentacovalent phosphorane intermediate i

294 rans-A(2)B(2) porphyrins were synthesized in two steps, via [2+2] condensation between thioglycosylat

295 rmodynamic parameters governing the one- and two-step VT behavior.

296 ishes a clear path to the next generation of two-step VT complexes through incorporation of mixed-val

297 ompounds provide an avenue toward controlled two-step VT interconversions of the form {Co(III)-cat-ca

298 complexes; one-step one-electron partial VT, two-step VT, incomplete VT, and temperature-invariant {C

299 The guest release occurs in two steps with the disordered nitrobenzene guests releas

300 ted assembling of lipid bilayers proceeds in two steps, with a slow second step occurring over many d