ライフサイエンスコーパス: twofold

1 cells (sixfold) and in spinal cord in mice (twofold).

2 liver glucokinase activity by approximately twofold.

3 lipid utilization in cancer cells jumped by twofold.

4 rides further improved ferritin formation by twofold.

5 The purpose of the present letter is twofold.

6 ATEMENT The significance of this research is twofold.

7 TATEMENT Our research expands the literature twofold.

8 iously studied; however, the effect was only twofold.

9 th discovery of QD compositions, by at least twofold.

10 oncentration in CRPs increases approximately twofold.

11 e in expression in nearby genes of more than twofold.

12 Our results were twofold.

13 ty by 99-fold and increasing Mg(2+) affinity twofold.

14 he elongation rate of new edges by more than twofold.

15 cantly enriched in miR-200c binding at least twofold.

16 eading exonuclease activity reduced fidelity twofold.

17 ated) adiponectin release level was elevated twofold.

18 ion by 38% and slowed amyloid propagation by twofold.

19 The significance of this study is twofold.

20 t ratio is artificially reduced by more than twofold.

21 ppression of only 26 transcripts by at least twofold.

22 The key findings of this study are twofold.

23 alf-life predictions] are accurate to within twofold.

24 Therefore, the goals of this study were twofold.

25 he implications of our lack of knowledge are twofold.

26 none of the categories have enrichment above twofold.

27 increases in TRPM4 channel expression above twofold.

28 and the nonendogenous protein Kaede decrease twofold.

29 The goals of this work are twofold: 1) to categorize secretion features that deviat

30 The aim of this research is twofold: 1) to shed light on zika's binding and entry me

31 The objectives of the study were twofold: (1) observe how stress distribution changes aro

32 duration of spring green-up by approximately twofold (2.5 weeks) and resulted in less sequential gree

33 -to-head [2 + 2]-photodimerization or from a twofold [2 + 2] photocycloaddition of the enone to the o

34 severe COPD compared with control subjects (twofold, 44.7% vs. 25.2%), and this was significant in d

35 Conventional twofold-accelerated four-dimensional (4D) flow of the th

36 ere obtained by using a previously described twofold-accelerated wideband perfusion pulse sequence wi

37 ncoding the Npas4 transcription factor, was >twofold altered (downregulated) in MET mice; strikingly,

38 bronchitic symptoms was increased by almost twofold among past users (odds ratio [OR], 1.85; 95% con

39 72%).The ALD WL addition rate increased over twofold among young (18-39 years) and middle-aged (40-59

40 ddition, HCV-infected patients experienced a twofold and a nearly 17-fold higher risk of MPGN (HR, 2.

41 nd budesonide reduced MR1 surface expression twofold and decreased NTHi-induced IFN-gamma secretion e

42 = 2.2 mmol(-1) . sec(-1)) were approximately twofold and fivefold lower, respectively, compared with

43 These range from twofold and fourfold degenerate Weyl and Dirac points, r

44 /G group demonstrated greater bone volume by twofold and higher osteoblast number by threefold, compa

45 pathogen loads, increasing disease more than twofold and increasing mortality up to eightfold.

46 lasma leucine concentration by approximately twofold and muscle p-mTOR(Ser2448) by approximately 30%

47 Accuracy has been improved more than twofold and this improvement is sufficient to establish

48 These differences were large (>twofold) and highly stable across images and time.

49 -order reduction rate constant, k, decreased twofold, and the photoreduced Hg amount, Hg(II)red, incr

50 rface friction of the coated fiber increases twofold as a result of the ceramic nanoparticles.

51 The implications for public health are twofold, as these products may represent a novel source

52 edly large, enhancing currents by as much as twofold at physiological voltages.

53 es to the mineral nucleation sites along the twofold axes.

54 rands are juxtaposed, creating an additional twofold axis along the filament.

55 ere the two Cas2 domains form a central hub (twofold axis of symmetry) flanked by two Cas1 lobes and

56 and replaces one dimer of coat proteins at a twofold axis.

57 mechanism has been proposed to mediate this twofold behavioral improvement: the rhythmic entrainment

58 rganic polymers (MHPs) obtained using simple twofold benzoquinones, MHP-P5Q is demonstrated to have a

59 nal mutations per year differed by more than twofold between families.

60 > 50% of abundant proteins varying more than twofold between the lowest and highest irradiance.

61 Insulin granule exocytosis was accelerated twofold, but the secreted insulin had diminished bioacti

62 ium-catalyzed [3 + 2] reaction that utilizes twofold C(sp(3))-H activation to generate the three-carb

63 able cascade process inducing the collective twofold C-H/threefold C-F bond activations, where each C

64 999 down-regulated transcripts with at least twofold change (FDR corrected p < 0.05) in needle tissue

65 Without optimization, the switch exhibited a twofold change in binding affinity for SspB with light s

66 ultiple high-affinity binding sites with the twofold change in FOX-1 concentration between XX and XO

67 lure in patients or conferred a greater than twofold change in susceptibility compared with a referen

68 differentially expressed genes (greater than twofold change) and their functional annotations.

69 l, 33 proteins in patients with stable SA (>=twofold change; P <= 0.05) and 13 proteins in patients w

70 status, 21 proteins in normal epithelium (>=twofold change; P <= 0.05) and 6 proteins in metaplastic

71 patients with persistently symptomatic SA (>=twofold change; P <= 0.05) were enriched significantly.

72 and 6 proteins in metaplastic epithelium (>=twofold change; P <= 0.05) were enriched significantly.

73 Most importantly, while the twofold clustering did not differ significantly between

74 nd that the MC ATP concentration rises about twofold coincident with increasing cleavage of Pro-sigma

75 gh-voltage lithium metal battery by at least twofold compared to bare lithium metal.

76 e increased the proportion of theaflavins by twofold compared to black tea.

77 tivity toward lead ions was raised more than twofold compared to the unmodified nanoparticles.

78 table MRD, PNB nanosurgery improved survival twofold compared with standard surgery.

79 tion energy by a factor of 2.7 larger in the twofold compared with the threefold polymorph, whereas D

80 The effects of single and twofold continuous pressure change technology (PCT) appl

81 ity toward Cs-conformers is templated by the twofold coordination to Ag adatoms.

82 crease in ET transfer for raspberry juice, a twofold decrease for blackberry and wild strawberry juic

83 f the spreading drop and thereby a more than twofold decrease in contact time.

84 er 6 days of exposure to aged Ag NPs, with a twofold decrease in EC(50) (316 mug/L) compared to prist

85 enfold enhancement in the photocurrent and a twofold decrease in the response time after an external

86 assays show that the R21H mutation causes a twofold decrease in tropomyosin's affinity for F-actin a

87 erms of imaging settings, we observed that a twofold decrease of the pixel size, e.g., from 100 to 50

88 2 allele is associated with an approximately twofold decreased risk for AD.

89 ent the order parameter of any system with a twofold degenerate broken-symmetry phase, including elec

90 ing owing to a participation of the bridging twofold degenerate oxygen's virtual singlet state are de

91 pectroscopy, crossing points formed by three twofold degenerate parabolic bands are directly observed

92 rge-2 Weyl points identified here are simply twofold degenerate, and the dispersions around them are

93 n in the absence of spatial symmetries and a twofold-degenerate spectrum over the entire Brillouin zo

94 Mechanistic investigations indicate that the twofold deoxygenation of the sulfonyl substrate proceeds

95 fference in size structure translates into a twofold difference in reproductive output.

96 fter FP was greater in non-smokers (1.5- and twofold doubling dose difference from placebo after FP 1

97 quantified 518 twofold up-regulated and 811 twofold down-regulated proteins common to both AUY922 an

98 46, which showed consistent and reproducible twofold down-regulation in Bullies.

99 pollutants such as NOx and CO were enhanced twofold during PCAPs, O3 concentrations were approximate

100 Our results highlight a twofold effect of cholesterol on the amyloidogenicity of

101 pproximately 100-fold, whereas it had only a twofold effect on the rate of the first.

102 Thus, desensitization had a twofold effect: It abbreviated signaling between IHC and

103 but not VAMP, Cplx2, or synaptotagmin, were twofold enriched in SNAP25 immunoprecipitated products f

104 the effective flux responses in the case of twofold enzyme overexpression.

105 al cells in SR-1-treated hESCs, as well as a twofold expansion of CD34(+)CD45(+) hematopoietic progen

106 in the MJO life cycle are associated with a twofold expansion of the Indo-Pacific warm pool, the lar

107 nriched RNAs that interacted with WT PKR (>/=twofold, false discovery rate </= 5%) were small nucleol

108 experiments, isolated kinesin-3 motors moved twofold faster and had threefold higher landing rates th

109 ter than the median plant rubisco and nearly twofold faster than the fastest measured rubisco to date

110 Telomeres exhibit approximately twofold fewer photoproducts compared with the bulk genom

111 t of retroviruses on vertebrate evolution is twofold: first, as with other viruses, retroviruses act

112 s more than eightfold during CE and can vary twofold from individual to individual, we have proposed

113 ever, the magnitude of increase in pCa50 was twofold greater at short SL than at long SL.

114 oss a 480-mm rainfall gradient, resulting in twofold greater carbon loss on average in historically w

115 markedly insulin resistant and had more than twofold greater IMCL in the subsarcolemmal (SSL) region.

116 Vascular permeability was twofold greater in inflamed blood vessels in Nrp2-defici

117 mulated SkM glucose uptake was approximately twofold greater in mdKO mice in vivo.

118 icle was fivefold greater than free drug and twofold greater than Abraxane.

119 Our estimate of FCO2 is approximately twofold greater than previous estimates, as a result of

120 boxykinase (PCK) photosynthetic pathways was twofold greater than the kcatc of Rubisco from NAD-ME sp

121 d helical screw in solution, flattens into a twofold helical screw ribbon to bind intimately to cellu

122 Similarly, twofold higher BT200 concentrations were necessary to in

123 Similarly, twofold higher BT200 concentrations were needed after en

124 Gadopiclenol resulted in twofold higher DeltaCNR at 0.1 mmol/kg (P < .001 vs gado

125 adjacent to the transgene are approximately twofold higher for speckle-associated alleles 15 min aft

126 On average, enAsCas12a exhibits a twofold higher genome editing activity on sites with can

127 r human SNCA mRNA expression in the gut, and twofold higher gut expression of NADPH oxidase (NOX2) an

128 ed (r(s) = 0.186, P = 0.027) but were almost twofold higher in FF (P < 0.001).

129 and liver graft loss were about 1.2-fold and twofold higher in the LIST group.

130 mation, and their numbers were approximately twofold higher in wild-type mice than in Mac-1(-/-) mice

131 mation system (GIS) analysis, we uncovered a twofold higher incidence of Beijing strains in a hotspot

132 imulation by the littermates, support: (1) a twofold higher level of cortical activity than in the is

133 The results demonstrate a nearly twofold higher mortality rate among individuals with tre

134 discernible concentration reached as low as twofold higher or lower than basal concentration.

135 Despite the twofold higher prevalence of major depressive and posttr

136 dopiclenol, a macrocyclic GBCA with at least twofold higher relaxivity, is currently undergoing clini

137 a) are shown to attain a stiffness, which is twofold higher than any known organic biogenic structure

138 oablative chemotherapy alone, although still twofold higher than in the general population.

139 per intergenic kilobase, was comparable and twofold higher than that found in the gene-dense genomes

140 The expression of miR-146a was approximately twofold higher than that of miR-146b in healthy human sk

141 e length ranging from 2.0 to 2.8 mum, almost twofold higher than those with three repeats (3R).

142 ts and adults without these antibodies had a twofold-higher parasite density.

143 The goal of the current study was twofold: (i) to characterize the relationship between br

144 ree height and survival, our objectives were twofold: (i) to identify the source of differential popu

145 Escherichia coli treated with S6 exhibits a twofold improvement in butanol tolerance, a relevant fea

146 -nucleophilic amino acids led to a more than twofold improvement in cyclopropanation performance (tot

147 ced dynamic response (PHId), and a more than twofold improvement in glucose tolerance (disposition in

148 teins were found to be reduced approximately twofold in clathrin-depleted cells as a whole and approx

149 nd that CPLX3 expression level was decreased twofold in cone-Bmal1(-/-) cones.

150 by 20-fold in low-salinity sediments and by twofold in mesohaline sediments, after one day.

151 d by ablation of blue cones, and are reduced twofold in mutant larval retina with few UV cones.

152 Fasting Adipo-IR was increased twofold in obese subjects with NGT and IGT versus lean s

153 y excretion of pentosidine was increased ca. twofold in patients with MA, compared to normoalbuminuri

154 ed exosomal alpha-synuclein was increased by twofold in prodromal and clinical Parkinson's disease wh

155 Boosting the FruA level twofold in the C-signaling mutant had little effect on t

156 he frequency of spontaneous firing more than twofold in the two groups of interneurons, and more than

157 local background), decreasing steadily to a twofold increase 18 km downwind.

158 atients (ie, antibody titer above cutoff and twofold increase between pre and postvaccination values

159 [U-(13)C]glucose metabolism showed a twofold increase in alanine levels and sixfold increase

160 death due to growth limitation resulted in a twofold increase in allomer production, relative to chl-

161 reert2)/Met(fl/fl)/Apc(fl/fl) mice) caused a twofold increase in apoptosis in microadenomas, resultin

162 l vector expressing UT-B resulted in about a twofold increase in AXR at the site of virus injection.

163 ting "Rag-5xfAD" mice exhibit a greater than twofold increase in beta-amyloid (Abeta) pathology.

164 for a reduction in microstrain along with a twofold increase in charge-carrier mobilities leading to

165 a study was conducted in Arabidopsis, where twofold increase in folates occurred in foliage upon SA

166 Surprisingly, there was a twofold increase in hnRNP H protein in the striatal syna

167 ith the co-benzothiadiazole polymer having a twofold increase in hole mobility when compared to the I

168 abled the design of a mutant that displays a twofold increase in its off-to-on photoswitching quantum

169 sol-gel transition pH value to ca. 6, with a twofold increase in loss moduli at low frequencies and t

170 We find that there is a twofold increase in lumenal pressure during blastocyst d

171 thelial cells from human ADPKD kidneys had a twofold increase in mitochondria and MFN2 expression.

172 id transcriptome signature translated into a twofold increase in overall survival, indicating that th

173 ly, fibroblasts carrying the mutation showed twofold increase in proliferation rate associated with h

174 logical and morphometric analyses revealed a twofold increase in proliferative ECs and a 1.35-fold in

175 n response to Ti implants, contributing to a twofold increase in pullout strength compared to SS impl

176 Meanwhile, GRDs exhibit a twofold increase in r(1) relaxivity over gadopentetic ac

177 evels often surpassing the power gained by a twofold increase in sample size.

178 the cell than conventional TFM, leading to a twofold increase in spatial resolution (of up to 500 nm)

179 rough an extensive field survey, we detect a twofold increase in species diversity in the surveyed ar

180 Mutant mice demonstrate a twofold increase in T-regulatory cells, consistent with

181 re evident than during T-cell development: A twofold increase in the abundance of transcription facto

182 te the mutations conferring only a less than twofold increase in the affinity of its hemagglutinin fo

183 The resulting complex yielded a twofold increase in the amount of reducing sugars releas

184 ved from immature pig ovaries and provides a twofold increase in the efficiency of blastocyst product

185 s exacerbated response was associated with a twofold increase in the expression of Tlr4.

186 with the PPO inhibitor tropolone produced a twofold increase in the phenolic fraction, which would t

187 As a result of MRSA importations, an almost twofold increase in the prevalence of carriage was estim

188 domide augments NK-cell responses, causing a twofold increase in the proportion of primary NK cells p

189 wed the actin-induced powerstroke, despite a twofold increase in the rate constant for actin-activate

190 tissue culture cells results in a more than twofold increase in the rate of cell movement, in part d

191 e synthetic feed to color trout flesh (up to twofold increase in the retention of the main ketocarote

192 at lower decompression pressures is 8.2 K, a twofold increase in the same crystal structure as in com

193 discovered that cells lacking Ulp2 display a twofold increase in transcript levels across two particu

194 ATRX-deficient embryos exhibit a twofold increase in transcripts for aurora kinase B, the

195 dly, mice lacking hepatic lipogenesis have a twofold increase in tumour incidence and multiplicity co

196 l and anti-inflammatory activities, showed a twofold increase in vaginal delivery compared to CS with

197 n, future climatic conditions cause a nearly twofold increase of grain inorganic arsenic concentratio

198 fteen of 16 patients demonstrated at least a twofold increase of XPO1 mRNA, indicating inhibition of

199 DP and typical CIDP presentations, support a twofold increased relative risk of diabetes compared wit

200 FMF was associated with more than twofold increased risk for death after transplantation,

201 carriers had higher mean birth weights and a twofold increased risk for type 2 diabetes with a 7-year

202 g dnDSA (vs. no dnDSA) was associated with a twofold increased risk of CLAD (hazard ratio, 2.04; 95%

203 479R and C394S mutations resulted in similar twofold increases in amiloride-sensitive ENaC current.

204 s, CRF+urocortin2, resulted in approximately twofold increases in peak Ca(2+) responses, whereas stim

205 Accompanying twofold increases in photosynthetic CO2-assimilation rat

206 A series of porous twofold interpenetrated In-Co(III) (porphyrin) metal-org

207 The twofold interpenetrating structure brings adjacent Co(II

208 spontaneous IPSCs in CA1 pyramidal neurons >twofold (KA: P = 0.04; pilocarpine: P = 0.0002) which wa

209 persivity is changing with saturation, being twofold larger at the saturation of 0.52 compared to tha

210 ctional experiments implied an approximately twofold larger Ca(2+) channel density in high release pr

211 onse during a burst was on average more than twofold larger than the response to the first spike.

212 sponsiveness of piriform neurons is at least twofold less sparse than currently believed.

213 hese data, HigBA binding to each operator is twofold less tight than HigA alone.

214 ed to reduced tumor growth and approximately twofold longer survival in an orthotopic, isograft breas

215 ve for monitoring HOCs using fish, showing a twofold lower confidence range and requiring less sample

216 s, we show that M1 (A213) exhibits an almost twofold lower dissociation constant with its primary tar

217 anical feedback on cell growth can act via a twofold mechanism.

218 s were identified, and these were three- and twofold more likely, respectively, to encompass a known

219 in V. alginolyticus Faster cells accumulate twofold more tightly by chemotaxis compared with slower

220 it cell are related to each other by a local twofold noncrystallographic symmetry axis, a conformatio

221 Importantly, the IC50 for NSAH is within twofold of gemcitabine for growth inhibition of multiple

222 he overall increase in Et over land is about twofold of the decrease in Es.

223 g polypyrimidines although decreasing nearly twofold on ssDNA containing equal amounts of the four ba

224 For many of them, ribosome occupancy dropped twofold or even more.

225 f genes that are differentially expressed by twofold or greater in the Bullies; one of these was a pu

226 As is reviewed here, twofold or more improvements are possible as regards (a)

227 ds of these mRNAs have increased half-lives (twofold or more) in Mettl3 knockout cells compared with

228 re more mRNA targets than expected (often by twofold or more) relative to stringent controls.

229 26.7% of transcripts changed in abundance by twofold or more.

230 centrations, which decreased from tenfold to twofold over the same distance, but the spatial patterns

231 we either decrease nuclear deformability by twofold overexpression of the nuclear protein lamin A or

232 sed the odds of having an infant with BPD by twofold (P = 0.02).

233 eexisting hypertension was associated with a twofold (P = 0.04) increase in odds for BPD.

234 ted significantly increased speed (more than twofold, P < .0001), with mean repetition times compared

235 xenografts, were significantly higher (about twofold, P < 0.0001), compared with non-expressing contr

236 the expression levels of the full-length AR (twofold, P < 0.05) and the AR splice variants 1 (threefo

237 mutations produced substantial (greater than twofold) phenotypes of either increased or decreased spl

238 n Sestrin2 (hSesn2), and show that hSesn2 is twofold pseudo-symmetric with two globular subdomains, w

239 The twofold purpose of this systematic review was to: (i) pr

240 ymous changes at Thr6 and Leu9 resulted in a twofold range in FlgM activity.

241 improves editing efficiency by approximately twofold, reduces toxicity, and enables lyophilized stora

242 NRXN1(+/-) hiPSC-neurons show a greater than twofold reduction in half of the wild-type NRXN1alpha is

243 n per dot on average, we achieve a more than twofold reduction in the amplified spontaneous emission

244 cedented efficiency of 80%, accompanied by a twofold reduction in the exciton binding energy.

245 considering the total amount of volatiles, a twofold reduction was observed.

246 located adjacent to seagrass meadows showed twofold reductions in disease levels compared to corals

247 rowth in the tobRsLS::X lines were improved >twofold relative to tobRsLS.

248 se previously reported for Kilauea by nearly twofold, resembling a purer hotspot plume signature, suc

249 o C assimilation increased up to sixfold and twofold, respectively, with an increase of 3 degrees C a

250 onding to cytosolic signals and initiating a twofold response.

251 nce of degenerating axons is mechanistically twofold, resulting from deferred initiation of axonal WD

252 ombined results support the hypothesis for a twofold role of K in the mechanism of membrane fusion: 1

253 1D topological hinge states protected by the twofold rotational symmetry.

254 mer both in the crystal and in solution with twofold rotational symmetry.

255 logical crystalline insulator protected by a twofold rotational symmetry.

256 uently, xylan adopts a flattened ribbon-like twofold screw conformation when bound to cellulose in th

257 The twofold screw xylan is spatially close to cellulose, and

258 so during the active catalytic process; this twofold set of insights is significant in advancing the

259 strated to enhance ATP responses at P2X4 by ~twofold, similar to potentiation by the known positive m

260 Beyond the twofold stage, embryonic elongation in Caenorhabditis el

261 We also observe a twofold steepening of the relationship between sea level

262 tory of CT+ women exhibited an approximately twofold steeper increase after the pCRH inflection point

263 mineralization processes the organisms use a twofold strategy to control magnetite formation: the min

264 to 77 mum, the specific surface increases by twofold, structural integrity was lost and water extract

265 siRNA-L2 tumor accumulation diminished only twofold, suggesting that the superior tumor distribution

266 ANE contribution of the isolated FM alloy is twofold, surface and bulk.

267 the dynamics in the threefold symmetric and twofold symmetric polymorphs of native Abeta as well as

268 a 2:1 stoichiometry induces an extended and twofold symmetrical conformation of IgE, which retains a

269 display domains of anisotropic friction with twofold symmetry and anisotropy exceeding 200%.

270 in hexamers (intrahexamer) and threefold and twofold symmetry between neighboring hexamers (interhexa

271 homometallic congeners, due to threefold-to-twofold symmetry reduction, resulting in cuprophilic sen

272 Here, we take on the twofold task of deriving features directly from empirica

273 Together, the pathogenic effects of MDM2 are twofold, that is, p53-independent NF-kappaB activation i

274 oop mutations that reduced the koff value by twofold, these mutations resulted in an overall selectiv

275 ren associated with schizophrenia itself was twofold to 15-fold greater than the positive effect asso

276 ometry of the nuclear envelope, ranging from twofold to an order magnitude larger than the correspond

277 -silenced osteosarcoma cells caused a marked twofold to fivefold decrease in spontaneous lung metasta

278 R/Cas9 cleavage, increases HDR efficiency by twofold to fivefold relative to circular plasmid donors

279 UT1, GLUT3, GLUT6, and GLUT10 protein levels twofold to fivefold.

280 in self-renewing proliferation leading to a twofold to fourfold expansion of the HSPC pool in the BM

281 f their class, activated neurons exhibited a twofold to fourfold increase in their firing, which star

282 Diabetic patients have a twofold to fourfold increased risk of cardiovascular dis

283 ression, resulting in a subset of Tregs with twofold- to fivefold-lower levels of FoxP3 protein.

284 Our objectives were twofold: to evaluate the incidence and time to recovery

285 The aim of this study was twofold: to explore potential age- and sex-specific thre

286 The purpose of this study is twofold: to understand how cardiovascular system models

287 ) as compared to incompatible interaction (> twofold unique transcripts, 314:681:487 :: 1:3:8 DPI).

288 esulted in distinct plant gene activation (> twofold unique transcripts, 335:191:1762 :: 1:3:8 DPI) a

289 An unprecedented ruthenium (Ru)-catalyzed twofold unsymmetrical annulation of 3-O/N-allyl benzoic

290 Our proteomic study quantified 518 twofold up-regulated and 811 twofold down-regulated prot

291 ome degeneration, X-linked genes have become twofold up-regulated, restoring ancestral expression lev

292 oth the (24)Mg and (26)Mg isotopes and up to twofold using a 10(11) Omega resistor for the most abund

293 ng relaxation time maps demonstrated up to a twofold variation in mean regional T1 and T2 after ablat

294 for the formation of benzothiophenes by the twofold vicinal C-H functionalization of arenes that doe

295 nd by increasing the concentration of VMO by twofold, we could knockdown six genes simultaneously.

296 The significance of this work is twofold: we have both uncovered genomic features by whic

297 The goals of this study were twofold; we sought to (1) identify the molecular mechani

298 stress to increase bleaching severity up to twofold when nitrogen was high and heat stress was relat

299 These levels increased additionally twofold when the stored samples were heated (40 degrees

300 actinin-4 homodimers increases approximately twofold within the cellular range of cortical mechanical