1 n K16 are shorter than those formed by other
type I keratins.
2 The
type I keratins 14 (K14) and 16 (K16) are distinct in th
3 We previously hypothesized that the
type I keratin 16 (K16) plays a role in the process of k
4 e existence of the mouse equivalent of human
type I keratin 16 (K16).
5 Mutations in the
type I keratin 16 (Krt16) and its partner type II kerati
6 study, we analyzed the distribution of mouse
type I keratin 16 during skin morphogenesis, in the adul
7 The type II keratin 6 and
type I keratins 16 and 17 are induced well before cell m
8 The
type I keratin 17 (K17) shows a peculiar localization in
9 Onset of
type I keratin 17 (K17) synthesis marks the adoption of
10 Inactivating the
type I keratin 17 gene (mK17) causes severe but reversib
11 in protein that bears high similarity to the
type I keratins and displays a unique expression profile
12 Our results indicate that
type I keratins are targets of apoptosis-activated caspa
13 keratin gene cluster on 12q; and K12 to the
type-I keratin cluster on 17q using radiation hybrids.
14 been removed, or copolymers of K5 and K19, a
type I keratin featuring a short tail domain.
15 8 and D17S957, a region known to contain the
type I keratin gene cluster and other genes expressed in
16 ocated at the beginning of the rod domain of
type I keratins,
is particularly sensitive to amino acid
17 eton and developed massive aggregates of the
type I keratin,
K10.
18 tate of VEMDA, a consensus sequence found in
type I keratins K12-17 with similar but not identical se
19 We show here that yet another related
type I keratin,
K17, forms stable heterotetramers with a
20 Type I keratins K18 and K19 undergo caspase-mediated deg
21 ssion of the type-II keratin K8 up-regulated
type-I keratins K18, K19, and K20 and generated K19/K20-
22 tion that maps to chromosome 11 close to the
type I keratin locus.
23 Several K14 (another
type I keratin)
mutations within the caspase cleavage mo
24 understood, caspase-mediated degradation of
type I keratins occurs during apoptosis and the proteaso
25 stream from mK17 is functional and encodes a
type I keratin protein highly analogous to mK17.
26 bait in a yeast two-hybrid screen pulls out
type I keratin sequences from a skin cDNA library.
27 9 regulation or function, and the only other
type I keratin that has been studied in terms of regulat
28 Keratin 15 (K15), a
type I keratin,
which pairs with K5 in epidermis, has be
29 perties that suggest different regulation of
type I keratins within the same cells.
30 Keratin 15 (K15) is a
type I keratin without a defined type II partner whose e