ライフサイエンスコーパス: type IV collagen

1 ies to the NC1 domain of the alpha3 chain of type IV collagen.

2 ong triple helix domain of basement membrane type IV collagen.

3 rface also showed positive stain results for type IV collagen.

4 scular endothelial marker CD31 surrounded by type IV collagen.

5 GPOGAAVMGPOGPO found in the alpha5 chain of type IV collagen.

6 terations in the triple helical structure of type IV collagen.

7 inhibits the secretion of mutant and normal type IV collagen.

8 ten, is derived from the carboxy terminal of type IV collagen.

9 icroscopy to show positive stain results for type IV collagen.

10 he COL4A5 gene, encoding the alpha5 chain of type IV collagen.

11 3 degradation of both human type I and human type IV collagen.

12 iveness of ARCaP cells across fibronectin or type IV collagen.

13 at do not bind to DAF, but retain binding to type IV collagen.

14 croscopy, and immunolocalization of CD31 and type IV collagen.

15 agglutinin, also binds to a second receptor, type IV collagen.

16 GR/MYOC bound fibronectin but not laminin or type IV collagen.

17 or, the DraE fusion proteins did not bind to type IV collagen.

18 s to extracellular matrix proteins including type IV collagen.

19 e adhesion of glomerular epithelial cells to type IV collagen.

20 to the consensus sequence are found in human type IV collagen.

21 to the alpha3, alpha4, and alpha5 chains of type IV collagen.

22 in genetic and acquired diseases that affect type IV collagen.

23 a3 non-collagenous globular (NC1) domains of type IV collagen.

24 genous 1 (NC1) domain of the alpha3 chain of type IV collagen.

25 fibronectin, laminin-5, type I collagen, and type IV collagen.

26 ha1 integrins impaired only cell adhesion to type IV collagen.

27 at all to fibronectin, type I collagen, and type IV collagen.

28 hains designated alpha1-alpha6 that comprise type IV collagen.

29 ased (p < 0.05) levels of the 7S fragment of type IV collagen.

30 in pericyte-conditioned medium and purified type IV collagen.

31 n and matrix accumulation of fibronectin and type IV collagen.

32 ntional Ser/Thr kinase for basement membrane type IV collagen.

33 on to extracellular matrix proteins, such as type IV collagen.

34 gene was COL4A2 (P = 1.41 x 10(-8)) encoding type IV collagen.

35 ar matrix proteins fibronectin, laminin, and type IV collagen.

36 l a site in heterotrimeric basement membrane type IV collagen.

37 n response to laminin 1 but not to type-I or type-IV collagen.

38 lagenase 3 can degrade aggrecan, type II and type IV collagens.

39 le-helical regions within basement membrane (type IV) collagen.

40 of the alpha3, alpha4, and alpha5 chains of type IV collagen: (1) type IV collagen alpha1 and alpha2

41 ally exclusive expression pattern to that of type IV collagen, a basement membrane marker.

42 Type IV collagen, a major constituent of BMs, is critica

43 einase 2 (MMP-2), which specifically cleaves type IV collagen, a major structural component of baseme

44 rum with recombinant alpha5(IV)NC1 domain of type IV collagen abolished immunoreactivity with the 185

45 genetic studies have shown that mutations in type IV collagen account for a significant proportion of

46 (adventitia) into the vascular media, while type IV collagen accumulates in an internal pattern (int

47 se zymography, proteins by Western blot, and type IV collagen accumulation by ELISA and immunostainin

48 tern blot, MMP-2 activity by zymography, and type IV collagen accumulation by ELISA.

49 mation of this mesenchyme is the turnover of type IV collagen along the basal surface of endocardial

50 Here, we show that a mutation in the type IV collagen alpha 1 (Col4a1) gene can cause both AS

51 Mutations in the type IV collagen alpha 1 gene (COL4A1) cause dominantly

52 , and alpha5 chains of type IV collagen: (1) type IV collagen alpha1 and alpha2 chains, (2) type V co

53 e have utilized triple-helical models of the type IV collagen alpha1(IV)1263-1277 sequence to (a) det

54 In the infant DM, type IV collagen alpha1-alpha6 chains, perlecan, nidogen

55 ncollagenous domain 1 of the alpha1 chain of type IV collagen [alpha1(IV)NC1], or arresten, is derive

56 ne, and recently we identified a fragment of type IV collagen alpha2 chain with specific anti-angioge

57 sence of type XVIII collagen (endostatin) or type IV collagen alpha3 chain (tumstatin) or TSP-1 to as

58 The second model is a mouse with deletion of type IV collagen alpha3 chain in the glomerular basement

59 o a partial restoration of expression of the type IV collagen alpha3 chain with concomitant emergence

60 genous domain-1 (NC1) of the alpha3 chain of type IV collagen (alpha3(IV)NC1), the Goodpasture autoan

61 ecombinant NC1 domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] develop anti-GBM antibo

62 man alpha3 chain, a noncollagenous domain of type IV collagen [alpha3(IV)NC1], inhibits angiogenesis

63 ecombinant NC1 domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1].

64 noncollagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1, but critical early T ce

65 oncollagenous domain of the alpha 3 chain of type IV collagen, alpha3(IV)NC1.

66 elf-epitope derived from the alpha3 chain of type IV collagen (alpha3135-145).

67 ncollagenous domain 1 of the alpha3-chain of type IV collagen (alpha3IV-NC1).

68 noncollagenous domain of the alpha3 chain of type IV collagen (alpha3NC1) developed albuminuria assoc

69 MDA-MB-435 cells stimulated cell adhesion to type IV collagen and activated the p38 MAPK pathway, inc

70 collagen molecules known as alpha 3 chain of type IV collagen and alpha1 chain of type XVIII collagen

71 of the basement membrane components, alpha1-type IV collagen and alpha2-type IV collagen, gamma1-lam

72 fibronectin, laminin-5, type I collagen, and type IV collagen and also supported human dermal fibrobl

73 A-MET cells show increased early adhesion to type IV collagen and are significantly more invasive thr

74 enal receptors for Dr-fimbriated E. coli are type IV collagen and decay-accelerating factor (DAF).

75 erium tuberculosis (Mtb) causes breakdown of type IV collagen and decreases tight junction protein (T

76 ron microscope analysis, the distribution of type IV collagen and effects of fibrosis on myocyte memb

77 hibit a marked increase in chemotaxis toward type IV collagen and fibronectin but not to laminin, col

78 id-Schiff staining and immunofluorescence of type IV collagen and fibronectin) and proteinuria.

79 751, exhibited greatly increased adhesion to type IV collagen and fibronectin.

80 ctive metalloproteinase, which degraded both type IV collagen and gelatin prepared from fibrillar col

81 unique in this family since it also binds to type IV collagen and its binding is inhibited by the pre

82 embrane integrity, as seen by degradation of type IV collagen and laminin 5.

83 n (entactin) can form a ternary complex with type IV collagen and laminin and is thought to play a cr

84 acellular matrix (ECM) components type I and type IV collagen and laminin were analyzed by Western bl

85 revealed diminished glomerular deposition of type IV collagen and laminin, and diminished interstitia

86 rins likely to be the main receptors for GBM type IV collagen and laminin.

87 increased MMP9 coincided with degradation of type IV collagen and loss of vascular integrity.

88 erated in different matrices and attached to type IV collagen and Matrigel as efficiently as the wild

89 These give rise to AS-DL by disruption of type IV collagen and perhaps other as yet unidentified g

90 ve induction of apoptosis in the presence of type IV collagen and TNF-alpha in vitro.

91 s diffuse and increased levels of type I and type IV collagen and transforming growth factor-beta 1 m

92 ned by two-color immunofluorescence for C4d, type IV collagen and Ulex europaeus agglutinin I.

93 Separate specimens were labeled for Type-IV collagen and fibronectin.

94 scular endothelial growth factor, and alpha5 type IV collagen) and associated with widened foot proce

95 umstatin (the NC1 domain of alpha 3 chain of type IV collagen) and its deletion mutant tum-5 possess

96 etal organization, similar to those grown on type IV collagen, and demonstrated reduced synthesis of

97 emonstrated that ADAM 12-S degrades gelatin, type IV collagen, and fibronectin but not type I collage

98 ed, as well as the increases in PAI-1, VEGF, type IV collagen, and fibronectin expression.

99 , vascular endothelial growth factor (VEGF), type IV collagen, and fibronectin, resulting in glomerul

100 o self-assemble, interact with nidogen-1 and type IV collagen, and form extracellular matrices on cul

101 ithelial cells, but also to type I collagen, type IV collagen, and laminin.

102 xtracellular matrix proteins fibronectin and type IV collagen, and loss of podocyte markers WT1 and s

103 ) is required for increased cell adhesion to type IV collagen, and this activation is sensitive to in

104 heroids adhered to fibronectin, laminin, and type IV collagen, and this adhesion was partially inhibi

105 ith extracellular matrix components, such as type IV collagen, and with the innate immune protein ser

106 s quantitated by immunolabeling with an anti-type-IV collagen antibody.

107 sited antibodies that bind basement membrane type IV collagen antigens in the glomerulus and lung alv

108 evious ones, indicate that the six chains of type IV collagen are distributed in three major networks

109 Compositionally, our results identify type IV collagen as the first macromolecular biomarker o

110 inverted polarized cysts, with no laminin or type IV collagen assembly at cell/extracellular matrix c

111 Inhibition of type IV collagen assembly by the alpha1NC1 domain up-reg

112 onstrating that nidogen is not essential for type IV collagen assembly into basement membranes.

113 These findings support the notion that type IV collagen assembly may be regulated by tissue-spe

114 that protomer (the trimeric building unit of type IV collagen) assembly is mediated by the NC1 domain

115 vidence that the interaction between Dpp and type IV collagen augments Dpp signalling in the embryo b

116 Anti-human type IV collagen basement membrane immunoreactivity and

117 toantibodies against the alpha3(IV) chain of type IV collagen bind to the glomerular and alveolar bas

118 We conclude that type IV collagen binding mediated by DraE adhesin is a c

119 binds to alpha1beta1 integrin, competes with type IV collagen binding to alpha1beta1 integrin, and in

120 On the basis of our findings that human type IV collagen binds BMP4, we predict that this role o

121 We observed upregulation of type IV collagen but downregulation of both laminin and

122 DraE adhesin subunit that was unable to bind type IV collagen but retained binding to DAF and examine

123 C colocalized with fibronectin, laminin, and type IV collagen, but not thrombospondin in both dexamet

124 le factor 1alpha and VEGF in ECs cultured on type IV collagen by inhibiting ERK1/2 and p38 activation

125 d modification of vascular basement membrane type IV collagen by methylglyoxal, a dicarbonyl glycatin

126 scorbate-dependent maturation and release of type IV collagen by the cells in culture.

127 tal loss of retinal neuron responsiveness to type IV collagen, by promoting the function of integrin

128 alpha5(IV)NC1, among the six NC1 domains of type IV collagen, by Western blot and enzyme-linked immu

129 e I collagen (C1M), type III collagen (C3M), type IV collagen (C4M) and a pro-peptide of type III col

130 alpha2, alpha3, alpha4, and alpha5 chains of type IV collagen can be detected using alpha chain-speci

131 associated with mutations in genes encoding type IV collagen chains present in the glomerular baseme

132 aracterize the role of signal transducers in type IV collagen (CIV) induced A2058 human melanoma cell

133 in cells stimulated with VEGF and plated on type IV collagen-coated dishes.

134 AM-OOC contained 2 chambers connected by type IV collagen-coated microchannels, allowing independ

135 of gelatinase B bound to either gelatin- or type IV collagen-coated surfaces.

136 us (NC-1) domain of the alpha3 (IV) chain of type IV collagen (COL IV) enhanced tumor cell adhesion.

137 with hearing loss, results from mutations in type IV collagen COL4A3, COL4A4, or COL4A5 genes.

138 In mice lacking the alpha3 chain of type IV collagen (Col4A3 knockout mice), a model for Alp

139 gh previous work has shown that VWF can bind type IV collagen (collagen 4), little characterization o

140 MDA-MB-435 breast carcinoma cell adhesion to type IV collagen (collagen IV) in vitro.

141 Heterotrimeric type IV collagen, composed of different combinations of

142 Type IV collagen composition of infant corneal central E

143 Laminin and type IV collagen composition of the glomerular basement

144 ed the possible interaction between CLIC and type IV collagen, confirmed by protein structure predict

145 The network organization of type IV collagen consisting of alpha3, alpha4, and alpha

146 dditionally, tumor cell binding sites within type IV collagen contain glycosylated hydroxylysine resi

147 Without reduction, type IV collagen contained macromolecular alpha-chains o

148 cellular hypertrophy, and matrix laminin and type IV collagen content was inhibited by sodium hydrosu

149 Here we show that type IV collagen contributes to the maintenance of the e

150 nished interstitial deposition of type I and type IV collagen correlated with decreases in TGF-beta 1

151 ombinant form of the alpha2(IV)NC1 domain of type-IV collagen could bind integrins alpha1beta1 and al

152 Inhibition of MMPs or targeting of type IV collagen cryptic sites by antibody HUIV26 did no

153 obulin G, Evans blue leakage into brain, and type IV collagen degradation were markedly reduced in th

154 gions of low matrix protein (laminin-511 and type IV collagen) deposition that have been termed low-e

155 more, cathepsin S affected the production of type IV collagen-derived anti-angiogenic peptides and th

156 Immunoreactivity for both laminin 5 and Type IV collagen did not show any significant difference

157 In vitro experiments suggest that type IV collagen does not provide a suitable migratory s

158 Type-IV collagen EF distinctly outlined the AF beams in

159 Type IV collagen exists in a highly complex suprastructu

160 nscriptional and developmental regulation of type IV collagen expression is unknown.

161 TGF-beta-dependent fibronectin and type IV collagen expression under high glucose condition

162 was evaluated by detection of laminin 5 and Type IV collagen expressions on immunohistochemically st

163 Here we show that type IV collagen extracellular matrix proteins bind Dpp

164 s and potentially disrupts the deposition of type IV collagen, facilitating EMT in vitro.

165 Members of the type IV collagen family are essential components of all

166 proteinase inhibitor, alpha(2)-macrogobulin, type IV collagen, fibronectin, lactoferrin, transferrin,

167 lymeric networks - one of laminin and one of type IV collagen (Figure 1, bottom).

168 ation (PRO-C3 and PRO-C5), basement membrane type IV collagen formation (PRO-C4) and degradation (C4M

169 mponents, alpha1-type IV collagen and alpha2-type IV collagen, gamma1-laminin and beta2-laminin, were

170 on frame its roles in a hierarchy regulating type IV collagen gene expression.

171 fecting kidneys, mutations in GBM-associated type IV collagen genes (COL4A3, COL4A4, or COL4A5) lead

172 h regulates the expression of key glomerular type IV collagen genes COL4A3 and COL4A4 or nephrin, a g

173 e-specific expression patterns of the paired type IV collagen genes COL4A5 and COL4A6 form the basis

174 ns encompassing the 5' termini of the paired type IV collagen genes COL4A5 and COL4A6 on chromosome X

175 Mutations in both alleles of the autosomal type IV collagen genes, or hemizygous mutations in the X

176 embrane (GBM) disease caused by mutations in type IV collagen genes.

177 genetic disorder resulting from mutations in type IV collagen genes.

178 Thus, prolyl 3-hydroxylation of type IV collagen has an important function preventing ma

179 Structural abnormalities of type IV collagen have been associated with diverse biolo

180 ment, the cellular origins for the different type IV collagen heterotrimers that appear during develo

181 to evaluate the expression of laminin 5 and Type IV collagen histologically in regenerating gingival

182 Type IV collagen-immunoreactive sleeves were also presen

183 aining platelet aggregates exhibited loss of type IV collagen immunoreactivity and both intra- and ex

184 evealed that basement membrane identified by type IV collagen immunoreactivity covered >99.9% of the

185 A significant (n=7; P<0.01) diffuse loss of type IV collagen immunoreactivity in microvessels was te

186 me (AS), a rare disease of basement membrane type IV collagen, impacts the kidneys, ears, and eyes.

187 Both nid-1 mutants assemble type IV collagen in a completely wild-type pattern, demo

188 th an intraocular lens (IOL) on a surface of type IV collagen in an evaluation of the importance of t

189 domains of non-fibrillar collagens, such as type IV collagen in basement membranes.

190 by the alpha3, alpha4, and alpha5 chains of type IV collagen in establishing and maintaining the com

191 ence of alpha3, alpha4, and alpha5 chains of type IV collagen in the Alport kidney leads to alloantib

192 differences were seen in the distribution of type IV collagen in the BMZ of both budding and resting

193 bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GB

194 lose renal function as a result of defective type IV collagen in their glomerular basement membrane.

195 This novel approach to explore the assembly type IV collagen in vivo offers novel insights in the sp

196 hese results identify a critical function of type IV collagens in modulating Dpp in the extracellular

197 roitin and heparan sulfate proteoglycans and type IV collagen, in or adjacent to all injection sites.

198 The NC1 domains of human type IV collagen, in particular alpha3NC1, are inhibitor

199 Type IV collagen includes six genetically distinct polyp

200 We now show that type IV collagen is a component within the morphological

201 Type IV collagen is a major and crucial component of bas

202 Type IV collagen is a major component of basement membra

203 Type IV collagen is a major component of vascular baseme

204 Type IV collagen is a predominant component of basement

205 In the airways, where type IV collagen is abundant, but not the spleen, the CD

206 Type IV collagen is critical for BM function, yet how it

207 ion and cell-matrix adhesion by showing that type IV collagen is essential for inter-adipocyte adhesi

208 Although type IV collagen is heavily glycosylated, the influence

209 Type IV collagen is the major structural component of th

210 x metalloproteinase 2 (MMP2), which degrades Type IV collagen, is produced as proMMP2.

211 endopeptidase that digests basement-membrane type IV collagen, is related to tumor progression in vit

212 Expression of type IV collagen isoforms and keratan sulfate proteoglyc

213 o hydrolyze the basement membrane components type IV collagen, laminin, and nidogen, as well as the l

214 ed to immunostaining with ZO-1, connexin 43, type IV collagen, laminin-5, and perlecan, and apoptosis

215 mposed of a mixture of laminin, entactin and type-IV collagen (LEC matrix) 'resets' these endothelial

216 n enhancement of the size of laminin-511 and type IV collagen LERs.

217 4 and/or TIMP-2 contributed to the return of type IV collagen levels to normal.

218 atelet endothelial cell adhesion molecule 1, type IV collagen, matrix metalloproteinase 9, platelet-d

219 ed for intracellular ascorbate to facilitate type IV collagen maturation and release by endothelial c

220 pha3beta1 integrins and impaired adhesion to type IV collagen may contribute to the glomerular epithe

221 l fibrillation and that CLICs and structural type IV collagen may interact on each other to promote t

222 In contrast, loss of type IV collagen may represent a biochemical rationale f

223 e of these regions, alpha1(IV)1263-1277 from type IV collagen, mediates these responses via melanoma

224 transwell cell culture inserts coated with a type-IV collagen membrane on which an IOL (one-piece Tec

225 eraction between GPVI and non-3-hydroxylated type IV collagen might also play a role in the progressi

226 sence of aromatic residues on both ends of a type IV collagen model peptide is observed to greatly ac

227 Type IV collagen mutations are associated with a continu

228 and immunoblotting with GBM constituents and type IV collagen NC1 domains from bovine, human, and rec

229 human alpha1NC1 domain inhibits assembly of type IV collagen NC1 hexamers and potentially disrupts t

230 n identified on the noncollagenous domain of type IV collagen (NC1 domain) of the alpha3(IV) chain as

231 re sequestered within the NC1 hexamer of the type IV collagen network containing the alpha3(IV), alph

232 n the NC1 hexamer complex that occurs in the type IV collagen network found in tissues and inaccessib

233 suggested that assembly of alpha5 chain into type IV collagen network is dependent on alpha3 expressi

234 supramolecular matrices built on laminin and type IV collagen networks that provide structural and si

235 ajor components of the GBM include laminins, type IV collagen, nidogens and heparan sulfate proteogly

236 An amino-terminal region of alpha3 chain of type IV collagen noncollagenous domain [alpha3(IV)NC1] t

237 P), a nonconventional Ser/Thr kinase for the type IV collagen of basement membrane, are regulated by

238 Accumulation of type IV collagen onto the cell surface was found to requ

239 s did not inhibit attachment or spreading on type IV collagen or fibronectin.

240 BmpA did not bind mammalian type I or type IV collagens or fibronectin.

241 the binding of divalent cations, full-length type IV collagen, or a function-blocking monoclonal anti

242 lls spread on fibronectin, VCAM-1, type I or type IV collagen, or beta1 integrin antibodies.

243 tibodies to TIGR/MYOC, fibronectin, laminin, type IV collagen, or thrombospondin were used to determi

244 five (alpha1 to alpha5) of the six chains of type IV collagen, organized into an alpha1.alpha2(IV) an

245 f endothelial cells leaving behind avascular type IV collagen-positive empty sleeves with remaining p

246 in, a ligand of alpha(5)beta(1) integrin, or type IV collagen produced patchy sites of leakage instea

247 hyma expressed CD49a, the alpha-chain of the type IV collagen receptor VLA-1, and these cells were hi

248 We hypothesized that type IV collagen receptor-mediated BM-interstitial tropi

249 Furthermore, type IV collagen recruitment into the laminin extracellu

250 urthermore, the basement membrane-associated type IV collagens regulate ISC self-renewal by confining

251 nent in the gonadal BM, where it facilitates type IV collagen removal during BM expansion and tissue

252 X-linked gene encoding the alpha 5 chain of type IV collagen, result in progressive renal disease th

253 with type VII collagen, we hypothesized that type IV collagen should also be localized to the DEJ in

254 ppearance of dissociated pericytes and empty type IV collagen sleeves.

255 Preincubation of PLTs with type IV collagen specifically increased TLR9 and CD62P s

256 hils stained positively for laminins but not type IV collagen, suggesting that different mechanisms e

257 ne-aminated poly(glycidyl methacrylate)) and type IV collagen targeted peptide (ColIV) for targeted n

258 the 26-kDa NC1 domain of the alpha1 chain of type IV collagen, termed arresten.

259 egrin-dull keratinocytes were more motile on type IV collagen than beta1 integrin-bright keratinocyte

260 reater migratory response to fibronectin and type IV collagen than their non-CS-attached counterparts

261 mmune disease is caused by autoantibodies to type IV collagen that bind to the glomerular basement me

262 Tumstatin is a 28-kilodalton fragment of type IV collagen that displays both anti-angiogenic and

263 ied a peptide p13 of alpha3(IV)NC1 domain of type IV collagen that induces experimental autoimmune gl

264 tigen (the NC1 domain of the alpha3 chain of type IV collagen) that are rapidly destroyed during anti

265 Type IV collagen, the major component of basement membra

266 mice deficient in either the alpha3 chain of type IV collagen, the major constituent of glomerular ba

267 In type IV collagen, these sites are normally 3-hydroxylate

268 ese peptides are derived from members of the type IV collagen, thrombospondin, and CXC chemokine prot

269 al transduction events that are initiated by type IV collagen through beta1 integrins and demonstrate

270 hat ROS can alter the hexameric structure of type IV collagen to expose or destroy selectively immuno

271 d with monoclonal antibodies for laminin and type IV collagen to highlight the presence of small bloo

272 iptional levels remained unaffected, whereas type IV collagen transcripts decreased with HQ.

273 d associates with other alpha-chains to form type IV collagen triple helical networks.

274 nd the sequence to which it binds within the type IV collagen triple-helix has been identified.

275 To test the role of the type IV collagen tropism of Dr-fimbriated E. coli in ren

276 sion of matrix metalloproteinase (MMP)-2 and type IV collagen, two molecules that are necessary for r

277 ssion of BM components, including laminin-5, type IV collagen, type VII collagen, perlecan, integrin

278 sion of alpha1, alpha2, and alpha5 chains of type IV collagen was detectable.

279 Expression of MMP-2 and type IV collagen was examined by real-time RT-PCR on tot

280 esidue sequence from human basement membrane type IV collagen was introduced between (Gly-Xaa-Yaa)(n)

281 sibility of extracellular deglycosylation of type IV collagen was investigated, but no beta-galactosi

282 focal microscopy revealed that immunostained type IV collagen was restricted to the 5- to 10-microm-w

283 Type IV collagen was strictly intimal/medial.

284 tumstatin (the NC1 domain of alpha3 chain of type IV collagen) was identified as possessing anti-angi

285 lagenous (NC1) domain of the alpha2 chain of type IV collagen, was previously shown to induce apoptos

286 Canstatin, a fragment of the alpha2 chain of type IV collagen, was produced as a recombinant molecule

287 ellular channel (CLIC) 1, 4, 5 and a rise in type IV collagen were revealed.

288 ally distinct noncollagenous (NC) domains of type-IV collagen were shown to interact with integrin re

289 d cornea (type I collagen) and lens capsule (type IV collagen) were dissected from mouse eyes, and mu

290 in, a marker of new matrix synthesis, and of type IV collagen, were reduced in glomeruli and intersti

291 hibited both RhoA activation and adhesion on type IV collagen, whereas a constitutively active p115Rh

292 and to a lesser extent the alpha5-chains of type IV collagen, which are exposed following disruption

293 ding the alpha3, alpha4, or alpha5 chains of type IV collagen, which form the collagenous network of

294 icate that Slit binds to Dragnet (Col4a5), a type IV Collagen, which forms the basement membrane on t

295 Type IV collagen, which is present in all metazoan, exis

296 Finally, we show that type IV collagen, which lacks clustering activity on its

297 ) by uncontrolled buildup of ECM, especially type IV collagen, which progressively occludes the capil

298 gen binds BMP4, we predict that this role of type IV collagens will be conserved.

299 interaction of non-3-hydroxylated embryonic type IV collagen with the maternal platelet-specific gly

300 ch there is diffuse perisinusoidal fibrosis (type IV collagen) without zonal predilection.