ライフサイエンスコーパス: type VI collagen

1 bronectin, fibrillin-1, MAGP-1, decorin, and type VI collagen.

2 , and MAGP-1 and moderately with decorin and type VI collagen.

3 ell matrix and when it was bound to purified type VI collagen.

4 nctional interaction of these receptors with type VI collagen.

5 I transmembrane proteoglycan that binds with type VI collagen.

6 ha 1 beta 1 mediates chondrocyte adhesion to type VI collagen.

7 75% of the adhesion of human chondrocytes to type VI collagen.

8 subunit to block adhesion of chondrocytes to type VI collagen.

9 reated cells also have decreased adhesion to type VI collagen.

10 ted that the NG2 proteoglycan interacts with type VI collagen.

11 NG2 was shown to bind to pepsin-solubilized type VI collagen.

12 ndibular condylar cartilage (MCC) is rich in type VI collagen.

13 work we analysed the amino acid sequence of type VI collagen, a non-fibrillar collagen that forms an

14 Type VI collagen, a soluble extracellular matrix protein

15 These data indicate that two receptors for type VI collagen, alpha 3 beta 1 and NG2, are present du

16 The occasional co-localization of type VI collagen and fibrillin adjacent to internal elas

17 ayed dipeptidase activity and degraded human type VI collagen and fibrinogen, but not salivary amylas

18 The metabolic roles of type VI collagen and its cleavage peptide endotrophin in

19 ures in the dense collar that correlate with type VI collagen and LOX, both of which are associated w

20 re investigated the relationships among vWF, type VI collagen, and fibrillin in human vascular subend

21 and alpha2 chains, (2) type V collagen, (3) type VI collagen, and most recently (4) the laminin alph

22 llagen and interacts with type III collagen, type VI collagen, and type X collagen, but not with type

23 ple-helical domain or the globular domain of type VI collagen appear to cause Bethlem myopathy.

24 model, localized disruptions of pericellular type VI collagen are observed on the central and medial

25 To identify type VI collagen binding proteins, the amino-terminal do

26 ave proposed that vWF is not associated with type VI collagen but rather with the thicker elastin-ass

27 ults are consistent with the hypothesis that type VI collagen, but not fibrillin-containing microfibr

28 Type VI collagen (COL6), a widely distributed ECM molecu

29 lies and the alpha 1 and alpha 2 subunits of type VI collagen (COL6A1 and COL6A2) have been postulate

30 is had higher levels of collagens, including type VI collagen, compared with tissue from control indi

31 ith stable knockdown of COL6A1 revealed that type VI collagen-deficient matrices were significantly t

32 en and sulfated proteoglycans present in the type VI collagen-depleted matrices.

33 e corneal stroma is associated with abundant type VI collagen deposition.

34 sts cultured on de-cellularized CDMs lacking type VI collagen displayed increased cell spreading, mig

35 Type VI collagen filaments are found associated with int

36 The strong interaction of type VI collagen filaments with basement membrane collag

37 y of type VI collagen tetramers or stabilize type VI collagen filaments, a two-hybrid screen of a hum

38 n chromosome 2q where the alpha 3 subunit of type VI collagen has been localized.

39 study we examined the expression pattern of type VI collagen in normal and wounded skin and investig

40 NG2 is found to colocalize with pericellular type VI collagen in superficial layer cells in the MCC p

41 onstrate for the first time that deletion of type VI collagen in this knockout model plays a critical

42 Colocalization of NG2 and type VI collagen indicated that this collagen was presen

43 ologically identical to decorin proteins and type VI collagen, indicating that the expression of spec

44 y defines the temporospatial dynamics of NG2-type VI collagen interactions during the progression of

45 Taken together, these findings indicate that type VI collagen is a key regulator of dermal matrix ass

46 Type VI collagen is a nonfibrillar collagen expressed in

47 Type VI collagen is well known for its role in muscular

48 These included proteins such as type IV and type VI collagen, laminin, nidogen and perlecan/HSPG2 th

49 are closely associated with, and enmesh, the type VI collagen microfibrils and have structural simila

50 We found that vWF co-localizes only with the type VI collagen microfibrils in subendothelium but not

51 We previously presented evidence that type VI collagen microfibrils serve as a binding site fo

52 The classical double-beaded appearance of type-VI collagen microfibrils was evident on mica coated

53 ive supramolecular assemblies: fibrillin and type-VI collagen microfibrils.

54 s coding the alpha 1 and alpha 2 subunits of type VI collagen on chromosome 21q, we carried out linka

55 In addition to the type VI collagen polypeptides, an extra 68-kDa protein b

56 ix components such as laminin, tenascin, and type VI collagen, produces cells with mosaic characteris

57 hanol or dithiothreitol, the alpha chains of type VI collagen ran into the gel.

58 To clarify the role of this collagen, two type VI collagen receptors were studied during corneal d

59 We hypothesized that type VI collagen regulates matrix assembly and cell func

60 o effect on secretion of the alpha3 chain of type VI collagen, secretion of the protein hormone adipo

61 family linked to 2q37, implicating the three type VI collagen subunit genes, COL6A1 (chromosome 21),

62 eased release and evidence of proteolysis of type VI collagen subunits, cartilage oligomeric matrix p

63 ression of alpha 1 beta 1 and on adhesion to type VI collagen suggest that alpha 1 beta 1 mediates ch

64 o identify proteins that promote assembly of type VI collagen tetramers or stabilize type VI collagen

65 c muscle, a goat antibody recognizing bovine type VI collagen to stain the lining of vessels, and the

66 th tissue-derived decorin including collagen type VI, collagen type I, and fibronectin.

67 WF in the vascular subendothelium, where the type VI collagen-vWF complex may play an important role

68 Type VI collagen was adventitial or adventitial/medial.

69 Type VI collagen was expressed throughout the dermis of

70 Type VI collagen was extracted from cornea with urea and

71 Binding of NG2 to type VI collagen was shown to be concentration-dependent

72 bronectin, fibrillin-1, MAGP-1, decorin, and type VI collagen were all localized to clusters of the b

73 esenchyme cells and corneal fibroblasts with type VI collagen, whereas only a subset of cells express

74 s) and restored basement membrane-associated type VI collagen, which were associated with an attenuat

75 decrease in the adhesion of chondrocytes to type VI collagen, while adhesion to type II collagen and