ライフサイエンスコーパス: typhoid fever

1 ment of novel therapeutic strategies against typhoid fever.

2 ing live attenuated vaccines for measles and typhoid fever.

3 aride are licensed or in development against typhoid fever.

4 nd may help the development of therapies for typhoid fever.

5 i is an exclusive human pathogen that causes typhoid fever.

6 systemic infections like gastroenteritis and typhoid fever.

7 potentially life-saving therapeutics against typhoid fever.

8 life-threatening systemic infection known as typhoid fever.

9 of mice that models acute and chronic human typhoid fever.

10 ic agent of human gastroenteritis and murine typhoid fever.

11 nduce many of the symptoms characteristic of typhoid fever.

12 hemophagocytes in a natural model of murine typhoid fever.

13 cimens from 30 patients were consistent with typhoid fever.

14 fication of correlates of protection against typhoid fever.

15 and devise strategies for the prevention of typhoid fever.

16 human infections including enterocolitis and typhoid fever.

17 ellin-deficient mutants of Salmonella causes typhoid fever.

18 monella enterica serovar Typhi, the cause of typhoid fever.

19 phoid fever and has been used as a model for typhoid fever.

20 of diseases ranging from gastroenteritis to typhoid fever.

21 epatitis A and B, tuberculosis, malaria, and typhoid fever.

22 e commercial kits for serologic diagnosis of typhoid fever.

23 cause systemic infection in mouse models of typhoid fever.

24 ht play an important role in protection from typhoid fever.

25 train Ty2, a human-specific pathogen causing typhoid fever.

26 ey factor influencing host susceptibility to typhoid fever.

27 ly step in the infectious process leading to typhoid fever.

28 was also depressed during the acute stage of typhoid fever.

29 y protective immune responses against murine typhoid fever.

30 oach to adjusting estimates of the burden of typhoid fever.

31 cted enteric fever, of whom 89 had confirmed typhoid fever.

32 is a human-restricted pathogen which causes typhoid fever.

33 ritis, and is used as a mouse model of human typhoid fever.

34 ny NRAMP1 variants were at increased risk of typhoid fever.

35 in mice and confer protection against murine typhoid fever.

36 TR carriers may have increased resistance to typhoid fever.

37 terica serovar Typhi, the etiologic agent of typhoid fever.

38 athogen that causes the murine equivalent of typhoid fever.

39 re effective as live vaccines against murine typhoid fever.

40 ve little or no effect in the mouse model of typhoid fever.

41 ouse intestine and the development of murine typhoid fever.

42 heterozygotes may decrease susceptibility to typhoid fever.

43 ing the incidence of blood culture-confirmed typhoid fever.

44 liver is commonly involved in patients with typhoid fever.

45 h a first episode of blood culture-confirmed typhoid fever.

46 o identify communities with a high burden of typhoid fever.

47 mediates the neuropathology associated with typhoid fever.

48 eep-tissue colonization in a murine model of typhoid fever.

49 te the severe neurological manifestations of typhoid fever.

50 s effective population-based tools to combat typhoid fever.

51 faecal-oral route and causative organism of typhoid fever.

52 Salmonella enterica serovar Typhi causes typhoid fever.

53 for a reliable, simple diagnostic assay for typhoid fever.

54 and other global efforts for the control of typhoid fever.

55 or better prevention and control efforts for typhoid fever.

56 itulates in an animal model many symptoms of typhoid fever.

57 to protect against S. sonnei shigellosis and typhoid fever.

58 ca serovar Typhi causes the systemic disease typhoid fever.

59 manifestations ranging from enterocolitis to typhoid fever.

60 rapeutic and prevention strategies to combat typhoid fever.

61 ca serovar Typhi is the etiological agent of typhoid fever.

62 nce factor of Salmonella Typhi, the cause of typhoid fever.

63 tryptophan metabolism in the pathogenesis of typhoid fever.

64 -typhoid fever (vaccine efficacy against non-typhoid fever -0.4% [95% CI -4.9 to 3.9] vs -1% [-5.6 to

65 emonstrated an overall adjusted incidence of typhoid fever 2-3 times higher than previous estimates i

66 Salmonella Typhi is the cause of typhoid fever, a disease that has challenged humans thro

67 serovar Typhi can infect only humans causing typhoid fever, a life-threatening systemic disease.

68 yphi (S. typhi) is the aetiological agent of typhoid fever, a serious invasive bacterial disease of h

69 We therefore estimate that typhoid fever accounts for 43% of all bowel perforation

70 cines provide significant protection against typhoid fever, albeit by distinct immune mechanisms.

71 s with neurologic findings, determined to be typhoid fever, along the Malawi-Mozambique border.

72 Ag from Salmonella typhi can protect against typhoid fever, although the mechanism for its efficacy i

73 vada Health District detected an outbreak of typhoid fever among persons who had not recently travell

74 yphi causes an estimated 22 million cases of typhoid fever and 216 000 deaths annually worldwide.

75 January through 30 June 1997, 8901 cases of typhoid fever and 95 associated deaths were reported in

76 var Typhi (Salmonella Typhi) is the cause of typhoid fever and a human host-restricted organism.

77 VD 908-htrA as a single-dose vaccine against typhoid fever and as a possible live vector for oral del

78 s the potential to reduce both the burden of typhoid fever and associated health inequality.

79 Individuals with blood culture-confirmed typhoid fever and control subjects from 2 distinct geogr

80 Measuring the burden of typhoid fever and developing effective strategies to red

81 l and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in huma

82 lts in an enteric fever that resembles human typhoid fever and has been used as a model for typhoid f

83 Patients with blood-culture-confirmed typhoid fever and healthy control subjects were genotype

84 INTERPRETATION: Typhoid fever and iNTS disease are major causes of invas

85 Typhoid fever and iNTS disease incidences were corrected

86 measure the adjusted incidence estimates of typhoid fever and invasive non-typhoidal salmonella (iNT

87 h Salmonella typhimurium provides models for typhoid fever and long-lasting protective immunity confe

88 fies a genetic association in humans between typhoid fever and MHC class II and III genes.

89 Typhoid fever and nontyphoidal bacteremia caused by Salm

90 anding of age and geographic distribution of typhoid fever and other invasive salmonelloses in Africa

91 ntigen targets: lipopolysaccharide (LPS) for typhoid fever and plasmodium lactate dehydrogenase (pLDH

92 ence of S. typhimurium in the mouse model of typhoid fever and proposed that FlgM is required to modu

93 Reporting of individual cases of typhoid fever and subtyping of isolates by PFGE resulted

94 cation of sensitive and specific markers for typhoid fever and technology to manufacture practical an

95 ng by studies that reported the incidence of typhoid fever and those that estimated incidence by usin

96 city limits the ability to recognize endemic typhoid fever and to detect outbreaks.

97 terica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the

98 for causing an estimated 27 million cases of typhoid fever annually, leading to 217,000 deaths, and c

99 Vaccines for cholera and typhoid fever are available, and new vaccines are in var

100 Current serological diagnostic assays for typhoid fever are based on detecting antibodies against

101 Contemporary incidence estimates of typhoid fever are needed to guide policy decisions and c

102 Malaria and typhoid fever are two febrile illnesses prevalent in the

103 n Salmonella Typhi, the bacteria that causes Typhoid fever, are now challenging this view.

104 ebrile illness and measured the incidence of typhoid fever (as confirmed on blood culture) in a prosp

105 protecting against S. sonnei shigellosis and typhoid fever, as compared with the current Ty21a vaccin

106 s in humans but have been used as models for typhoid fever because these organisms cause a disease in

107 previous-TCV group had an increased risk of typhoid fever between 2021-23, with an adjusted incidenc

108 antyre, Malawi, with blood culture-confirmed typhoid fever between April 2015 and January 2017 were r

109 Greater understanding of the typhoid fever burden, the increasing threat of antimicro

110 ican sentinel sites with previous reports of typhoid fever: Burkina Faso (two sites), Ethiopia, Ghana

111 typhoid fever in patients who have clinical typhoid fever but are culture negative or in regions whe

112 a selective advantage in the mouse model of typhoid fever but have no such advantage in invasion of

113 almonella enterica serovar Typhi can lead to typhoid fever, but this serovar does not typically cause

114 d the ability of the mutants to cause murine typhoid fever by an oral route of infection.

115 National surveillance for typhoid fever can inform prevention and treatment recomm

116 an excess of 0.046 perforations per clinical typhoid fever case (95% CI, .03-.06).

117 We report a typhoid fever case with a Salmonella enterica serovar Ty

118 onella Typhi) causes an estimated 22 million typhoid fever cases and 216 000 deaths annually worldwid

119 etween Oct 1, 2016, and Aug 31, 2019, of 177 typhoid fever cases confirmed by whole-genome sequencing

120 In Blantyre, Malawi, a dramatic increase in typhoid fever cases has recently occurred, and may be li

121 plore hypotheses for the increased number of typhoid fever cases in Blantyre, we fit a mathematical m

122 improving typhoid diagnostics, and reducing typhoid fever cases through the use of an efficacious va

123 munogenic vaccine that significantly reduces typhoid fever cases when assessed using a stringent cont

124 Humans are uniquely susceptible to typhoid fever caused by infection with Salmonella enteri

125 Typhoid fever caused by Salmonella Typhi is a major publ

126 m in mice resembles the acute phase of human typhoid fever caused by Salmonella typhi, and experiment

127 Because typhoid fever-causing Salmonella have no known environme

128 e gastrointestinal illness, bloody diarrhea, typhoid fever, cholera, hepatitis, and deaths of childre

129 Using a mouse model of chronic typhoid fever combined with major histocompatibility com

130 The primary outcome was typhoid fever confirmed by blood culture.

131 ory properties in serum of participants with typhoid fever confirmed the activity of this pathway, an

132 Typhoid fever continues to be a major public health conc

133 nd acceleration of the global agenda towards typhoid fever control with a strong World Health Organiz

134 acity for detection is critical to improving typhoid fever control.

135 Here we investigate whether typhoid fever could be one such disease.

136 s the following outcomes: cases of suspected typhoid fever, culture-confirmed S Typhi, and antimicrob

137 fewer households with >/=1 reported case of typhoid fever (cumulative incidence ratio [CIR] = 0.58,

138 to improve water pressure, the incidence of typhoid fever declined dramatically.

139 individuals as well as from 9 patients with typhoid fever did not show any amplification with the pr

140 r than 2 years to sustain protection against typhoid fever during the school years when the risk is t

141 1977 to 1986, Chile experienced an important typhoid fever epidemic, despite statistics that indicate

142 var Typhi (S. Typhi), the causative agent of typhoid fever, exhibits limited DNA sequence variation,

143 erica serotype Typhi, the causative agent of typhoid fever, expression of the Vi capsular antigen red

144 development of a diagnostic assay for acute typhoid fever focused on detecting IgA responses against

145 en a recent expansion of multidrug-resistant typhoid fever globally.

146 Typhoid fever has been endemic on the island nation of S

147 Although typhoid fever has been intensively studied, chronic typh

148 The incidence of typhoid fever has been most reported in children 5-15 ye

149 Typhoid fever has had a major impact on human population

150 Our understanding of the global burden of typhoid fever has improved in recent decades, with both

151 ver a century, a correlate of protection for typhoid fever has yet to be identified.

152 la enterica, the cause of food poisoning and typhoid fever, has evolved sophisticated mechanisms to m

153 Available commercial serologic assays for typhoid fever have limited sensitivity and specificity.

154 appropriate empirical therapy for suspected typhoid fever; however, resistance may be anticipated.

155 Typhoid fever illnesses are responsible for more than 10

156 s in 10.3%, urinary tract infection in 5.9%, typhoid fever in 3.7%, skin or mucosal infection in 1.5%

157 vel manifests as increased susceptibility to typhoid fever in a Vietnamese population.

158 ance in Africa Program (TSAP) and the Severe Typhoid Fever in Africa (SETA) program have refined our

159 ng blood culture, to populations at risk for typhoid fever in Africa will improve outbreak detection,

160 hi, reproduces many of the acute symptoms of typhoid fever in an animal model.

161 -restricted pathogen that is responsible for typhoid fever in approximately 10.9 million people annua

162 the diagnosis, treatment, and prevention of typhoid fever in different locations with endemic diseas

163 An outbreak of typhoid fever in Florida involving at least 16 persons d

164 s also implicated in a 1998-1999 outbreak of typhoid fever in Florida.

165 g of S Typhi isolated from clinical cases of typhoid fever in Harare, Zimbabwe, between Jan 1, 2012,

166 thogen Salmonella Typhi (6,7) , the cause of typhoid fever in humans (8-12) .

167 terica serovar Typhi, the causative agent of typhoid fever in humans, forms biofilms encapsulated by

168 athogenic bacterium known for causing severe typhoid fever in humans, making it important to study du

169 phoid-like disease in mice and is a model of typhoid fever in humans.

170 rial pathogen Salmonella Typhi, which causes typhoid fever in humans.

171 use food- and waterborne gastroenteritis and typhoid fever in humans.

172 has been studied extensively as a model for typhoid fever in humans.

173 is an established model system for studying typhoid fever in humans.

174 ileum and subsequently disseminates to cause typhoid fever in humans.

175 of Salmonella typhi, a licensed vaccine for typhoid fever in individuals > or = 5 years old, induces

176 The AIR of iNTS and typhoid fever in individuals younger than 15 years old w

177 by exploring the historical experience with typhoid fever in industrialized countries.

178 floxacin is the first-line drug for treating typhoid fever in many countries in Africa with a high di

179 Salmonella serotypes which cause typhoid fever in mice have been shown to target the gut-

180 (S. Typhi) has become the dominant cause of typhoid fever in Pakistan.

181 e tests could be of use for the diagnosis of typhoid fever in patients who have clinical typhoid feve

182 he human homologue, NRAMP1, in resistance to typhoid fever in southern Vietnam.

183 Data on the age distribution of typhoid fever in sSA are scarce but essential for typhoi

184 st response of 29 individuals who contracted typhoid fever in the Mekong Delta region of Vietnam.

185 Typhoid fever in the United States has increasingly been

186 Typhoid fever in the United States is acquired primarily

187 he rate reduction of blood culture-confirmed typhoid fever in the vaccination arm as compared to the

188 ort a large laboratory-confirmed outbreak of typhoid fever in Uganda with a high proportion of intest

189 Typhoid fever in United States is often associated with

190 ican countries are now thought to experience typhoid fever incidence >100 per 100,000 per year with a

191 Estimated typhoid fever incidence in the community survey was 8092

192 Typhoid fever incidence remains high at many sites.

193 mented over 12 months in a historically high typhoid fever incidence setting (Vellore, India) and a l

194 nd geographic representation of high-quality typhoid fever incidence studies, and greater sophisticat

195 oss-referenced with model-based estimates of typhoid fever incidence to identify the countries at hig

196 children in low-income households and lower typhoid fever incidence, suggesting that intermittently

197 We found that typhoid fever induced a distinct and highly reproducible

198 la enterica, the cause of food poisoning and typhoid fever, induces actin cytoskeleton rearrangements

199 a, the causative agent of food poisoning and typhoid fever, induces programmed cell death in macropha

200 Typhoid fever is a continuing public health problem in m

201 Typhoid fever is a life-threatening disease, but little

202 ich result in self-limiting gastroenteritis, typhoid fever is a life-threatening systemic disease.

203 Typhoid fever is a major cause of morbidity and mortalit

204 Typhoid fever is a major cause of morbidity and mortalit

205 Typhoid fever is a major global health problem, the cont

206 Typhoid fever is a significant cause of morbidity and mo

207 Typhoid fever is an acute infection characterized by pro

208 Typhoid fever is an acute systemic infectious disease re

209 Typhoid fever is an enteric disease caused by the pathog

210 tant S. Typhi strains among US patients with typhoid fever is associated with travel to the Indian su

211 Typhoid fever is caused by Salmonella enterica subspecie

212 Typhoid fever is common in developing countries.

213 typhimurium) infection in the mouse model of typhoid fever is critically dependent on the natural res

214 Currently, the laboratory diagnosis of typhoid fever is dependent upon either the isolation of

215 Typhoid fever is endemic in the urban Kathmandu Valley o

216 In Bangladesh, typhoid fever is endemic, with incidence rates between 2

217 ar Typhi have been reported in regions where typhoid fever is endemic.

218 Typhoid fever is estimated to affect over 20 million peo

219 a strong indication that the pathogenesis of typhoid fever is fundamentally different from that of ba

220 Salmonella Typhi, the cause of typhoid fever, is a bacterial pathogen of substantial gl

221 Salmonella Typhi, the causative agent of typhoid fever, is a monophyletic, human-restricted bacte

222 Salmonella typhi, the etiologic agent of typhoid fever, is adapted to the human host and unable t

223 Typhi (S. Typhi), the aetiological agent of typhoid fever, is an exclusively human pathogen.

224 monella enterica serovar Typhi, the cause of typhoid fever, is host-adapted to humans and unable to c

225 phi, a human obligatory pathogen that causes typhoid fever, is normally unable to infect mice.

226 tion by examining its estimated incidence of typhoid fever, its history of introducing new vaccines,

227 ible for a wide variety of diseases, such as typhoid fever, large-scale food-borne illnesses, dysente

228 el estimates that culture-confirmed cases of typhoid fever lead to an excess of 0.046 perforations pe

229 which allows for intrahost dissemination and typhoid fever (low host mortality).

230 s typhoid and malaria epidemics suggest that typhoid fever might activate P vivax hypnozoites.

231 Protection against typhoid fever might be best achieved by a vaccine that s

232 In the murine typhoid fever model, Deltanth/nei was fivefold attenuate

233 ibute to the virulence of the bacterium in a typhoid fever-mouse model, based on results from strains

234 Few instances of typhoid fever (n = 8), acute HIV infection (n = 5), and

235 Blood culture-confirmed typhoid fever occurred in 12 children in the Vi-TCV grou

236 Blood culture-confirmed typhoid fever occurred in 7 participants who received TC

237 ospitalizations, 249 IPs, and 47 deaths from typhoid fever occurred; Salmonella Typhi was isolated fr

238 Salmonella enterica serovar Typhi causes typhoid fever only in humans.

239 A typhoid fever outbreak in Harare, Zimbabwe, in 2018 from

240 lassic study by Austin Flint of a waterborne typhoid fever outbreak in North Boston in 1843.

241 This typhoid fever outbreak was detected because of an elevat

242 included in the review deal with additional typhoid fever outbreaks, tuberculosis, breast cancer, an

243 te, an important but underresearched area of typhoid fever pathogenesis.

244 of neutrophils in intestinal infiltrates of typhoid fever patients is due to a capsule-mediated redu

245 Among 1992 pediatric typhoid fever patients, 1616 (81%) had traveled internat

246 hils are scarce in intestinal infiltrates of typhoid fever patients.

247 to improvements in therapeutic treatment of typhoid fever patients.

248 common travel-related diseases (eg, malaria, typhoid fever, pneumonia, and meningococcemia) may resul

249 Salmonella Typhi, the cause of typhoid fever, produces an unusual A(2)B(5) toxin known

250 ica serotype Typhi, the etiological agent of typhoid fever, produces the Vi capsular antigen, a virul

251 nce factor of Salmonella Typhi (the cause of typhoid fever), recapitulates in an animal model many sy

252 Control of typhoid fever relies on clinical information, diagnosis,

253 g causative agents of dysentery, plague, and typhoid fever, rely on a type III secretion system - a m

254 Typhoid fever remains a major source of morbidity and mo

255 While typhoid fever remains an important cause of illness in m

256 Enteric (typhoid) fever remains a problem in low- and middle-inco

257 Laboratory diagnosis of typhoid fever requires isolation and identification of S

258 , we demonstrate that the causative agent of typhoid fever, Salmonella enterica serovar Typhi, can pa

259 Typhoid fever seen in the United States was multidrug re

260 that have been drawn from the mouse model of typhoid fever should be interpreted conservatively.

261 The recent Typhoid Fever Surveillance in Africa Program demonstrate

262 and without the need for resource-intensive typhoid fever surveillance programs.

263 how VAC14 regulates Salmonella invasion and typhoid fever susceptibility and may open doors to new p

264 complex (MHC) class II and class III loci on typhoid fever susceptibility was investigated.

265 as identified between the NRAMP1 alleles and typhoid fever susceptibility.

266 ulence factor that can reproduce most of the typhoid fever symptoms in experimental animals.

267 d for infection and the development of early typhoid fever symptoms within the context of a human cha

268 ted blood was found to be lower during acute typhoid fever than after a course of antimicrobial thera

269 a lower incidence of blood culture-confirmed typhoid fever than the MenA vaccine.

270 In acute typhoid fever, the ability of peripheral blood leukocyte

271 s of assays that included the mouse model of typhoid fever, the mouse macrophage survival assay, an i

272 we demonstrate that, in adult patients with typhoid fever, the sensitivity of a serological test bas

273 vaccines in use in humans to protect against typhoid fever, there are none that prevent enterocolitis

274 nfection in mice is often used as a model of typhoid fever, these findings suggest that, at least in

275 For every true case of typhoid fever, three to 25 patients without typhoid dise

276 -308].DRB1*04) or predisposed individuals to typhoid fever (TNFA*2 [-308].DRB1*0301) were determined.

277 were followed up for blood culture-confirmed typhoid fever until Sept 30, 2021.

278 rain (Ty800) was tested as a live attenuated typhoid fever vaccine in human volunteers.

279 eipt of Vi-TT did not affect the risk of non-typhoid fever (vaccine efficacy against non-typhoid feve

280 A suspected case of typhoid fever was defined as fever and abdominal pain in

281 c, and their usefulness for the diagnosis of typhoid fever was evaluated.

282 or parasitic infection other than malaria or typhoid fever was found in 13.3% of children, nasopharyn

283 ride (LPS) of whole blood from patients with typhoid fever was investigated.

284 high, especially among newborn infants, but typhoid fever was uncommon.

285 Although effective in preventing typhoid fever, we were unable to identify any effect of

286 from patients with the clinical symptoms of typhoid fever were also investigated.

287 5131 cases of typhoid fever were diagnosed and 5004 Typhi isolates tes

288 es, 241 microbiologically confirmed cases of typhoid fever were identified, and 198 isolates from 195

289 ifty-four outbreaks of domestically acquired typhoid fever were reported between 1960 and 1999.

290 ractical reference standard for diagnosis of typhoid fever, where culture testing is available, but n

291 -308) were associated with susceptibility to typhoid fever, whereas HLA-DRB1*04, HLA-DQB1*0401/2, and

292 sseminated febrile illness in humans, termed typhoid fever, while Salmonella enterica serovar Typhimu

293 sera from 74 volunteers without a history of typhoid fever who were immunized orally with CVD 908-htr

294 a, including the causative agents of plague, typhoid fever, whooping cough, sexually transmitted infe

295 ive bacteria, including purveyors of plague, typhoid fever, whooping cough, sexually transmitted infe

296 rologically based tests for the diagnosis of typhoid fever (Widal TO and TH, anti-serotype Typhi immu

297 evelop a hematopathological syndrome akin to typhoid fever with splenomegaly, microcytic anemia, extr

298 In 2017, more than half the cases of typhoid fever worldwide were projected to have occurred

299 serovar Typhi (S. Typhi) to multiply during typhoid fever, yet our understanding of how human macrop

300 ent remain powerful tools for the control of typhoid fever, yet the huge economic costs and long time