ライフサイエンスコーパス: tyrosinase

1 claveryi lipoxygenase and Agaricus bisporus tyrosinase).

2 k that is required for copper acquisition by tyrosinase.

3 biting ATP7A and by enhancing degradation of tyrosinase.

4 equence oligopeptides at inhibiting mushroom tyrosinase.

5 matic reaction of BPA oxidation catalyzed by tyrosinase.

6 ells loaded with melanoma antigens gp100 and tyrosinase.

7 melanoma antigens MART1, MAGE-3, gp100, and tyrosinase.

8 y activity with respect to alpha-amylase and tyrosinase.

9 coding TCRs recognizing the melanoma antigen tyrosinase.

10 ognize an epitope of the melanocyte protein, tyrosinase.

11 us containing TYR (P=1.60x10(-18)), encoding tyrosinase.

12 nd P4 are competitive inhibitors of mushroom tyrosinase.

13 e to excess melanin production by the enzyme tyrosinase.

14 towards alpha-amylase, alpha-glucosidase and tyrosinase.

15 nism of the coupled binuclear copper protein tyrosinase.

16 odel of the coupled binuclear copper protein tyrosinase.

17 tinal neuron-the proapoptotic gene, Bax, and tyrosinase.

18 ners, with a focus on the melanogenic enzyme tyrosinase.

19 r and non-polar region on the active site of tyrosinase.

20 might disturb the catalytic conformation of tyrosinase.

21 anoparticles followed by covalent binding of tyrosinase.

22 oot and multiple proteins including expanded tyrosinases.

23 nfiltrating lymphocyte, which recognized the tyrosinase 368-376 peptide in the context of HLA-A2, wer

24 or the standard proteasome (Melan-A(26-35), tyrosinase(369-377), gp100(209-217)).

25 Tyrosinase, a key copper-containing enzyme involved in m

26 n biological assays performed using mushroom tyrosinase (abTYR), producing a plethoric literature, of

27 , they also showed poor anti-urease and anti-tyrosinase activities.

28 Meanwhile, WFI also inhibited tyrosinase activity and NO generation in lipopolysacchar

29 Meanwhile, WLT also inhibited tyrosinase activity and NO generation in lipopolysacchar

30 silencing in isolated melanocytes increased tyrosinase activity and TYRP1/2 expression.

31 The designed biosensor is used to inhibit tyrosinase activity by Captopril, which is generally use

32 lanin content, gp100 protein expression, and tyrosinase activity in human skin.

33 elanization effect resulting from AgNP since tyrosinase activity is essential for melanin biosynthesi

34 kinetic analysis revealed that BA inhibited tyrosinase activity non-competitively.

35 Cu-dependent tyrosinase activity was also markedly reduced in both ty

36 , the capability of caftaric acid to inhibit tyrosinase activity was evaluated by spectrophotometric

37 Melanin content, tyrosinase activity, and tyrosinase protein levels were

38 tion of melanogenesis is due to reduction in tyrosinase activity.

39 ibit increased levels of melanin pigment and tyrosinase activity.

40 ed the strongest inhibitory activity against tyrosinase among the components in this fruit, with an I

41 acetylcholinesterase, butyrylcholinesterase, tyrosinase, amylase and glucosidase inhibition) were use

42 Tyrosinase, an enzyme involved in melanin synthesis, is

43 erase (AChE), butyryl cholinesterase (BChE), tyrosinase and alkaline phosphatase or enzyme (organopho

44 thalmia-associated transcription factor) and tyrosinase and by elevated protein levels of tyrosinase,

45 Polyphenol oxidase (PPO), also known as tyrosinase and catechol oxidase, is the enzyme responsib

46 The highly conserved tyrosinase and chitin related proteins were identified i

47 activity of copper dependent enzymes, namely tyrosinase and Cu-Zn superoxide dismutase, are decreased

48 n factor MITF and of the melanogenic enzymes tyrosinase and dopachrome tautomerase, all major players

49 CRISPR/Cas9-mediated disruption of the genes Tyrosinase and FGF8/17/18 in the sea lamprey Petromyzon

50 ue (bioET) based on combinations of enzymes (tyrosinase and glucose oxidase) and polypyrrole (Ppy) or

51 estricted tumor-associated antigens (TAA) of tyrosinase and gp100, depending on their HLA-DR4 status.

52 tor of tyrosine degradation, could stabilize tyrosinase and improve pigmentation in individuals with

53 e via chelating copper at the active site of tyrosinase and in flow mode by thioquinone formation.

54 Polyphenol oxidases (PPOs) such as tyrosinase and laccase catalyze the enzymatic oxidation

55 at resulted from a preserved activity of the tyrosinase and laccase combined with the electron transf

56 mmetric biosensors based on phenol oxidases (tyrosinase and laccase) has been developed.

57 The main tea catechins were incubated with tyrosinase and laccase, and product formation was monito

58 By employing tyrosinase and laccase, both from Agaricus bisporus, on

59 n larvae resulted in increased expression of tyrosinase and laccase2 mRNA after 10 days.

60 fferentiation resulted in an upregulation of tyrosinase and melanin expression levels, in comparison

61 ignificantly reduced by a DGK inhibitor, but tyrosinase and microphthalmia-associated transcription f

62 factor (MITF), and subsequent reductions in tyrosinase and other genes required for melanogenesis.

63 on the tandem enzymatic reaction of a fungal tyrosinase and the mammalian catechol-O-methyltransferas

64 The strong interaction between tyrosinase and the nanocomposite was revealed by the hig

65 Individuals with the former lack functional tyrosinase and therefore lack melanin, while individuals

66 M for chelating copper at the active site of tyrosinase and thioquinone formation, respectively.

67 s via chelating copper at the active site of tyrosinase and thioquinone formation.

68 1 pathways, the melanin-synthesizing enzymes tyrosinase and tyrosinase-related protein-1.

69 with melanosome-destined cargo, specifically tyrosinase and Tyrp-1.

70 Tyrosinases and catechol oxidases belong to the family o

71 In the current study, we describe the use of tyrosinases and decarboxylases and combine these with a

72 a tumor antigens, MelA/MART-1, gp100/pmel17, tyrosinase, and MAGE-A3, was used to trigger functional

73 ition of DGK reduced only the mature form of tyrosinase, and the decrease of tyrosinase resulting fro

74 Tyrosinases are ubiquitous binuclear copper enzymes that

75 ditions of an oxidase enzyme biosensor using tyrosinase as a model example.

76 Identifying tyrosinase as a potential GPR143 binding protein opens n

77 demonstrate a more flexible conformation of tyrosinase at higher temperature.

78 were achieved when 10mM cysteine and 200U/ml tyrosinase at pH 6.8 to 7.2 were used for a 60-min incub

79 ing protein tyrosine kinase activity using a tyrosinase-based amperometric biosensor (tyrosine kinase

80 ensor, a sentinel platinum sensor, a laccase/tyrosinase-based biosensor and a sentinel carbon sensor,

81 nd application involved the fabrication of a tyrosinase-based biosensor capable of determining catech

82 We report on the design of an amperometric tyrosinase-based biosensor using a self-assembled monola

83 tides that inhibited both mushroom and human tyrosinase but showed no cytotoxicity to human melanocyt

84 At 100 microM, P3 and P4 inhibited human tyrosinase by 25-35%.

85 d as competitive inhibitors against mushroom tyrosinase by using the phenol ring of tyrosine to stack

86 ion mimicked the defective expression of the tyrosinase cargo in dendrites of HPS-5 melanocytes, but

87 Ubiquitous tyrosinase catalyses the aerobic oxidation of phenols to

88 Tyrosinases catalyze theo-hydroxylation and oxidation of

89 servation that phosphorylation can block the tyrosinase-catalyzed oxidation of tyrosine or tyrosyl re

90 nase II inhibitory peptide; MK2i) by using a tyrosinase-catalyzed oxidative reaction for preventing t

91 Tyrosinase catalyzes the conversion of dopamine to o-dop

92 Tyrosinase-COMT are shown to provide highly versatile an

93 We present a tyrosinase-conjugated zinc oxide-reduced graphene oxide

94 ermore, fully-printed biosensors made with a tyrosinase-containing ink were used to detect catechol i

95 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes.

96 The enzyme tyrosinase contains two Cu(I) centres, trigonally coordi

97 Tyrosinase did not have effect on zeta-potential or coll

98 ed human tyrosinase or on the mRNA levels of tyrosinase, dopachrome tautomerase, Pmel17, or MITF mRNA

99 differentiation markers such as melan-A and tyrosinase, enhanced aldehyde dehydrogenase (ALDH) activ

100 e tyrosinase gene (TYR), which expresses the tyrosinase enzyme and has an important role in the synth

101 We used tyrosinase enzyme as a proof of concept receptor with in

102 d using nickel oxide nanoparticles (NPs) and tyrosinase enzyme conjugate.

103 The tyrosinase enzyme functionalized NiO platform has good b

104 o filter paper and physically entrapping the tyrosinase enzyme in between these layers.

105 activity was determined by alpha-amylase and tyrosinase enzyme inhibition.

106 Using a tyrosinase enzyme isolated from Agaricus bisporus (abTYR

107 Afterwards, tyrosinase enzyme molecules were adsorbed on NiO NPs sur

108 n excellent electrode surface for loading of tyrosinase enzyme molecules.

109 TO) were designed by covalently immobilizing tyrosinase enzyme on spin-coated films of ZnO-rGO nanoco

110 We also introduce a new bacterial tyrosinase enzyme that shows improved activation for som

111 eraction sites of ED and PAED compounds with tyrosinase enzyme.

112 sor consisting of salicylate hydroxylase and tyrosinase enzymes immobilized on carbon nanotube modifi

113 esterase, butyrylcholinesterase, urease, and tyrosinase enzymes.

114 Using h3T TCR transgenic mice, with human tyrosinase epitope-reactive T cells developed on p53 kno

115 Using the human tyrosinase epitope-reactive, CD8-independent, high-affin

116 is peptide, Tyr(369)(N), is not presented by tyrosinase-expressing cells, and this has been presumed

117 Furthermore, tyrosinase expression and activity, as well as TYRP1 and

118 own of DGKzeta decreased melanin content and tyrosinase expression in melanocytic cells.

119 ted genes VIM, MITF-M, melan A, and TYRP1 (a tyrosinase family member critical for melanin biosynthes

120 features consistent with those of oxygenated tyrosinase, formed through the self-assembly of monodent

121 E1, Zn(II)-HDAC, Fe(II)/(III)-5-LO or Cu(II)-tyrosinase from a curated mixture (1-17).

122 to investigate the heat induced behaviour of tyrosinase from Agaricus bisporus.

123 Tyrosinase from Bacillus megaterium (TyrBm) was previous

124 's melanocytes caused the mislocalization of tyrosinase from melanosomes to the plasma membrane and a

125 lutaminase from Streptomyces mobaraensis and tyrosinase from Trichoderma reesei to modify the colloid

126 egulatory molecules and pathways involved in tyrosinase function.

127 dy, we identified a gene (Hs-Tyr) encoding a tyrosinase functional domain (PF00264).

128 on of epicatechin with epigallocatechin with tyrosinase gave a high, stable theaflavin content.

129 cells, as determined with the Ca(2+) sensor tyrosinase-GCaMP6.

130 Mutation of the tyrosinase gene (TYR) causes oculocutaneous albinism, ty

131 er animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentat

132 phenotype may be caused by mutations in the tyrosinase gene (TYR), which expresses the tyrosinase en

133 ntly stimulate melanin synthesis and enhance tyrosinase gene expression and activity ( approximately

134 Tyrosinase greatly reduced the solubility of oat protein

135 Tyrosinase had limited crosslinking ability on both plan

136 Human tyrosinase (hsTYR) is the key enzyme ensuring the conver

137 The biosensor is fabricated using tyrosinase immobilized in a biocompatible matrix consist

138 s in microphthalmia transcription factor and tyrosinase immunoreactivity inversely related to SMPD3 a

139 By covalently immobilizing the enzyme tyrosinase in a preformed cross-linked chitosan film via

140 expression of the melanoma-associated marker tyrosinase in adherent melanoma cell lines corresponding

141 of two polyphenol oxidases (PPOs): mushroom tyrosinase in buffer and the PPO present in coconut wate

142 tyrosinase-related proteins 1 and 2 but not tyrosinase, in addition to gp100 and MART-1, and were de

143 In a green tea extract, tyrosinase increased the proportion of theaflavins by tw

144 While oxidation by tyrosinase increased their antioxidant activity laccase

145 spectral features identical to those of oxy-tyrosinase indicates that oxy-NspF contains a Cu(2)O(2)

146 increased the proportion of EndoH sensitive tyrosinase, indicating that tyrosinase maturation was im

147 and chromatographic separation coupled with tyrosinase inhibition assay.

148 ng 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and tyrosinase inhibition kinetics, and the release of aroma

149 ion of a new thiosemicarbazone with improved tyrosinase inhibition properties and fresh-cut apple sli

150 Mushroom tyrosinase inhibition was dose-dependent with IC(50) (ha

151 The extracts exerted weak cholinesterase and tyrosinase inhibition, and remarkable inhibition against

152 its toxicity to melanocytes rather than via tyrosinase inhibition.

153 We studied the tyrosinase-inhibition activity (activity test) and struc

154 lit-face study to assess the efficacy of the tyrosinase inhibitor Thiamidol compared to hydroquinone

155 M), which was superior to those of the known tyrosinase inhibitors (arbutin and kojic acid) and outpe

156 Tyrosinase inhibitors are of great interest in medicine

157 is broad range of applications in the use of tyrosinase inhibitors for suppressing unwanted hyperpigm

158 In searching effective tyrosinase inhibitors from natural products, the compone

159 Here we report on the activity as mushroom tyrosinase inhibitors of a series of hydroxyphenyl thios

160 Known tyrosinase inhibitors possess adverse side effects, and

161 scribe a novel platform for the discovery of tyrosinase inhibitors, based on (a) one-pot preparation

162 nd abTYR, including for widely used standard tyrosinase inhibitors.

163 gen-like activators and acetylcholinesterase/tyrosinase inhibitors.

164 good stability over time and antioxidant and tyrosinase inhibitory activities, which make it suitable

165 enolic antioxidants with metal chelating and tyrosinase inhibitory activities.

166 anthocyanin and IC50 value of 1.60mg/ml for tyrosinase inhibitory activity.

167 ameters maximizing bioactive metabolites and tyrosinase inhibitory activity.

168 lation of BA from D. indica and explored its tyrosinase inhibitory mechanism.

169 Tyrosinase inhibitory potential also decreased following

170 t, respectively, which also expressed strong tyrosinase inhibitory property.

171 tically and comprehensively investigated the tyrosinase-inhibitory abilities of N- and C-terminal cys

172 ning tetrapeptides exhibited the most potent tyrosinase-inhibitory abilities.

173 apeptides significantly contributed to their tyrosinase-inhibitory function.

174 ng tetrapeptide CRVI exhibited the strongest tyrosinase-inhibitory potency (with an IC50 of 2.7 +/- 0

175 embrane and also led to the incorporation of tyrosinase into exosomes and secretion into the culture

176 r(369)(D), derived from the membrane protein tyrosinase, involves retrotranslocation of glycosylated

177 Tyrosinase is a metalloenzyme involved in o-hydroxylatio

178 These findings confirm that tyrosinase is a novel lymphangiogenesis regulator in dev

179 fails to be presented because unglycosylated tyrosinase is degraded rapidly and relatively nonselecti

180 For the preparation of the biosensor, tyrosinase is immobilized onto screen printed electrode

181 Tyrosinase is the central and rate-limiting enzyme in me

182 Tyrosinase is the rate-limiting enzyme for the productio

183 Another member of this enzyme family, tyrosinase, is able to mono-oxygenate monophenols (monop

184 of the molecules and pathways that regulate tyrosinase levels and activity could identify target are

185 le synthesis, we report an iridium-catalysed tyrosinase-like approach to catechols, employing an oxya

186 ecies that leads to ortho-hydroxylation in a tyrosinase-like fashion and (ii) addition of stoichiomet

187 olinesterases, monoaminoxidases A and B, and tyrosinase) linked to a set of events that contribute to

188 Furthermore, tyrosinase localized to the plasma membrane when coexpre

189 EndoH sensitive tyrosinase, indicating that tyrosinase maturation was impaired.

190 -tyrosine was the substrate, suggesting that tyrosinase may contain contains two distinct catalytic s

191 Recently, we reported that the tyrosinase-mediated oxidation of phenol-tagged cargo mol

192 Using a novel tyrosinase minigene-tagged Sleeping Beauty transposon-me

193 we also established that proteasomes degrade tyrosinase molecules that are still glycosylated, giving

194 d was shown to be a competitive inhibitor of tyrosinase, more potent than the related caffeic and chl

195 osinase protein levels, but did not increase tyrosinase mRNA levels.

196 he BALB/c albino phenotype-associated Tyr(c) tyrosinase mutation appeared to contribute to the phenot

197 the C57BL/6 Tyr(c-2J/c-2J) strain, in which tyrosinase, necessary for melanogenesis, is mutated.

198 Tyrosinase-negative mice showed significantly increased

199 The fabricated Tyrosinase/NiO/ITO electrode exhibits high sensitivity o

200 eact with monophenols, indicating that, like tyrosinase, NspF also possesses monophenolase activity.

201 in water has been developed by immobilizing tyrosinase onto a diazonium-functionalized boron doped d

202 Silencing of tyrosinase or microphthalmia-associated transcription fa

203 y effect on the activities of purified human tyrosinase or on the mRNA levels of tyrosinase, dopachro

204 carry T cells with a HLA-A2-restricted human tyrosinase peptide (h-Tyr)-reactive TCR and develop spon

205 a proposed role for Hsp70 family members in tyrosinase post-translational modification.

206 st characterized member of a small family of tyrosinases present in fluorescent pseudomonads that are

207 ast, glycosylation alters the selectivity of tyrosinase processing by the proteasome, enhancing the p

208 We assert that the tyrosinase promoter is the distinct target for genetic m

209 Using the intermediate cell (IC)-specific tyrosinase promoter, under the control of diphtheria tox

210 In addition, omeprazole reduced tyrosinase protein abundance in the presence of cyclohex

211 Melanin content, tyrosinase activity, and tyrosinase protein levels were significantly reduced by

212 Overexpression of DGKzeta increased tyrosinase protein levels, but did not increase tyrosina

213 ore is known to be driven by the periplasmic tyrosinase PvdP.

214 mice, in which depigmentation is mediated by tyrosinase-reactive T cells.

215 ther lentivector delivering a self/tumor Ag, tyrosinase related protein 1 (TRP1), could stimulate eff

216 Melanocyte differentiation Ags, including tyrosinase-related protein (TRP) 1, are relevant to both

217 we combined peptide vaccines with mAb to the tyrosinase-related protein (TRP)-1 surface Ag for the tr

218 ch CD4+ T cells recognize a novel epitope in tyrosinase-related protein 1 (TRP-1), an antigen express

219 ssing of melanocyte differentiation antigen, tyrosinase-related protein 1 (TRP1).

220 ed by a low-affinity MHC class I ligand from tyrosinase-related protein 1 (TRP1).

221 , including the self-antigen and melanoma Ag tyrosinase-related protein 1 (TRP1).

222 eine change at a highly conserved residue in tyrosinase-related protein 1 (TYRP1) as a major determin

223 c for the melanocyte differentiation antigen tyrosinase-related protein 1 (Tyrp1), then constructed b

224 uestions, a mutated self-antigen, designated tyrosinase-related protein 1 (Tyrp1)-WM, derived from Ty

225 rane lacked the melanosomal membrane protein tyrosinase-related protein 1 (TYRP1).

226 was 100% penetrance in the progeny from the tyrosinase-related protein 1-mGluR5 lines generated from

227 lines under a melanocyte-specific promoter, tyrosinase-related protein 1.

228 Immunization with hsp110- or grp170-tyrosinase-related protein 2 (TRP2(175-192)) peptide com

229 high-avidity T cells targeting the tumor Ag tyrosinase-related protein 2 (TRP2).

230 -boost vaccination with the melanoma antigen tyrosinase-related protein 2, which also showed a signif

231 melanin synthesis and expression/activity of tyrosinase-related protein-1 (Tyrp-1).

232 melanin-synthesizing enzymes tyrosinase and tyrosinase-related protein-1.

233 ctors encoding the endogenous tumor Ags (TA) tyrosinase-related protein-2 (TRP-2) and glycoprotein 10

234 -Dopachrome tautomerase (l-DCT), also called tyrosinase-related protein-2 (TRP-2), is a melanoma anti

235 transgene specific for the melanoma antigen tyrosinase-related protein-2 (TRP-2, Dct) harbor T cells

236 Additionally, analysis of tyrosinase-related protein-2 and total melanin productio

237 combined with melanocyte differentiation Ag tyrosinase-related protein-2 peptide-based vaccination,

238 Tumors expressed tyrosinase-related proteins 1 and 2 but not tyrosinase,

239 enzyme of previously unknown function, is a tyrosinase required for the maturation of the pyoverdine

240 rylcholinesterase, alkaline phosphatase, and tyrosinase, respectively.

241 ture form of tyrosinase, and the decrease of tyrosinase resulting from DGK inhibition could be blocke

242 ne encoding the integral melanosomal protein tyrosinase, resulting in aberrant melanosome formation,

243 endent dopamine interacting with immobilized tyrosinase showed a linear dependence into a physiologic

244 e, volume of iridium oxide nanoparticles and tyrosinase solution.

245 e melanocyte-specific protein tyrosinase, to tyrosinase-specific CD8 T cells, leading to their deleti

246 Rescue of tyrosinase-specific T(CD8) by interference with PD-1 or

247 hese results suggest that this highly active tyrosinase-specific TCR could be of value in adoptive ce

248 Detailed insights into tyrosinase structure after performing molecular dynamics

249 These significant changes in tyrosinase structure at temperatures over 60 degrees C m

250 As AUS1 did not accept common tyrosinase substrates (tyrosine and tyramine), the enzym

251 not correlated with the acceptance of common tyrosinase substrates.

252 Furthermore, the HLA-A2(+)/human tyrosinase TCR double-transgenic mice developed spontane

253 fluorescence intensity results suggest that tyrosinase tends to form aggregates after 10min at 75 de

254 utational molecular docking studies on novel tyrosinase tetrapeptide inhibitors.

255 ioadhesion, such as enzymatic activation (by tyrosinase), the switchability from weak to strong binde

256 ALP1), part of the inflammasome cascade, and tyrosinase, the enzyme that produces melanin.

257 ues, including Met 374 in the active site of tyrosinase, the key enzyme in melanogenesis, limits enzy

258 e in the activities of adenylate cyclase and tyrosinase, the rate-limiting enzyme for melanogenesis.

259 ither the level or the enzymatic activity of tyrosinase, the rate-limiting enzyme in melanin producti

260 tyrosinase and by elevated protein levels of tyrosinase, the rate-limiting factor in melanin biogenes

261 sion significantly correlated with levels of tyrosinase, the rate-limiting melanogenic enzyme, consis

262 se, butyrylcholinesterase, lipoxygenase, and tyrosinase; the enzymes linked to neurodegeneration.

263 e compounds, (b) biological evaluation using tyrosinase TLC bioautography, (c) inhibitor identificati

264 h down-regulates melanogenic enzymes such as tyrosinase to decrease melanin synthesis and prevent nor

265 ne of these, the melanocyte-specific protein tyrosinase, to tyrosinase-specific CD8 T cells, leading

266 ith a chimeric murine/human TCR specific for tyrosinase, together with lymphodepletion conditioning,

267 +) T cells in the skin, quantifiable loss of tyrosinase transcript, and local IFN-gamma production.

268 icrophthalmia transcription factor) and TYR (tyrosinase), two pivotal genes in melanogenesis.

269 n copper-/dioxygen-dependent enzymes such as tyrosinase (Ty) and particulate methane monooxygenase (p

270 yme (ACE), histone deacetylase (HDAC-2), and tyrosinase (TY), was selected based on their clinical im

271 The biosensor architecture is based on tyrosinase (Tyr(ase)) immobilization on glassy carbon el

272 We mapped the albino locus to tyrosinase (tyr) and identified polymorphisms shared bet

273 he findings that alpha-Syn can interact with tyrosinase (TYR) and inhibit tyrosine hydroxylase (TH),

274 With tyrosinase (Tyr) and TiO(2) as representative enzyme and

275 Nowadays, electrochemical tyrosinase (Tyr) based biosensors constitute a promising

276 experiment, we used CRISPR-EZ to target the tyrosinase (Tyr) gene, achieving 88% bi-allelic editing

277 a guide RNA, which is embedded in the mouse tyrosinase (Tyr) gene, to evaluate whether targeted gene

278 R strain is known to carry a mutation in the tyrosinase (Tyr) gene.

279 through autosomal recessive mutations in the Tyrosinase (TYR) gene.

280 h iridium oxide nanoparticles (IrOx NPs) and tyrosinase (Tyr) immobilized onto screen printed electro

281 Using the mouse tyrosinase (Tyr) locus as an experimental model, a gene

282 ineered to include gene trap sequences and a tyrosinase (Tyr) pigmentation reporter to rescue the alb

283 Rb1 allele with mice expressing Cre from the tyrosinase (Tyr) promoter.

284 The enzyme Tyrosinase (Tyr) was used in the active layer of the bio

285 pe 3" Cu sites are found in hemocyanin (Hc), tyrosinase (Tyr), and the multicopper oxidases (MCOs), s

286 oma biomarker, here the intracellular enzyme tyrosinase (TYR), was imaged on the tape-collected cells

287 ther to serve as multimodal reporters, human tyrosinase (TYR)--the key enzyme in melanin production--

288 ci, the strongest on chromosome 7 containing tyrosinase (Tyr).

289 (AChE) and butyrylcholinesterase (BChE), and tyrosinase (TYRO) by microtitre plate assays.

290 The enzyme molecule, tyrosinase (Tyrs) has been covalently immobilized on the

291 well maintained as the Michaelis constant of tyrosinase was determined to be 0.90 mmol/L, which is ju

292 or heavy cysteine (d(2)) in the presence of tyrosinase was developed.

293 Activity against tyrosinase was the highest at 210 degrees C (17.92 mgKAE

294 de-MHC epitope of the melanoma-associated Ag tyrosinase were analyzed in detail.

295 Unlike tyrosinase, which also engages AP-3 for optimal melanoso

296 pores allowed the physical immobilization of tyrosinase, which is an enzyme that oxidizes dopamine, o

297 ation of the posttranslational processing of tyrosinase, which may be related with the protein degrad

298 GPR143 coimmunoprecipitated with tyrosinase, while confocal microscopy demonstrated coloc

299 Further, conformational analysis of tyrosinase with BA was measured by fluorescence and circ

300 d structural changes (circular dichroism) of tyrosinase with ED and plasma activated eugenol derivati