ライフサイエンスコーパス: tyrosine hydroxylase

1 ther dimorphic cell populations (kisspeptin, tyrosine hydroxylase).

2 axons were stained immunohistochemically for tyrosine hydroxylase.

3 A neurons, identified by their expression of tyrosine hydroxylase.

4 ng somatostatin, calretinin, parvalbumin, or tyrosine hydroxylase.

5 om chromaffin cells and in the expression of tyrosine hydroxylase.

6 ns that also stained for neurturin, RET, and tyrosine hydroxylase.

7 )/calmodulin-dependent protein kinase II and tyrosine hydroxylase.

8 d with dopamine antibodies but not with anti-tyrosine hydroxylase.

9 urons (DaNs) using the intracellular marker, tyrosine hydroxylase.

10 in knockdown did not alter the expression of tyrosine hydroxylases 1 and 2, choline acetyltransferase

11 continuously generates neurons that express tyrosine hydroxylase 2 (th2).

12 Expression of tyrosine hydroxylase 2 in the brain was elevated in cdnf

13 Here, we demonstrate that tyrosine-hydroxylase-2-expressing (th2+) DA neurons in t

14 human alpha-synuclein and overexpression of tyrosine hydroxylase (a model of sporadic PD).

15 rain and show that Syt2a is colocalized with tyrosine hydroxylase, a biosynthetic enzyme in the dopam

16 We examined the distribution of tyrosine hydroxylase, a conserved precursor for the synt

17 Surprisingly, these cells immunolabeled for tyrosine hydroxylase, a key component in dopamine synthe

18 The absence of coexpression of tyrosine hydroxylase, a marker for dopamine production,

19 from striatal neurons, and many also express tyrosine hydroxylase, a marker of dopaminergic neurons.

20 Human tyrosine hydroxylase activity is regulated by phosphoryl

21 cyclo-DOPA, CYP76AD6 uniquely exhibits only tyrosine hydroxylase activity.

22 ir targeting miRNAs, 145 and 133b; increased tyrosine hydroxylase and alpha-synuclein expression with

23 staining using antibodies targeted for anti-tyrosine hydroxylase and anti-calcitonin gene-related pe

24 s, including reductions in the expression of tyrosine hydroxylase and catechol-O-methyltransferase (C

25 the other brain areas and in the analysis of tyrosine hydroxylase and dopamine D2 receptor levels.

26 ofilament proteins and evidence of decreased tyrosine hydroxylase and dopamine transporter expression

27 antia nigra pars compacta were processed for tyrosine hydroxylase and dopamine transporter immunohist

28 NA levels were decreased in the NAc, whereas tyrosine hydroxylase and dopamine transporter mRNA level

29 ine cell number and volume and expression of tyrosine hydroxylase and dopamine transporter.

30 imbic dopaminergic system was assessed using tyrosine hydroxylase and dynorphin in situ hybridization

31 Tyrosine hydroxylase and Early Growth Response factor-1

32 Viral vector delivery of the two enzymes, tyrosine hydroxylase and guanosine-5'-tri-phosphate-cycl

33 delivery of the l-DOPA synthesizing enzymes, tyrosine hydroxylase and guanosine-tri-phosphate-cyclohy

34 ic input, as indicated by abundant levels of tyrosine hydroxylase and neuropeptide Y.

35 typic downregulation of the dopamine markers tyrosine hydroxylase and Nurr1.

36 the B2AR and catecholamine synthetic enzymes tyrosine hydroxylase and phenylethanolamine-N-methyltran

37 Melanized neurons displayed intense tyrosine hydroxylase and RET proto-oncogene expression i

38 ne (CRH), vasoactive intestinal polypeptide, tyrosine hydroxylase, and aromatase, and labeling densit

39 the dopaminergic neuronal markers, dopamine, tyrosine hydroxylase, and dopamine transporter are defic

40 tered mRNA expression of dopamine receptors, tyrosine hydroxylase, and dopamine transporter genes in

41 eptors (GalR1-R3), tryptophan hydroxylase 2, tyrosine hydroxylase, and nitric oxide synthase as well

42 Wounding downregulated B2AR, tyrosine hydroxylase, and phenylethanolamine-N-methyltra

43 rease of immunoreactivity of neuropeptide Y, tyrosine hydroxylase, and somatostatin.

44 Contents of dopamine, tyrosine hydroxylase, and the 5-HT5A serotonin receptor

45 striatal levels of the dopamine transporter, tyrosine hydroxylase, and the dopamine receptor D1, effe

46 DNA methylation of a specific set of genes, tyrosine hydroxylase, brain-derived neurotrophic factor

47 also led to a decrease in protein levels of tyrosine hydroxylase, but not of tryptophan hydroxylase.

48 compartment as identified by costaining with tyrosine hydroxylase, but not outside these clusters.

49 We find that transgenes under control of the tyrosine hydroxylase, but not the dopamine transporter,

50 one opsin, as well as other retinal markers (tyrosine hydroxylase, calbindin, PKCalpha and Brna3), in

51 Numbers of tyrosine hydroxylase-, calbindin-, and calretinin-expres

52 Efferent nerve fibers were predominant (tyrosine hydroxylase/calcitonin gene-related peptide rat

53 urons that exhibited dual immunostaining for tyrosine hydroxylase (catecholaminergic neurons) and c-F

54 anges were associated with a greater loss of tyrosine hydroxylase cell content and intense neuroinfla

55 ucted for simultaneous detection of NOS with tyrosine hydroxylase, choline acetyltransferase, calbind

56 ns were identified as DA neurons (defined by tyrosine hydroxylase colocalization).

57 ons, implying cholinergic regulation; and by tyrosine hydroxylase-containing axons, implying adrenerg

58 In mice expressing ChR2 in tyrosine hydroxylase-containing neurons, optical activat

59 (d) Immunostains for tyrosine hydroxylase demonstrate that there is selective

60 g Kluver-Barrera (myelin and cell bodies) or tyrosine hydroxylase (dopaminergic neurons) immunohistoc

61 ation, whereas mutations decreasing VMAT and tyrosine hydroxylase exacerbated toxicity.

62 genetics we show the involvement of striatal tyrosine hydroxylase-expressing interneurons in mediatin

63 loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccu

64 ur study identifies a specific population of tyrosine hydroxylase-expressing neurons that is critical

65 ly thought to originate exclusively from the tyrosine-hydroxylase-expressing (TH(+)) neurons in the v

66 dopamine levels or dopamine transporter and tyrosine hydroxylase expression after lesioning with MPT

67 e, release, D2 autoreceptor sensitivity, and tyrosine hydroxylase expression and activity as mechanis

68 AT) undergo alternative activation to induce tyrosine hydroxylase expression and catecholamine produc

69 AT) undergo alternative activation to induce tyrosine hydroxylase expression and catecholamine produc

70 ral alpha-synuclein content, restores nigral tyrosine hydroxylase expression and striatal neurotransm

71 as: an increase in LC bursting activity; in tyrosine hydroxylase expression and that of the noradren

72 n, gene expression analysis revealed reduced tyrosine hydroxylase expression and the regulation of ge

73 tive turnover throughout life and regulating tyrosine hydroxylase expression in an activity-dependent

74 pancreas, GLUT2 expression in the liver, and tyrosine hydroxylase expression in dopaminergic neurons.

75 Additionally, we found no difference in tyrosine hydroxylase expression in the substantia nigra

76 brain cortex neurotransmitter synthesis and tyrosine hydroxylase expression on intracellular ascorba

77 nts but not adults, there was an increase in tyrosine hydroxylase expression that was selective to th

78 macrine cells (brain nitric oxide synthetase/tyrosine hydroxylase expression) and ganglion cell axons

79 ling attenuated the stress-induced change in tyrosine hydroxylase expression.

80 (CT-alpha-syn) in axons, rescued the loss of tyrosine hydroxylase fibers in striatum, and improved mo

81 Regulation of tyrosine hydroxylase gene (Th) transcription is critical

82 d yellow fluorescent protein driven from the tyrosine hydroxylase gene, and then used RNA sequencing

83 essing neurons almost invariably stained for tyrosine hydroxylase, identifying them as dopaminergic.

84 ditory end organ, the saccule, combined with tyrosine hydroxylase immunofluorescence (TH-ir) revealed

85 tracer injections, both in combination with tyrosine hydroxylase immunohistochemistry, to characteri

86 ergic neurons was quantitatively assessed by tyrosine hydroxylase immunohistochemistry.

87 Tyrosine hydroxylase-immunolabeled (sympathetic) nerve t

88 nt did not alter Fos-immunoreactivity within tyrosine hydroxylase-immunolabeled neurons of VTA, but d

89 Dopamine- and tyrosine hydroxylase-immunopositive cells (TH cells) mod

90 easuring striatal dopamine levels, total and tyrosine hydroxylase immunoreactive neuron numbers and B

91 allopregnanolone promotes the restoration of tyrosine hydroxylase immunoreactive neurons and total ce

92 O-treated rats had increased preservation of tyrosine hydroxylase immunoreactive neurons in the subst

93 mid-forebrain bundle increased the number of tyrosine hydroxylase immunoreactive neurons in the subst

94 with melanin concentrating hormone (MCH) and tyrosine hydroxylase immunoreactive neurons of the hypot

95 ed significant increases in the diameters of tyrosine hydroxylase immunoreactive soma in cave Astyana

96 mmunoreactive bipolar cells (one likely also tyrosine hydroxylase immunoreactive) that bore ciliated

97 mmunohistochemistry revealed that almost all tyrosine hydroxylase-immunoreactive (TH-ir) axons in the

98 eatment resulted in a significant sparing of tyrosine hydroxylase-immunoreactive (THir) neurons in th

99 is possibility, we quantified the density of tyrosine hydroxylase-immunoreactive axons as a measure o

100 More tyrosine hydroxylase-immunoreactive neurons and signific

101 ates of the number of melanin-containing and tyrosine hydroxylase-immunoreactive neurons in the subst

102 Lower density of tyrosine hydroxylase-immunoreactive neurons in the ventr

103 noreactive plexus and an apparently separate tyrosine hydroxylase-immunoreactive plexus.

104 d the innervation patterns of both 5-HT- and tyrosine hydroxylase-immunoreactive processes relative t

105 ad1b and gad2 expression in combination with tyrosine hydroxylase immunoreactivity in 4-day-old larva

106 Another finding was a loss of tyrosine hydroxylase immunoreactivity in gut neurons wit

107 ity measurements of dopamine transporter and tyrosine hydroxylase immunoreactivity, which were all si

108 striatal dopamine, and stereologic counts of tyrosine hydroxylase-immunostained neurons in substantia

109 (Nacc) shell, accompanied by a reduction of tyrosine hydroxylase immunostaining and postsynaptic den

110 ring abstinence, as well as the reduction in tyrosine hydroxylase immunostaining and postsynaptic den

111 n using virally mediated RNA interference of tyrosine hydroxylase impaired temporal control, and seco

112 rons in the sympathetic ganglia, increase in tyrosine hydroxylase in both nerve terminals in the SAT

113 activity, expression of the D2 receptor and tyrosine hydroxylase in brain tissue, while markers of n

114 The absence of tyrosine hydroxylase in GABAergic nerve terminals in the

115 a and astrocytes and decreased expression of tyrosine hydroxylase in periglomerular cells, vesicular

116 -mouse IgG1(a) autoantibody colocalized with tyrosine hydroxylase in the basal ganglia within dopamin

117 (PFB) significantly increased the levels of tyrosine hydroxylase in the brain of the Nile Grass rat

118 erations in dopaminergic phenotypic markers (tyrosine hydroxylase) in the early stages of Parkinson's

119 nsity of sensory (CGRP) but not sympathetic (tyrosine hydroxylase) innervation for Old versus Young M

120 dependent on thalamic activation of striatal tyrosine hydroxylase interneurons (THINs).

121 rate-limiting enzyme for dopamine synthesis, tyrosine hydroxylase, is specifically disrupted in the r

122 comprising the first 50 amino acids of human tyrosine hydroxylase, isoform 1 (hTH1), that contain the

123 In mice after tMCAO, tyrosine hydroxylase levels in sympathetic fibers and bo

124 r alpha-synuclein neuropathological load and tyrosine hydroxylase levels in the nucleus accumbens, do

125 I1, nestin); and chromaffin (chromogranin A, tyrosine hydroxylase) markers similar to those of the po

126 onal protein C/D, choline acetyltransferase, tyrosine hydroxylase, neuronal nitric oxide synthase, an

127 it for both at embryonic day [E]12.5-E13.5), tyrosine hydroxylase neurons (E15.5), nitric oxide synth

128 Survival of tyrosine hydroxylase neurons in the substantia nigra was

129 s localized to neurons in the VTA, including tyrosine hydroxylase neurons, but not astrocytes.

130 hat express channel-rhodopsin-2 (ChR2) in LC tyrosine hydroxylase neurons.

131 n C/D, as well as choline acetyltransferase, tyrosine hydroxylase, nitric oxide synthetase, and vasoa

132 iminished, consistent with the dependence of tyrosine hydroxylase on BH4.

133 aSWNTs attenuated METH-induced increases in tyrosine hydroxylase or synaptic protein expression.

134 ased in both Snca-/-, and SNCA-A30P mice but tyrosine hydroxylase+ periglomerular OB neurons were onl

135 f D2S but not D2L prevents the inhibition of tyrosine hydroxylase phosphorylation and, thereby, of do

136 m neurons expressing Per2 and Per3 and their tyrosine hydroxylase phosphorylation is regulated in a c

137 ode the enzymes dopa decarboxylase (Ddc) and tyrosine hydroxylase (ple).

138 n the loss of neuromelanin-containing versus tyrosine hydroxylase positive nigral cells.

139 genitor cells give rise to new dopaminergic [tyrosine hydroxylase-positive (TH(+))] neurons.

140 Mice lacking ErbB4 in tyrosine hydroxylase-positive (TH+) neurons, but not in

141 ve study to determine the plastic changes of tyrosine hydroxylase-positive (TH1(+); mainly dopaminerg

142 with allopregnanolone restored the number of tyrosine hydroxylase-positive and total cell numbers in

143 Sympathetic innervation (tyrosine hydroxylase-positive axon density) and endothel

144 esicular ACh transporter immunoreactivity in tyrosine hydroxylase-positive cardiac sympathetic fibers

145 with motor impairment, as well as postmortem tyrosine hydroxylase-positive cell counts and striatal d

146 osure reduces serotonin immunoreactivity and tyrosine hydroxylase-positive cell populations in specif

147 recovered brain serotonin immunoreactivity, tyrosine hydroxylase-positive cell populations, and resc

148 dures demonstrated that these cells were not tyrosine hydroxylase-positive cells in the Kolliker-Fuse

149 nts, there were more melanin-containing than tyrosine hydroxylase-positive cells.

150 ositive neurons in the nigra and decrease in tyrosine hydroxylase-positive fibers and neurotransmitte

151 In the putamen, dense staining of tyrosine hydroxylase-positive fibres was observed in are

152 ned how dopamine is stored and released from tyrosine hydroxylase-positive GFP (TH(+)-GFP) mouse peri

153 ra pars compacta, there was a 50-90% loss of tyrosine hydroxylase-positive neurons from the earliest

154 rdingly, castration also induced the loss of tyrosine hydroxylase-positive neurons in the nigra and d

155 showed neuroprotective effects by preserving tyrosine hydroxylase-positive neurons in the substantia

156 it of motor function, diminished the loss of tyrosine hydroxylase-positive neurons in the substantia

157 striatal denervation and loss of melanin and tyrosine hydroxylase-positive neurons, is poorly underst

158 at microRNA-7 (miR-7), which is expressed in tyrosine hydroxylase-positive nigral neurons in mice and

159 RDN reduced tyrosine hydroxylase-positive sympathetic nerve staining

160 hysiotropic tuberoinfundibular dopaminergic (tyrosine hydroxylase-positive) neurons; however, <10% of

161 tran-labeled axons (135 of 136 sampled) were tyrosine hydroxylase-positive.

162 ats with loxP-flanked (floxed) alleles and a tyrosine hydroxylase promoter-driven cre allele and demo

163 tional activity, as measured by induction of tyrosine hydroxylase promoter-luciferase activity, compa

164 s elicits a non-cell-autonomous reduction of tyrosine hydroxylase protein level in the axonal project

165 nt reduction of DANs (~35%) in the SNpc, the tyrosine hydroxylase protein level in the striatum (~60%

166 n measured immunolabeling for phosphorylated tyrosine hydroxylase (pTH-ir), the rate-limiting enzyme

167 deletion led to decreases in phosphorylated tyrosine hydroxylase (pTH-Ser40) levels in the VTA and d

168 GABA neurons were not numerous, and most non-tyrosine hydroxylase/retrogradely labeled cells lacked G

169 stochemistry of the sympathetic nerve marker tyrosine hydroxylase revealed a progressive loss of adre

170 n sections in this same plane is stained for tyrosine hydroxylase, revealing the distribution of cate

171 Tyrosine hydroxylase score, which assesses functional ne

172 t with 6-OHDA and brains were stained with a tyrosine hydroxylase-silver nucleolar (TH-AgNOR) stain.

173 ff and was accompanied by a higher number of tyrosine hydroxylase(+) SN neurons (increase of approxim

174 dopamine measurements and unbiased counts of tyrosine hydroxylase-stained nigral cells.

175 There was no significant difference in tyrosine hydroxylase staining between control subjects a

176 We found differences in tyrosine hydroxylase staining in regions that are associ

177 ortem study, a semi-quantitative analysis of tyrosine hydroxylase staining was conducted in nigral do

178 In the post-mortem study we found that tyrosine hydroxylase staining was significantly increase

179 me of these additional fibers also expressed tyrosine hydroxylase, suggesting a sympathetic origin.

180 gene product (pan-neuronal marker; PGP9.5), tyrosine hydroxylase (sympathetic neuron marker; TH), ca

181 well as with the dopamine synthesis enzymes tyrosine hydroxylase (TH) and aromatic amino acid decarb

182 In this work, we evaluated whether tyrosine hydroxylase (TH) and cytochrome P450s (CYPs) ca

183 The full length cDNA sequences of tyrosine hydroxylase (TH) and dopa decarboxylase (DDC),

184 nstrate that Hand1 is dispensable for normal tyrosine hydroxylase (TH) and dopamine beta-hydroxylase

185 in vivo microdialysis, quantified levels of tyrosine hydroxylase (TH) and dopamine transporter (DAT)

186 europathy was studied by staining femurs for tyrosine hydroxylase (TH) and neurofilament 200 (NF-200)

187 tiation into dopaminergic neurons expressing tyrosine hydroxylase (TH) and nuclear receptor related-1

188 ly it also greatly reduced the expression of tyrosine hydroxylase (Th) and other markers of the dopam

189 Expression of the genes Tyrosine Hydroxylase (Th) and Phenylethanolamine N-methy

190 thetic enzymes of DA and 5-HT, respectively, tyrosine hydroxylase (TH) and tryptophan hydroxylase (TP

191 ted to express the neuronal markers Tuj1 and tyrosine hydroxylase (TH) at E10.5, they exited the cell

192 Tyrosine hydroxylase (TH) catalyzes the conversion of l-

193 Tyrosine hydroxylase (TH) catalyzes the hydroxylation of

194 Tyrosine hydroxylase (TH) catalyzes the rate-limiting st

195 as approximately 20% and 38% of oxytocin and tyrosine hydroxylase (TH) cells, respectively, were resp

196 There was a reduction in tyrosine hydroxylase (TH) density in the striatum in the

197 e-derived Dpp stems from modulation of brain tyrosine hydroxylase (TH) expression and dopamine biosyn

198 ation of the flight circuit in pupae reduces Tyrosine Hydroxylase (TH) expression in the PAM neurons

199 PAC) and homovanillic acid (HVA)] levels and tyrosine hydroxylase (TH) expression in the striatum.

200 Neither a knockdown of tyrosine hydroxylase (TH) expression in the VTA by THsiR

201 d dendrite degeneration, progressive loss of tyrosine hydroxylase (TH) expression, and enlarged mitoc

202 O1 directly targets and negatively regulates tyrosine hydroxylase (TH) expression, the rate-limiting

203 nism in acute PD animal models by recovering tyrosine hydroxylase (TH) from the TH-negative dormant d

204 vealed that this enhancer targets the nearby tyrosine hydroxylase (TH) gene responsible for dopamine

205 Also, REV-ERBalpha repressed tyrosine hydroxylase (TH) gene transcription via competi

206 ergic interneurons that express the gene for tyrosine hydroxylase (TH) have been identified previousl

207 ally, we combined in situ hybridization with tyrosine hydroxylase (TH) immunochemistry for better cha

208 grity by measuring fiber length density with tyrosine hydroxylase (TH) immunohistology and dopamine t

209 neurons were dopaminergic (DA), revealed by tyrosine hydroxylase (TH) immunoreactivity.

210 n (PSG) express the catecholaminergic marker tyrosine hydroxylase (TH) in developing murine and human

211 ulated phosphoprotein of 32 kDa (DARPP32) or tyrosine hydroxylase (TH) in tissue sections of adult mo

212 tegmental area (VTA) dopaminergic activity, tyrosine hydroxylase (TH) levels and dopamine synthesis.

213 luciferase reporter gene into the endogenous tyrosine hydroxylase (TH) locus enables rapid and easy q

214 the number of neurons expressing the enzyme tyrosine hydroxylase (TH) near the injected site.

215 ns were significantly reduced by 29% and the tyrosine hydroxylase (TH) negative neurons unaffected af

216 Here we introduce an unexpected neuron, the tyrosine hydroxylase (TH) neuron of the arcuate nucleus

217 whether hypothalamic arcuate (ARC) dopamine/tyrosine hydroxylase (TH) neurons interact with other AR

218 We find that >90% of VTA tyrosine hydroxylase (TH) neurons projecting to the LHb

219 PPG(+) neurons express tyrosine hydroxylase (TH) only in the A1 region of the V

220 neuromelanin pigment or immunolabeling with tyrosine hydroxylase (TH) or calbindin.

221 techolaminergic fibers with somatostatin and tyrosine hydroxylase (TH) or dopamine beta-hydroxylase (

222 with immunofluorescence experiments against tyrosine hydroxylase (TH) or dopamine transporter (DAT).

223 ade tracing with immunocytochemistry against tyrosine hydroxylase (TH) or glutamate decarboxylase (GA

224 PD models when there has been a decrease in tyrosine hydroxylase (TH) positive cells.

225 urons after 25 days of differentiation ( 40% tyrosine hydroxylase (TH) positive, maturing into 25% ce

226 te that VTA GABAergic neurons that coexpress tyrosine hydroxylase (TH) projecting to lateral habenula

227 nced green fluorescent protein driven by the tyrosine hydroxylase (TH) promoter (TH-EGFP) to identify

228 ollowed by an upstream enhancer from the rat tyrosine hydroxylase (TH) promoter, to a neurofilament h

229 ine that expresses eGFP under control of the tyrosine hydroxylase (TH) promoter, we found that mu opi

230 REB-mediated transcriptional activity at the tyrosine hydroxylase (TH) promoter, which is mediated by

231 (3-NT), an indirect index of NO production, tyrosine hydroxylase (TH) protein levels (dopamine termi

232 rograde tracing and immunohistochemistry for tyrosine hydroxylase (TH) to identify bulbospinal catech

233 In contrast, expression of tyrosine hydroxylase (TH) was reduced in the DS, but not

234 opeptide Y (NPY)(+), parvalbumin (PV)(+) and tyrosine hydroxylase (TH)(+), we further elucidate this

235 -mediated loss of SDHC in cells that express tyrosine hydroxylase (TH), a compartment where PPGL is k

236 abeling and immunohistochemical detection of tyrosine hydroxylase (TH), a DA marker.

237 (IL)-4 stimulation induces the expression of tyrosine hydroxylase (TH), a key enzyme in the catechola

238 luorescent protein (GFP) and the promoter of tyrosine hydroxylase (TH), a key synthetic enzyme for ca

239 tochemistry to detect the phosphorylation of tyrosine hydroxylase (TH), a rate-limiting enzyme in the

240 RTqPCR for paired-like homeobox 2b (PHOX2B), tyrosine hydroxylase (TH), and doublecortin (DCX) mRNA i

241 th that of choline acetyltransferase (ChAT), tyrosine hydroxylase (TH), and serotonin (5HT) by double

242 esicular acetylcholine transporter [VAChT]), tyrosine hydroxylase (TH), and serotonin (5HT) to identi

243 to stimulate VTA glutamate neurons in which tyrosine hydroxylase (TH), and thus DA biosynthesis, was

244 d from tyrosine by the rate-limiting enzyme, tyrosine hydroxylase (TH), and tyrosine is catabolized b

245 besides neuroprotection, BRF110 up-regulates tyrosine hydroxylase (TH), aromatic l-amino acid decarbo

246 n interact with tyrosinase (TYR) and inhibit tyrosine hydroxylase (TH), both of which are enzymes inv

247 n blot analysis to compare protein levels of tyrosine hydroxylase (TH), glutamate decarboxylase (GAD6

248 projections labeled with antibodies against tyrosine hydroxylase (TH), melanin-concentrating hormone

249 Immunostaining for tyrosine hydroxylase (TH), sodium channels (Nav ) and an

250 pha), specific to pain-sensing C-fibers, and tyrosine hydroxylase (Th), specific to low-threshold mec

251 immunohistochemical techniques for detecting tyrosine hydroxylase (TH), the initial rate-limiting enz

252 rein, we evaluated whether the expression of tyrosine hydroxylase (TH), the rate limiting enzyme in d

253 In contrast, myeloid-specific deletion of tyrosine hydroxylase (TH), the rate-limiting enzyme in c

254 ely labeled with an antiserum raised against tyrosine hydroxylase (TH), the rate-limiting enzyme in c

255 protein 1 (MTA1) is an upstream modulator of tyrosine hydroxylase (TH), the rate-limiting enzyme in d

256 elanization and reduced immunoreactivity for tyrosine hydroxylase (TH), the rate-limiting enzyme in d

257 used immunohistochemical methods to localize tyrosine hydroxylase (TH), the rate-limiting enzyme in t

258 ion, we decided to study the distribution of tyrosine hydroxylase (TH), the rate-limiting enzyme in t

259 dopaminergic, as judged by the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme of d

260 Intriguingly, fibers expressing tyrosine hydroxylase (TH), the rate-limiting enzyme of d

261 eased expression of DA neuron-enriched genes tyrosine hydroxylase (TH), vesicular monoamine transport

262 ss a noradrenergic phenotype, which includes tyrosine hydroxylase (TH), vesicular monoamine transport

263 tivate expression of neuronal genes, such as tyrosine hydroxylase (TH), which is the rate-limiting en

264 ein or mCherry was injected into the RVLM of tyrosine hydroxylase (TH)-Cre rats.

265 mesolimbic reward system, it was absent from tyrosine hydroxylase (TH)-expressing cells, but tac3a ce

266 Although tyrosine hydroxylase (TH)-immunoreactive neurons in NPPa

267 -immunoreactive(ir) axonal varicosities were tyrosine hydroxylase (TH)-ir and the same proportion wer

268 iation with GAD65/67-immunoreactive (ir) and tyrosine hydroxylase (TH)-ir neurons.

269 t are further divided into two subtypes: (1) tyrosine hydroxylase (TH)-positive C-LTMRs that form the

270 he diagnosis of PD and demonstrated >300,000 tyrosine hydroxylase (TH)-positive grafted cells per sid

271 in a significant reduction in the number of tyrosine hydroxylase (TH)-positive mDA neurons.

272 d significant protection against the loss of tyrosine hydroxylase (TH)-positive neurons of substantia

273 pression of the dopamine-synthesizing enzyme tyrosine hydroxylase (TH).

274 minergic neurons marked by the expression of tyrosine hydroxylase (TH).

275 f the rate-limiting enzyme for CA synthesis, tyrosine hydroxylase (TH).

276 tified following injury using an antibody to tyrosine hydroxylase (TH).

277 of the rate-limiting enzyme in DA synthesis, tyrosine hydroxylase (TH).

278 GLAST, and dopaminergic function, including tyrosine hydroxylase (TH).

279 Multiple tyrosine hydroxylase (Th)::Cre and choline acetyltransfe

280 ], dopamine function [striatal expression of tyrosine hydroxylase (Th)], glucocorticoid receptor (GR)

281 s assessed using antibodies directed against tyrosine hydroxylase (TH, DAergic marker), Iba-1 (pan-mi

282 by simultaneous detection of VGluT2 mRNA and tyrosine hydroxylase (TH; for identification of dopamine

283 protein 43 (GAP-43; sprouted nerve fibers), tyrosine hydroxylase (TH; sympathetic nerve fibers), CD3

284 calabaricus, by means of antibodies against tyrosine hydroxylase (TH; the first enzyme in the synthe

285 esicular acetylcholine transporter [VAChT]), tyrosine hydroxylase (TH; the rate-limiting enzyme in ca

286 photoperiods alters the number of dopamine (tyrosine hydroxylase, TH+) and somatostatin (SST+) neuro

287 es the survival of grafted dopamine neurons (tyrosine hydroxylase: TH+).

288 translation of the two non-allelic forms of tyrosine hydroxylase (th1 and th2) in zebrafish larvae.

289 d parkinsonian phenotypes, including loss of tyrosine hydroxylase (Th1)-positive dopaminergic (DA) ne

290 t attributable to lack of phosphorylation of tyrosine hydroxylase, the key enzyme involved in DA synt

291 ion of Foxa1/2 results in down-regulation of tyrosine hydroxylase, the rate-limiting enzyme of dopami

292 -ligated heme-dependent dehaloperoxidase and tyrosine hydroxylase, thiolate-ligated heme-dependent cy

293 Tyrosine hydroxylase (TyrH) catalyzes the hydroxylation

294 levels, sympathetic axons (immunostained for tyrosine hydroxylase) undergo robust collateral sproutin

295 Starting from wild-type rats, knockout of tyrosine hydroxylase was achieved with adeno-associated

296 Colocalization of NOS and tyrosine hydroxylase was observed in numerous cells of t

297 ons, leading to downregulation of the enzyme tyrosine hydroxylase, which is essential for dopamine sy

298 sion also caused ectopic zonal expression of tyrosine hydroxylase, which is only expressed in adult P

299 de, vesicular acetylcholine transporter, and tyrosine hydroxylase, which selectively label spinal aff

300 Nigrally targeted expression of mutant tyrosine hydroxylase with enhanced catalytic activity in