ライフサイエンスコーパス: tyrosyl

1 -[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-l-tyrosyl]-4-phenylpiperazine (KN-62) blocks MOR-mediated

2 rentially modulated SHP-2 phosphorylation at tyrosyl 542 and 580 residues, which may regulate Erk1/2

3 blocked in vivo by a resveratrol-displacing tyrosyl adenylate analogue.

4 eviously described for synthesis of 1 mol of tyrosyl adenylate by the dimeric class I tyrosyl-tRNA sy

5 ivity," with respect to tyrosine binding and tyrosyl-adenylate formation.

6 tly affect the kinetics for formation of the tyrosyl-adenylate intermediate and actually increases th

7 ep, tyrosine is activated by ATP to form the tyrosyl-adenylate intermediate.

8 expressed in E. coli, using archaea-derived tyrosyl and pyrrolysyl pairs.

9 s two intermediates corresponding to neutral tyrosyl and tryptophanyl radicals that are formed along

10 by a "hopping" mechanism involving multiple tyrosyl (and perhaps one tryptophanyl) radical intermedi

11 Both the Escherichia coli tyrosyl- and leucyl-RS/tRNA(CUA) pairs were shown to be

12 nucleotide reductase (RNR) houses a diferric tyrosyl cofactor (Fe2(III)-Y(*)) that initiates nucleoti

13 ), with decreased phosphorylation of various tyrosyl-containing proteins, EphB4, and its downstream t

14 xerts a unique regulatory fingerprint of RTK tyrosyl dephosphorylation and suggest a complex signalin

15 the involvement of the RPTP subfamily in RTK tyrosyl dephosphorylation has not been established.

16 phosphorylated, much less is known about RTK tyrosyl dephosphorylation.

17 ides were identified after chloramination of tyrosyl dipeptides in the presence of I(-) and were dete

18 Tyrosyl dipeptides produced N-Cl-, 3-I-/3,5-di-I-, and N

19 N-di-Br- as well as N-Br- N-Cl- and N-Br-3-I-tyrosyl dipeptides were identified using infusion electr

20 produced N-Cl-, 3-I-/3,5-di-I-, and N-Cl-3-I-tyrosyl dipeptides, while Phe-Gly formed only N-Cl-/ N,

21 actin binding activity of ACTN4 by inducing tyrosyl-directed phosphorylation.

22 afeguards genome integrity by hydrolyzing 5'-tyrosyl DNA adducts formed by abortive topoisomerase II

23 DP2; aka TTRAP/EAPII) that possesses weak 3'-tyrosyl DNA phosphodiesterase (3'-TDP) activity, in vitr

24 Recently, we identified a second tyrosyl DNA phosphodiesterase (TDP2; aka TTRAP/EAPII) th

25 Tyrosyl DNA phosphodiesterase 1 (TDP1) and human AP-endo

26 We recently showed that tyrosyl DNA phosphodiesterase 1 (Tdp1) regulates the acc

27 Here, we report that depletion of Tyrosyl DNA phosphodiesterase 1 (TDP1) sensitizes human

28 This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1), which removes st

29 Repair of such damage by tyrosyl DNA phosphodiesterase 2 (TDP2) could render canc

30 Tyrosyl DNA phosphodiesterase 2 (TDP2) is a multifunctio

31 Tyrosyl DNA phosphodiesterase 2 (Tdp2) is a recently dis

32 Tyrosyl DNA phosphodiesterase 2 (TDP2), a newly discover

33 ural compounds in the presence or absence of tyrosyl DNA phosphodiesterase I (TDP1); a key TOP1-media

34 Tyrosyl DNA phosphodiesterase II (TDP2) is a recently di

35 thesis of a potential selective inhibitor of tyrosyl DNA phosphodiesterase II is performed.

36 Importantly, we identified TDP2, a 5'-tyrosyl DNA phosphodiesterase involved in the repair of

37 e 2 (Tdp2) is a recently discovered human 5'-tyrosyl DNA phosphodiesterase that repairs this topoisom

38 RAP is, to our knowledge, the first human 5'-tyrosyl DNA phosphodiesterase to be identified, and we s

39 Tyrosyl DNA phosphodiesterase-1 protects cells from abor

40 , and we suggest that this enzyme is denoted tyrosyl DNA phosphodiesterase-2 (TDP2).

41 mozygous mutations in the TDP2 gene encoding tyrosyl DNA phosphodiesterase-2, an enzyme that repairs

42 Tyrosyl DNA-phosphodiesterase I (TDP1) repairs type IB t

43 l of polymerase from rcDNA via unlinking the tyrosyl-DNA phosphodiester bond during rcDNA deproteinat

44 o the viral polymerase (P protein) through a tyrosyl-DNA phosphodiester bond.

45 (PLD), phosphatidylserine synthase (PSS) and tyrosyl-DNA phosphodiesterase (TDP), and conserved catal

46 Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phos

47 Human tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phos

48 Tyrosyl-DNA phosphodiesterase (TDP1) is a phylogenetical

49 Human tyrosyl-DNA phosphodiesterase (Tdp1) processes 3'-blocki

50 critical enzyme for TOP1cc resolution is the tyrosyl-DNA phosphodiesterase (TDP1), which hydrolyses t

51 ssess moderate inhibitory activities against tyrosyl-DNA phosphodiesterase 1 (TDP1) and tyrosyl-DNA p

52 Interestingly, the CRISPR/Cas9 mutants of TYROSYL-DNA PHOSPHODIESTERASE 1 (TDP1) are insensitive t

53 Tyrosyl-DNA phosphodiesterase 1 (Tdp1) catalyzes the hyd

54 vity of the potential anticancer drug target tyrosyl-DNA phosphodiesterase 1 (TDP1) in a very simple,

55 Here, we reveal the importance of tyrosyl-DNA phosphodiesterase 1 (TDP1) in the repair of

56 Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme i

57 Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a molecular ta

58 Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an enzyme that

59 Tyrosyl-DNA phosphodiesterase 1 (TDP1), a key repair enz

60 rved in individuals containing a mutation in tyrosyl-DNA phosphodiesterase 1 (TDP1), an enzyme that c

61 d the involvement of topoisomerase 1 (TOP1), tyrosyl-DNA phosphodiesterase 1 (TDP1), and single-stran

62 ir cross-complementing protein 1 (XRCC1) and tyrosyl-DNA phosphodiesterase 1 (TDP1), using fluorescen

63 mal cells, suggesting a significant role for tyrosyl-DNA phosphodiesterase 1 in removing 3'-PG blocki

64 osphate termini, and were more persistent in tyrosyl-DNA phosphodiesterase 1-mutant SCAN1 than in nor

65 ntermediates, e.g. polynucleotide kinase and tyrosyl-DNA phosphodiesterase 1.

66 nd were further increased by inactivation of tyrosyl-DNA phosphodiesterase 1.

67 mage as an alternative pathway from PARP and tyrosyl-DNA phosphodiesterase 1.

68 However, knockout of cellular 5' tyrosyl-DNA phosphodiesterase 2 (TDP2) did not markedly

69 The recently discovered enzyme tyrosyl-DNA phosphodiesterase 2 (TDP2) has been implicat

70 TOP2cc facilitates a proteasome-independent tyrosyl-DNA phosphodiesterase 2 (TDP2) hydrolase activit

71 Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a multifunctio

72 Tyrosyl-DNA phosphodiesterase 2 (TDP2) reverses Topoisom

73 Mammalian Tyrosyl-DNA phosphodiesterase 2 (Tdp2) reverses Topoisom

74 t tyrosyl-DNA phosphodiesterase 1 (TDP1) and tyrosyl-DNA phosphodiesterase 2 (TDP2), two enzymes that

75 double-strand breaks are rejoined in part by tyrosyl-DNA phosphodiesterase 2 (TDP2)-dependent non-hom

76 TDP2 possesses both 3'- and 5'-tyrosyl-DNA phosphodiesterase activity, which is general

77 Tyrosyl-DNA phosphodiesterase I (Tdp1) catalyzes the rep

78 Tyrosyl-DNA phosphodiesterase I (Tdp1) is a cellular enz

79 Tyrosyl-DNA phosphodiesterase I (Tdp1) is a member of th

80 Tyrosyl-DNA phosphodiesterase I (Tdp1) plays a key role

81 Tyrosyl-DNA phosphodiesterase I (TDP1) repairs stalled t

82 Substances with dual tyrosyl-DNA phosphodiesterase I-topoisomerase I inhibito

83 ingle-strand break repair factors, including tyrosyl-DNA phosphodiesterase-1 or XRCC1, resulted in in

84 f VPg unlinkase as the DNA repair enzyme, 5'-tyrosyl-DNA phosphodiesterase-2 (TDP2).

85 By interacting with another nuclear protein TYROSYL-DNA PHOSPHODIESTERASE1 (TDP1), AN imposes transc

86 Tdp1 and Tdp2 are two tyrosyl-DNA phosphodiesterases that can repair damaged D

87 We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12, an RNA polymera

88 merase-DNA adducts and their known repair by tyrosyl-DNA-phosphodiesterase (TDP) 1 or TDP2 suggested

89 Tyrosyl-DNA-phosphodiesterase 1 (Tdp1) can disjoin pepti

90 was attributed to the reduced expression of tyrosyl-DNA-phosphodiesterase 1 (TDP1), a DNA repair enz

91 covalent complexes are excised (in part) by tyrosyl-DNA-phosphodiesterase 2 (TDP2/TTRAP/EAP2/VPg unl

92 s(-1)M(-1) for TDP2 using single-stranded 5'-tyrosyl-DNA.

93 sulting in a Y --> H substitution in the tri-tyrosyl domain of the enamel extracellular matrix protei

94 rromagnetically coupled iron centers and one tyrosyl free radical, Y122*/beta2.

95 netic resonance (EPR) parameters such as the tyrosyl g-tensor, allowing us to map the correspondence

96 In tyrosyl-glycine and Leu-enkephalin, which have N-termina

97 onically coupled along dynamics to the Tyr-Z tyrosyl group, releases a proton from the nearby W1 wate

98 The cleaved MeP-tyrosyl intermediate formed by Flp(R191A) can be targete

99 nt for understanding redox chains relying on tyrosyl intermediates.

100 most efficient when the DNA attached to the tyrosyl is in a single-stranded configuration and that T

101 oduction of iodine substituents onto cyclo(l-tyrosyl-l-tyrosine) results in sub-muM binding affinity

102 A series of analogues of cyclo(l-tyrosyl-l-tyrosine), the substrate of the Mycobacterium

103 A transient tyrosyl-like radical with a narrow doublet X-band EPR si

104 sphodiester bond at a DNA 3'-end linked to a tyrosyl moiety and has been implicated in the repair of

105 In the second step, the tyrosyl moiety is transferred to the 3' end of tRNA.

106 and actually increases the rate at which the tyrosyl moiety is transferred to tRNA(Tyr).

107 ter bond between the DNA 3'-end and the Top1 tyrosyl moiety.

108 sphodiester bond at a DNA 3' end linked to a tyrosyl moiety.

109 interactions mediated via the amelogenin tri-tyrosyl motif are a key mechanistic factor underpinning

110 hanyl pair can be combined with the archaeal tyrosyl or the pyrrolysyl pair in ATMW1 E. coli to incor

111 The scaffold protein Gab2 is a major tyrosyl phosphoprotein in the CSF-1R signaling network.

112 mutant PI3K remained associated with several tyrosyl phosphoproteins, potentially explaining the disp

113 Here, we further investigate the role of the tyrosyl phosphorylated PAK1 (pTyr-PAK1) in regulation of

114 a detailed understanding of how RTKs become tyrosyl phosphorylated, much less is known about RTK tyr

115 kinases (RTKs) exist in equilibrium between tyrosyl-phosphorylated and dephosphorylated states.

116 d modular units, which recognize and bind to tyrosyl-phosphorylated peptide sequences on their target

117 to promote cell migration, as a major hyper-tyrosyl-phosphorylated protein in mouse and zebrafish mo

118 Binding of the tyrosyl-phosphorylated proteins at the fructose 1,6-bisp

119 at each RPTP induced a unique fingerprint of tyrosyl phosphorylation among 42 RTKs.

120 ted SHP-2 mutants enhanced SIRPalpha and PZR tyrosyl phosphorylation either by impairing SIRPalpha de

121 sphatase PTPN9 significantly increases ErbB2 tyrosyl phosphorylation in the SKBR3 breast cancer cell

122 PZR hyper-tyrosyl phosphorylation is facilitated in a phosphatase-

123 expression of PTPN9 DA dramatically enhances tyrosyl phosphorylation of ErbB2 and EGFR, respectively.

124 expression of PTPN9 wild type (WT) inhibits tyrosyl phosphorylation of ErbB2 and EGFR.

125 ion of PTPN9 WT or DA mutant does not affect tyrosyl phosphorylation of ErbB3 and Shc.

126 We show that the tyrosyl phosphorylation of PAK1 promotes PAK1 binding to

127 NA/C6 interaction leads to increased tyrosyl phosphorylation of Src, FAK, Akt, GSK3beta, and

128 in- and interferon gamma (IFN-gamma)-induced tyrosyl phosphorylation of STAT1 and STAT5.

129 odies (intrabodies) enhanced insulin-induced tyrosyl phosphorylation of the beta subunit of the insul

130 knockdown of PTPN9 expression also enhances tyrosyl phosphorylation of the ErbB1/epidermal growth fa

131 findings are characterized by enhancement of tyrosyl phosphorylation of the insulin receptor, insulin

132 ne MCF-7 because it is kept downregulated by tyrosyl phosphorylation of Y(296) by EGFR kinase.

133 ha treatment triggered a robust induction of tyrosyl phosphorylation on Shp2.

134 Palpha dephosphorylation or by promoting PZR tyrosyl phosphorylation.

135 s 153, 201, and 285 in PAK1 as sites of JAK2 tyrosyl phosphorylation.

136 gastrulation in a manner dependent upon PZR tyrosyl phosphorylation.

137 Here we report tyrosyl-phosphorylation of endogenous RAS and demonstrat

138 a native (40-95) disulfide bond by a nearby tyrosyl-prolyl stacking interaction, when disulfide bond

139 Tyrosyl protein sulfotransferase (TPST) is an enzyme req

140 By in planta co-expression of tyrosyl protein sulfotransferase 1, we installed O-sulfa

141 or VHZ mediates dephosphorylation of phospho-tyrosyl (pTyr) and phospho-seryl/threonyl (pSer/pThr) re

142 h Fe(II) and O2 can self-assemble a diferric-tyrosyl radical (Fe(III)2-Y(*)) cofactor (1.2 Y(*)/beta2

143 bonucleotide reductase (RNR) uses a diferric-tyrosyl radical (Fe(III)2-Y(*)) cofactor to initiate nuc

144 Ib RNR self-assembles an essential diferric-tyrosyl radical (Fe(III)2-Y(*)) in vitro, whereas assemb

145 leotide reductases (RNRs) require a diferric-tyrosyl radical (Fe(III)2-Y*) cofactor to produce deoxyn

146 onstrate that this enzyme uses a dimanganese-tyrosyl radical (Mn(III)2-Y(*)) cofactor in vivo.

147 in vitro, whereas assembly of a dimanganese-tyrosyl radical (Mn(III)2-Y(*)) cofactor requires NrdI,

148 lpha), CDP and effector ATP to trap an amino tyrosyl radical (NH2Y*) in the active alpha2beta2 comple

149 and Ib RNRs, this reaction requires a stable tyrosyl radical (Y(*)) generated by oxidation of a reduc

150 In a class Ia or Ib RNR, a stable tyrosyl radical (Y(*)) is the C oxidant, whereas a Mn(IV

151 ribonucleotide reductase (RNR) uses either a tyrosyl radical (Y(*)) or a Mn(IV)/Fe(III) cluster in it

152 sfer (PCET) from tyrosine produces a neutral tyrosyl radical (Y(*)) that is vital to many catalytic r

153 beta2 contains a stable di-iron tyrosyl radical (Y(122)(*)) cofactor required to generat

154 esides in alpha2, and the essential diferric-tyrosyl radical (Y(122)(*)) cofactor that initiates tran

155 beta2 contains the essential diferric tyrosyl radical (Y(122)(*)) cofactor which, in the prese

156 eine (C(439)) in alpha2 by a stable diferric tyrosyl radical (Y(122)*) cofactor in beta2.

157 long-range radical transfer over 35 A from a tyrosyl radical (Y(122)*) within the beta2 subunit to a

158 During turnover, a stable tyrosyl radical (Y*) at Y(122)-beta2 reversibly oxidizes

159 tal clusters for activity: an Fe(III)Fe(III)-tyrosyl radical (Y*) cofactor (class Ia), a Mn(III)Mn(II

160 subunit is transiently oxidized by a stable tyrosyl radical (Y*) in the RNR small (beta2) subunit ov

161 s to deoxynucleotides with either a Mn(III)2-tyrosyl radical (Y*) or a Fe(III)2-Y* cofactor in the Nr

162 RNR was rapidly produced with 0.25 +/- 0.03 tyrosyl radical (Y*) per beta2 and a specific activity o

163 beta2 contains the essential tyrosyl radical (Y122(*)) that generates a thiyl radical

164 A diferric-tyrosyl radical (Y122*) in one subunit (beta2) generates

165 coupled mu-oxo bridged diiron cluster and a tyrosyl radical (Y122*).

166 quires a reversible oxidation over 35 A by a tyrosyl radical (Y122*, Escherichia coli) in subunit bet

167 beta2 subunit contains an essential diferric-tyrosyl radical (Y122O(*)) cofactor that is needed to in

168 nce electron transfer involving an essential tyrosyl radical (Y122O.) in the beta2 subunit.

169 ecombinant NrdF (rNrdF) contained a diferric-tyrosyl radical [Fe(III)(2)-Y(*)] cofactor.

170 RNR is inactivated by loss of the essential tyrosyl radical and formation of a new radical.

171 rule out the possibility that MCR(BES) is a tyrosyl radical and indicate that if a tyrosyl radical i

172 he nearly diffusion-limited reaction between tyrosyl radical and superoxide.

173 logue of the redox reaction between the PSII tyrosyl radical and the oxygen-evolving complex.

174 f interaction of the proximal water with the tyrosyl radical and the position of the phenolic proton

175 tions on the related interaction between the tyrosyl radical and the water in biological systems.

176 ry stable products of superoxide addition to tyrosyl radical are para-hydroperoxide derivatives (para

177 by redox-linked electrostatic changes in the tyrosyl radical aromatic ring.

178 The Cu(II)-tyrosyl radical center entails the formation of signific

179 cleotide reductase (RNR) contains a diferric tyrosyl radical cofactor (Fe(2)(III)-Tyr(*)) that is ess

180 eductase (RNR) employs a mu-oxo-Fe2(III/III)/tyrosyl radical cofactor in its beta subunit to oxidize

181 radical transfer (RT) from a stable diferric-tyrosyl radical cofactor located >35 A away across the a

182 on the magnetic properties of the manganese-tyrosyl radical cofactor of Bacillus anthracis NrdF and

183 e direct precursor of the essential diferric-tyrosyl radical cofactor of the beta2 subunit of Escheri

184 cleotide reductases (RNRs) use a dimanganese-tyrosyl radical cofactor, Mn(III)(2)-Y(*), in their homo

185 nit is denoted NrdF, and harbors a manganese-tyrosyl radical cofactor.

186 ne, we report herein direct observation of a tyrosyl radical during both reactions of H2O2 with oxidi

187 c site and RR2 (beta) that houses a diferric-tyrosyl radical essential for ribonucleoside diphosphate

188 n state of the metal site, as opposed to the tyrosyl radical generated by other R2 subclasses.

189 The tyrosyl radical in NrdF is stabilized through its intera

190 ectroscopy, providing a firm support for the tyrosyl radical in the HCO enzymatic mechanism.

191 enesis pathway that proceeds through a Cu(I)-tyrosyl radical intermediate, but consistent with a path

192 is a tyrosyl radical and indicate that if a tyrosyl radical is formed during the reaction, it does n

193 yptophan residue, revealed a decrease of the tyrosyl radical lifetime by almost two orders of magnitu

194 conserved location of the cysteine-oxidizing tyrosyl radical of class Ia and Ib RNRs, we suggested th

195 Reduction of the tyrosyl radical reveals Y122* Raman bands at 1499 and 15

196 ethyl peroxide led to some narrowing of the tyrosyl radical signal detected by EPR spectroscopy, con

197 This is the position proximal to the tyrosyl radical site in other R2 proteins and consistent

198 h H(2)O(2) at higher pHs is a singlet Cu(II)-tyrosyl radical species, which is inactive for the oxida

199 This dramatic modulation of tyrosyl radical stability by cyclooxygenase site ligands

200 the novel cofactor functionally replaces the tyrosyl radical used by conventional class I RNRs to ini

201 The half-life of total tyrosyl radical was 4.1 min in the control, >10 h with a

202 length aCRY revealed an unusually long-lived tyrosyl radical with a lifetime of 2.6 s, which is prese

203 rsion of the flavin, an unusually long-lived tyrosyl radical with a red-shifted ultraviolet-visible s

204 roscopic observation of chemically competent tyrosyl radical(s).

205 ferric DHP contains both a ferryl heme and a tyrosyl radical, analogous to Compound ES of cytochrome

206 he widely proposed mechanism that involves a tyrosyl radical, its direct observation under O2 reducti

207 is fully capable of generating the oxidized, tyrosyl radical-containing form of Mn-NrdF when exposed

208 e responsible for the characteristics of the tyrosyl radical.

209 diate that contains both a ferryl heme and a tyrosyl radical.

210 ies functions as a direct substitute for the tyrosyl radical.

211 giving rise to the temporary appearance of a tyrosyl radical.

212 SOMO of the Cu(II) is orientated toward the tyrosyl radical.

213 the iron cluster and by the reduction of the tyrosyl radical.

214 and a shift in g values away from the native tyrosyl radical.

215 rom the kinetics of formation and decay of a tyrosyl radical.

216 g a conserved hydrogen bond to the catalytic tyrosyl radical/tyrosine, was examined for the first tim

217 a distance of ~35 A from the stable diferric/tyrosyl-radical (Y122(*)) cofactor in the beta subunit t

218 ucleotide reductase that requires a diferric-tyrosyl-radical [(Fe(III)(2)-Y.)(Fe(III)(2))] cofactor f

219 Both tyrosyl radicals are transient and rapidly dissipated by

220 X-band EPR demonstrates that the two tyrosyl radicals differ in the orientation of their beta

221 heir unprotonated neutral form, but to date, tyrosyl radicals have only been observed in their unprot

222 generated on L-Tyr by UV-irradiation and to tyrosyl radicals identified in many other enzyme systems

223 he framework of the important role played by tyrosyl radicals in biological systems.

224 ) EPR reveals the presence of two species of tyrosyl radicals in Cpd ES with their g-tensor component

225 d assignments and to deduce the role(s) that tyrosyl radicals play in DHP, stopped-flow UV-visible an

226 Stabilization of the tyrosyl radicals was evident even at substoichiometric l

227 inhibitors on the stability of the preformed tyrosyl radicals were dramatic.

228 hanism for regulating the reactivity of PGHS tyrosyl radicals with cellular antioxidants.

229 ical derivatives of the amino acid tyrosine (tyrosyl radicals) which are also involved in physiologic

230 nhibitors that bind rapidly to COX-2, quench tyrosyl radicals, and reduce higher oxidation states of

231 xanthine oxidase, to several peptide-derived tyrosyl radicals, formed from horseradish peroxidase.

232 aromatic residues and stabilize on oxidized tyrosyl radicals, giving rise to a distinct EPR spectrum

233 sines, Y(Z) and Y(D), which form the neutral tyrosyl radicals, Y(z)(*) and Y(D)(*).

234 -dependent, effects on the stability of both tyrosyl radicals.

235 .00186) similar to but not typical of native tyrosyl radicals.

236 protein alterations and increased oxidative tyrosyl radicals.

237 yrosinase-catalyzed oxidation of tyrosine or tyrosyl residue in peptides.

238 onsible for dephosphorylating the C-terminal tyrosyl residue of histone H2A.X.

239 riant H2A.X is characterized by a C-terminal tyrosyl residue, Tyr-142, which is phosphorylated by an

240 ents and two helical re-entry loops and that tyrosyl residues are the structural specialization of th

241 cond phase, Src family kinases phosphorylate tyrosyl residues within the transmembrane and cytoplasmi

242 8 flies were defective in hydrolyzing 3'-DNA-tyrosyl residues, demonstrating that gkt is the Drosophi

243 elective hydroxylation of 3-substituted beta-tyrosyl-S-SgcC2 analogues, including the chloro-, bromo-

244 nalogues, but does not accept 3-hydroxy-beta-tyrosyl-S-SgcC2 as a substrate.

245 yzes the hydroxylation of ( S)-3-chloro-beta-tyrosyl-S-SgcC2 as the final step in the biosynthesis of

246 iciency, between (S)-3-chloro-5-hydroxy-beta-tyrosyl-(S)-SgcC2 and (R)-2-amino-1-phenyl-1-ethanol, an

247 SgcC5 uses (S)-3-chloro-5-hydroxy-beta-tyrosyl-SgcC2 as the donor substrate and exhibits regios

248 ex structures indicate that aromatic, mostly tyrosyl, side chains constitute the major part of the pr

249 nt family member interaction that depends on tyrosyl sulfation.

250 e enhanced markedly by overexpression of the tyrosyl sulfotransferase TPST2.

251 The propensity of the cYY tyrosyl to point toward Arg(386) was dependent on the pr

252 Because human tyrosyl transfer-RNA (tRNA) synthetase (TyrRS) transloca

253 The Methanococcus jannaschii tyrosyl-transfer-RNA synthetase-tRNA(CUA) (MjTyrRS-tRNA(

254 In this manner, a natural fragment of human tyrosyl tRNA synthetase (TyrRS), mini-TyrRS, has been sh

255 etic code, only the Methanococcus jannaschii tyrosyl tRNA synthetase and tRNA have been used extensiv

256 has a mutation in the gene (dtd) encoding D-tyrosyl-tRNA deacylase, an enzyme that prevents the misi

257 Puromycin is a tyrosyl-tRNA mimic that blocks translation by labeling a

258 alleles of the nuclear-encoded mitochondrial tyrosyl-tRNA synthetase (Aatm) and the mitochondrial-enc

259 bifunctional Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) both aminoacyla

260 y explores the twin attributes of Leishmania tyrosyl-tRNA synthetase (LdTyrRS) namely, aminoacylation

261 The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (mtTyrRS; CYT-18 protein) evolve

262 ral effect of three CMT-causing mutations in tyrosyl-tRNA synthetase (TyrRS or YARS).

263 nation of methods, here we showed that human tyrosyl-tRNA synthetase (TyrRS) distributes to the nucle

264 The single tyrosyl-tRNA synthetase (TyrRS) gene in trypanosomatid g

265 Here we show that a nuclear function of tyrosyl-tRNA synthetase (TyrRS) is implicated in a Droso

266 Tyrosyl-tRNA synthetase (TyrRS) is known for its essenti

267 ecent work demonstrated that RSV facilitates tyrosyl-tRNA synthetase (TyrRS)-dependent activation of

268 utation of the gene encoding the cytoplasmic tyrosyl-tRNA synthetase (TyrRS).

269 internally deleted, SVs of homodimeric human tyrosyl-tRNA synthetase (TyrRS).

270 children homozygous for a novel mutation in tyrosyl-tRNA synthetase (YARS, c.499C > A, p.Pro167Thr)

271 Expression of CMT-mutant tyrosyl-tRNA synthetase also impairs translation, sugges

272 Bacillus stearothermophilus tyrosyl-tRNA synthetase binds d-tyrosine with an 8.5-fol

273 Catalysis of tRNA(Tyr) aminoacylation by tyrosyl-tRNA synthetase can be divided into two steps.

274 ed sigmoidal behavior presents a paradox, as tyrosyl-tRNA synthetase displays an extreme form of nega

275 Furthermore, as is the case for l-tyrosine, tyrosyl-tRNA synthetase exhibits "half-of-the-sites" rea

276 The activation of D-tyrosine by tyrosyl-tRNA synthetase has been investigated using sing

277 e van't Hoff plots for the binding of ATP to tyrosyl-tRNA synthetase in the absence and presence of s

278 dy, and in vivo functional verification of a tyrosyl-tRNA synthetase mutant for the genetic encoding

279 dy-state kinetic analyses of CHO cytoplasmic tyrosyl-tRNA synthetase revealed a 25-fold lower specifi

280 ional comparisons of mammalian and bacterial tyrosyl-tRNA synthetase revealed key differences at resi

281 ora crassa CYT-18 protein is a mitochondrial tyrosyl-tRNA synthetase that also promotes self-splicing

282 DI-CMTC is due to a defect in the ability of tyrosyl-tRNA synthetase to catalyze the aminoacylation o

283 ytokine function of the 528-amino acid human tyrosyl-tRNA synthetase was associated with pinpointed u

284 charging of tRNA(Tyr) with noncognate Phe by tyrosyl-tRNA synthetase was responsible for mistranslati

285 rmore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by da

286 of tyrosyl adenylate by the dimeric class I tyrosyl-tRNA synthetase, operates as well in this homote

287 ly>Val) in YARS2 gene encoding mitochondrial tyrosyl-tRNA synthetase, which interacts with m.11778G>A

288 An example is the 528-amino acid human tyrosyl-tRNA synthetase, which is made up of an N-termin

289 DI-CMTC is not due to a catalytic defect in tyrosyl-tRNA synthetase.

290 Its genome encodes a single copy of tyrosyl-tRNA synthetase.

291 ts the non-canonical function of L. donovani tyrosyl-tRNA synthetase.

292 zed 1 and evolved a Methanococcus jannaschii tyrosyl-tRNA synthetase/tRNA(CUA) pair to genetically en

293 The mitochondrial tyrosyl-tRNA synthetases (mt TyrRSs) of Pezizomycotina f

294 The mitochondrial tyrosyl-tRNA synthetases (mtTyrRSs) of Pezizomycotina fu

295 netic reconstruction, two types of bacterial tyrosyl-tRNA synthetases (TyrRS) form distinct clades wi

296 Our results suggest that mitochondrial tyrosyl-tRNA synthetases with group I intron splicing ac

297 ptations compared with nonsplicing bacterial tyrosyl-tRNA synthetases.

298 ocaldococcus jannaschii and Escherichia coli tyrosyl-tRNA synthetases.

299 thetase (Aatm) and the mitochondrial-encoded tyrosyl-tRNA that it aminoacylates.

300 reaction between amino acid hydroperoxides (tyrosyl, tryptophan, and histidine hydroperoxides) and C

301 correct positioning of the hydroxyl of this tyrosyl was essential for conversion of cYY.