ライフサイエンスコーパス: ubiquitin C-terminal hydrolase

1 enes, one of which encodes a neuron-specific ubiquitin C-terminal hydrolase.

2 , glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase.

3 gy to the known de-ubiquitinating enzymes or ubiquitin C-terminal hydrolases.

4 served Cys and His domains characteristic of ubiquitin C-terminal hydrolases.

5 zymes, and UCH-L3, a member of the family of ubiquitin C-terminal hydrolases.

6 690 amino acid protein with high homology to ubiquitin C-terminal hydrolases.

7 Ubiquitin C-terminal hydrolase 37 (UCH37 also known as U

8 point blockade (ICB) response, including the ubiquitin C-terminal hydrolase 5 (UCHL5).

9 ly weaker inhibitory activity towards UCHL5 (ubiquitin-C-terminal hydrolase-5).

10 The deubiquitylating enzyme ubiquitin C-terminal hydrolase 6 [Ubp6; ubiquitin-specif

11 form a protein complex with the unidentified ubiquitin C-terminal hydrolase and recruit UbC1 to this

12 lement-binding protein 1 (CREB1), CREB2, and ubiquitin C-terminal hydrolase (Ap-uch) have been implic

13 and the regulation of one of its components, ubiquitin C-terminal hydrolase (ap-uch), in LTD.

14 Ubiquitin C-terminal hydrolases catalyze the removal of

15 smodium falciparum homologue, members of the ubiquitin C-terminal hydrolase family, use a unique acti

16 accomplished in part by members of the UCH (ubiquitin C-terminal hydrolase) family of enzymes.

17 was immunoprecipitated with NUB1 served as a ubiquitin C-terminal hydrolase for UbC1.

18 quence of UCH-L1 is similar to that of other ubiquitin C-terminal hydrolases, including the ubiquitou

19 the unfolded state of the 52-knotted protein ubiquitin C-terminal hydrolase isoenzyme L1 (UCH-L1) and

20 f glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) as day-of-inj

21 Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been wid

22 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiqui

23 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiqui

24 ifunctional molecule of the ubiquitin system ubiquitin C-terminal hydrolase L1 (UCH-L1) is induced in

25 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the

26 Ubiquitin C-terminal hydrolase L1 (UCH-L1), a blood-base

27 key mechanism mediating the deficit involves ubiquitin C-terminal hydrolase L1 (UCH-L1), a deubiquiti

28 h harbor a deletion within the gene encoding ubiquitin C-terminal hydrolase L1 (Uch-L1), display sens

29 We now show that a component of the pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required

30 A mutant of ubiquitin C-terminal hydrolase L1 (UCHL1) detected in ea

31 cantly increase the levels of Abeta, Tau and Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in mouse cereb

32 Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique br

33 al fibrillary acidic protein (GFAP), tau and ubiquitin c-terminal hydrolase L1 (UCHL1) were assessed

34 Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitin

35 amyloid-beta 1-42, neuropeptide Y (NPY), and ubiquitin C-terminal hydrolase L1 (UCHL1), whose CSF lev

36 ic enolase, glial fibrillary acidic protein, ubiquitin C-terminal hydrolase L1 [UCH-L1], neurofilamen

37 3% decrease; annexin VII, 8.8-fold increase; ubiquitin C-terminal hydrolase L1, 2.5-fold increase; AI

38 the ubiquitin-proteasome system, parkin and ubiquitin C-terminal hydrolase L1, are also associated w

39 associated with neurodegenerative diseases (ubiquitin C-terminal hydrolase L1, rat ortholog of human

40 lues, 0.34; 95% CI, 0.18-0.50; P < .001) and ubiquitin C-terminal hydrolase-L1 (mean difference in ln

41 f Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in a cohort o

42 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a highly e

43 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is linked to

44 The deubiquitinating enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) is required f

45 lenged by the linkage of the neuronal enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) to Parkinson'

46 We show that a deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1 (UCH-L1), is highly ex

47 asma glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), neurofilamen

48 asma glial fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase-L1 (UCH-L1), neurofilamen

49 Here we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the

50 Ubiquitin C-terminal hydrolase-L1 (UCHL1), a neuron-spec

51 Here, we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1), which we prev

52 ed included glial fibrillary acidic protein, ubiquitin C-terminal hydrolase-L1, neurofilament light c

53 Glial fibrillary acidic protein, ubiquitin c-terminal hydrolase-L1, S100 calcium binding

54 ription of the binding site on ubiquitin for ubiquitin C-terminal hydrolase L3 (UCH-L3).

55 in (KIAA0603), a novel protein AK000009, the ubiquitin C-terminal hydrolase L3 (UCHL3) and an F-box/P

56 The mouse Uch-L3 (ubiquitin C-terminal hydrolase L3) gene was mapped withi

57 Here, we identified ubiquitin C-terminal hydrolase like 5 (UCHL5), a deubiqu

58 However, p62 has homology neither with ubiquitin C-terminal hydrolases nor with the S5a subunit

59 This might allow the ubiquitin C-terminal hydrolase to hydrolyze UbC1, in ord

60 The ubiquitin C-terminal hydrolase UCH-L1 (PGP9.5) comprises

61 PGP9.5 (UCH-L1) is a member of the ubiquitin C-terminal hydrolase (UCH) family of proteins

62 e approach to tag active DUBs, we identified ubiquitin C-terminal hydrolase (UCH) isoform L3 as the p

63 The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been lin

64 esent study measured serum concentrations of ubiquitin C-terminal hydrolase (UCH-L1) and glial fibril

65 Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal hydrolase (UCH-L1) have been FDA-ap

66 f glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) levels became th

67 Ubiquitin C-terminal hydrolase (UCH-L1), also called neu

68 e crystal structure of the recombinant human Ubiquitin C-terminal Hydrolase (UCH-L3) by X-ray crystal

69 Ubiquitin C-terminal hydrolases (UCH's) are a newly-defi

70 Ubiquitin C-terminal hydrolases (UCH) are deubiquitinati

71 The human ubiquitin C-terminal hydrolase, UCH-L1, is an abundant n

72 report a novel interaction between Smads and ubiquitin C-terminal hydrolase UCH37, a deubiquitinating

73 members (USP4, USP15, USP11, and USP2), the ubiquitin C-terminal hydrolase UCHL3, and the Machado-Jo

74 d of K48 linkages, the proteasome-associated ubiquitin C-terminal hydrolase UCHL5/UCH37 serves as a p

75 Ubiquitin C-terminal hydrolases (UCHs) are a subset of d

76 Ubiquitin C-terminal hydrolases (UCHs) cleave Ub-X bonds

77 Ubiquitin C-terminal hydrolases (UCHs) comprise a family