コーパス検索結果 (１語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 easomal inhibitors and required a functional ubiquitin-activating enzyme.
2 rors its sequence conservation with the Uba1 ubiquitin-activating enzyme.
3 sequence homology to the N-terminal half of ubiquitin-activating enzyme.
4 similarity to the amino-terminal half of the ubiquitin-activating enzyme.
5 in a temperature-sensitive mutant of E1, the ubiquitin-activating enzyme.
6 is was reduced by inhibition or depletion of ubiquitin-activating enzymes.
7 which shares homology with the E1 family of ubiquitin-activating enzymes.
8 s associated with myeloid lineage-restricted ubiquitin-activating enzyme 1 (UBA1) somatic variations
10 of the ubiquitin system through blocking E1 (ubiquitin-activating enzyme) activity preferentially ind
11 nNOS with a purified system containing an E1 ubiquitin-activating enzyme, an E2 ubiquitin carrier pro
12 sine in an enzymatic cascade involving an E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating
14 cal evidence that it can function with an E1 ubiquitin-activating enzyme and E2 ubiquitin-conjugating
15 ure to blue light, upregulated the levels of ubiquitin-activating enzyme and increased conjugation ac
16 alysis in CHO-ts20 cells with a thermolabile ubiquitin-activating enzyme, and direct detection of ubi
17 T1 degradation, whereas the inhibition of E1 ubiquitin-activating enzyme by a specific inhibitor and
19 ted data on the X inactivation status of the ubiquitin activating enzyme E1 (UBE1) gene have been con
20 ct sequence and structural similarity to the ubiquitin activating enzyme E1 and the molybdopterin bio
21 n ubiquitination is mediated sequentially by ubiquitin activating enzyme E1, ubiquitin conjugating en
22 53, the viral oncogene protein pp60src, or a ubiquitin activating enzyme E1, were incubated at the no
25 (AXR1), which encodes the N-terminal half of ubiquitin-activating enzyme E1 and functions in auxin si
28 vels in living cells and the inactivation of ubiquitin-activating enzyme E1 does not prevent IPS degr
30 gnant progression, indicating that targeting ubiquitin-activating enzyme E1 homolog has therapeutic p
31 the ability of MLN7243, a recently described ubiquitin-activating enzyme E1 inhibitor, to block overa
32 pressing a thermally inactivated form of the ubiquitin-activating enzyme E1 or (ii) following express
33 present evidence that gigaxonin binds to the ubiquitin-activating enzyme E1 through its amino-termina
35 tion I (CFI) contained endogenous PCNA, RPA, ubiquitin-activating enzyme E1, and ubiquitin conjugase
36 bear a temperature-sensitive mutation in the ubiquitin-activating enzyme E1, at a nonpermissive tempe
37 esistant) protein, which has features of the ubiquitin-activating enzyme E1, is required for normal r
38 ch express a temperature-sensitive mutant of ubiquitin-activating enzyme E1, ubiquitination of IRS-1
39 predicted to encode a protein composed of a ubiquitin-activating enzyme E1-like domain and a Rhodane
41 yses previously revealed induction of UBE1L (ubiquitin-activating enzyme E1-like) after RA treatment
42 r example, loss-of-function mutations of the ubiquitin activating enzyme (E1) or proteasome subunits
44 h requires no eukaryotic proteins other than ubiquitin-activating enzyme (E1) and an ubiquitin-conjug
47 njugating enzymes (E2s) collaborate with the ubiquitin-activating enzyme (E1) and ubiquitin ligases (
48 malian cells and proposed that activities of ubiquitin-activating enzyme (E1) and ubiquitin-conjugati
50 ificity between ubiquitin and RUB1 and their ubiquitin-activating enzyme (E1) or E1-like activating e
51 utant cell line that contains a thermolabile ubiquitin-activating enzyme (E1) that is inactivated at
52 es a temperature sensitivity mutation in the ubiquitin-activating enzyme (E1) upon shift to the nonpe
54 ivation of a heterodimeric Aos1-Uba2 enzyme (ubiquitin-activating enzyme (E1)) followed by the conjug
55 DSB signals were shown to require ubiquitin, ubiquitin-activating enzyme (E1), a CUL-3-based ubiquiti
56 substrate involves four classes of enzymes:a ubiquitin-activating enzyme (E1), a ubiquitin-conjugatin
57 sequential action of three enzymes called a ubiquitin-activating enzyme (E1), a ubiquitin-conjugatin
58 quitin conjugation activity, the activity of ubiquitin-activating enzyme (E1), as determined by thiol
59 r IkappaB(alpha)(ee) ubiquitination over the ubiquitin-activating enzyme (E1), E2UBCH7, nonspecific u
60 ite the well-defined and central role of the ubiquitin-activating enzyme (E1), no cell permeable inhi
61 hree enzymes or protein complexes called the ubiquitin-activating enzyme (E1), the ubiquitin-conjugat
62 ee-enzyme cascade; the initial step requires ubiquitin-activating enzyme (E1), which couples ubiquiti
63 ch can be efficiently prepared by a one-pot, ubiquitin-activating enzyme (E1)-catalyzed condensation
66 ndent reductions in the levels of endogenous ubiquitin-activating enzyme (E1)-ubiquitin thiol esters
69 S is demonstrated by the presence of (i) the ubiquitin-activating enzyme (E1); (ii) four ubiquitin ca
70 with regard to the primary sequences of the ubiquitin-activating enzymes (E1), the three-dimensional
71 cess involves a cascade of enzymes including ubiquitin-activating enzymes (E1), ubiquitin-conjugating
73 g domain and catalytic site of the family of ubiquitin activating enzymes, E1 (UBA1, UBA2, and UBA3).
78 71 kDa protein similar to the C-terminus of ubiquitin-activating enzymes (E1s), and Aos1p (activatio
79 ed out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugatin
80 rocesses using four key enzyme families: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-carrier pro
81 the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating
86 Kinetic and equilibrium studies of the human ubiquitin-activating enzyme (HsUba1a) reveal that mutati
87 ng inactivation of the temperature-sensitive ubiquitin-activating enzyme, IkappaBalpha proteolysis oc
88 ne that contained a temperature-sensitive E1 ubiquitin-activating enzyme indicated that the degradati
90 iquitin coexpression and by mutations in the ubiquitin activating enzyme, indicating that their degra
91 be enhanced through combination therapy with ubiquitin-activating enzyme inhibitors or by specific in
93 ination, and here we show that inhibition of ubiquitin-activating enzymes reduces the processing of T
95 d by proteasome inhibitors and a mutation in ubiquitin-activating enzyme, suggesting that both UV-C a
96 ed cells in the absence of a functional host ubiquitin-activating enzyme, suggesting that viral entry
101 Somatically acquired mutations in the E1 ubiquitin-activating enzyme UBA1 within haematopoietic s
102 n the ubiquitylation machinery including the ubiquitin-activating enzyme Uba1, the ubiquitin--conjuga
105 Using this methodology, we identified the ubiquitin-activating enzyme UBA6 and the hybrid ubiquiti
106 monoubiquitination of LC3B catalyzed by the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugati
107 iated with incomplete phosphorylation of the ubiquitin activating enzyme Ube1, which is required for
108 nally, we demonstrate that inhibition of the ubiquitin-activating enzyme UBE1 by the small-molecule i
110 nt cell line, which expresses a thermolabile ubiquitin-activating enzyme, we observed a differential
111 erature-sensitive defect in the essential E1 ubiquitin-activating enzyme, we show that Id3 and the re
112 n several human cell lines by inhibiting the ubiquitin-activating enzyme with TAK243, there was an un
113 yndrome (vacuoles in myeloid progenitors, E1 ubiquitin activating enzyme, X-linked, autoinflammatory
114 Somatic mutations in UBA1 cause vacuoles, E1 ubiquitin-activating enzyme, X-linked, autoinflammatory